ATE246524T1 - Temperaturgeregelte, ph-abhängige bildung von ionischen polysaccharidgelen - Google Patents

Temperaturgeregelte, ph-abhängige bildung von ionischen polysaccharidgelen

Info

Publication number
ATE246524T1
ATE246524T1 AT98914751T AT98914751T ATE246524T1 AT E246524 T1 ATE246524 T1 AT E246524T1 AT 98914751 T AT98914751 T AT 98914751T AT 98914751 T AT98914751 T AT 98914751T AT E246524 T1 ATE246524 T1 AT E246524T1
Authority
AT
Austria
Prior art keywords
chitosan
temperature
phosphate
organo
aqueous
Prior art date
Application number
AT98914751T
Other languages
English (en)
Inventor
Abdellatif Chenite
Cyril Chaput
Christele Combes
Fayrouz Jalal
Amine Selmani
Original Assignee
Biosyntech Canada Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biosyntech Canada Inc filed Critical Biosyntech Canada Inc
Application granted granted Critical
Publication of ATE246524T1 publication Critical patent/ATE246524T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/08—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0052—Mixtures of macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0061—Use of materials characterised by their function or physical properties
    • A61L26/008—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/20—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/26—Mixtures of macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Dispersion Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Surgery (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Cosmetics (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Physical Vapour Deposition (AREA)
AT98914751T 1997-08-04 1998-04-06 Temperaturgeregelte, ph-abhängige bildung von ionischen polysaccharidgelen ATE246524T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CA002212300A CA2212300A1 (en) 1997-08-04 1997-08-04 In vitro or in vivo gelfying chitosan and therapeutic uses thereof
PCT/CA1998/000326 WO1999007416A1 (en) 1997-08-04 1998-04-06 TEMPERATURE-CONTROLLED pH-DEPENDANT FORMATION OF IONIC POLYSACCHARIDE GELS

Publications (1)

Publication Number Publication Date
ATE246524T1 true ATE246524T1 (de) 2003-08-15

Family

ID=4161194

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98914751T ATE246524T1 (de) 1997-08-04 1998-04-06 Temperaturgeregelte, ph-abhängige bildung von ionischen polysaccharidgelen

Country Status (14)

Country Link
US (1) US6344488B1 (de)
EP (1) EP1003567B1 (de)
JP (1) JP3634748B2 (de)
AT (1) ATE246524T1 (de)
AU (1) AU724878B2 (de)
CA (1) CA2212300A1 (de)
DE (1) DE69816996T2 (de)
DK (1) DK1003567T3 (de)
ES (1) ES2205471T3 (de)
IL (1) IL134368A (de)
NO (1) NO330580B1 (de)
NZ (1) NZ502919A (de)
PT (1) PT1003567E (de)
WO (1) WO1999007416A1 (de)

