EE200100233A - N-(2-arüülpropionüül)sulfoonamiidid, neid sisaldavad farmatseutilised kompositsioonid ning kasutamine inhibiitorina - Google Patents

N-(2-arüülpropionüül)sulfoonamiidid, neid sisaldavad farmatseutilised kompositsioonid ning kasutamine inhibiitorina

Info

Publication number: EE200100233A
Authority: EE; Estonia
Prior art keywords: arylpropionyl; sulfonamides; inhibitors; pharmaceutical compositions; compositions containing
Prior art date: 1998-10-23

Application number

EEP200100233A

Other languages

English (en)

Inventor

Bertini Riccardo

Bizzarri Cinzia

Sabbatini Vilma

Porzio Stefano

Caselli Gianfranco

Allegretti Marcello

Candida Cesta Maria

A. Gandolfi Carmelo

Mantovanini Marco

Colotta Francesco

Original Assignee

Domp S.P.A.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-10-23

Filing date

1999-10-14

Publication date

2002-08-15

1999-10-14 Application filed by Domp S.P.A. filed Critical Domp S.P.A.

2002-08-15 Publication of EE200100233A publication Critical patent/EE200100233A/et

2007-10-15 Publication of EE04912B1 publication Critical patent/EE04912B1/et

Links

239000003112 inhibitor Substances 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
229940124530 sulfonamide Drugs 0.000 title 1
150000003456 sulfonamides Chemical class 0.000 title 1
210000003622 mature neutrocyte Anatomy 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 1
230000002757 inflammatory effect Effects 0.000 abstract 1
210000000265 leukocyte Anatomy 0.000 abstract 1
230000002265 prevention Effects 0.000 abstract 1
230000007115 recruitment Effects 0.000 abstract 1
230000000451 tissue damage Effects 0.000 abstract 1
231100000827 tissue damage Toxicity 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
- C07C311/51—Y being a hydrogen or a carbon atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/32—Sulfur atoms
- C07D213/34—Sulfur atoms to which a second hetero atom is attached
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/70—Sulfur atoms
- C07D213/71—Sulfur atoms to which a second hetero atom is attached
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/22—Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

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Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Rheumatology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Dermatology (AREA)
Transplantation (AREA)
Pain & Pain Management (AREA)
Pulmonology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Urology & Nephrology (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pyridine Compounds (AREA)

EEP200100233A 1998-10-23 1999-10-14 N-(2-arlpropionl)sulfoonamiidid, neid sisaldavad farmatseutilised kompositsioonid ning kasutamine inhibiitorina EE04912B1 (et)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT1998MI002280A IT1303249B1 (it)	1998-10-23	1998-10-23	Alcune n-(2-aril-propionil)-solfonammidi e preparazionifarmaceutiche che le contengono.
PCT/EP1999/007740 WO2000024710A1 (en)	1998-10-23	1999-10-14	N-(2-aryl-propionyl)-sulfonamides and pharmaceutical preparations containing them

Publications (2)

Publication Number	Publication Date
EE200100233A true EE200100233A (et)	2002-08-15
EE04912B1 EE04912B1 (et)	2007-10-15

Family

ID=11380926

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EEP200100233A EE04912B1 (et)	1998-10-23	1999-10-14	N-(2-arlpropionl)sulfoonamiidid, neid sisaldavad farmatseutilised kompositsioonid ning kasutamine inhibiitorina

Country Status (26)

Country	Link
US (2)	US6887903B1 (et)
EP (1)	EP1123276B1 (et)
JP (1)	JP4194761B2 (et)
KR (1)	KR100484370B1 (et)
CN (2)	CN100368394C (et)
AT (1)	ATE230723T1 (et)
AU (1)	AU769850B2 (et)
BR (1)	BRPI9914741B8 (et)
CA (1)	CA2347752C (et)
CZ (1)	CZ296434B6 (et)
DE (1)	DE69904852T2 (et)
DK (1)	DK1123276T3 (et)
EE (1)	EE04912B1 (et)
ES (1)	ES2190264T3 (et)
HK (1)	HK1041255B (et)
HU (1)	HU225107B1 (et)
IL (1)	IL142496A0 (et)
IT (1)	IT1303249B1 (et)
NO (1)	NO327537B1 (et)
NZ (2)	NZ511077A (et)
PL (1)	PL212210B1 (et)
PT (1)	PT1123276E (et)
RU (1)	RU2255084C2 (et)
SK (1)	SK286372B6 (et)
TR (1)	TR200101124T2 (et)
WO (1)	WO2000024710A1 (et)

