ATE241626T1 - Kondensierte imidazolderivate als modulatoren vielfacher medikamentenresistenz - Google Patents

Kondensierte imidazolderivate als modulatoren vielfacher medikamentenresistenz

Info

Publication number
ATE241626T1
ATE241626T1 AT97908226T AT97908226T ATE241626T1 AT E241626 T1 ATE241626 T1 AT E241626T1 AT 97908226 T AT97908226 T AT 97908226T AT 97908226 T AT97908226 T AT 97908226T AT E241626 T1 ATE241626 T1 AT E241626T1
Authority
AT
Austria
Prior art keywords
modulators
drug resistance
imidazole derivatives
multiple drug
condensed imidazole
Prior art date
Application number
AT97908226T
Other languages
English (en)
Inventor
Frans Eduard Janssens
Joseph Elisabeth Leenaerts
Francois Maria Sommen
Dominique Louis Nest Surleraux
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Application granted granted Critical
Publication of ATE241626T1 publication Critical patent/ATE241626T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/04—Amoebicides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT97908226T 1996-03-19 1997-03-11 Kondensierte imidazolderivate als modulatoren vielfacher medikamentenresistenz ATE241626T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP96200755 1996-03-19
PCT/EP1997/001264 WO1997034897A1 (en) 1996-03-19 1997-03-11 Fused imidazole derivatives as multidrug resistance modulators

Publications (1)

Publication Number Publication Date
ATE241626T1 true ATE241626T1 (de) 2003-06-15

Family

ID=8223797

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97908226T ATE241626T1 (de) 1996-03-19 1997-03-11 Kondensierte imidazolderivate als modulatoren vielfacher medikamentenresistenz

Country Status (29)

Country Link
US (3) US6218381B1 (de)
EP (1) EP0888352B1 (de)
JP (3) JP3630434B2 (de)
KR (2) KR100330698B1 (de)
CN (1) CN1083453C (de)
AR (1) AR006271A1 (de)
AT (1) ATE241626T1 (de)
BG (1) BG62734B1 (de)
BR (1) BR9708140A (de)
CA (1) CA2237594C (de)
CZ (1) CZ294060B6 (de)
DE (1) DE69722389T2 (de)
EA (1) EA001004B1 (de)
EE (1) EE03773B1 (de)
ES (1) ES2200159T3 (de)
HR (1) HRP970161B1 (de)
HU (1) HU224528B1 (de)
ID (1) ID16375A (de)
IL (1) IL124572A (de)
MX (1) MX9804426A (de)
MY (1) MY118282A (de)
NO (1) NO310659B1 (de)
NZ (1) NZ330466A (de)
PL (1) PL193444B1 (de)
SK (1) SK284434B6 (de)
TR (1) TR199801191T2 (de)
TW (1) TW527186B (de)
WO (1) WO1997034897A1 (de)
ZA (1) ZA972351B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1146099A (en) * 1997-09-18 1999-04-05 Janssen Pharmaceutica N.V. Fused imidazole derivatives for improving oral bioavailability of pharmaceuticalagents
DE69931617T2 (de) * 1998-04-01 2007-05-24 Jagotec Ag Taxan-mikroemulsionen
US6743794B2 (en) 1999-12-22 2004-06-01 Eli Lilly And Company Methods and compounds for inhibiting MRP1
US6376514B1 (en) 2000-10-17 2002-04-23 The Procter & Gamble Co. Substituted six-membered heterocyclic compounds useful for treating multidrug resistance and compositions and methods thereof
US6693099B2 (en) 2000-10-17 2004-02-17 The Procter & Gamble Company Substituted piperazine compounds optionally containing a quinolyl moiety for treating multidrug resistance
WO2002100862A2 (en) 2001-06-12 2002-12-19 Janssen Pharmaceutica N.V. Novel substituted tetracyclic imidazole derivatives, processes for their preparation, pharmaceutical compositions comprising them and their use as a medicine
WO2003044023A1 (en) * 2001-11-23 2003-05-30 Janssen Pharmaceutica N.V. The use of anti-histaminics for acute reduction of elevated intracranial pressure
GB0301736D0 (en) * 2003-01-24 2003-02-26 Xenova Ltd Pharmaceutical compounds
EP2978765B1 (de) * 2013-03-25 2018-05-02 Crystal Pharma S.A.U Verfahren zur herstellung von alcaftadin
CN103408549B (zh) * 2013-06-14 2016-01-20 苏州汇和药业有限公司 一种阿卡他定中间体的制备方法

