ATE230723T1 - N-(2-aryl-propionyl)sulfonamide und sie enthaltende pharmazeutische zubereitungen - Google Patents

N-(2-aryl-propionyl)sulfonamide und sie enthaltende pharmazeutische zubereitungen

Info

Publication number: ATE230723T1
Authority: AT; Austria
Prior art keywords: sulfonamides; propionyl; aryl; pharmaceutical preparations; preparations containing
Prior art date: 1998-10-23

Application number

AT99953824T

Other languages

English (en)

Inventor

Riccardo Bertini

Cinzia Bizzarri

Vilma Sabbatini

Stefano Porzio

Gianfranco Caselli

Marcello Allegretti

Maria Candida Cesta

Carmelo A Gandolfi

Marco Mantovanini

Francesco Colotta

Original Assignee

Dompe Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-10-23

Filing date

1999-10-14

Publication date

2003-01-15

1999-10-14 Application filed by Dompe Spa filed Critical Dompe Spa

2003-01-15 Application granted granted Critical

2003-01-15 Publication of ATE230723T1 publication Critical patent/ATE230723T1/de

Links

239000000825 pharmaceutical preparation Substances 0.000 title 1
229940124530 sulfonamide Drugs 0.000 title 1
150000003456 sulfonamides Chemical class 0.000 title 1
210000003622 mature neutrocyte Anatomy 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 1
230000002757 inflammatory effect Effects 0.000 abstract 1
210000000265 leukocyte Anatomy 0.000 abstract 1
230000002265 prevention Effects 0.000 abstract 1
230000007115 recruitment Effects 0.000 abstract 1
230000000451 tissue damage Effects 0.000 abstract 1
231100000827 tissue damage Toxicity 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
- C07C311/51—Y being a hydrogen or a carbon atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/32—Sulfur atoms
- C07D213/34—Sulfur atoms to which a second hetero atom is attached
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/70—Sulfur atoms
- C07D213/71—Sulfur atoms to which a second hetero atom is attached
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/22—Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Cardiology (AREA)
Rheumatology (AREA)
Heart & Thoracic Surgery (AREA)
Dermatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Pulmonology (AREA)
Pain & Pain Management (AREA)
Transplantation (AREA)
Physical Education & Sports Medicine (AREA)
Urology & Nephrology (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pyridine Compounds (AREA)

AT99953824T 1998-10-23 1999-10-14 N-(2-aryl-propionyl)sulfonamide und sie enthaltende pharmazeutische zubereitungen ATE230723T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT1998MI002280A IT1303249B1 (it)	1998-10-23	1998-10-23	Alcune n-(2-aril-propionil)-solfonammidi e preparazionifarmaceutiche che le contengono.
PCT/EP1999/007740 WO2000024710A1 (en)	1998-10-23	1999-10-14	N-(2-aryl-propionyl)-sulfonamides and pharmaceutical preparations containing them

Publications (1)

Publication Number	Publication Date
ATE230723T1 true ATE230723T1 (de)	2003-01-15

Family

ID=11380926

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99953824T ATE230723T1 (de)	1998-10-23	1999-10-14	N-(2-aryl-propionyl)sulfonamide und sie enthaltende pharmazeutische zubereitungen

Country Status (26)