Families Citing this family (116)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7767452B2 (en) 1997-02-20 2010-08-03 Kleinsek Don A Tissue treatments with adipocyte cells
US6245740B1 (en) * 1998-12-23 2001-06-12 Amgen Inc. Polyol:oil suspensions for the sustained release of proteins
FR2799371A1 (fr) * 1999-10-12 2001-04-13 Univ Paris Curie Compositions de tenocytes preparation et utilisations
WO2001032129A2 (en) * 1999-11-05 2001-05-10 Gerigene Medical Corporation Augmentation and repair of age-related soft tissue defects
AU2005202256B2 (en) * 1999-11-05 2008-04-03 Gerigene Medical Corporation Augmentation and repair of age-related soft tissue defects
WO2001036000A1 (en) * 1999-11-15 2001-05-25 Bio Syntech Canada, Inc. Temperature-controlled and ph-dependant self-gelling biopolymeric aqueous solution
AU1792601A (en) * 1999-12-07 2001-06-18 Amgen, Inc. Thermosensitive biodegradable hydrogels based on low molecular weight pluronics
AU1848601A (en) * 1999-12-09 2001-06-18 Bio Syntech Canada Inc Mineral-polymer hybrid composition
US20030158302A1 (en) * 1999-12-09 2003-08-21 Cyric Chaput Mineral-polymer hybrid composition
DE60143517D1 (de) * 2000-04-25 2011-01-05 Osiris Therapeutics Inc Wiederherstellung der gelenken mit mesenchymalen stammzellen
JP5089006B2 (ja) * 2000-06-29 2012-12-05 ピラマル ヘルスケア （カナダ） リミテッド 軟骨および他の組織の修復および再生のための組成物および方法
DE60125973D1 (de) * 2000-11-15 2007-02-22 Biosyntech Canada Inc Verfahren zur wiederherstellung einer geschädigten bandscheibe
EP1333869A2 (de) * 2000-11-15 2003-08-13 Bio Syntech Canada Inc. Füllerzusammensetzung zur vermehrung von weichgewebe
US6989373B2 (en) * 2000-11-15 2006-01-24 Bio Syntech Canada Inc. Method for restoring a fat-pad
US7449180B2 (en) * 2001-02-06 2008-11-11 John Kisiday Macroscopic scaffold containing amphiphilic peptides encapsulating cells
EP1465521A4 (de) 2001-11-01 2008-10-08 Spine Wave Inc System und verfahren zur vorbehandlung der endplatten einer bandscheibe
JP3993855B2 (ja) 2001-11-01 2007-10-17 スパイン・ウェイブ・インコーポレーテッド 脊椎椎間板の回復のための装置
TWI245634B (en) * 2001-12-28 2005-12-21 Ind Tech Res Inst Preparation of a biodegradable thermal-sensitive gel system
NZ535270A (en) 2002-03-12 2006-11-30 Univ Montreal Composition having gelling properties for the sustained delivery of bioactive substances
US20050031650A1 (en) * 2002-08-26 2005-02-10 Ethypharm Composition with gelling properties for the sustained delivery of bioactive substances
RU2294751C2 (ru) * 2002-09-30 2007-03-10 Реджен Байотек, Инк. Композиция для стимулирования образования костной ткани и сращения кости
JP2006503614A (ja) * 2002-09-30 2006-02-02 リージェン バイオテック インコーポレーテッド 骨形成及び骨硬化促進用組成物
WO2004050100A1 (en) * 2002-12-03 2004-06-17 Bio Syntech Canada Inc. Method for treating a tumor using a thermo-gelling chitosan composition
EP1620140B1 (de) 2003-05-05 2013-10-09 Ben-Gurion University Of The Negev Research And Development Authority Injizierbare vernetzte polymere zusammensetzungen und deren verwendungen
US7524514B2 (en) 2003-12-01 2009-04-28 Tissue Engineering Consultants, Inc. Biomimetic composition reinforced by a polyelectrolytic complex of hyaluronic acid and chitosan
GB0403938D0 (en) * 2004-02-21 2004-03-24 West Pharm Serv Drug Res Ltd Chitosan containing solution
CA2560432C (en) * 2004-03-22 2012-10-09 Universite De Geneve Pseudo-thermosetting neutralized chitosan composition forming a hydrogel and a process for producing the same
