ATE236906T1 - Zyklische polyamine - Google Patents

Zyklische polyamine

Info

Publication number
ATE236906T1
ATE236906T1 AT95904653T AT95904653T ATE236906T1 AT E236906 T1 ATE236906 T1 AT E236906T1 AT 95904653 T AT95904653 T AT 95904653T AT 95904653 T AT95904653 T AT 95904653T AT E236906 T1 ATE236906 T1 AT E236906T1
Authority
AT
Austria
Prior art keywords
pct
sec
polyamine
date
cyclic
Prior art date
Application number
AT95904653T
Other languages
English (en)
Inventor
Gary James Bridger
Sreenivasan Padmanabhan
Renato Tony Skerlj
Original Assignee
Anormed Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Anormed Inc filed Critical Anormed Inc
Application granted granted Critical
Publication of ATE236906T1 publication Critical patent/ATE236906T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Lubricants (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Biological Depolymerization Polymers (AREA)
AT95904653T 1994-01-11 1995-01-06 Zyklische polyamine ATE236906T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9400411A GB9400411D0 (en) 1994-01-11 1994-01-11 Improvements in chemical compounds
PCT/GB1995/000019 WO1995018808A1 (en) 1994-01-11 1995-01-06 Cyclic polyamines

Publications (1)

Publication Number Publication Date
ATE236906T1 true ATE236906T1 (de) 2003-04-15

Family

ID=10748627

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95904653T ATE236906T1 (de) 1994-01-11 1995-01-06 Zyklische polyamine

Country Status (14)

Country Link
US (1) US5698546A (de)
EP (1) EP0739345B1 (de)
JP (1) JP3749253B2 (de)
AT (1) ATE236906T1 (de)
AU (1) AU681478B2 (de)
CA (1) CA2179530C (de)
DE (1) DE69530281T2 (de)
ES (1) ES2191699T3 (de)
FI (1) FI962810A0 (de)
GB (1) GB9400411D0 (de)
HU (1) HU219238B (de)
NO (1) NO309680B1 (de)
NZ (1) NZ277859A (de)
WO (1) WO1995018808A1 (de)

