PH19727A - C-23 modified derivatives of demycinosyltylosin - Google Patents

C-23 modified derivatives of demycinosyltylosin

Info

Publication number: PH19727A
Authority: PH; Philippines
Prior art keywords: optionally substituted; alkanoyl; hydrogen; phenylacetyl; phenylpropionyl
Prior art date: 1982-07-19

Application number

PH29239A

Other languages

English (en)

Inventor

Herbert Andrew Kirst

John Eldon Toth

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-07-19

Filing date

1983-07-18

Publication date

1986-06-17

1983-07-18 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

1986-06-17 Publication of PH19727A publication Critical patent/PH19727A/en

Links

ZVOOGERIHVAODX-QWWGUZMMSA-N 2-[(4r,5s,6s,7r,9r,11e,13e,15r,16r)-6-[(2r,3r,4r,5r,6r)-5-[(2s,4r,5s,6s)-4,5-dihydroxy-4,6-dimethyloxan-2-yl]oxy-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-16-ethyl-4-hydroxy-15-(hydroxymethyl)-5,9,13-trimethyl-2,10-dioxo-1-oxacyclohexadeca-11,13-d Chemical class O=CC[C@H]1C[C@@H](C)C(=O)\C=C\C(\C)=C\[C@H](CO)[C@@H](CC)OC(=O)C[C@@H](O)[C@H](C)[C@H]1O[C@H]1[C@H](O)[C@@H](N(C)C)[C@@H](O[C@@H]2O[C@@H](C)[C@H](O)[C@](C)(O)C2)[C@@H](C)O1 ZVOOGERIHVAODX-QWWGUZMMSA-N 0.000 title abstract 3
-1 -S-R4 Chemical group 0.000 abstract 11
229910052739 hydrogen Inorganic materials 0.000 abstract 5
239000001257 hydrogen Substances 0.000 abstract 5
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 5
125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 4
239000003242 anti bacterial agent Substances 0.000 abstract 2
229940088710 antibiotic agent Drugs 0.000 abstract 2
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
ZVOOGERIHVAODX-UHFFFAOYSA-N O-demycinosyltylosin Natural products O=CCC1CC(C)C(=O)C=CC(C)=CC(CO)C(CC)OC(=O)CC(O)C(C)C1OC1C(O)C(N(C)C)C(OC2OC(C)C(O)C(C)(O)C2)C(C)O1 ZVOOGERIHVAODX-UHFFFAOYSA-N 0.000 abstract 1
125000002252 acyl group Chemical group 0.000 abstract 1
125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
125000001246 bromo group Chemical group Br* 0.000 abstract 1
125000001309 chloro group Chemical group Cl* 0.000 abstract 1
125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 1
125000001153 fluoro group Chemical group F* 0.000 abstract 1
125000002541 furyl group Chemical group 0.000 abstract 1
125000001072 heteroaryl group Chemical group 0.000 abstract 1
125000002883 imidazolyl group Chemical group 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
125000002346 iodo group Chemical group I* 0.000 abstract 1
125000001786 isothiazolyl group Chemical group 0.000 abstract 1
125000000842 isoxazolyl group Chemical group 0.000 abstract 1
125000001715 oxadiazolyl group Chemical group 0.000 abstract 1
125000002971 oxazolyl group Chemical group 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
125000003373 pyrazinyl group Chemical group 0.000 abstract 1
125000003226 pyrazolyl group Chemical group 0.000 abstract 1
125000002098 pyridazinyl group Chemical group 0.000 abstract 1
JUJWROOIHBZHMG-UHFFFAOYSA-O pyridinium Chemical compound C1=CC=[NH+]C=C1 JUJWROOIHBZHMG-UHFFFAOYSA-O 0.000 abstract 1
125000004076 pyridyl group Chemical group 0.000 abstract 1
125000000714 pyrimidinyl group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000003831 tetrazolyl group Chemical group 0.000 abstract 1
125000001113 thiadiazolyl group Chemical group 0.000 abstract 1
125000000335 thiazolyl group Chemical group 0.000 abstract 1
125000001544 thienyl group Chemical group 0.000 abstract 1
125000004306 triazinyl group Chemical group 0.000 abstract 1
125000001425 triazolyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Communicable Diseases (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Oncology (AREA)
Animal Behavior & Ethology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Hydrogenated Pyridines (AREA)
Pyrane Compounds (AREA)
Liquid Crystal Substances (AREA)
Train Traffic Observation, Control, And Security (AREA)
Emergency Protection Circuit Devices (AREA)
Steroid Compounds (AREA)