Country	Link
US (2)	US6887903B1 (de)
EP (1)	EP1123276B1 (de)
JP (1)	JP4194761B2 (de)
KR (1)	KR100484370B1 (de)
CN (2)	CN100368394C (de)
AT (1)	ATE230723T1 (de)
AU (1)	AU769850B2 (de)
BR (1)	BRPI9914741B8 (de)
CA (1)	CA2347752C (de)
CZ (1)	CZ296434B6 (de)
DE (1)	DE69904852T2 (de)
DK (1)	DK1123276T3 (de)
EE (1)	EE04912B1 (de)
ES (1)	ES2190264T3 (de)
HK (1)	HK1041255B (de)
HU (1)	HU225107B1 (de)
IL (1)	IL142496A0 (de)
IT (1)	IT1303249B1 (de)
NO (1)	NO327537B1 (de)
NZ (2)	NZ511077A (de)
PL (1)	PL212210B1 (de)
PT (1)	PT1123276E (de)
RU (1)	RU2255084C2 (de)
SK (1)	SK286372B6 (de)
TR (1)	TR200101124T2 (de)
WO (1)	WO2000024710A1 (de)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1318466B1 (it) *	2000-04-14	2003-08-25	Dompe Spa	Ammidi di acidi r-2-(amminoaril)-propionici, utili nella prevenzionedell'attivazione leucocitaria.
ITMI20010206A1 (it) *	2001-02-02	2002-08-02	Dompe Spa	Uso della metansolfonammide di (r)-ibuprofene e dei suoi sali non tossici per la preparazione di medicamenti per il trattamento e la prevenz
ITMI20010395A1 (it)	2001-02-27	2002-08-27	Dompe Spa	Omega-amminoalchilammidi di acidi r-2-aril-propionici come inibitori della chemiotassi di cellule polimorfonucleate e mononucleate
AR037097A1 (es)	2001-10-05	2004-10-20	Novartis Ag	Compuestos acilsulfonamidas, composiciones farmaceuticas y el uso de dichos compuestos para la preparacion de un medicamento
ITMI20012434A1 (it)	2001-11-20	2003-05-20	Dompe Spa	Acidi 2-aril-propionici e composizioni farmaceutiche che li contengono
DK1581474T3 (da) *	2002-12-10	2008-12-08	Dompe Spa	Chirale arylketoner i behandlingen af neutrofilt afhængige inflammatoriske sygdomme
EP1457485A1 (de) *	2003-03-14	2004-09-15	Dompé S.P.A.	Sulfonsäuren, deren Derivate sowie sie enthaltenden pharmazeutischen Zubereitungen
US7271188B2 (en)	2003-06-12	2007-09-18	Chugai Seikayu Kabushiki Kaisha	Imidazolidine derivatives
HRP20090681T1 (hr) *	2004-03-23	2010-02-28	Dompe' S.P.A.	Derivati 2-fenilpropionske kiseline i farmaceutski pripravci koji ih sadrže
DE602004003673T2 (de) *	2004-03-25	2007-10-04	Dompe' Pha.R.Ma S.P.A.	Verwendung von N-(2-Aryl-propionyl)-sulfonamiden zur Behandlung von Rückenmarkverletzungen
KR101291483B1 (ko)	2004-12-15	2013-07-30	돔페 파르마 에스.피.에이.	2-아릴프로피온산 유도체 및 이들을 함유하는 제약학적조성물
CN101146764A (zh) *	2005-01-25	2008-03-19	冬姆佩制药股份公司	2-芳基丙酸衍生物的代谢产物及包含它们的药物组合物
JP5374157B2 (ja)	2005-11-24	2013-12-25	ドムペ・ファ．ル．マ・ソチエタ・ペル・アツィオーニ	（ｒ）−アリールアルキルアミノ誘導体類と、それらを含有する薬剤組成物
WO2010009212A1 (en) *	2008-07-17	2010-01-21	Schering Corporation	Niacin derivatives useful to treat metabolic syndromes
EP2166006A1 (de) *	2008-09-18	2010-03-24	Dompe' S.P.A.	2-Arylpropionsäuren und -Derivate und pharmazeutische Zusammensetzungen, die diese enthalten
EP2308484A1 (de)	2009-10-06	2011-04-13	Dompé S.p.a.	Hemmer von CXCRL1/2 als Adjuvanzien bei der Transplantation von Langerhans-Zellen
EP2308485A1 (de)	2009-10-06	2011-04-13	Dompé S.p.a.	Sulfonamide zur Diabetesprävention
CN103159650B (zh) *	2011-12-19	2016-04-20	天津市国际生物医药联合研究院	芳香杂环磺酰胺类化合物的制备及其应用
CN103159649B (zh) *	2011-12-19	2016-03-09	天津市国际生物医药联合研究院	磺酰胺类化合物的制备及其应用
CN103159652B (zh) *	2011-12-19	2016-06-08	天津市国际生物医药联合研究院	亚磺酰胺类化合物的制备及其应用
CN103172547B (zh) *	2011-12-20	2016-10-12	天津市国际生物医药联合研究院	磺酰胺衍生物的制备及其应用
CN103159674A (zh) *	2013-04-03	2013-06-19	苏州安诺生物医药技术有限公司	2-苯烷酰胺类化合物及其制备方法、药物组合物和用途
EP3402474B1 (de) *	2016-01-15	2021-07-21	Dompé farmaceutici S.p.A.	Il-8-inhibitoren zur verwendung bei der behandlung von durch chemotherapie ausgelöster peripherer neuropathie
WO2018067548A1 (en)	2016-10-03	2018-04-12	The Children's Medicial Center Corporation	Prevention and treatment of diabetic nephropathy
US10660909B2 (en)	2016-11-17	2020-05-26	Syntrix Biosystems Inc.	Method for treating cancer using chemokine antagonists
EP3409277A1 (de)	2017-05-30	2018-12-05	Dompé farmaceutici s.p.a.	Il-8-inhibitoren zur verwendung bei der behandlung und/oder prävention von bakteriellen sekundärinfektionen
EP3476390A1 (de)	2017-10-24	2019-05-01	Dompé farmaceutici S.p.A.	Il-8-inhibitoren zur verwendung bei der behandlung von sarkomen
WO2019165315A1 (en)	2018-02-23	2019-08-29	Syntrix Biosystems Inc.	Method for treating cancer using chemokine antagonists alone or in combination
EP3868368A1 (de)	2020-02-21	2021-08-25	Dompe' Farmaceutici S.P.A.	Inhibitor der aktivität von cxcl8 (interleukin-8) und corticosteroidkombination und pharmazeutische zusammensetzung und verwendung davon
EP3868369A1 (de)	2020-02-21	2021-08-25	Dompe' Farmaceutici S.P.A.	Cxcl8-inhibitor und pharmazeutische zusammensetzung davon zur verwendung in der behandlung von krebsbedingter ermüdung
US12636268B2 (en)	2020-03-26	2026-05-26	Dompe' Farmaceutici Spa	CXCL8 inhibitors for use in the treatment of COVID-19
EP4008325A1 (de)	2020-12-02	2022-06-08	Dompe' Farmaceutici S.P.A.	Cxcl8-inhibitoren zur verwendung bei der behandlung von covid-19
EP3884932A1 (de)	2020-03-26	2021-09-29	Dompe' Farmaceutici S.P.A.	Cxcl8-inhibitoren zur verwendung bei der behandlung von covid-19
CA3196979A1 (en) *	2020-11-05	2022-05-12	Icahn School Of Medicine At Mount Sinai	Cxcr1/cxcr2 inhibitors for use in treating myelofibrosis
EP4052702A1 (de)	2021-03-04	2022-09-07	Dompé farmaceutici S.p.a.	Cxcl8-inhibitor und dessen pharmazeutische zusammensetzung zur verwendung bei der behandlung von krampfanfällen
EP4397305A1 (de)	2023-01-05	2024-07-10	Dompe' Farmaceutici S.P.A.	Cxcl8-inhibitoren zur verwendung bei der behandlung von augenschleimhaut-pemphigoid und/oder mundschleimhaut-pemphigoid
EP4563594A1 (de)	2023-11-28	2025-06-04	Dompe' Farmaceutici SpA	Cxcl8-inhibitoren zur verwendung bei der behandlung von tumoren mit niedrigem stroma-cav1-gehalt
EP4678171A1 (de)	2024-07-10	2026-01-14	Dompé farmaceutici SpA	Systemisch verabreichte cxcl8-inhibitoren zur verwendung bei der vorbeugung oder behandlung von augenschleimhaut-pemphigoid und/oder mundschleimhaut-pemphigoid
EP4686469A1 (de)	2024-07-31	2026-02-04	Dompé farmaceutici SpA	Cxcl8-inhibitoren zur verwendung bei der behandlung von diabetes-assoziierten erkrankungen
EP4686472A1 (de)	2024-08-02	2026-02-04	Dompé farmaceutici SpA	Cxcl8-inhibitoren zur verwendung bei der behandlung von graft-versus-host-reaktion des auges