US20050255161A1 (en) * 2004-05-10 2005-11-17 Servet Buyuktimkin Method for the long term stabilization of labile compounds at room temperature in pharmaceutical preparations containing water
US7789913B2 (en) * 2004-06-29 2010-09-07 Spine Wave, Inc. Methods for injecting a curable biomaterial into an intervertebral space
US8512730B2 (en) * 2004-07-12 2013-08-20 Isto Technologies, Inc. Methods of tissue repair and compositions therefor
CA2570521C (en) * 2004-07-12 2013-06-25 Isto Technologies, Inc. Tissue matrix system
ATE397941T1 (de) * 2005-09-02 2008-07-15 Jordanian Pharmaceutical Mfg Chitosan-siliziumdioxid-co-präzipitat und verwendung als hilfsstoff in festen dosierungsformen
US20090149421A1 (en) * 2005-11-04 2009-06-11 Bio Syntech Canada Inc. Gel formation of polyelectrolyte aqueous solutions by thermally induced changes in ionization state
CA2628313A1 (en) * 2005-11-04 2007-05-31 Bio Syntech Canada Inc. Composition and method for efficient delivery of nucleic acids to cells using chitosan
ES2528272T3 (es) * 2005-12-07 2015-02-06 Isto Technologies Inc. Métodos de reparación de cartílago
RU2385710C1 (ru) * 2005-12-23 2010-04-10 Лаборатуар Медидом С.А. Термореактивная нейтрализованная композиция хитозана, образующая гидрогель, ее лиофилизат и способы получения
CA2634479C (en) * 2005-12-23 2013-02-05 Universite De Geneve Thermosetting neutralized chitosan composition forming a hydrogel, lyophilizate, and processes for producing the same
EP1986692B1 (de) * 2006-01-25 2018-03-07 University Of Virginia Patent Foundation Verfahren zur steuerung der gelierung von chitosan-lösungen und anwendungen davon
FR2897775B1 (fr) * 2006-02-24 2013-05-03 Elisabeth Laugier Biomateriau, implant injectable le comprenant, son procede de preparation et ses utilisations
WO2007123993A2 (en) * 2006-04-19 2007-11-01 University Of South Florida Niosome-hydrogel drug delivery
ITPD20060203A1 (it) * 2006-05-22 2007-11-23 Univ Degli Studi Trieste Idrogeli di miscele di polisaccaridi per l'ingegneria tissutale e la veicolazione di composti attivi
WO2008072230A1 (en) * 2006-12-11 2008-06-19 Chit2Gel Ltd. Novel injectable chitosan mixtures forming hydrogels
US8153612B2 (en) 2006-12-11 2012-04-10 Chi2Gel Ltd. Injectable chitosan mixtures forming hydrogels
US9034348B2 (en) 2006-12-11 2015-05-19 Chi2Gel Ltd. Injectable chitosan mixtures forming hydrogels
ITMI20062513A1 (it) * 2006-12-27 2008-06-28 Univ Parma Composizioni di gel stabili citocompatibili adatti a fungere da supporto per la crescita cellulare
EP2476411A1 (de) * 2007-03-13 2012-07-18 Biolinerx Ltd. Verfahren zur Förderung von Gewebereparatur
US8932560B2 (en) 2007-09-04 2015-01-13 University of Maryland, College Parke Advanced functional biocompatible polymeric matrix used as a hemostatic agent and system for damaged tissues and cells
DE102007034580B4 (de) 2007-07-13 2012-11-08 NMI Naturwissenschaftliches und Medizinisches Institut an der Universität Tübingen Biomaterial basierend auf einem hydrophilen polymeren Träger
US8480651B2 (en) 2007-08-02 2013-07-09 Covidien Lp Cannula system
US20110097408A1 (en) * 2007-12-10 2011-04-28 O'malley Bert W Chitosan-based matrices and uses thereof
CL2008000156A1 (es) 2008-01-18 2008-08-01 Igloo Zone Chile S A Gel estable hidrofilo en base a un polimero para aplicacion topica porque comprende quitosano disuelto en un solvente; proceso para obtener el gel para uso topico antes mencionado; uso del gel.
DE102008008071A1 (de) 2008-01-28 2009-08-06 NMI Naturwissenschaftliches und Medizinisches Institut an der Universität Tübingen Injizierbare biokompatible Zusammensetzung