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IT1318466B1 (it) *	2000-04-14	2003-08-25	Dompe Spa	Ammidi di acidi r-2-(amminoaril)-propionici, utili nella prevenzionedell'attivazione leucocitaria.
ITMI20010206A1 (it) *	2001-02-02	2002-08-02	Dompe Spa	Uso della metansolfonammide di (r)-ibuprofene e dei suoi sali non tossici per la preparazione di medicamenti per il trattamento e la prevenz
ITMI20010395A1 (it)	2001-02-27	2002-08-27	Dompe Spa	Omega-amminoalchilammidi di acidi r-2-aril-propionici come inibitori della chemiotassi di cellule polimorfonucleate e mononucleate
AR037097A1 (es)	2001-10-05	2004-10-20	Novartis Ag	Compuestos acilsulfonamidas, composiciones farmaceuticas y el uso de dichos compuestos para la preparacion de un medicamento
ITMI20012434A1 (it)	2001-11-20	2003-05-20	Dompe Spa	Acidi 2-aril-propionici e composizioni farmaceutiche che li contengono
ES2312834T3 (es) *	2002-12-10	2009-03-01	Dompe S.P.A.	Arilcetonas quirales en el tratamiento de enfermedades inflamatorias dependientes de neutrofilos.
EP1457485A1 (en) *	2003-03-14	2004-09-15	Dompé S.P.A.	Sulfonic acids, their derivatives and pharmaceutical compositions containing them
JP4664814B2 (ja)	2003-06-12	2011-04-06	中外製薬株式会社	イミダゾリジン誘導体
PL1776336T3 (pl)	2004-03-23	2010-06-30	Dompe Farm Spa	Pochodne kwasu 2-fenylopropionowego i zawierające je kompozycje farmaceutyczne
DK1579859T3 (da) *	2004-03-25	2007-04-10	Dompe Pha R Ma Spa Res & Mfg	Anvendelse af N-(2-arylpropionyl)-sulfonamider til behandling af rygmarvsskader
CA2589495C (en)	2004-12-15	2013-10-01	Dompe Pha.R.Ma. S.P.A.	2-arylpropionic acid derivatives and pharmaceutical compositions containing them
EP1844001B1 (en) *	2005-01-25	2009-06-10	DOMPE' pha.r.ma s.p.a.	Metabolites of 2-arylpropionic acid derivatives and pharmaceutical compositions containing them
ES2597843T3 (es) *	2005-11-24	2017-01-23	Dompé Farmaceutici S.P.A.	Derivados de (R)-arilalquilamino y composiciones farmacéuticas que los contienen
WO2010009212A1 (en) *	2008-07-17	2010-01-21	Schering Corporation	Niacin derivatives useful to treat metabolic syndromes
EP2166006A1 (en) *	2008-09-18	2010-03-24	Dompe' S.P.A.	2-aryl-propionic acids and derivatives and pharmaceutical compositions containing them
EP2308485A1 (en)	2009-10-06	2011-04-13	Dompé S.p.a.	Sulfonamides for the prevention of diabetes
EP2308484A1 (en)	2009-10-06	2011-04-13	Dompé S.p.a.	Inhibitors of cxcr1/2 as adjuvants in the transplant of pancreatic islets
CN103159649B (zh) *	2011-12-19	2016-03-09	天津市国际生物医药联合研究院	磺酰胺类化合物的制备及其应用
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CN103159650B (zh) *	2011-12-19	2016-04-20	天津市国际生物医药联合研究院	芳香杂环磺酰胺类化合物的制备及其应用
CN103172547B (zh) *	2011-12-20	2016-10-12	天津市国际生物医药联合研究院	磺酰胺衍生物的制备及其应用
CN103159674A (zh) *	2013-04-03	2013-06-19	苏州安诺生物医药技术有限公司	2-苯烷酰胺类化合物及其制备方法、药物组合物和用途
PL3402474T3 (pl)	2016-01-15	2021-12-27	Dompé Farmaceutici S.P.A.	Inhibitory il-8 do zastosowania w leczeniu wywołanej chemioterapią neuropatii obwodowej
US11291641B2 (en)	2016-10-03	2022-04-05	The Children's Medical Center Corporation	Prevention and treatment of diabetic nephropathy
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WO2019165315A1 (en)	2018-02-23	2019-08-29	Syntrix Biosystems Inc.	Method for treating cancer using chemokine antagonists alone or in combination
EP3868369A1 (en)	2020-02-21	2021-08-25	Dompe' Farmaceutici S.P.A.	Cxcl8 inhibitor and pharmaceutical composition thereof for use in the treatment of cancer-related fatigue
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EP4008325A1 (en)	2020-12-02	2022-06-08	Dompe' Farmaceutici S.P.A.	Cxcl8 inhibitors for use in the treatment of covid-19