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4082707A (en) *	1973-01-08	1978-04-04	Societa Italo-Britannica L. Manetti-H. Roberts & Co.	2-(4-isobutylphenyl)-propiohydroxamic acid and a procedure for its preparation
JPS53111030A (en) *	1977-02-08	1978-09-28	Hisamitsu Pharmaceut Co Inc	Novel phenylacetic acid derivatives
US4786316A (en) *	1984-07-13	1988-11-22	E. I. Du Pont De Nemours And Company	Herbicidal ortho-sulfamoyl sulfonamides
US5006542A (en) *	1988-10-31	1991-04-09	E. R. Squibb & Sons, Inc.	Arylthioalkylphenyl carboxylic acids, derivatives thereof, compositions containing same and method of use
WO1992018641A1 (en) *	1991-04-10	1992-10-29	The Trustees Of Boston University	Interleukin-8 receptors and related molecules and methods
IL109431A (en) *	1993-05-14	2001-01-11	Warner Lambert Co	Pharmaceutical compositions containing n-acyl sulfamic acid esters (or thioesters), n-acyl sulfonamides, and n-sulfonyl carbamic acid esters (or thioesters), for regulating plasma cholesterol concentration, and certain such novel compounds
CN1192140A (zh) *	1995-08-04	1998-09-02	沃尼尔·朗伯公司	氨基磺酸衍生物、酰基磺酰氨或磺酰基氨基甲酸酯在制备降低脂蛋白水平的药物中的用途
CA2502764A1 (en)	1995-08-22	1997-03-06	Japan Tobacco Inc.	Amide compounds
WO1998007418A1 (en) *	1996-08-21	1998-02-26	Smithkline Beecham Corporation	Il-8 receptor antagonists
DK1270565T3 (da) *	1997-01-29	2004-10-04	Pfizer	4-substitueret furan-2-sulfonamid og dets anvendelse i fremstillingen af sulfonylurinstofderivater