US8653319B2 (en) 2008-04-24 2014-02-18 Medtronic, Inc. Cold ionizing radiation sterilization
US9198997B2 (en) 2008-04-24 2015-12-01 Medtronic, Inc. Rehydratable thiolated polysaccharide particles and sponge
AU2009240512B2 (en) 2008-04-24 2014-07-10 Medtronic, Inc. Protective gel based on chitosan and oxidized polysaccharide
CN102883715B (zh) 2008-04-24 2014-11-12 麦德托尼克公司 包含壳聚糖的保护性组合物
JP5746617B2 (ja) * 2008-06-11 2015-07-08 チ２ジェル リミテッドＣｈｉ２Ｇｅｌ Ｌｔｄ． キトサン混合物を形成する注入可能なヒドロゲル
EP2307065B1 (de) * 2008-07-02 2018-02-14 Allergan, Inc. Zusammensetzungen und verfahren für gewebeauffüllung und geweberegeneration
US20110229565A1 (en) 2008-09-17 2011-09-22 Karp Jeffrey M Drug Delivery Composition Comprising a Self-Assembled Gelator
JP2012506912A (ja) 2008-11-04 2012-03-22 ユニバーシティ オブ ケンタッキー リサーチ ファウンデーション アテローム硬化症、メタボリックシンドロームおよびそれらの症状を予防および処置するためのｄ−タガトースベースの組成物および方法
CA2771365A1 (en) 2009-09-01 2011-03-10 Medovent Gmbh Chitosan tissue dressing
EP2498820B1 (de) 2009-11-13 2019-01-09 University of Maryland, College Park Erweiterter funktioneller biokompatibler schaumstoff als hämostasemittel für komprimierbare und nicht komprimierbare akute wunden
WO2011060554A1 (en) * 2009-11-19 2011-05-26 Corporation De L'ecole Polytechnique De Montreal Presolidified composition and method for in situ delivery of broad molecular weight range of chitosan implants with or without therapeutics for regenerative medicine and cartilage repair applications
US9427469B2 (en) 2009-11-19 2016-08-30 Ortho Regenerative Technologies Inc. Soluble physiological chitosan formulations combined with platelet-rich plasma (PRP) for tissue repair
WO2011060553A1 (en) * 2009-11-19 2011-05-26 Corporation De L'ecole Polytechnique De Montreal Formulation and method for rapid preparation of isotonic and cytocompatible chitosan solutions without inducing chitosan precipitation
US8623403B2 (en) * 2009-12-02 2014-01-07 University Of Virginia Patent Foundation Methods for regulating gelation of hydrogel solutions and uses thereof
US8840867B2 (en) * 2010-05-20 2014-09-23 Val-Chum Limited Partnership Embolizing sclerosing hydrogel
WO2012024785A1 (en) * 2010-08-27 2012-03-01 Oligo Medic Inc. Highly biocompatible dual thermogelling chitosan/glucosamine salt compositions
TWI386224B (zh) * 2010-09-07 2013-02-21 Univ Nat Chiao Tung 可注射性智慧凝膠及其製備方法
EP2618821A4 (de) 2010-09-24 2014-08-13 Brigham & Womens Hospital Nanostrukturierte gele zur kontrollierten freisetzung verkapselter mittel
NL2007179C2 (en) * 2011-07-26 2013-01-29 Stichting Katholieke Universiteit Chitosan-based hydrogels containing enzyme alkaline phosphatase.
WO2013076305A1 (en) 2011-11-25 2013-05-30 Danmarks Tekniske Universitet Formulation of solid nano-sized particles in a gel-forming system
TWI473627B (zh) * 2012-02-17 2015-02-21 Taipei Veterans General Hospital 用於幹細胞療法注射傳輸系統的雙性幾丁質奈米膠
ES2627868T3 (es) 2012-10-25 2017-07-31 Mdt Int'l S.A. Composiciones mucoadhesivas que comprenden ácido hialurónico y quitosano para aplicación tópica
US10245306B2 (en) 2012-11-16 2019-04-02 Isto Technologies Ii, Llc Flexible tissue matrix and methods for joint repair
WO2014160136A1 (en) 2013-03-13 2014-10-02 University Of Maryland, Office Of Technology Commercialization Advanced functional biocompatible polymer putty used as a hemostatic agent for treating damaged tissue and cells
EP3052083A4 (de) 2013-09-30 2017-05-03 Bioactive Regenerative Therapeutics, Inc. Biomimetische hybridgelzusammensetzungen und verfahren zur verwendung