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1998
- 1998-10-23 IT IT1998MI002280A patent/IT1303249B1/it active IP Right Grant
1999
- 1999-10-14 JP JP2000578281A patent/JP4194761B2/ja not_active Expired - Fee Related
- 1999-10-14 CA CA002347752A patent/CA2347752C/en not_active Expired - Lifetime
- 1999-10-14 EE EEP200100233A patent/EE04912B1/et unknown
- 1999-10-14 SK SK538-2001A patent/SK286372B6/sk not_active IP Right Cessation
- 1999-10-14 TR TR2001/01124T patent/TR200101124T2/xx unknown
- 1999-10-14 HU HU0103793A patent/HU225107B1/hu unknown
- 1999-10-14 ES ES99953824T patent/ES2190264T3/es not_active Expired - Lifetime
- 1999-10-14 DK DK99953824T patent/DK1123276T3/da active
- 1999-10-14 CN CNB998124516A patent/CN100368394C/zh not_active Expired - Lifetime
- 1999-10-14 US US09/830,075 patent/US6887903B1/en not_active Expired - Lifetime
- 1999-10-14 DE DE69904852T patent/DE69904852T2/de not_active Expired - Lifetime
- 1999-10-14 PL PL347947A patent/PL212210B1/pl unknown
- 1999-10-14 CN CNA2004100856352A patent/CN1615833A/zh active Pending
- 1999-10-14 PT PT99953824T patent/PT1123276E/pt unknown
- 1999-10-14 KR KR10-2001-7004865A patent/KR100484370B1/ko not_active Expired - Lifetime
- 1999-10-14 BR BRPI9914741 patent/BRPI9914741B8/pt not_active IP Right Cessation
- 1999-10-14 RU RU2001113733/04A patent/RU2255084C2/ru active
- 1999-10-14 AT AT99953824T patent/ATE230723T1/de active
- 1999-10-14 IL IL14249699A patent/IL142496A0/xx not_active IP Right Cessation
- 1999-10-14 EP EP99953824A patent/EP1123276B1/en not_active Expired - Lifetime
- 1999-10-14 CZ CZ20011441A patent/CZ296434B6/cs not_active IP Right Cessation
- 1999-10-14 AU AU10375/00A patent/AU769850B2/en not_active Expired
- 1999-10-14 HK HK02102780.8A patent/HK1041255B/zh unknown
- 1999-10-14 NZ NZ511077A patent/NZ511077A/en not_active IP Right Cessation
- 1999-10-14 WO PCT/EP1999/007740 patent/WO2000024710A1/en not_active Ceased
2001
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2003
- 2003-04-01 NZ NZ525084A patent/NZ525084A/en not_active IP Right Cessation
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Publication number	Publication date
HK1041255A1 (zh)	2002-07-05
NO20012000D0 (no)	2001-04-23
RU2255084C2 (ru)	2005-06-27
BRPI9914741B1 (pt)	2012-11-27
US6881755B2 (en)	2005-04-19
IT1303249B1 (it)	2000-11-06
NO20012000L (no)	2001-06-20
EP1123276A1 (en)	2001-08-16
BRPI9914741B8 (pt)	2021-07-06
DK1123276T3 (da)	2003-04-28
CZ296434B6 (cs)	2006-03-15
KR20010086435A (ko)	2001-09-12
WO2000024710A1 (en)	2000-05-04
EP1123276B1 (en)	2003-01-08
ITMI982280A1 (it)	2000-04-23
HUP0103793A2 (hu)	2002-03-28
CN1324344A (zh)	2001-11-28
JP2002528434A (ja)	2002-09-03
AU769850B2 (en)	2004-02-05
IL142496A0 (en)	2002-03-10
CA2347752A1 (en)	2000-05-04
TR200101124T2 (tr)	2001-10-22
CN100368394C (zh)	2008-02-13
PL212210B1 (pl)	2012-08-31
SK286372B6 (sk)	2008-08-05
KR100484370B1 (ko)	2005-04-22
US6887903B1 (en)	2005-05-03
AU1037500A (en)	2000-05-15
DE69904852D1 (de)	2003-02-13
HK1041255B (zh)	2008-07-18
NO327537B1 (no)	2009-08-03
HU225107B1 (en)	2006-06-28
ITMI982280A0 (it)	1998-10-23
CZ20011441A3 (cs)	2001-10-17
SK5382001A3 (en)	2001-12-03
ES2190264T3 (es)	2003-07-16
HUP0103793A3 (en)	2003-09-29
US20030216392A1 (en)	2003-11-20
JP4194761B2 (ja)	2008-12-10
CN1615833A (zh)	2005-05-18
EE04912B1 (et)	2007-10-15
DE69904852T2 (de)	2003-11-13
BRPI9914741A (pt)	2001-07-03
NZ525084A (en)	2004-08-27
PL347947A1 (en)	2002-04-22
NZ511077A (en)	2003-08-29
CA2347752C (en)	2009-12-22
ATE230723T1 (de)	2003-01-15
PT1123276E (pt)	2003-04-30

