ZA989722B - Aggregates of human insulin derivatives - Google Patents

Aggregates of human insulin derivatives

Info

Publication number
ZA989722B
ZA989722B ZA989722A ZA989722A ZA989722B ZA 989722 B ZA989722 B ZA 989722B ZA 989722 A ZA989722 A ZA 989722A ZA 989722 A ZA989722 A ZA 989722A ZA 989722 B ZA989722 B ZA 989722B
Authority
ZA
South Africa
Prior art keywords
aggregates
derivatives
human insulin
soluble
insulin derivatives
Prior art date
Application number
ZA989722A
Other languages
English (en)
Inventor
Svend Havelund
Per Balschmidt
Ib Jonassen
Thomas Hoeg-Jensen
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Publication of ZA989722B publication Critical patent/ZA989722B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin

Landscapes

  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Emergency Medicine (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Obesity (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
ZA989722A 1997-10-24 1998-10-26 Aggregates of human insulin derivatives ZA989722B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK121897 1997-10-24
US6417097P 1997-11-04 1997-11-04

Publications (1)

Publication Number Publication Date
ZA989722B true ZA989722B (en) 1999-04-26

Family

ID=26065414

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA989722A ZA989722B (en) 1997-10-24 1998-10-26 Aggregates of human insulin derivatives

Country Status (20)

Country Link
EP (1) EP1025125B1 (de)
JP (1) JP2003525846A (de)
KR (1) KR100539193B1 (de)
CN (1) CN1240718C (de)
AT (1) ATE243711T1 (de)
AU (1) AU757933B2 (de)
BR (1) BR9813128A (de)
CA (1) CA2308705A1 (de)
DE (1) DE69815877T2 (de)
DK (1) DK1025125T3 (de)
ES (1) ES2202899T3 (de)
HU (1) HUP0004096A3 (de)
IL (2) IL135400A0 (de)
NO (1) NO20002050L (de)
PL (1) PL195845B1 (de)
PT (1) PT1025125E (de)
RU (1) RU2218349C2 (de)
UA (1) UA69393C2 (de)
WO (1) WO1999021888A1 (de)
ZA (1) ZA989722B (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7316999B2 (en) 2000-06-02 2008-01-08 Novo Nordisk A/S Glucose dependent release of insulin from glucose sensing insulin derivatives
CA2447236A1 (en) 2001-05-21 2002-11-28 Nektar Therapeutics Pulmonary administration of chemically modified insulin
US7317000B2 (en) 2001-12-02 2008-01-08 Novo Nordisk A/S Glucose-dependent insulins
EP2107069B1 (de) * 2003-08-05 2013-01-16 Novo Nordisk A/S Neuartige Insulinderivate
ES2472421T3 (es) * 2003-08-05 2014-07-01 Novo Nordisk A/S Nuevos derivados de insulina
CN103223160B (zh) * 2004-07-19 2015-02-18 比奥孔有限公司 胰岛素-低聚物共轭物,制剂及其用途
WO2006125765A2 (en) * 2005-05-26 2006-11-30 Novo Nordisk A/S Acylated insulin with high purity
US20090074882A1 (en) 2005-12-28 2009-03-19 Novo Nordisk A/S Insulin compositions and method of making a composition
JP5202338B2 (ja) * 2006-02-27 2013-06-05 ノボ・ノルデイスク・エー／エス 新規インシュリン誘導体
EP2021368A4 (de) * 2006-06-08 2010-01-20 Diabecore Medical Inc Derivatisierte insulinoligomere
JP5550338B2 (ja) 2006-07-31 2014-07-16 ノボ・ノルデイスク・エー／エス ペグ化持続型インスリン
HUE029512T2 (en) 2006-09-22 2017-03-28 Novo Nordisk As Protease Resistant Insulin Analogs
JP5496082B2 (ja) 2007-04-30 2014-05-21 ノボ・ノルデイスク・エー／エス タンパク質組成物を乾燥させる方法、乾燥タンパク質組成物、及び乾燥タンパク質を含有する薬学的組成物
JP5552046B2 (ja) 2007-06-13 2014-07-16 ノボ・ノルデイスク・エー／エス インスリン誘導体を含有する薬学的製剤
JP5762001B2 (ja) 2008-03-14 2015-08-12 ノボ・ノルデイスク・エー／エス プロテアーゼ安定化インスリンアナログ
WO2009115469A1 (en) 2008-03-18 2009-09-24 Novo Nordisk A/S Protease stabilized, acylated insulin analogues
KR20110085985A (ko) 2008-10-30 2011-07-27 노보 노르디스크 에이/에스 하루 한번 주사 빈도보다 적은 인슐린 주사를 사용한 진성 당뇨병의 치료
BR112013010345A2 (pt) 2010-10-27 2017-07-25 Novo Nordisk As tratamento de diabetes melitus usando as injeções de insulina administradas com intervalos de variação da injeção
CN103191416A (zh) * 2012-01-05 2013-07-10 四川大学 一种猪胰岛素超分子聚集体及其制备方法
CA2870313A1 (en) 2012-04-11 2013-10-17 Novo Nordisk A/S Insulin formulations
JP2016519127A (ja) 2013-04-30 2016-06-30 ノヴォ ノルディスク アー／エス 新規投与レジメン
AU2014333979B2 (en) 2013-10-07 2018-02-15 Novo Nordisk A/S Novel derivative of an insulin analogue
AR099569A1 (es) 2014-02-28 2016-08-03 Novo Nordisk As Derivados de insulina y los usos médicos de estos
ES2886837T3 (es) 2016-12-16 2021-12-21 Novo Nordisk As Composiciones farmacéuticas que contienen insulina
HUE066356T2 (hu) 2017-08-24 2024-07-28 Novo Nordisk As GLP-1 készítmények és alkalmazásaik
US10335464B1 (en) 2018-06-26 2019-07-02 Novo Nordisk A/S Device for titrating basal insulin
US12343383B2 (en) 2019-07-12 2025-07-01 Novo Nordisk A/S High concentration insulin formulation
PE20221575A1 (es) 2020-02-18 2022-10-06 Novo Nordisk As Formulaciones farmaceuticas