US9192692B2 (en) 2013-10-24 2015-11-24 Medtronic Xomed, Inc. Chitosan stenting paste
US9192574B2 (en) 2013-10-24 2015-11-24 Medtronic Xomed, Inc. Chitosan paste wound dressing
RU2016129138A (ru) * 2013-12-19 2018-01-24 Новартис Аг Системы доставки лекарственных средств
US9522114B1 (en) 2014-03-27 2016-12-20 University Of South Florida Enhanced targeted drug delivery system via chitosan hydrogel and chlorotoxin
FR3024362A1 (fr) 2014-08-01 2016-02-05 Synolyne Pharma Sa Composition thermogelifiable sterilisee
TWI569809B (zh) * 2014-10-08 2017-02-11 國立交通大學 長效型持續釋放藥物之注射式凝膠組成物及其製備方法
US10179191B2 (en) 2014-10-09 2019-01-15 Isto Technologies Ii, Llc Flexible tissue matrix and methods for joint repair
EP3234000A4 (de) * 2014-12-17 2018-06-20 Socovar, L.P. Chitosanbasiertes hydrogel und anwendungen davon
BR112017013251A2 (pt) * 2014-12-23 2018-02-27 Koninklijke Philips Nv dispositivo para a aplicação aos dentes ou gengiva, método de gelificação, e, kit de tratamento bucal
EA026104B1 (ru) * 2015-04-02 2017-03-31 Общество С Ограниченной Ответственностью "Тектум" Кровоостанавливающее и ранозаживляющее средство
FR3038318B1 (fr) * 2015-07-02 2017-08-04 Univ De Lille 1 Sciences Et Technologies Procede de fabrication d'hydrogel a base de chitosan et de polyelectrolytes charges negativement et materiau poreux alveolaire issu dudit hydrogel
FR3038838B1 (fr) 2015-07-13 2017-08-18 Synolyne Pharma Chitosane pour melange avec un fluide coagulable
AU2016335846B2 (en) 2015-10-08 2019-04-04 The Brigham And Women's Hospital, Inc. Stabilized assembled nanostructures for delivery of encapsulated agents
EP3370698B1 (de) * 2015-11-03 2022-01-26 Zoetis Services LLC Polymere sol-gel-verbundwerkstoffe und verwendungen davon
US9655842B1 (en) 2015-12-04 2017-05-23 Covidien Lp Injectable non-aqueous compositions and methods of treating vascular disease
US9732303B2 (en) 2016-01-06 2017-08-15 The Procter & Gamble Company Microcapsules formed from phosphate esters and compositions containing same
US10154947B2 (en) 2016-01-06 2018-12-18 The Procter & Gamble Company Antiperspirant composition
US9730867B2 (en) 2016-01-06 2017-08-15 The Procter & Gamble Company Methods of forming a slurry with microcapsules formed from phosphate esters
BR112018068794A2 (pt) * 2016-03-18 2019-04-09 Her Majesty The Queen In Right Of Canada As Represented By The Mini Of Agriculture And Agri Food composição para a prevenção de infecção intramamária e método de prevenção de infecção intramamária
EP3452094B1 (de) * 2016-05-06 2021-11-17 The Brigham and Women's Hospital, Inc. Binäre selbstangeordnete gele zur kontrollierten abgabe von verkapselten wirkstoffen an knorpel
US11020410B2 (en) 2017-02-03 2021-06-01 The Brigham And Women's Hospital, Inc. Self-assembled gels formed with anti-retroviral drugs, prodrugs thereof, and pharmaceutical uses thereof
JP7123971B2 (ja) * 2017-04-20 2022-08-23 ゾエティス・サービシーズ・エルエルシー 乳腺炎を処置する際に使用する動物用組成物、及び関連方法
JP7211974B2 (ja) 2017-05-08 2023-01-24 アリヴィオ セラピューティクス， インコーポレイテッド 増大した薬剤負荷および接着のためのナノ構造化ゲルの製剤
WO2019094568A1 (en) * 2017-11-09 2019-05-16 Isp Investments Llc Thickener systems for oral care compositions and a method for preparing the same
US10784440B2 (en) 2017-11-10 2020-09-22 Taiwan Semiconductor Manufacturing Co., Ltd. Magnetic random access memory with various size magnetic tunneling junction film stacks
CN111629766A (zh) 2017-12-01 2020-09-04 硕腾服务有限责任公司 水凝胶组合物及其用途
