BRPI9914741B1 - n-(2-aril-proprionil)-sulfonamidas, usos e composições farmacêuticas contendo as mesmas. - Google Patents

n-(2-aril-proprionil)-sulfonamidas, usos e composições farmacêuticas contendo as mesmas.

Info

Publication number: BRPI9914741B1
Authority: BR; Brazil
Prior art keywords: proprionyl; sulfonamides; aryl; pharmaceutical compositions; compositions containing
Prior art date: 1998-10-23

Application number

BRPI9914741-6A

Other languages

English (en)

Inventor

Riccardo Bertini

Cinzia Bizzarri

Vilma Sabbatini

Stefano Porzio

Gianfranco Caselli

Marcello Allegretti

Maria Candida Cesta

Carmelo A Gandolfi

Marco Mantovanini

Francesco Colotta

Original Assignee

Dompe Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-10-23

Filing date

1999-10-14

Publication date

2012-11-27

1999-10-14 Application filed by Dompe Spa filed Critical Dompe Spa

2001-07-03 Publication of BRPI9914741A publication Critical patent/BRPI9914741A/pt

2012-11-27 Publication of BRPI9914741B1 publication Critical patent/BRPI9914741B1/pt

2021-07-06 Publication of BRPI9914741B8 publication Critical patent/BRPI9914741B8/pt

Links

239000008194 pharmaceutical composition Substances 0.000 title 1
229940124530 sulfonamide Drugs 0.000 title 1
210000003622 mature neutrocyte Anatomy 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 1
230000002757 inflammatory effect Effects 0.000 abstract 1
210000000265 leukocyte Anatomy 0.000 abstract 1
230000002265 prevention Effects 0.000 abstract 1
230000007115 recruitment Effects 0.000 abstract 1
230000000451 tissue damage Effects 0.000 abstract 1
231100000827 tissue damage Toxicity 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
- C07C311/51—Y being a hydrogen or a carbon atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/32—Sulfur atoms
- C07D213/34—Sulfur atoms to which a second hetero atom is attached
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/70—Sulfur atoms
- C07D213/71—Sulfur atoms to which a second hetero atom is attached
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/22—Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

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Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Rheumatology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Dermatology (AREA)
Transplantation (AREA)
Pain & Pain Management (AREA)
Pulmonology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Urology & Nephrology (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pyridine Compounds (AREA)

BRPI9914741 1998-10-23 1999-10-14 n-(2-aril-proprionil)-sulfonamidas, usos e composições farmacêuticas contendo as mesmas. BRPI9914741B8 (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT1998MI002280A IT1303249B1 (it)	1998-10-23	1998-10-23	Alcune n-(2-aril-propionil)-solfonammidi e preparazionifarmaceutiche che le contengono.
PCT/EP1999/007740 WO2000024710A1 (en)	1998-10-23	1999-10-14	N-(2-aryl-propionyl)-sulfonamides and pharmaceutical preparations containing them

Publications (3)

Publication Number	Publication Date
BRPI9914741A BRPI9914741A (pt)	2001-07-03
BRPI9914741B1 true BRPI9914741B1 (pt)	2012-11-27
BRPI9914741B8 BRPI9914741B8 (pt)	2021-07-06

Family

ID=11380926

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI9914741 BRPI9914741B8 (pt)	1998-10-23	1999-10-14	n-(2-aril-proprionil)-sulfonamidas, usos e composições farmacêuticas contendo as mesmas.

Country Status (26)

Country	Link
US (2)	US6887903B1 (pt)
EP (1)	EP1123276B1 (pt)
JP (1)	JP4194761B2 (pt)
KR (1)	KR100484370B1 (pt)
CN (2)	CN100368394C (pt)
AT (1)	ATE230723T1 (pt)
AU (1)	AU769850B2 (pt)
BR (1)	BRPI9914741B8 (pt)
CA (1)	CA2347752C (pt)
CZ (1)	CZ296434B6 (pt)
DE (1)	DE69904852T2 (pt)
DK (1)	DK1123276T3 (pt)
EE (1)	EE04912B1 (pt)
ES (1)	ES2190264T3 (pt)
HK (1)	HK1041255B (pt)
HU (1)	HU225107B1 (pt)
IL (1)	IL142496A0 (pt)
IT (1)	IT1303249B1 (pt)
NO (1)	NO327537B1 (pt)
NZ (2)	NZ511077A (pt)
PL (1)	PL212210B1 (pt)
PT (1)	PT1123276E (pt)
RU (1)	RU2255084C2 (pt)
SK (1)	SK286372B6 (pt)
TR (1)	TR200101124T2 (pt)
WO (1)	WO2000024710A1 (pt)

