ATE23047T1 - Makrolide antibiotika-derivate modifiziert an position c-23. - Google Patents

Makrolide antibiotika-derivate modifiziert an position c-23.

Info

Publication number: ATE23047T1
Authority: AT; Austria
Prior art keywords: optionally substituted; alkanoyl; hydrogen; phenylacetyl; phenylpropionyl
Prior art date: 1982-07-19

Application number

AT83304153T

Other languages

English (en)

Inventor

Herbert Andrew Kirst

John Eldon Toth

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-07-19

Filing date

1983-07-18

Publication date

1986-11-15

1983-07-18 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

1986-11-15 Application granted granted Critical

1986-11-15 Publication of ATE23047T1 publication Critical patent/ATE23047T1/de

Links

230000003115 biocidal effect Effects 0.000 title 1
-1 -S-R4 Chemical group 0.000 abstract 11
229910052739 hydrogen Inorganic materials 0.000 abstract 5
239000001257 hydrogen Substances 0.000 abstract 5
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 5
125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 4
ZVOOGERIHVAODX-QWWGUZMMSA-N 2-[(4r,5s,6s,7r,9r,11e,13e,15r,16r)-6-[(2r,3r,4r,5r,6r)-5-[(2s,4r,5s,6s)-4,5-dihydroxy-4,6-dimethyloxan-2-yl]oxy-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-16-ethyl-4-hydroxy-15-(hydroxymethyl)-5,9,13-trimethyl-2,10-dioxo-1-oxacyclohexadeca-11,13-d Chemical class O=CC[C@H]1C[C@@H](C)C(=O)\C=C\C(\C)=C\[C@H](CO)[C@@H](CC)OC(=O)C[C@@H](O)[C@H](C)[C@H]1O[C@H]1[C@H](O)[C@@H](N(C)C)[C@@H](O[C@@H]2O[C@@H](C)[C@H](O)[C@](C)(O)C2)[C@@H](C)O1 ZVOOGERIHVAODX-QWWGUZMMSA-N 0.000 abstract 2
239000003242 anti bacterial agent Substances 0.000 abstract 2
229940088710 antibiotic agent Drugs 0.000 abstract 2
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
ZVOOGERIHVAODX-UHFFFAOYSA-N O-demycinosyltylosin Natural products O=CCC1CC(C)C(=O)C=CC(C)=CC(CO)C(CC)OC(=O)CC(O)C(C)C1OC1C(O)C(N(C)C)C(OC2OC(C)C(O)C(C)(O)C2)C(C)O1 ZVOOGERIHVAODX-UHFFFAOYSA-N 0.000 abstract 1
125000002252 acyl group Chemical group 0.000 abstract 1
125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
125000001246 bromo group Chemical group Br* 0.000 abstract 1
125000001309 chloro group Chemical group Cl* 0.000 abstract 1
125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 1
125000001153 fluoro group Chemical group F* 0.000 abstract 1
125000002541 furyl group Chemical group 0.000 abstract 1
125000001072 heteroaryl group Chemical group 0.000 abstract 1
125000002883 imidazolyl group Chemical group 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
125000002346 iodo group Chemical group I* 0.000 abstract 1
125000001786 isothiazolyl group Chemical group 0.000 abstract 1
125000000842 isoxazolyl group Chemical group 0.000 abstract 1
125000001715 oxadiazolyl group Chemical group 0.000 abstract 1
125000002971 oxazolyl group Chemical group 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
125000003373 pyrazinyl group Chemical group 0.000 abstract 1
125000003226 pyrazolyl group Chemical group 0.000 abstract 1
125000002098 pyridazinyl group Chemical group 0.000 abstract 1
JUJWROOIHBZHMG-UHFFFAOYSA-O pyridinium Chemical compound C1=CC=[NH+]C=C1 JUJWROOIHBZHMG-UHFFFAOYSA-O 0.000 abstract 1
125000004076 pyridyl group Chemical group 0.000 abstract 1
125000000714 pyrimidinyl group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000003831 tetrazolyl group Chemical group 0.000 abstract 1
125000001113 thiadiazolyl group Chemical group 0.000 abstract 1
125000000335 thiazolyl group Chemical group 0.000 abstract 1
125000001544 thienyl group Chemical group 0.000 abstract 1
125000004306 triazinyl group Chemical group 0.000 abstract 1
125000001425 triazolyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Communicable Diseases (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Oncology (AREA)
Animal Behavior & Ethology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Hydrogenated Pyridines (AREA)
Pyrane Compounds (AREA)
Steroid Compounds (AREA)
Train Traffic Observation, Control, And Security (AREA)
Emergency Protection Circuit Devices (AREA)
Liquid Crystal Substances (AREA)