PH29239A 1982-07-19 1983-07-18 C-23 modified derivatives of demycinosyltylosin PH19727A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US06/399,656 US4452784A (en)	1982-07-19	1982-07-19	C-23-Modified derivatives of DMT

Publications (1)

Publication Number	Publication Date
PH19727A true PH19727A (en)	1986-06-17

Family

ID=23580425

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PH29239A PH19727A (en)	1982-07-19	1983-07-18	C-23 modified derivatives of demycinosyltylosin

Country Status (19)

Country	Link
US (1)	US4452784A (de)
EP (1)	EP0099746B1 (de)
JP (1)	JPS5931796A (de)
KR (1)	KR850000966B1 (de)
AT (1)	ATE23047T1 (de)
AU (1)	AU1693583A (de)
CA (1)	CA1202964A (de)
DD (1)	DD210059A5 (de)
DE (1)	DE3367104D1 (de)
DK (1)	DK330483D0 (de)
ES (1)	ES8504841A1 (de)
FI (1)	FI832604A7 (de)
GB (1)	GB2123827B (de)
GR (1)	GR78387B (de)
NZ (1)	NZ204940A (de)
PH (1)	PH19727A (de)
PL (1)	PL243091A1 (de)
PT (1)	PT77040A (de)
ZA (1)	ZA835216B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS58219197A (ja) *	1982-06-15	1983-12-20	Sanraku Inc	マクロライド系抗生物質の誘導体
US4436729A (en) *	1982-06-30	1984-03-13	Schering Corporation	23-Demycinosyltylosin compounds, pharmaceutical compositions and method of use
US4629786A (en) *	1983-02-28	1986-12-16	Eli Lilly And Company	C-20- and C-23 modified macrolide derivatives
US4656258A (en) *	1983-03-03	1987-04-07	Eli Lilly And Company	Macrocin derivatives
JPS62103098A (ja) *	1985-05-13	1987-05-13	Microbial Chem Res Found	タイロシン誘導体
PT87417B (pt) *	1987-05-06	1992-08-31	Adir	Processo para a preparacao de novos compostos macrolidos

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BE667952A (de) *	1964-08-05
US4358584A (en) *	1979-05-23	1982-11-09	Eli Lilly And Company	Antibiotics A6888C and A6888X
JPS56122397A (en) *	1980-02-29	1981-09-25	Satoshi Omura	Marcolides
US4321361A (en) *	1980-06-12	1982-03-23	Eli Lilly And Company	Demycinosyltylosin and process for its production
ZA813578B (en) *	1980-06-12	1983-01-26	Lilly Co Eli	Macrolide antibiotics
US4438109A (en) *	1980-07-25	1984-03-20	Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai	Tylosin derivatives
US4304856A (en) *	1980-11-10	1981-12-08	Eli Lilly And Company	Process for producing 20-dihydro-20-deoxy-23-demycinosyltylosin
US4341771A (en) *	1981-04-20	1982-07-27	Eli Lilly And Company	Method of controlling Pasteurella infections
US4341770A (en) *	1981-04-20	1982-07-27	Eli Lilly And Company	Method of controlling ureaplasma infections
AU551142B2 (en) *	1981-07-09	1986-04-17	Zaidan Hojin Biseibutsu Kagaku Kenkyukai	Tylosin derivatives
JPS58219197A (ja) *	1982-06-15	1983-12-20	Sanraku Inc	マクロライド系抗生物質の誘導体
US4436729A (en) *	1982-06-30	1984-03-13	Schering Corporation	23-Demycinosyltylosin compounds, pharmaceutical compositions and method of use