1998
- 1998-10-23 IT IT1998MI002280A patent/IT1303249B1/it active IP Right Grant
1999
- 1999-10-14 KR KR10-2001-7004865A patent/KR100484370B1/ko not_active Expired - Lifetime
- 1999-10-14 CZ CZ20011441A patent/CZ296434B6/cs not_active IP Right Cessation
- 1999-10-14 PT PT99953824T patent/PT1123276E/pt unknown
- 1999-10-14 AT AT99953824T patent/ATE230723T1/de active
- 1999-10-14 HU HU0103793A patent/HU225107B1/hu unknown
- 1999-10-14 SK SK538-2001A patent/SK286372B6/sk not_active IP Right Cessation
- 1999-10-14 AU AU10375/00A patent/AU769850B2/en not_active Expired
- 1999-10-14 RU RU2001113733/04A patent/RU2255084C2/ru active
- 1999-10-14 DK DK99953824T patent/DK1123276T3/da active
- 1999-10-14 BR BRPI9914741-6 patent/BRPI9914741B8/pt not_active IP Right Cessation
- 1999-10-14 CN CNB998124516A patent/CN100368394C/zh not_active Expired - Lifetime
- 1999-10-14 US US09/830,075 patent/US6887903B1/en not_active Expired - Lifetime
- 1999-10-14 HK HK02102780.8A patent/HK1041255B/zh unknown
- 1999-10-14 TR TR2001/01124T patent/TR200101124T2/xx unknown
- 1999-10-14 EP EP99953824A patent/EP1123276B1/de not_active Expired - Lifetime
- 1999-10-14 PL PL347947A patent/PL212210B1/pl unknown
- 1999-10-14 CA CA002347752A patent/CA2347752C/en not_active Expired - Lifetime
- 1999-10-14 WO PCT/EP1999/007740 patent/WO2000024710A1/en not_active Ceased
- 1999-10-14 ES ES99953824T patent/ES2190264T3/es not_active Expired - Lifetime
- 1999-10-14 CN CNA2004100856352A patent/CN1615833A/zh active Pending
- 1999-10-14 DE DE69904852T patent/DE69904852T2/de not_active Expired - Lifetime
- 1999-10-14 NZ NZ511077A patent/NZ511077A/en not_active IP Right Cessation
- 1999-10-14 JP JP2000578281A patent/JP4194761B2/ja not_active Expired - Fee Related
- 1999-10-14 IL IL14249699A patent/IL142496A0/xx not_active IP Right Cessation
- 1999-10-14 EE EEP200100233A patent/EE04912B1/xx unknown
2001
- 2001-04-23 NO NO20012000A patent/NO327537B1/no not_active IP Right Cessation
2003
- 2003-04-01 NZ NZ525084A patent/NZ525084A/en not_active IP Right Cessation
- 2003-06-13 US US10/460,203 patent/US6881755B2/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
ITMI982280A0 (it)	1998-10-23
KR20010086435A (ko)	2001-09-12
SK286372B6 (sk)	2008-08-05
BRPI9914741A (pt)	2001-07-03
KR100484370B1 (ko)	2005-04-22
PL347947A1 (en)	2002-04-22
CZ296434B6 (cs)	2006-03-15
NO327537B1 (no)	2009-08-03
NO20012000D0 (no)	2001-04-23
NZ525084A (en)	2004-08-27
US6881755B2 (en)	2005-04-19
EE04912B1 (et)	2007-10-15
SK5382001A3 (en)	2001-12-03
JP4194761B2 (ja)	2008-12-10
BRPI9914741B1 (pt)	2012-11-27
EP1123276A1 (de)	2001-08-16
CN1615833A (zh)	2005-05-18
HK1041255A1 (zh)	2002-07-05
ES2190264T3 (es)	2003-07-16
NO20012000L (no)	2001-06-20
HUP0103793A2 (hu)	2002-03-28
DK1123276T3 (da)	2003-04-28
US20030216392A1 (en)	2003-11-20
HUP0103793A3 (en)	2003-09-29
DE69904852T2 (de)	2003-11-13
CA2347752A1 (en)	2000-05-04
US6887903B1 (en)	2005-05-03
TR200101124T2 (tr)	2001-10-22
PT1123276E (pt)	2003-04-30
NZ511077A (en)	2003-08-29
HU225107B1 (en)	2006-06-28
EP1123276B1 (de)	2003-01-08
PL212210B1 (pl)	2012-08-31
JP2002528434A (ja)	2002-09-03
IL142496A0 (en)	2002-03-10
DE69904852D1 (de)	2003-02-13
CA2347752C (en)	2009-12-22
ITMI982280A1 (it)	2000-04-23
CZ20011441A3 (cs)	2001-10-17
CN1324344A (zh)	2001-11-28
BRPI9914741B8 (pt)	2021-07-06
IT1303249B1 (it)	2000-11-06
HK1041255B (zh)	2008-07-18
CN100368394C (zh)	2008-02-13
EE200100233A (et)	2002-08-15
AU1037500A (en)	2000-05-15
RU2255084C2 (ru)	2005-06-27
WO2000024710A1 (en)	2000-05-04
AU769850B2 (en)	2004-02-05