Families Citing this family (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6506770B1 (en) * 1996-06-06 2003-01-14 Anormed, Inc. Antiviral compounds
GB9511357D0 (en) * 1995-06-06 1995-08-02 Johnson Matthey Plc Improved antiviral compounds
US6365583B1 (en) 1999-02-02 2002-04-02 Anormed, Inc. Methods to enhance white blood cell count
US6750348B1 (en) 1999-03-24 2004-06-15 Anormed, Inc. Chemokine receptor binding heterocyclic compounds
AP1654A (en) * 1999-03-24 2006-09-01 Anormed Inc Chemokine receptor binding heterocyclic compounds.
WO2001044229A1 (en) * 1999-12-17 2001-06-21 Anormed Inc. Chemokine receptor binding heterocyclic compounds
US6864265B2 (en) * 2000-09-15 2005-03-08 Anormed, Inc. Chemokine receptor binding heterocyclic compounds
DK1317451T3 (da) 2000-09-15 2006-12-18 Anormed Inc Kemokinreceptorbindende heterocykliske forbindelser
MXPA03002325A (es) * 2000-09-15 2003-06-24 Anormed Inc Compuestos heterociclicos que se unen a receptor de quimiocina.
MXPA03002772A (es) 2000-09-29 2003-07-28 Anormed Inc Procedimiento para la preparacion de poliaminas ciclicas que contienen nitrogeno en el anillo n-1 protegidos y productos de los mismos.
JP5137288B2 (ja) * 2001-07-31 2013-02-06 アノーメッド インコーポレイティド 前駆／幹細胞を動員する方法
US7169750B2 (en) * 2001-07-31 2007-01-30 Anormed, Inc. Methods to mobilize progenitor/stem cells
PL372705A1 (en) * 2001-09-12 2005-07-25 Anormed Inc. Synthesis of enantiomerically pure amino-substituted fused bicyclic rings
CN1596255A (zh) 2001-12-21 2005-03-16 阿诺麦德股份有限公司 具有强效的与趋化因子受体结合的杂环化合物
US7354932B2 (en) * 2001-12-21 2008-04-08 Anormed, Inc. Chemokine receptor binding heterocyclic compounds with enhanced efficacy
CA2520259A1 (en) 2003-04-11 2004-10-28 Anormed Inc. Cxcr4 chemokine receptor binding compounds
US7501518B2 (en) * 2003-04-22 2009-03-10 Genzyme Corporation Methods of making 2,6-diaryl piperidine derivatives
CA2517077C (en) * 2003-04-22 2013-03-12 Anormed Inc. Chemokine receptor binding heterocyclic compounds with enhanced efficacy
WO2005059107A2 (en) 2003-12-11 2005-06-30 Anormed Inc. Chemokine receptor binding compounds
US7498346B2 (en) * 2003-12-11 2009-03-03 Genzyme Corporation Chemokine receptor binding compounds
WO2005090308A1 (en) * 2004-03-15 2005-09-29 Anormed, Inc. Process for the synthesis of a cxcr4 antagonist
EP1796716A4 (de) * 2004-08-13 2010-09-08 Anormed Inc Chemokin-kombinationen zur mobilisierung von vorläufer/stammzellen
TW200619206A (en) * 2004-09-29 2006-06-16 Anormed Inc Chemokine-binding heterocyclic compound salts, and methods of use thereof
WO2006138350A2 (en) * 2005-06-15 2006-12-28 Anormed Inc. Chemokine receptor binding compounds
EP1924265A4 (de) * 2005-08-16 2010-06-02 Genzyme Corp Chemokinrezeptor-bindende verbindungen
CA2619828A1 (en) 2005-08-19 2007-02-22 Genzyme Corporation Methods to enhance chemotherapy
AU2006340074A1 (en) 2006-02-24 2007-09-20 Genzyme Corporation Methods for increasing blood flow and/or promoting tissue regeneration
MX2009001445A (es) * 2006-08-07 2009-02-18 Genzyme Corp Terapia de combinacion.
WO2009114614A2 (en) * 2008-03-11 2009-09-17 Yale University Compositions and methods for controlled delivery of inhibitory ribonucleic acids
US9822364B2 (en) 2008-03-11 2017-11-21 Yale University Compositions and methods for controlled delivery of inhibitory ribonucleic acids
US20150030561A1 (en) 2011-05-16 2015-01-29 Genzyme Corp. Use of CXCR4 Antagonists
US10465042B2 (en) 2011-12-02 2019-11-05 Yale University Poly(amine-co-ester) nanoparticles and methods of use thereof
US9895451B2 (en) 2011-12-02 2018-02-20 Yale University Formulations for targeted release of agents to low pH tissue environments or cellular compartments and methods of use thereof
WO2013082529A1 (en) 2011-12-02 2013-06-06 Yale University Enzymatic synthesis of poly(amine-co-esters) and methods of use thereof for gene delivery
EP3139909B1 (de) 2014-05-09 2025-01-01 Yale University Mit hyperverzweigtem polyglycerin beschichtete partikeln
US11918695B2 (en) 2014-05-09 2024-03-05 Yale University Topical formulation of hyperbranched polymer-coated particles
US10682422B2 (en) 2014-11-18 2020-06-16 Yale University Formulations for targeted release of agents under low pH conditions and methods of use thereof
WO2016081621A1 (en) 2014-11-18 2016-05-26 Yale University Formulations for targeted release of agents under low ph conditions and methods of use thereof