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI0792290T1 (en) * 1993-09-17 2001-12-31 Novo Nordisk As Acylated insulin
US5559094A (en) * 1994-08-02 1996-09-24 Eli Lilly And Company AspB1 insulin analogs
US6451970B1 (en) * 1996-02-21 2002-09-17 Novo Nordisk A/S Peptide derivatives

Also Published As

Publication number Publication date
PL340032A1 (en) 2001-01-15
KR100539193B1 (ko) 2005-12-27
AU9622198A (en) 1999-05-17
DK1025125T3 (da) 2003-10-06
JP2003525846A (ja) 2003-09-02
IL135400A (en) 2007-08-19
NO20002050L (no) 2000-06-23
WO1999021888A1 (en) 1999-05-06
ES2202899T3 (es) 2004-04-01
KR20010031247A (ko) 2001-04-16
DE69815877D1 (de) 2003-07-31
RU2218349C2 (ru) 2003-12-10
ATE243711T1 (de) 2003-07-15
EP1025125B1 (de) 2003-06-25
AU757933B2 (en) 2003-03-13
IL135400A0 (en) 2001-05-20
CA2308705A1 (en) 1999-05-06
PT1025125E (pt) 2003-11-28
EP1025125A1 (de) 2000-08-09
BR9813128A (pt) 2000-08-15
HUP0004096A3 (en) 2001-12-28
CN1281466A (zh) 2001-01-24
CN1240718C (zh) 2006-02-08
HUP0004096A2 (hu) 2001-05-28
UA69393C2 (uk) 2004-09-15
PL195845B1 (pl) 2007-10-31
NO20002050D0 (no) 2000-04-18
DE69815877T2 (de) 2004-05-19

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