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2009-02-16	KB4A	Valid patent at the end of a year	Effective date: 20081231
2011-02-15	KB4A	Valid patent at the end of a year	Effective date: 20101231
2015-09-15	GB1A	Change in the ownership or in the address of the owner

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EA200200938A1 (ru)	2003-02-27	Фармацевтические композиции, содержащие производные азетидина, новые производные азетидина и их получение
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MA27040A1 (fr)	2004-12-20	Nucleosides substitues en 4'
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ATE269312T1 (de)	2004-07-15	N-(amidinophenyl)-n'-(subst.)-3h-2,4- benzodiazepin-3-on derivative als faktor xa inhibitoren
ECSP045378A (es)	2004-11-26	Derivados novedosos de diazabiciclononeno
DE69933897D1 (de)	2006-12-14	Carbamat und Carbazat Ketolid Antibiotika
BR0307071A (pt)	2004-12-28	ésteres hidroxamato do ácido n-(fenil 4-substituìdo)-antranìlico
PT992509E (pt)	2004-12-31	Novos derivados macrolidos
ATE318810T1 (de)	2006-03-15	3-oxadiazol-5-yl-1-aminoalkyl-1h-indolderivate
IL140070A0 (en)	2002-02-10	Benzamide derivatives and pharmaceutical compositions containing the same
DE59903759D1 (de)	2003-01-23	Ektoparasitizide mittel
BR0212899A (pt)	2004-11-03	Compostos orgânicos
TR200001909T2 (tr)	2000-12-21	Matris metaloprotez inhibitörleri.
DE60225155D1 (de)	2008-04-03	3-substituierte 6,7-dihydroxytetrahydroisochinolin-derivate zur verwendung als antibkaterielle mittel
DE60005517D1 (de)	2003-10-30	Kaliumkanal-blockierende mittel
HRP20010885B1 (en)	2010-07-31	Ethanesulfonyl-piperidine derivatives
FR2707496B1 (fr)	1995-09-22	Compositions pharmaceutiques antiradicalaires et/ou antilipoperoxydantes et/ou hépatotropes.
DE59509727D1 (de)	2001-11-22	Uracilderivate
TR200402443T4 (tr)	2004-12-21	1-(4-hidroksifenil)-2- (4-hidroksi-4-fenilpiperidin-1-il)-1-propanol ve faydalı aracılar mesilat tuz trihidratlarının hazırlanması prosesi.