NO20002050L - Aggregater av humaninsulinderivater - Google Patents

Aggregater av humaninsulinderivater

Info

Publication number: NO20002050L
Authority: NO; Norway
Prior art keywords: aggregates; derivatives; human insulin; soluble; insulin derivatives
Prior art date: 1997-10-24

Application number

NO20002050A

Other languages

English (en)

Norwegian (no)

Other versions

NO20002050D0 (no

Inventor

Svend Havelund

Per Balschmidt

Ib Jonassen

Thomas Hoeg-Jensen

Original Assignee

Novo Nordisk As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-10-24

Filing date

2000-04-18

Publication date

2000-06-23

2000-04-18 Application filed by Novo Nordisk As filed Critical Novo Nordisk As

2000-04-18 Publication of NO20002050D0 publication Critical patent/NO20002050D0/no

2000-06-23 Publication of NO20002050L publication Critical patent/NO20002050L/no

Links

PBGKTOXHQIOBKM-FHFVDXKLSA-N insulin (human) Chemical class C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 PBGKTOXHQIOBKM-FHFVDXKLSA-N 0.000 title abstract 2
102000001390 Fructose-Bisphosphate Aldolase Human genes 0.000 abstract 1
108010068561 Fructose-Bisphosphate Aldolase Proteins 0.000 abstract 1
102000004877 Insulin Human genes 0.000 abstract 1
108090001061 Insulin Proteins 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
238000002523 gelfiltration Methods 0.000 abstract 1
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical class N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin

Landscapes

Health & Medical Sciences (AREA)
Diabetes (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Endocrinology (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Zoology (AREA)
General Chemical & Material Sciences (AREA)
Biochemistry (AREA)
Emergency Medicine (AREA)
Immunology (AREA)
Hematology (AREA)
Epidemiology (AREA)
Toxicology (AREA)
Obesity (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

NO20002050A 1997-10-24 2000-04-18 Aggregater av humaninsulinderivater NO20002050L (no)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DK121897		1997-10-24
US6417097P	1997-11-04	1997-11-04
PCT/DK1998/000461 WO1999021888A1 (en)	1997-10-24	1998-10-23	Aggregates of human insulin derivatives

Publications (2)

Publication Number	Publication Date
NO20002050D0 NO20002050D0 (no)	2000-04-18
NO20002050L true NO20002050L (no)	2000-06-23

Family

ID=26065414

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20002050A NO20002050L (no)	1997-10-24	2000-04-18	Aggregater av humaninsulinderivater

Country Status (20)