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IT1318466B1 (it) *	2000-04-14	2003-08-25	Dompe Spa	Ammidi di acidi r-2-(amminoaril)-propionici, utili nella prevenzionedell'attivazione leucocitaria.
ITMI20010206A1 (it) *	2001-02-02	2002-08-02	Dompe Spa	Uso della metansolfonammide di (r)-ibuprofene e dei suoi sali non tossici per la preparazione di medicamenti per il trattamento e la prevenz
ITMI20010395A1 (it)	2001-02-27	2002-08-27	Dompe Spa	Omega-amminoalchilammidi di acidi r-2-aril-propionici come inibitori della chemiotassi di cellule polimorfonucleate e mononucleate
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ITMI20012434A1 (it)	2001-11-20	2003-05-20	Dompe Spa	Acidi 2-aril-propionici e composizioni farmaceutiche che li contengono
ES2312834T3 (es) *	2002-12-10	2009-03-01	Dompe S.P.A.	Arilcetonas quirales en el tratamiento de enfermedades inflamatorias dependientes de neutrofilos.
EP1457485A1 (en) *	2003-03-14	2004-09-15	Dompé S.P.A.	Sulfonic acids, their derivatives and pharmaceutical compositions containing them
JP4664814B2 (ja)	2003-06-12	2011-04-06	中外製薬株式会社	イミダゾリジン誘導体
PL1776336T3 (pl)	2004-03-23	2010-06-30	Dompe Farm Spa	Pochodne kwasu 2-fenylopropionowego i zawierające je kompozycje farmaceutyczne
DK1579859T3 (da) *	2004-03-25	2007-04-10	Dompe Pha R Ma Spa Res & Mfg	Anvendelse af N-(2-arylpropionyl)-sulfonamider til behandling af rygmarvsskader
CA2589495C (en)	2004-12-15	2013-10-01	Dompe Pha.R.Ma. S.P.A.	2-arylpropionic acid derivatives and pharmaceutical compositions containing them
EP1844001B1 (en) *	2005-01-25	2009-06-10	DOMPE' pha.r.ma s.p.a.	Metabolites of 2-arylpropionic acid derivatives and pharmaceutical compositions containing them
ES2597843T3 (es) *	2005-11-24	2017-01-23	Dompé Farmaceutici S.P.A.	Derivados de (R)-arilalquilamino y composiciones farmacéuticas que los contienen
WO2010009212A1 (en) *	2008-07-17	2010-01-21	Schering Corporation	Niacin derivatives useful to treat metabolic syndromes
EP2166006A1 (en) *	2008-09-18	2010-03-24	Dompe' S.P.A.	2-aryl-propionic acids and derivatives and pharmaceutical compositions containing them
EP2308485A1 (en)	2009-10-06	2011-04-13	Dompé S.p.a.	Sulfonamides for the prevention of diabetes
EP2308484A1 (en)	2009-10-06	2011-04-13	Dompé S.p.a.	Inhibitors of cxcr1/2 as adjuvants in the transplant of pancreatic islets
CN103159649B (zh) *	2011-12-19	2016-03-09	天津市国际生物医药联合研究院	磺酰胺类化合物的制备及其应用
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CN103159650B (zh) *	2011-12-19	2016-04-20	天津市国际生物医药联合研究院	芳香杂环磺酰胺类化合物的制备及其应用
CN103172547B (zh) *	2011-12-20	2016-10-12	天津市国际生物医药联合研究院	磺酰胺衍生物的制备及其应用
CN103159674A (zh) *	2013-04-03	2013-06-19	苏州安诺生物医药技术有限公司	2-苯烷酰胺类化合物及其制备方法、药物组合物和用途
PL3402474T3 (pl)	2016-01-15	2021-12-27	Dompé Farmaceutici S.P.A.	Inhibitory il-8 do zastosowania w leczeniu wywołanej chemioterapią neuropatii obwodowej
US11291641B2 (en)	2016-10-03	2022-04-05	The Children's Medical Center Corporation	Prevention and treatment of diabetic nephropathy
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WO2019165315A1 (en)	2018-02-23	2019-08-29	Syntrix Biosystems Inc.	Method for treating cancer using chemokine antagonists alone or in combination
EP3868369A1 (en)	2020-02-21	2021-08-25	Dompe' Farmaceutici S.P.A.	Cxcl8 inhibitor and pharmaceutical composition thereof for use in the treatment of cancer-related fatigue
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EP3884932A1 (en)	2020-03-26	2021-09-29	Dompe' Farmaceutici S.P.A.	Cxcl8 inhibitors for use in the treatment of covid-19
EP4008325A1 (en)	2020-12-02	2022-06-08	Dompe' Farmaceutici S.P.A.	Cxcl8 inhibitors for use in the treatment of covid-19
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1998
- 1998-10-23 IT IT1998MI002280A patent/IT1303249B1/it active IP Right Grant
1999
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- 1999-10-14 CA CA002347752A patent/CA2347752C/en not_active Expired - Lifetime
- 1999-10-14 EE EEP200100233A patent/EE04912B1/xx unknown
- 1999-10-14 SK SK538-2001A patent/SK286372B6/sk not_active IP Right Cessation
- 1999-10-14 TR TR2001/01124T patent/TR200101124T2/xx unknown
- 1999-10-14 HU HU0103793A patent/HU225107B1/hu unknown
- 1999-10-14 ES ES99953824T patent/ES2190264T3/es not_active Expired - Lifetime
- 1999-10-14 DK DK99953824T patent/DK1123276T3/da active
- 1999-10-14 CN CNB998124516A patent/CN100368394C/zh not_active Expired - Lifetime
- 1999-10-14 US US09/830,075 patent/US6887903B1/en not_active Expired - Lifetime
- 1999-10-14 DE DE69904852T patent/DE69904852T2/de not_active Expired - Lifetime
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- 1999-10-14 CN CNA2004100856352A patent/CN1615833A/zh active Pending
- 1999-10-14 PT PT99953824T patent/PT1123276E/pt unknown
- 1999-10-14 KR KR10-2001-7004865A patent/KR100484370B1/ko not_active Expired - Lifetime
- 1999-10-14 BR BRPI9914741 patent/BRPI9914741B8/pt not_active IP Right Cessation
- 1999-10-14 RU RU2001113733/04A patent/RU2255084C2/ru active
- 1999-10-14 AT AT99953824T patent/ATE230723T1/de active
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- 1999-10-14 AU AU10375/00A patent/AU769850B2/en not_active Expired
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- 1999-10-14 WO PCT/EP1999/007740 patent/WO2000024710A1/en not_active Ceased
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2003
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Publication number	Publication date
HK1041255A1 (zh)	2002-07-05
EE200100233A (et)	2002-08-15
NO20012000D0 (no)	2001-04-23
RU2255084C2 (ru)	2005-06-27
US6881755B2 (en)	2005-04-19
IT1303249B1 (it)	2000-11-06
NO20012000L (no)	2001-06-20
EP1123276A1 (en)	2001-08-16
BRPI9914741B8 (pt)	2021-07-06
DK1123276T3 (da)	2003-04-28
CZ296434B6 (cs)	2006-03-15
KR20010086435A (ko)	2001-09-12
WO2000024710A1 (en)	2000-05-04
EP1123276B1 (en)	2003-01-08
ITMI982280A1 (it)	2000-04-23
HUP0103793A2 (hu)	2002-03-28
CN1324344A (zh)	2001-11-28
JP2002528434A (ja)	2002-09-03
AU769850B2 (en)	2004-02-05
IL142496A0 (en)	2002-03-10
CA2347752A1 (en)	2000-05-04
TR200101124T2 (tr)	2001-10-22
CN100368394C (zh)	2008-02-13
PL212210B1 (pl)	2012-08-31
SK286372B6 (sk)	2008-08-05
KR100484370B1 (ko)	2005-04-22
US6887903B1 (en)	2005-05-03
AU1037500A (en)	2000-05-15
DE69904852D1 (de)	2003-02-13
HK1041255B (zh)	2008-07-18
NO327537B1 (no)	2009-08-03
HU225107B1 (en)	2006-06-28
ITMI982280A0 (it)	1998-10-23
CZ20011441A3 (cs)	2001-10-17
SK5382001A3 (en)	2001-12-03
ES2190264T3 (es)	2003-07-16
HUP0103793A3 (en)	2003-09-29
US20030216392A1 (en)	2003-11-20
JP4194761B2 (ja)	2008-12-10
CN1615833A (zh)	2005-05-18
EE04912B1 (et)	2007-10-15
DE69904852T2 (de)	2003-11-13
BRPI9914741A (pt)	2001-07-03
NZ525084A (en)	2004-08-27
PL347947A1 (en)	2002-04-22
NZ511077A (en)	2003-08-29
CA2347752C (en)	2009-12-22
ATE230723T1 (de)	2003-01-15
PT1123276E (pt)	2003-04-30

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2012-11-27	B16A	Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]	Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 27/11/2012, MEDIANTE O RECOLHIMENTO DA TAXA QUINQUENAL DE MANUTENCAO (ARTIGOS 119 E 120 DA LPI) E OBSERVADAS AS DEMAIS CONDICOES LEGAIS.
2016-05-31	B25A	Requested transfer of rights approved
2021-07-06	B16C	Correction of notification of the grant [chapter 16.3 patent gazette]	Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 14/10/99, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF, QUE DETERMINA A ALTERACAO DO PRAZO DE CONCESSAO
2022-08-09	B21F	Lapse acc. art. 78, item iv - on non-payment of the annual fees in time	Free format text: REFERENTE A 23A ANUIDADE.
2022-11-29	B24J	Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)	Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2692 DE 09-08-2022 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.

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