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2418502C3 (de) * 1974-04-11 1980-04-24 Schering Ag, 1000 Berlin Und 4619 Bergkamen Dichlorbenzyl- [2-( a -imidazolylbutyl)-phenyl] -äther und -thioäther, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
US4153719A (en) * 1977-09-06 1979-05-08 Sterling Drug Inc. Aromatic diketones
JPS56125326A (en) * 1980-03-07 1981-10-01 Asahi Kagaku Kogyo Kk Preparation of chlorinated phenoxytoluenes in high selectivity
US4567184A (en) 1982-12-01 1986-01-28 Usv Pharmaceutical Corporation Certain aryl or hetero-aryl derivatives of 1-hydroxy-pentane or 1-hydroxy-hexane which are useful for treating inflammation and allergies
US4794188A (en) 1982-12-01 1988-12-27 Usv Pharmaceutical Corporation Certain unsymmetrical quinolinyl ethers having anti-inflammatory and anti-allergic activity
US4778931A (en) 1982-12-01 1988-10-18 Usv Pharmaceutical Corporation Certain [3-(1-hydroxy hexyl-tetrahydro)naphthalenes], the corresponding naphthalenes having anti-inflammatory and anti-allergic activity
US4588722A (en) 1984-01-09 1986-05-13 Janssen Pharmaceutica N.V. N-(4-piperidinyl) bicyclic condensed 2-imidazolamine derivatives
JPS61151176A (ja) * 1984-12-24 1986-07-09 Sumitomo Chem Co Ltd ベンズイミダゾール誘導体およびそれを有効成分とする殺虫、殺ダニ剤
US4631287A (en) * 1985-04-16 1986-12-23 Usv Pharmaceutical Corp. Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments
US4840971A (en) * 1986-04-07 1989-06-20 Sumitomo Chemical Company, Limited Novel ether compound, a process for manufacturing the same, a composition containing the same and a use thereof
JPS6475441A (en) * 1987-09-16 1989-03-22 Sumitomo Chemical Co Production of optically active ether compound
JPH01254680A (ja) * 1988-04-01 1989-10-11 Sumitomo Chem Co Ltd 複素環化合物、その製造法およびそれを有効成分とする殺菌剤
EP0552292B1 (de) * 1990-10-10 1995-06-21 Schering Corporation Substituierte imidazobenzazepine und imidazopyridoazepine
IL101851A (en) 1991-06-13 1996-05-14 Janssen Pharmaceutica Nv 10-(4-piperidinyl- and piperidinylidene)-imidazo [1,2-a] (pyrrolo thieno or furano) [2,3] azepine derivatives their preparation and pharmaceutical compositions containing them and certain novel intermediates therefor
IL101850A (en) 1991-06-13 1996-01-31 Janssen Pharmaceutica Nv 11-(4-Piperidinyl)-imidazo (2,1-b) (3) benzazepine derivatives their preparation and pharmaceutical compositions containing them
GB9122590D0 (en) * 1991-10-24 1991-12-04 Lilly Industries Ltd Pharmaceutical compounds
DK0643693T3 (da) * 1992-02-06 1999-11-29 Merrell Pharma Inc Reversering af multi-lægemiddelresistens med triphenyl-piperidin-derivater
CA2150805C (en) 1992-12-04 2006-08-15 Frans Eduard Janssens Antiallergic imidazo[1,2-a](pyrrolo, thieno or furano)[2,3-d]azepine derivatives
JPH08508270A (ja) * 1993-03-29 1996-09-03 ビーエーエスエフ アクチエンゲゼルシャフト マルチ・ドラッグ耐性のモジュレーターとしての１−アミノ−３−フェノキシ−プロパン誘導体
EP0708776B1 (de) 1993-07-13 2001-01-03 Janssen Pharmaceutica N.V. Antiallergische imidazoazepine
US5486612A (en) * 1993-12-14 1996-01-23 Eli Lilly And Company N-benzyl dihydroindole LTD4 antagonists
US5596008A (en) * 1995-02-10 1997-01-21 G. D. Searle & Co. 3,4-Diaryl substituted pyridines for the treatment of inflammation
FR2731708B1 (fr) 1995-03-13 1997-04-30 Synthelabo Derives de piperidine, leur procede de preparation et leur application en therapeutique
TW382017B (en) 1995-12-27 2000-02-11 Janssen Pharmaceutica Nv 1-(1,2-disubstituted piperidinyl)-4-(fused imidazole)-piperidine derivatives