AT83304153T 1982-07-19 1983-07-18 Makrolide antibiotika-derivate modifiziert an position c-23. ATE23047T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US06/399,656 US4452784A (en)	1982-07-19	1982-07-19	C-23-Modified derivatives of DMT
EP83304153A EP0099746B1 (de)	1982-07-19	1983-07-18	Makrolide Antibiotika-Derivate modifiziert an Position C-23

Publications (1)

Publication Number	Publication Date
ATE23047T1 true ATE23047T1 (de)	1986-11-15

Family

ID=23580425

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT83304153T ATE23047T1 (de)	1982-07-19	1983-07-18	Makrolide antibiotika-derivate modifiziert an position c-23.

Country Status (19)

Country	Link
US (1)	US4452784A (de)
EP (1)	EP0099746B1 (de)
JP (1)	JPS5931796A (de)
KR (1)	KR850000966B1 (de)
AT (1)	ATE23047T1 (de)
AU (1)	AU1693583A (de)
CA (1)	CA1202964A (de)
DD (1)	DD210059A5 (de)
DE (1)	DE3367104D1 (de)
DK (1)	DK330483D0 (de)
ES (1)	ES524197A0 (de)
FI (1)	FI832604A7 (de)
GB (1)	GB2123827B (de)
GR (1)	GR78387B (de)
NZ (1)	NZ204940A (de)
PH (1)	PH19727A (de)
PL (1)	PL243091A1 (de)
PT (1)	PT77040A (de)
ZA (1)	ZA835216B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS58219197A (ja) *	1982-06-15	1983-12-20	Sanraku Inc	マクロライド系抗生物質の誘導体
US4436729A (en) *	1982-06-30	1984-03-13	Schering Corporation	23-Demycinosyltylosin compounds, pharmaceutical compositions and method of use
US4629786A (en) *	1983-02-28	1986-12-16	Eli Lilly And Company	C-20- and C-23 modified macrolide derivatives
US4656258A (en) *	1983-03-03	1987-04-07	Eli Lilly And Company	Macrocin derivatives
JPS62103098A (ja) *	1985-05-13	1987-05-13	Microbial Chem Res Found	タイロシン誘導体
EP0292352A3 (de) *	1987-05-06	1988-12-28	Adir Et Compagnie	Makrolid-Derivate, Verfahren zu ihrer Herstellung und ihre pharmazeutischen Zusammensetzungen

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BE667952A (de) *	1964-08-05
US4358584A (en) *	1979-05-23	1982-11-09	Eli Lilly And Company	Antibiotics A6888C and A6888X
JPS56122397A (en) *	1980-02-29	1981-09-25	Satoshi Omura	Marcolides
US4321361A (en) *	1980-06-12	1982-03-23	Eli Lilly And Company	Demycinosyltylosin and process for its production
ZA813578B (en) *	1980-06-12	1983-01-26	Lilly Co Eli	Macrolide antibiotics
US4438109A (en) *	1980-07-25	1984-03-20	Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai	Tylosin derivatives
US4304856A (en) *	1980-11-10	1981-12-08	Eli Lilly And Company	Process for producing 20-dihydro-20-deoxy-23-demycinosyltylosin
US4341771A (en) *	1981-04-20	1982-07-27	Eli Lilly And Company	Method of controlling Pasteurella infections
US4341770A (en) *	1981-04-20	1982-07-27	Eli Lilly And Company	Method of controlling ureaplasma infections
AU551142B2 (en) *	1981-07-09	1986-04-17	Zaidan Hojin Biseibutsu Kagaku Kenkyukai	Tylosin derivatives
JPS58219197A (ja) *	1982-06-15	1983-12-20	Sanraku Inc	マクロライド系抗生物質の誘導体
US4436729A (en) *	1982-06-30	1984-03-13	Schering Corporation	23-Demycinosyltylosin compounds, pharmaceutical compositions and method of use