CA3026154A1 (en) 2015-06-03 2016-12-08 The University Of Queensland Mobilizing agents and uses therefor
ES2907489T3 (es) 2015-12-14 2022-04-25 X4 Pharmaceuticals Inc Métodos para el tratamiento del cáncer
WO2017106332A1 (en) 2015-12-14 2017-06-22 X4 Pharmaceuticals, Inc. Methods for treating cancer
HUE060517T2 (hu) 2015-12-22 2023-03-28 X4 Pharmaceuticals Inc Immunhiányos betegség kezelésére szolgáló eljárások
CA3014795A1 (en) 2016-02-16 2017-08-24 Yale University Compositions and methods for treatment of cystic fibrosis
EP3416976A2 (de) 2016-02-16 2018-12-26 Yale University Zusammensetzungen zur verbesserung von gezielter geneditierung und verfahren zur verwendung davon
WO2017177230A1 (en) 2016-04-08 2017-10-12 X4 Pharmaceuticals, Inc. Methods for treating cancer
WO2017197128A1 (en) 2016-05-11 2017-11-16 Yale University Poly(amine-co-ester) nanoparticles and methods of use thereof
WO2017223229A1 (en) 2016-06-21 2017-12-28 X4 Pharmaceuticals, Inc. Cxcr4 inhibitors and uses thereof
JP7054529B2 (ja) 2016-06-21 2022-04-14 エックス４ ファーマシューティカルズ， インコーポレイテッド Ｃｘｃｒ４阻害剤およびその使用
CA3027500A1 (en) 2016-06-21 2017-12-28 X4 Pharmaceuticals, Inc. Cxcr4 inhibitors and uses thereof
US20200113821A1 (en) 2017-04-04 2020-04-16 Yale University Compositions and methods for in utero delivery
US20190343885A1 (en) 2017-10-31 2019-11-14 Magenta Therapeutics Inc. Compositions and methods for hematopoietic stem and progenitor cell transplant therapy
JP7412341B2 (ja) 2017-10-31 2024-01-12 エディジーン バイオテクノロジー インコーポレイテッド 造血幹細胞および前駆細胞の増幅のための組成物および方法
US11260079B2 (en) 2017-12-06 2022-03-01 Magenta Therapeutics, Inc. Dosing regimens for the mobilization of hematopoietic stem and progenitor cells
CN111712262A (zh) 2017-12-06 2020-09-25 美真达治疗公司 用于动员造血干细胞和祖细胞的给药方案
AU2019205262A1 (en) 2018-01-03 2020-07-23 Magenta Therapeutics Inc. Compositions and methods for the expansion of hematopoietic stem and progenitor cells and treatment of inherited metabolic disorders
US20210189431A1 (en) 2018-08-10 2021-06-24 Yale University Compositions and methods for embryonic gene editing in vitro
US10548889B1 (en) 2018-08-31 2020-02-04 X4 Pharmaceuticals, Inc. Compositions of CXCR4 inhibitors and methods of preparation and use
US11814464B2 (en) 2019-04-29 2023-11-14 Yale University Poly(amine-co-ester) polymers and polyplexes with modified end groups and methods of use thereof
US20220243211A1 (en) 2019-06-21 2022-08-04 Yale University Peptide nucleic acid compositions with modified hoogsteen binding segments and methods of use thereof
US20220372474A1 (en) 2019-06-21 2022-11-24 Yale University Hydroxymethyl-modified gamma-pna compositions and methods of use thereof
WO2021022161A1 (en) 2019-07-31 2021-02-04 Yale University Compositions and methods for treating sickle cell disease
WO2021087406A1 (en) 2019-11-01 2021-05-06 Magenta Therapeutics, Inc. Dosing regimens for the mobilization of hematopoietic stem and progentor cells
JP2023517956A (ja) 2020-03-10 2023-04-27 エックス４ ファーマシューティカルズ， インコーポレイテッド 好中球減少症を処置する方法
MX2022013493A (es) 2020-04-27 2023-02-22 Magenta Therapeutics Inc Metodos y composiciones para transducir celulas madre y progenitoras hematopoyeticas in vivo.
WO2021257262A1 (en) 2020-06-19 2021-12-23 Yale University Poly(amine-co-ester) polymers with modified end groups and enhanced pulmonary delivery
US20220031633A1 (en) 2020-07-28 2022-02-03 Yale University Poly(amine-co-ester) polymeric particles for selective pulmonary delivery
EP4308694A1 (de) 2021-03-16 2024-01-24 Magenta Therapeutics, Inc. Dosierschemata zur mobilisierung hämatopoetischer stammzellen für stammzelltransplantationen bei patienten mit multiplem myelom
CA3240407A1 (en) 2021-12-08 2023-06-07 Akiko Iwasaki Nanoparticle immunogenic compositions and vaccination methods
WO2023159189A1 (en) 2022-02-18 2023-08-24 Yale University Branched poly(amine-co-ester) polymers for more efficient nucleic expression
CN116675708A (zh) * 2023-04-23 2023-09-01 华南师范大学 一类氧化响应的大环化合物、大环配合物及其应用
GB202307563D0 (en) 2023-05-19 2023-07-05 Univ King Abdullah Sci & Tech Methods and compositions
US20250032644A1 (en) 2023-07-25 2025-01-30 Massachusetts Institute Of Technology Compositions and methods for treating fan1 associated trinucleotide repeat expansion disorders