JP7370560B2 (ja) * 2018-05-29 2023-10-30 公立大学法人大阪 生体活性セメントペーストおよび生体活性セメントを製造するためのキット、生体活性セメントペーストおよびその製造方法
CA3113948A1 (en) 2018-10-11 2020-04-16 Alivio Therapeutics, Inc. Non-injectable hydrogel formulations for smart release
CN110180023B (zh) * 2019-06-17 2021-07-13 湖南工业大学 一种高强度生物质组织工程支架材料的制备方法
KR102100506B1 (ko) 2019-06-27 2020-04-13 주식회사 메디팹 온도 감응성 키토산 하이드로겔 조성물 및 그를 포함하는 바이오 잉크 조성물
CN112442139B (zh) * 2019-08-29 2021-09-03 武汉大学 一种基于弱碱体系均相制备不同壳聚糖衍生物的方法
CN110522947B (zh) * 2019-09-16 2021-04-02 青岛大学 一种4d-壳聚糖温敏凝胶制备方法
CN110935008B (zh) * 2019-12-10 2023-09-26 昆明医科大学第一附属医院 一种关节腔注射治疗骨关节炎的tn14003温敏型凝胶及其制备方法
CN111068116B (zh) * 2019-12-28 2022-03-22 河北柯瑞生物医药有限公司 一种注射用软骨修复温敏凝胶及其制备方法
CN111560244B (zh) * 2020-06-02 2023-08-18 安徽工程大学 一种pH响应的壳聚糖荧光复合胶束及其制备方法和应用
CN111939325B (zh) * 2020-08-14 2022-06-17 深圳市人民医院 一种可注射复合水凝胶及其制备方法和应用
US20240352157A1 (en) * 2021-04-30 2024-10-24 Oligo Médic Inc Dissolution of chitosan in aprotic aqueous medium composition, preparation methods and biomedical uses thereof
LU503425B1 (en) * 2022-02-11 2023-09-20 Heilongjiang Kaizhenglihua Biological And Chemical Tech Co Ltd Low-cost temperature-sensitive hydrogel for wound treatment and preparation method thereof
CN115193349B (zh) * 2022-06-17 2023-09-26 佳木斯大学 一种多孔空心碳纳米球的制备方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4185618A (en) 1976-01-05 1980-01-29 Population Research, Inc. Promotion of fibrous tissue growth in fallopian tubes for female sterilization
US4391909A (en) 1979-03-28 1983-07-05 Damon Corporation Microcapsules containing viable tissue cells
SE441009B (sv) * 1982-03-08 1985-09-02 Kjell Nilsson Sett att immobilisera levande biomaterial i perlformiga polymerer
US4474769A (en) 1983-05-13 1984-10-02 Pfanstiehl Laboratories, Inc. Chitosan as a contraceptive
US4659700A (en) * 1984-03-02 1987-04-21 Johnson & Johnson Products, Inc. Chitosan-glycerol-water gel
US4956350A (en) * 1988-08-18 1990-09-11 Minnesota Mining And Manufacturing Company Wound filling compositions
US5126141A (en) * 1988-11-16 1992-06-30 Mediventures Incorporated Composition and method for post-surgical adhesion reduction with thermo-irreversible gels of polyoxyalkylene polymers and ionic polysaccharides
US5073202A (en) * 1989-03-09 1991-12-17 Micro Vesicular Systems, Inc. Method of using a biodegradable superabsorbing sponge
US5318780A (en) * 1991-10-30 1994-06-07 Mediventures Inc. Medical uses of in situ formed gels
US5266326A (en) 1992-06-30 1993-11-30 Pfizer Hospital Products Group, Inc. In situ modification of alginate
US5871985A (en) * 1992-09-28 1999-02-16 Brown University Research Foundation Particulate non cross-linked chitosan core matrices for encapsulated cells
CA2130295A1 (en) * 1993-08-26 1995-02-27 Richard A. Berg Ionically crosslinked glycosaminoglycan gels for soft tissue augmentation and drug delivery
US5422116A (en) 1994-02-18 1995-06-06 Ciba-Geigy Corporation Liquid ophthalmic sustained release delivery system
TW389694B (en) * 1995-08-17 2000-05-11 Novartis Ag Compositions including o-carboxyalkyl chitosan and methods of use in ophthalmics
AU1051597A (en) * 1995-11-09 1997-05-29 University Of Massachusetts Tissue re-surfacing with hydrogel-cell compositions

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AU6915098A (en) 1999-03-01
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IL134368A0 (en) 2001-04-30
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US6344488B1 (en) 2002-02-05
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