1982
- 1982-07-19 US US06/399,656 patent/US4452784A/en not_active Expired - Fee Related
1983
- 1983-07-18 GR GR71960A patent/GR78387B/el unknown
- 1983-07-18 DE DE8383304153T patent/DE3367104D1/de not_active Expired
- 1983-07-18 DK DK3304/83A patent/DK330483D0/da not_active Application Discontinuation
- 1983-07-18 ZA ZA835216A patent/ZA835216B/xx unknown
- 1983-07-18 AU AU16935/83A patent/AU1693583A/en not_active Abandoned
- 1983-07-18 CA CA000432587A patent/CA1202964A/en not_active Expired
- 1983-07-18 PT PT77040A patent/PT77040A/pt unknown
- 1983-07-18 KR KR1019830003274A patent/KR850000966B1/ko not_active Expired
- 1983-07-18 AT AT83304153T patent/ATE23047T1/de not_active IP Right Cessation
- 1983-07-18 EP EP83304153A patent/EP0099746B1/de not_active Expired
- 1983-07-18 JP JP58131793A patent/JPS5931796A/ja active Pending
- 1983-07-18 FI FI832604A patent/FI832604A7/fi not_active Application Discontinuation
- 1983-07-18 ES ES524197A patent/ES524197A0/es active Granted
- 1983-07-18 NZ NZ204940A patent/NZ204940A/en unknown
- 1983-07-18 GB GB08319306A patent/GB2123827B/en not_active Expired
- 1983-07-18 PH PH29239A patent/PH19727A/en unknown
- 1983-07-19 PL PL24309183A patent/PL243091A1/xx unknown
- 1983-07-19 DD DD83253195A patent/DD210059A5/de unknown

Also Published As

Publication number	Publication date
PT77040A (en)	1983-08-01
ES8504841A1 (es)	1985-05-01
KR840005462A (ko)	1984-11-12
GR78387B (de)	1984-09-26
NZ204940A (en)	1985-11-08
US4452784A (en)	1984-06-05
EP0099746B1 (de)	1986-10-22
DK330483D0 (da)	1983-07-18
PH19727A (en)	1986-06-17
GB2123827A (en)	1984-02-08
DE3367104D1 (en)	1986-11-27
ZA835216B (en)	1984-03-28
DD210059A5 (de)	1984-05-30
GB8319306D0 (en)	1983-08-17
FI832604A0 (fi)	1983-07-18
AU1693583A (en)	1984-01-26
ES524197A0 (es)	1985-05-01
EP0099746A1 (de)	1984-02-01
JPS5931796A (ja)	1984-02-20
GB2123827B (en)	1986-07-30
PL243091A1 (en)	1984-07-16
CA1202964A (en)	1986-04-08
FI832604A7 (fi)	1984-01-20
KR850000966B1 (ko)	1985-07-02

Legal Events

Date	Code	Title	Description
1987-03-15	UEP	Publication of translation of european patent specification
1991-04-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DK0580692T3 (da)	2003-12-08	Autoinducer
JPS5317340A (en)	1978-02-17	Recording device
MY106399A (en)	1995-05-30	Cephalosporins and homologeus, preparation and pharmaceutical composition
ATE25689T1 (de)	1987-03-15	5-0-mycaminosyl-tylonolide derivate, modifiziert an position c-23.
ATE23047T1 (de)	1986-11-15	Makrolide antibiotika-derivate modifiziert an position c-23.
EP0456118A3 (en)	1993-03-24	Cyclohexenonoximethers, process and intermediates for their preparation and their use as herbicides
HK52089A (en)	1989-07-07	7-beta-(alpha-syn-methoxyimino-alpha-(2-amino-thiazol-4-yl)acetamido)-3-((1,2,3-thiadiazol-5-ylthio)methyl)-3-cephem-4-carboxylic acid and c1-c6 alkyl derivatives thereof
IE45654L (en)	1978-02-26	7-[2-(substituted benzoyl amino) acetamido]-cephalosporins.
SU785016A1 (ru)	1980-12-07	Устройство дл реализации малых перемещений
DK227889A (da)	1989-11-11	Antibiotiske forbindelser og fremgangsmaade til fremstilling deraf
TW233244B (de)	1994-11-01
FR2235685A1 (en)	1975-01-31	1-Amino alkyl-3,3-diphenyl-2-pyrrolidinones - useful as coronary dilators, anti histamines choleretics etc.
SE8205482D0 (sv)	1982-09-24	Nya mellanprodukter for framstellning av antibakteriella cefalosporinsyror
JPS5467036A (en)	1979-05-30	Cephalosporin preparation for oral administration
DK164987D0 (da)	1987-03-31	Elektrisk drivkraftsystem for cykler, som bestaar af to modsatrettede elektriske motorer med permanet magnet, og som driver den samme centrale drivrulle
JPS5624683A (en)	1981-03-09	Recording device