Legal Events

Date

Code

Title

Description

2003-07-15

UEP

Publication of translation of european patent specification

Ref document number: 1123276

Country of ref document: EP

2007-03-15

EEIH

Change in the person of patent owner

Publication	Publication Date	Title
DE69904852D1 (de)	2003-02-13	N-(2-aryl-propionyl)sulfonamide und sie enthaltende pharmazeutische zubereitungen
DE69908819D1 (de)	2003-07-17	Glycopeptid-derivate und pharmazeutische zusammensetzungen, die sie enthalten
RU95101048A (ru)	1996-10-27	Производные пролинамида, фармкомпозиция на их основе
AU1497692A (en)	1992-10-29	Sulfonamides and their medical use
DE69811111D1 (de)	2003-03-06	Hydroxamsäure- und carbonsäurederivate mit mmp und tnf hemmender wirkung
BR0111639A (pt)	2003-03-25	Uso de uma molécula de ácido oligodeoxinucléico, e composição farmacêutica contendo a mesma
RU94022258A (ru)	1996-04-20	Новые сульфониламинопиримидины
CA2318145A1 (en)	1999-08-26	Sulfonylamino derivatives which inhibit matrix-degrading metalloproteinases
BR9808366A (pt)	2000-05-23	Derivados de ácido hidroxâmico substituìdo com aril ou heteroaril sulfonamidas; processo para sua preparação e seu uso como produtos farmacêuticos
CO4290432A1 (es)	1996-04-17	Nuevos derivados de pirazinacarboxamida, su preparacion y su utilizacion en medicamentos.
TNSN04034A1 (en)	2006-06-01	Combined preparations, containing 1,4-benzothiepine-1,1-dioxide derivatives and other active substances, and the use thereof
BR9711586A (pt)	1999-08-24	Compostos e uso dos mesmo
TR200000272T2 (tr)	2000-09-21	Antitümör ve antimetastaz maddeleri olarak o-ikameli hidrosikumaranon türevleri.
DE59200277D1 (de)	1994-08-18	Substituierte Diaminophthalimide und Analoga.
IT1302264B1 (it)	2000-09-05	Derivati a struttura n-acil vanillinamidica in grado di attivare irecettori periferici dei cannabinoidi
PT992509E (pt)	2004-12-31	Novos derivados macrolidos
TR199900661T2 (xx)	1999-06-21	Cilt enfeksiyonlar�n�n tedavisi amac�yla 1-hidroksi-2-piridonlar�n kullan�m�
DK0866791T3 (da)	2002-04-22	Diaminopyrimidiner, farmaceutiske præparater indeholdende disse og deres anvendelse som antibakterielle midler
DE69530988D1 (de)	2003-07-10	Benzimidazolderivate mit dopaminerger wirkung
UA48958C2 (uk)	2002-09-16	9-o-оксимові похідні еритроміцину а та фармацевтична композиція на їх основі
KR960703863A (ko)	1996-08-31	암 치료용 신규 비스-나프탈이미드(New Bis-naphthalimides for the Treatment of Cancer)
DK1073447T3 (da)	2007-09-03	N1-modificerede glycopeptider
TR200003451T2 (tr)	2001-04-20	Pirimidin-Aminometil-Piridin Türevleri, Hazırlanmaları ve helikobakter bakterinin kontrolünde kullanımları
RU95106652A (ru)	1996-12-10	Оптически активные производные карбоксамида, аналгезирующее средство
DE69910787D1 (de)	2003-10-02	Neuartige, pharmazeutisch aktive verbindung