Country	Link
EP (1)	EP1025125B1 (de)
JP (1)	JP2003525846A (de)
KR (1)	KR100539193B1 (de)
CN (1)	CN1240718C (de)
AT (1)	ATE243711T1 (de)
AU (1)	AU757933B2 (de)
BR (1)	BR9813128A (de)
CA (1)	CA2308705A1 (de)
DE (1)	DE69815877T2 (de)
DK (1)	DK1025125T3 (de)
ES (1)	ES2202899T3 (de)
HU (1)	HUP0004096A3 (de)
IL (2)	IL135400A0 (de)
NO (1)	NO20002050L (de)
PL (1)	PL195845B1 (de)
PT (1)	PT1025125E (de)
RU (1)	RU2218349C2 (de)
UA (1)	UA69393C2 (de)
WO (1)	WO1999021888A1 (de)
ZA (1)	ZA989722B (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7316999B2 (en)	2000-06-02	2008-01-08	Novo Nordisk A/S	Glucose dependent release of insulin from glucose sensing insulin derivatives
KR20030097876A (ko)	2001-05-21	2003-12-31	넥타르 테라퓨틱스	화학적으로 개질된 인슐린의 폐 투여
US7317000B2 (en)	2001-12-02	2008-01-08	Novo Nordisk A/S	Glucose-dependent insulins
ES2472421T3 (es) *	2003-08-05	2014-07-01	Novo Nordisk A/S	Nuevos derivados de insulina
AU2004261353B2 (en) *	2003-08-05	2009-12-10	Novo Nordisk A/S	Novel insulin derivatives
CN101027318B (zh) *	2004-07-19	2016-05-25	比奥孔有限公司	胰岛素-低聚物共轭物，制剂及其用途
EP1888104A2 (de) *	2005-05-26	2008-02-20	Novo Nordisk A/S	Acyliertes insulin von hoher reinheit
EP1969004B1 (de)	2005-12-28	2011-08-10	Novo Nordisk A/S	Ein acyliertes insulin und zink enthaltende zusammensetzungen und verfahren zur herstellung dieser zusammensetzungen
JP5202338B2 (ja) *	2006-02-27	2013-06-05	ノボ・ノルデイスク・エー／エス	新規インシュリン誘導体
WO2007140619A1 (en) *	2006-06-08	2007-12-13	Diabecore Medical Inc.	Derivatized insulin oligomers
CN101573133B (zh)	2006-07-31	2014-08-27	诺沃-诺迪斯克有限公司	Peg化延长的胰岛素
CN101541830A (zh)	2006-09-22	2009-09-23	诺沃-诺迪斯克有限公司	蛋白酶抗性的胰岛素类似物
WO2008132224A2 (en)	2007-04-30	2008-11-06	Novo Nordisk A/S	Method for drying a protein composition, a dried protein composition and a pharmaceutical composition comprising the dried protein
JP5552046B2 (ja)	2007-06-13	2014-07-16	ノボ・ノルデイスク・エー／エス	インスリン誘導体を含有する薬学的製剤
CN101970477B (zh)	2008-03-14	2014-12-31	诺沃-诺迪斯克有限公司	蛋白酶稳定的胰岛素类似物
HUE032284T2 (en)	2008-03-18	2017-09-28	Novo Nordisk As	Protease-stabilized, acylated insulin analogues
CN102202683A (zh)	2008-10-30	2011-09-28	诺沃-诺迪斯克有限公司	用少于每日一次的注射频率注射胰岛素来治疗糖尿病
DK2632478T3 (da)	2010-10-27	2019-10-07	Novo Nordisk As	Behandling af diabetes melitus under anvendelse af insulinindsprøjtninger indgivet med varierende indsprøjtningsintervaller
CN103191416A (zh) *	2012-01-05	2013-07-10	四川大学	一种猪胰岛素超分子聚集体及其制备方法
EP2836508B1 (de)	2012-04-11	2016-06-29	Novo Nordisk A/S	Insulinformulierungen
EP2991672A1 (de)	2013-04-30	2016-03-09	Novo Nordisk A/S	Neuartiges verabreichungsschema
CA2926701A1 (en)	2013-10-07	2015-04-16	Novo Nordisk A/S	Novel derivative of an insulin analogue
AR099569A1 (es)	2014-02-28	2016-08-03	Novo Nordisk As	Derivados de insulina y los usos médicos de estos
ES2886837T3 (es)	2016-12-16	2021-12-21	Novo Nordisk As	Composiciones farmacéuticas que contienen insulina
BR112020002804A2 (pt)	2017-08-24	2020-07-28	Novo Nordisk A/S	composição farmacêutica líquida, e, kit
US10335464B1 (en)	2018-06-26	2019-07-02	Novo Nordisk A/S	Device for titrating basal insulin
CN114096269B (zh)	2019-07-12	2024-06-11	诺和诺德股份有限公司	高浓度胰岛素制剂
IL294521A (en)	2020-02-18	2022-09-01	Novo Nordisk As	glp-1 compounds and their uses

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ273285A (en) *	1993-09-17	1997-10-24	Novo Nordisk As	Insulin derivatives and compositions thereof
US5559094A (en) *	1994-08-02	1996-09-24	Eli Lilly And Company	AspB1 insulin analogs
US6451970B1 (en) *	1996-02-21	2002-09-17	Novo Nordisk A/S	Peptide derivatives