1982
- 1982-07-19 US US06/399,656 patent/US4452784A/en not_active Expired - Fee Related
1983
- 1983-07-18 GR GR71960A patent/GR78387B/el unknown
- 1983-07-18 ZA ZA835216A patent/ZA835216B/xx unknown
- 1983-07-18 PT PT77040A patent/PT77040A/pt unknown
- 1983-07-18 DK DK3304/83A patent/DK330483D0/da not_active Application Discontinuation
- 1983-07-18 NZ NZ204940A patent/NZ204940A/en unknown
- 1983-07-18 PH PH29239A patent/PH19727A/en unknown
- 1983-07-18 KR KR1019830003274A patent/KR850000966B1/ko not_active Expired
- 1983-07-18 CA CA000432587A patent/CA1202964A/en not_active Expired
- 1983-07-18 FI FI832604A patent/FI832604A7/fi not_active Application Discontinuation
- 1983-07-18 DE DE8383304153T patent/DE3367104D1/de not_active Expired
- 1983-07-18 GB GB08319306A patent/GB2123827B/en not_active Expired
- 1983-07-18 EP EP83304153A patent/EP0099746B1/de not_active Expired
- 1983-07-18 AT AT83304153T patent/ATE23047T1/de not_active IP Right Cessation
- 1983-07-18 JP JP58131793A patent/JPS5931796A/ja active Pending
- 1983-07-18 ES ES524197A patent/ES8504841A1/es not_active Expired
- 1983-07-18 AU AU16935/83A patent/AU1693583A/en not_active Abandoned
- 1983-07-19 DD DD83253195A patent/DD210059A5/de unknown
- 1983-07-19 PL PL24309183A patent/PL243091A1/xx unknown

Also Published As

Publication number	Publication date
ES524197A0 (es)	1985-05-01
KR840005462A (ko)	1984-11-12
ES8504841A1 (es)	1985-05-01
EP0099746B1 (de)	1986-10-22
GB8319306D0 (en)	1983-08-17
AU1693583A (en)	1984-01-26
GB2123827A (en)	1984-02-08
GB2123827B (en)	1986-07-30
NZ204940A (en)	1985-11-08
US4452784A (en)	1984-06-05
DK330483D0 (da)	1983-07-18
GR78387B (de)	1984-09-26
ZA835216B (en)	1984-03-28
DD210059A5 (de)	1984-05-30
FI832604A7 (fi)	1984-01-20
ATE23047T1 (de)	1986-11-15
JPS5931796A (ja)	1984-02-20
DE3367104D1 (en)	1986-11-27
FI832604A0 (fi)	1983-07-18
KR850000966B1 (ko)	1985-07-02
PL243091A1 (en)	1984-07-16
PT77040A (en)	1983-08-01
EP0099746A1 (de)	1984-02-01
CA1202964A (en)	1986-04-08

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JPS5317340A (en)	1978-02-17	Recording device
MY106399A (en)	1995-05-30	Cephalosporins and homologeus, preparation and pharmaceutical composition
DE3369997D1 (en)	1987-04-09	C-23-modified derivatives of 5-0-mycaminosyl tylonolide
GB2123827B (en)	1986-07-30	C-23-modified deritives of dmt
JPS568286A (en)	1981-01-28	Printer control ststem at ribbon end detection
HK52089A (en)	1989-07-07	7-beta-(alpha-syn-methoxyimino-alpha-(2-amino-thiazol-4-yl)acetamido)-3-((1,2,3-thiadiazol-5-ylthio)methyl)-3-cephem-4-carboxylic acid and c1-c6 alkyl derivatives thereof
GR69915B (de)	1982-07-21
ATE11042T1 (de)	1985-01-15	N-substituierte 2-methylnaphthylamide, verfahren zu ihrer herstellung und diese enthaltende fungizide.
JPS5242032A (en)	1977-04-01	Data processing unit
ES461911A1 (es)	1978-12-01	Un procedimiento para la preparacion de nuevos compuestos antibioticos de cefalosporina.
JPS53139542A (en)	1978-12-05	Intermittent fixation method
SU785016A1 (ru)	1980-12-07	Устройство дл реализации малых перемещений
JPS5399943A (en)	1978-08-31	Drive method for optical system of copier
EP0484030A3 (en)	1992-08-12	Antibiotic c-3 cyclobutenedione substituted (1-carba)cephalosporin compounds, compositions, and methods of use thereof
JPS5394142A (en)	1978-08-17	Input/output control system
PT81446A (en)	1985-12-01	Cephalosporin antibiotics
JPS5432714A (en)	1979-03-10	Dc drive linear motor
IE45548L (en)	1978-01-13	Pyridazinyl thiomethyl cephalosporins.
JPS55101086A (en)	1980-08-01	Hydrauric control device of control rod driving mechanism
JPS5624683A (en)	1981-03-09	Recording device
DK164987D0 (da)	1987-03-31	Elektrisk drivkraftsystem for cykler, som bestaar af to modsatrettede elektriske motorer med permanet magnet, og som driver den samme centrale drivrulle
JPS57158696A (en)	1982-09-30	Driving of piezo-electric bimorph vibrator
JPS5282023A (en)	1977-07-08	Shift drive of print hammer