Also Published As

Publication number Publication date
CN1083453C (zh) 2002-04-24
EE9800281A (et) 1999-02-15
MX9804426A (es) 1998-09-30
JP2002012594A (ja) 2002-01-15
HRP970161B1 (en) 2002-06-30
ZA972351B (en) 1998-09-18
CA2237594C (en) 2006-05-30
PL193444B1 (pl) 2007-02-28
SK66298A3 (en) 1999-06-11
EA199800586A1 (ru) 1998-12-24
JP3630434B2 (ja) 2005-03-16
NZ330466A (en) 1999-03-29
PL327985A1 (en) 1999-01-04
US6476018B1 (en) 2002-11-05
NO982124D0 (no) 1998-05-11
KR20000064358A (ko) 2000-11-06
TW527186B (en) 2003-04-11
JP2004067701A (ja) 2004-03-04
HRP970161A2 (en) 1998-04-30
SK284434B6 (sk) 2005-04-01
NO982124L (no) 1998-09-18
HK1015769A1 (en) 1999-10-22
IL124572A (en) 2002-03-10
AU709683B2 (en) 1999-09-02
EE03773B1 (et) 2002-06-17
ID16375A (id) 1997-09-25
BG62734B1 (bg) 2000-06-30
EP0888352A1 (de) 1999-01-07
HUP9900415A3 (en) 2001-11-28
DE69722389D1 (de) 2003-07-03
DE69722389T2 (de) 2009-09-24
HU224528B1 (hu) 2005-10-28
CA2237594A1 (en) 1997-09-25
BR9708140A (pt) 1999-07-27
TR199801191T2 (xx) 1998-10-21
JP4251447B2 (ja) 2009-04-08
CZ152998A3 (cs) 1999-02-17
KR100349500B1 (ko) 2002-08-21
EP0888352B1 (de) 2003-05-28
US20030087895A1 (en) 2003-05-08
IL124572A0 (en) 1998-12-06
US6218381B1 (en) 2001-04-17
CN1211985A (zh) 1999-03-24
NO310659B1 (no) 2001-08-06
HUP9900415A2 (hu) 1999-05-28
AU2026997A (en) 1997-10-10
EA001004B1 (ru) 2000-08-28
AR006271A1 (es) 1999-08-11
CZ294060B6 (cs) 2004-09-15
ES2200159T3 (es) 2004-03-01
BG102459A (en) 1999-06-30
MY118282A (en) 2004-09-30
JP2000505477A (ja) 2000-05-09
JP4205319B2 (ja) 2009-01-07
KR100330698B1 (ko) 2002-10-31
WO1997034897A1 (en) 1997-09-25

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Legal Events

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EEIH Change in the person of patent owner