1998
- 1998-10-23 PL PL98340032A patent/PL195845B1/pl unknown
- 1998-10-23 RU RU2000112882/04A patent/RU2218349C2/ru not_active IP Right Cessation
- 1998-10-23 HU HU0004096A patent/HUP0004096A3/hu unknown
- 1998-10-23 DK DK98949960T patent/DK1025125T3/da active
- 1998-10-23 CA CA002308705A patent/CA2308705A1/en not_active Abandoned
- 1998-10-23 CN CNB988104458A patent/CN1240718C/zh not_active Expired - Fee Related
- 1998-10-23 ES ES98949960T patent/ES2202899T3/es not_active Expired - Lifetime
- 1998-10-23 PT PT98949960T patent/PT1025125E/pt unknown
- 1998-10-23 AT AT98949960T patent/ATE243711T1/de not_active IP Right Cessation
- 1998-10-23 JP JP2000517995A patent/JP2003525846A/ja not_active Withdrawn
- 1998-10-23 BR BR9813128-1A patent/BR9813128A/pt not_active IP Right Cessation
- 1998-10-23 IL IL13540098A patent/IL135400A0/xx not_active IP Right Cessation
- 1998-10-23 AU AU96221/98A patent/AU757933B2/en not_active Ceased
- 1998-10-23 EP EP98949960A patent/EP1025125B1/de not_active Expired - Lifetime
- 1998-10-23 WO PCT/DK1998/000461 patent/WO1999021888A1/en not_active Ceased
- 1998-10-23 DE DE69815877T patent/DE69815877T2/de not_active Expired - Fee Related
- 1998-10-23 KR KR10-2000-7004229A patent/KR100539193B1/ko not_active Expired - Fee Related
- 1998-10-23 UA UA2000042275A patent/UA69393C2/uk unknown
- 1998-10-26 ZA ZA989722A patent/ZA989722B/xx unknown
2000
- 2000-03-31 IL IL135400A patent/IL135400A/en unknown
- 2000-04-18 NO NO20002050A patent/NO20002050L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
KR100539193B1 (ko)	2005-12-27
ATE243711T1 (de)	2003-07-15
ES2202899T3 (es)	2004-04-01
DE69815877D1 (de)	2003-07-31
HUP0004096A3 (en)	2001-12-28
EP1025125B1 (de)	2003-06-25
HUP0004096A2 (hu)	2001-05-28
DE69815877T2 (de)	2004-05-19
AU757933B2 (en)	2003-03-13
JP2003525846A (ja)	2003-09-02
WO1999021888A1 (en)	1999-05-06
EP1025125A1 (de)	2000-08-09
PL195845B1 (pl)	2007-10-31
PT1025125E (pt)	2003-11-28
UA69393C2 (uk)	2004-09-15
NO20002050D0 (no)	2000-04-18
BR9813128A (pt)	2000-08-15
RU2218349C2 (ru)	2003-12-10
CN1240718C (zh)	2006-02-08
KR20010031247A (ko)	2001-04-16
CN1281466A (zh)	2001-01-24
CA2308705A1 (en)	1999-05-06
ZA989722B (en)	1999-04-26
DK1025125T3 (da)	2003-10-06
AU9622198A (en)	1999-05-17
IL135400A0 (en)	2001-05-20
IL135400A (en)	2007-08-19
PL340032A1 (en)	2001-01-15

Legal Events

Date	Code	Title	Description
2008-11-24	FC2A	Withdrawal, rejection or dismissal of laid open patent application

Publication	Publication Date	Title
NO20002050D0 (no)	2000-04-18	Aggregater av humaninsulinderivater
CA2209060A1 (en)	1997-12-28	Water-soluble or water-swellable polymers
TR199600322A2 (tr)	1996-11-21	Arilsülfonil hidroksamik asit türevleri.
CA2119154A1 (en)	1994-02-03	Derivatives of Cyclodextrins Exhibiting Enhanced Aqueous Solubility and the Use Thereof
BR9809025B1 (pt)	2010-05-18	polìmero anfótero, e, veìculo cosmeticamente aceitável.
IS4963A (is)	1999-01-29	Setnar 6,5-heteró-bísýklískar afleiður
AU2002343557A1 (en)	2003-06-10	Substituted aryl 1,4-pyrazine derivatives
DE60035059D1 (de)	2007-07-12	Mittel zur verbesserung der hauttextur
AU2115988A (en)	1989-03-16	5-amino or substituted amino 1,2,3-triazoles useful as antiproliferative agents
MX9803728A (es)	1998-09-30	Agentes floculantes de polimero de alto rendimiento.
PT1140835E (pt)	2004-07-30	Derivados da 3,3-biarilpiperidina e 2,2-biarilmorfolina
AU3657100A (en)	2000-10-04	Use of water-soluble beta-(1,3) glucans as agents for producing therapeutic skintreatment agents
TR200002248T2 (tr)	2000-12-21	Yeni dihidroksiheksanoik asit türevleri
TR200001102T2 (tr)	2000-08-21	İkameli tetrahidropirimidinen türevleri, üretimleri ve kullanımları.
EP0882447A4 (de)	2000-02-23	Lösliche kosmetika
NO980303D0 (no)	1998-01-23	Vandige dispersjoner på basis av vannopplöselige polymerer
AU7624598A (en)	1998-06-29	1,4-diazabicyclo (2.2.2) Oct-2-ylmethyl derivatives, their preparation and the rapeutic application
DK0921793T3 (da)	2000-12-18	Faste, ikke-henflydende formuleringer af natriumvalproat
DE68900210D1 (de)	1991-09-26	Pyranobenzoxadiazolderivate, herstellung, verwendung und diese enthaltende zubereitungen.
FI965064A7 (fi)	1997-06-20	Veteenliukeneva suurimolekyylinen yhdiste, joka sisältää silikonia ja sen tuotanto ja käyttö
AU776463C (en)	2006-01-19	Decorative cosmetic preparations
DK0861120T3 (da)	2003-12-15	Oliefri, vandopløselig, flydende hydroxyethylcellulosepolymerdispersion
CA2314716A1 (en)	1999-06-17	Modified polysaccharides exhibiting altered biological recognition
NO971604L (no)	1997-04-08	Orale sabeluzolsuspensjoner
ATE220674T1 (de)	2002-08-15	12h-dibenzo(d,g)(1,3)dioxocin derivate