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5021409A (en) * 1989-12-21 1991-06-04 Johnson Matthey Plc Antiviral cyclic polyamines
GB9126677D0 (en) * 1991-12-16 1992-02-12 Johnson Matthey Plc Improvements in chemical compounds

Also Published As

Publication number Publication date
CA2179530A1 (en) 1995-07-13
DE69530281D1 (de) 2003-05-15
HU9601892D0 (en) 1996-09-30
DE69530281T2 (de) 2004-01-29
WO1995018808A1 (en) 1995-07-13
FI962810A7 (fi) 1996-07-10
NO309680B1 (no) 2001-03-12
FI962810L (fi) 1996-07-10
HUT74429A (en) 1996-12-30
EP0739345A1 (de) 1996-10-30
EP0739345B1 (de) 2003-04-09
US5698546A (en) 1997-12-16
JPH09509407A (ja) 1997-09-22
CA2179530C (en) 2005-07-05
NZ277859A (en) 1997-07-27
AU681478B2 (en) 1997-08-28
NO962899D0 (no) 1996-07-10
JP3749253B2 (ja) 2006-02-22
HU219238B (en) 2001-03-28
GB9400411D0 (en) 1994-03-09
AU1324595A (en) 1995-08-01
FI962810A0 (fi) 1996-07-10
ES2191699T3 (es) 2003-09-16
NO962899L (no) 1996-07-10

Similar Documents

Publication Publication Date Title
DE69530281D1 (de) Zyklische polyamine
DE69023748D1 (de) Verwendung von Stickstoff enthaltenden Makrozyklen zur Behandlung retroviraler Infektionen.
NO954346D0 (no) Ureidoderivater av naftalenfosfonsyrer og fremgangsmåte for deres fremstilling
DE69938003D1 (de) Sammlungen von verbindungen
GB9507799D0 (en) Metalloproteinase inhibitors
FI942849A7 (fi) Kytkettyjä syklisiä polyamiineja, joilla on HIV:n vastaista aktiivisuutta
FI935701A0 (fi) Fluoralkoxibensylaminoderivat av kvaeve-innehaollande heterocykliska foereningar
DK0609415T3 (da) Salpetersyreestere af 2-(2,6-di-halogen-phenylamino)phenyleddikesyrederivater og fremgangsmåde til deres fremstilling
YU89691A (sh) Postupak za dobijanje stereoselektivnih derivata fenilizoserina
DE69019533D1 (de) Behandlung von hiv-infizierungen und nützliche verbindungen dafür.
TR200001010T2 (tr) Ürokinaz önleyicileri olan izokinolinler.
MY113863A (en) Method for preparing n, n' - disubstituted cyclic ureas
ATE319715T1 (de) Antikonvulsive pseudofructopyranose sulfamate
NO975679L (no) Fremgangsmåte for fremstilling av N-monosubstituerte og N,N'-disubstituerte, usymmetriske, cykliske ureaer
BG103751A (bg) Метод за получаване на междинни съединения за синтез на пестициди
BG104232A (bg) Заместени 1,2,3,4,5,6-хексахидро-2,6-метано-3-бензазоцин- 10-оли, метод за тяхното получаване и приложението им като лекарствени средства
HUP9902465A1 (hu) Új amidínium-származékok, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
ES8601099A1 (es) Procedimiento para la preparacion de nuevos derivados de n-(metoxifenacil)-amina
SE9203824D0 (sv) Benzofuranylimidazole derivatives a process for the preparation and therapeutical compositions containing the same
NO961719D0 (no) 3-aryl-4-alkyl og 4,5-dialkyl-4H-1,2,4-triazoler som er anvendbare som hukommelsesforsterkere
DK0451626T3 (da) Anvendelse af benzodiazepinforbindelser til fremstilling af et farmaceutisk præparat mod med excitatoriske aminosyrer forbundne forstyrrelser i centralnervesystemet
GB2340490A (en) Diphenylacetic acid derivatives and their use as antiviral agents
ES2104416T3 (es) Glicosilamidas de 2-aminoacilamino-2-desoxi-azucares.
FR2684992B1 (fr) Procede de preparation d'amino-2 nitro-7 benzothiazoles.
TH45499C3 (de)

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties