PT1003567E - Formacao dependentes do ph e controlada pela temperatura de geis de polissacarido ionico - Google Patents
Formacao dependentes do ph e controlada pela temperatura de geis de polissacarido ionicoInfo
- Publication number
- PT1003567E PT1003567E PT98914751T PT98914751T PT1003567E PT 1003567 E PT1003567 E PT 1003567E PT 98914751 T PT98914751 T PT 98914751T PT 98914751 T PT98914751 T PT 98914751T PT 1003567 E PT1003567 E PT 1003567E
- Authority
- PT
- Portugal
- Prior art keywords
- chitosan
- temperature
- phosphate
- organo
- aqueous
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- 230000001419 dependent effect Effects 0.000 title 1
- 229920001661 Chitosan Polymers 0.000 abstract 6
- 229910019142 PO4 Inorganic materials 0.000 abstract 3
- 238000001879 gelation Methods 0.000 abstract 3
- 239000010452 phosphate Substances 0.000 abstract 3
- 239000007864 aqueous solution Substances 0.000 abstract 2
- 239000000499 gel Substances 0.000 abstract 2
- 239000000243 solution Substances 0.000 abstract 2
- 241001465754 Metazoa Species 0.000 abstract 1
- 239000003929 acidic solution Substances 0.000 abstract 1
- 230000007547 defect Effects 0.000 abstract 1
- 150000004676 glycans Chemical class 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 238000011065 in-situ storage Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 150000004712 monophosphates Chemical class 0.000 abstract 1
- 229920005862 polyol Polymers 0.000 abstract 1
- 150000003077 polyols Chemical class 0.000 abstract 1
- 229920001282 polysaccharide Polymers 0.000 abstract 1
- 239000005017 polysaccharide Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/08—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0052—Mixtures of macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/008—Hydrogels or hydrocolloids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/20—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/26—Mixtures of macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/52—Hydrogels or hydrocolloids
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
- C08L5/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Dermatology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Dispersion Chemistry (AREA)
- Materials Engineering (AREA)
- Neurosurgery (AREA)
- Inorganic Chemistry (AREA)
- Biomedical Technology (AREA)
- Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
- Physical Vapour Deposition (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA002212300A CA2212300A1 (en) | 1997-08-04 | 1997-08-04 | In vitro or in vivo gelfying chitosan and therapeutic uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1003567E true PT1003567E (pt) | 2003-12-31 |
Family
ID=4161194
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT98914751T PT1003567E (pt) | 1997-08-04 | 1998-04-06 | Formacao dependentes do ph e controlada pela temperatura de geis de polissacarido ionico |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US6344488B1 (pt) |
| EP (1) | EP1003567B1 (pt) |
| JP (1) | JP3634748B2 (pt) |
| AT (1) | ATE246524T1 (pt) |
| AU (1) | AU724878B2 (pt) |
| CA (1) | CA2212300A1 (pt) |
| DE (1) | DE69816996T2 (pt) |
| DK (1) | DK1003567T3 (pt) |
| ES (1) | ES2205471T3 (pt) |
| IL (1) | IL134368A (pt) |
| NO (1) | NO330580B1 (pt) |
| NZ (1) | NZ502919A (pt) |
| PT (1) | PT1003567E (pt) |
| WO (1) | WO1999007416A1 (pt) |
Families Citing this family (116)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7767452B2 (en) | 1997-02-20 | 2010-08-03 | Kleinsek Don A | Tissue treatments with adipocyte cells |
| US6245740B1 (en) * | 1998-12-23 | 2001-06-12 | Amgen Inc. | Polyol:oil suspensions for the sustained release of proteins |
| FR2799371A1 (fr) * | 1999-10-12 | 2001-04-13 | Univ Paris Curie | Compositions de tenocytes preparation et utilisations |
| AU2005202256B2 (en) * | 1999-11-05 | 2008-04-03 | Gerigene Medical Corporation | Augmentation and repair of age-related soft tissue defects |
| JP2003517858A (ja) * | 1999-11-05 | 2003-06-03 | ジェリジーン メディカル コーポレーション | 老齢関連の軟組織の欠陥の増強と修復 |
| DK1229940T3 (da) * | 1999-11-15 | 2014-08-18 | Piramal Healthcare Canada Ltd | Temperaturstyret og ph-afhængig selvgelerende, vandig biopolymeropløsning |
| AU1792601A (en) * | 1999-12-07 | 2001-06-18 | Amgen, Inc. | Thermosensitive biodegradable hydrogels based on low molecular weight pluronics |
| ATE243049T1 (de) * | 1999-12-09 | 2003-07-15 | Biosyntech Canada Inc | Mineral-polymer hybrid-zusammensetzung |
| US20030158302A1 (en) * | 1999-12-09 | 2003-08-21 | Cyric Chaput | Mineral-polymer hybrid composition |
| AU5723601A (en) | 2000-04-25 | 2001-11-07 | Osiris Therapeutics Inc | Joint repair using mesenchymal stem cells |
| IL153490A0 (en) * | 2000-06-29 | 2003-07-06 | Biosyntech Canada Inc | Composition and method for the repair and regeneration of cartilage and other tissues |
| US6989373B2 (en) * | 2000-11-15 | 2006-01-24 | Bio Syntech Canada Inc. | Method for restoring a fat-pad |
| CA2429165A1 (en) * | 2000-11-15 | 2002-05-23 | Bio Syntech Canada Inc. | Filler composition for soft tissue augmentation and reconstructive surgery |
| WO2002040070A2 (en) * | 2000-11-15 | 2002-05-23 | Bio Syntech Canada Inc. | Method for restoring a damaged or degenerated intervertebral disc |
| US7449180B2 (en) * | 2001-02-06 | 2008-11-11 | John Kisiday | Macroscopic scaffold containing amphiphilic peptides encapsulating cells |
| JP3993855B2 (ja) | 2001-11-01 | 2007-10-17 | スパイン・ウェイブ・インコーポレーテッド | 脊椎椎間板の回復のための装置 |
| JP4125234B2 (ja) | 2001-11-01 | 2008-07-30 | スパイン・ウェイブ・インコーポレーテッド | 椎間板間の終板の前処理のための装置及び方法 |
| TWI245634B (en) * | 2001-12-28 | 2005-12-21 | Ind Tech Res Inst | Preparation of a biodegradable thermal-sensitive gel system |
| EP1485066B1 (fr) | 2002-03-12 | 2016-09-21 | Ethypharm | Composition a proprietes gelifiantes destinee a la delivrance prolongee de substances bio-actives |
| US20050031650A1 (en) * | 2002-08-26 | 2005-02-10 | Ethypharm | Composition with gelling properties for the sustained delivery of bioactive substances |
| JP2006503614A (ja) * | 2002-09-30 | 2006-02-02 | リージェン バイオテック インコーポレーテッド | 骨形成及び骨硬化促進用組成物 |
| RU2294751C2 (ru) * | 2002-09-30 | 2007-03-10 | Реджен Байотек, Инк. | Композиция для стимулирования образования костной ткани и сращения кости |
| WO2004050100A1 (en) * | 2002-12-03 | 2004-06-17 | Bio Syntech Canada Inc. | Method for treating a tumor using a thermo-gelling chitosan composition |
| KR101180896B1 (ko) | 2003-05-05 | 2012-09-07 | 벤-구리온 유니버시티 오브 더 네게브 리서치 앤드 디벨럽먼트 어쏘러티 | 주사용 가교결합된 폴리머 제제 및 그의 용도 |
| US7524514B2 (en) | 2003-12-01 | 2009-04-28 | Tissue Engineering Consultants, Inc. | Biomimetic composition reinforced by a polyelectrolytic complex of hyaluronic acid and chitosan |
| GB0403938D0 (en) * | 2004-02-21 | 2004-03-24 | West Pharm Serv Drug Res Ltd | Chitosan containing solution |
| JP5083967B2 (ja) * | 2004-03-22 | 2012-11-28 | ラボラトラ メディドム エス.アー. | ヒドロゲルを形成する、偽熱硬化性の中和されたキトサン組成物、および、この組成物を製造するためのプロセス |
| US20050255161A1 (en) * | 2004-05-10 | 2005-11-17 | Servet Buyuktimkin | Method for the long term stabilization of labile compounds at room temperature in pharmaceutical preparations containing water |
| US7837733B2 (en) * | 2004-06-29 | 2010-11-23 | Spine Wave, Inc. | Percutaneous methods for injecting a curable biomaterial into an intervertebral space |
| US8512730B2 (en) * | 2004-07-12 | 2013-08-20 | Isto Technologies, Inc. | Methods of tissue repair and compositions therefor |
| EP1773299B1 (en) * | 2004-07-12 | 2017-07-05 | Isto Technologies Inc. | Tissue matrix system |
| DE602005007491D1 (de) * | 2005-09-02 | 2008-07-24 | Jordanian Pharmaceutical Mfg | Chitosan-Siliziumdioxid-Co-Präzipitat und Verwendung als Hilfsstoff in festen Dosierungsformen |
| CA2628313A1 (en) * | 2005-11-04 | 2007-05-31 | Bio Syntech Canada Inc. | Composition and method for efficient delivery of nucleic acids to cells using chitosan |
| EP1945712A4 (en) * | 2005-11-04 | 2013-05-01 | Piramal Healthcare Canada Ltd | BINDING OF AQUEOUS POLYELECTROLYTE SOLUTIONS BY THERMALLY INDUCED CHANGES IN THE IONIZATION CONDITION |
| JP2009518132A (ja) * | 2005-12-07 | 2009-05-07 | イスト・テクノロジーズ・インコーポレイテッド | 軟骨修復方法 |
| PL1978925T3 (pl) * | 2005-12-23 | 2010-01-29 | Laboratoire Medidom S A | Termoutwardzalna zobojętniona kompozycja chitozanu tworząca hydrożel, liofilizat i sposoby ich wytwarzania |
| RU2385710C1 (ru) * | 2005-12-23 | 2010-04-10 | Лаборатуар Медидом С.А. | Термореактивная нейтрализованная композиция хитозана, образующая гидрогель, ее лиофилизат и способы получения |
| US8536230B2 (en) * | 2006-01-25 | 2013-09-17 | University Of Virginia Patent Foundation | Methods for regulating gelation of polysaccharide solutions and uses thereof |
| FR2897775B1 (fr) * | 2006-02-24 | 2013-05-03 | Elisabeth Laugier | Biomateriau, implant injectable le comprenant, son procede de preparation et ses utilisations |
| WO2007123993A2 (en) * | 2006-04-19 | 2007-11-01 | University Of South Florida | Niosome-hydrogel drug delivery |
| ITPD20060203A1 (it) * | 2006-05-22 | 2007-11-23 | Univ Degli Studi Trieste | Idrogeli di miscele di polisaccaridi per l'ingegneria tissutale e la veicolazione di composti attivi |
| US8153612B2 (en) | 2006-12-11 | 2012-04-10 | Chi2Gel Ltd. | Injectable chitosan mixtures forming hydrogels |
| JP5539727B2 (ja) * | 2006-12-11 | 2014-07-02 | チット2ジェル リミテッド | ヒドロゲルを形成する新規な注入可能なキトサン混合物 |
| US9034348B2 (en) | 2006-12-11 | 2015-05-19 | Chi2Gel Ltd. | Injectable chitosan mixtures forming hydrogels |
| ITMI20062513A1 (it) * | 2006-12-27 | 2008-06-28 | Univ Parma | Composizioni di gel stabili citocompatibili adatti a fungere da supporto per la crescita cellulare |
| JP2010521215A (ja) * | 2007-03-13 | 2010-06-24 | バイオラインアールエックス リミテッド | 組織の修復を促進する方法 |
| US8932560B2 (en) | 2007-09-04 | 2015-01-13 | University of Maryland, College Parke | Advanced functional biocompatible polymeric matrix used as a hemostatic agent and system for damaged tissues and cells |
| DE102007034580B4 (de) | 2007-07-13 | 2012-11-08 | NMI Naturwissenschaftliches und Medizinisches Institut an der Universität Tübingen | Biomaterial basierend auf einem hydrophilen polymeren Träger |
| US8480651B2 (en) * | 2007-08-02 | 2013-07-09 | Covidien Lp | Cannula system |
| WO2009076369A1 (en) * | 2007-12-10 | 2009-06-18 | The Trustees Of The University Of Pennsylvania | Chitosan-based matrices and uses thereof |
| CL2008000156A1 (es) | 2008-01-18 | 2008-08-01 | Igloo Zone Chile S A | Gel estable hidrofilo en base a un polimero para aplicacion topica porque comprende quitosano disuelto en un solvente; proceso para obtener el gel para uso topico antes mencionado; uso del gel. |
| DE102008008071A1 (de) | 2008-01-28 | 2009-08-06 | NMI Naturwissenschaftliches und Medizinisches Institut an der Universität Tübingen | Injizierbare biokompatible Zusammensetzung |
| CN102065849B (zh) | 2008-04-24 | 2015-04-29 | 麦德托尼克公司 | 基于壳聚糖和氧化多糖的保护性凝胶 |
| CN102883715B (zh) | 2008-04-24 | 2014-11-12 | 麦德托尼克公司 | 包含壳聚糖的保护性组合物 |
| WO2009132229A2 (en) | 2008-04-24 | 2009-10-29 | Medtronic, Inc. | Cold ionizing radiation sterilization |
| JP2011518837A (ja) | 2008-04-24 | 2011-06-30 | メドトロニック,インコーポレイテッド | 再水和可能なチオール化多糖粒子およびスポンジ |
| EP2294126A1 (en) * | 2008-06-11 | 2011-03-16 | Chi2Gel Ltd. | Injectable hydrogel forming chitosan mixtures |
| ES2729962T3 (es) * | 2008-07-02 | 2019-11-07 | Allergan Inc | Composiciones para el relleno y la regeneración de tejido blando |
| WO2010033726A2 (en) | 2008-09-17 | 2010-03-25 | The Brigham And Women's Hospital, Inc. | Drug delivery composition comprising a self-assembled gelator |
| RU2484827C2 (ru) | 2008-11-04 | 2013-06-20 | Юниверсити Оф Кентукки Рисерч Фаундэйшн | Композиции на основе d-тагатозы и способы предупреждения и лечения атеросклероза, метаболического синдрома и их симптомов |
| US10207022B2 (en) * | 2009-09-01 | 2019-02-19 | Medoderm Gmbh | Chitosan tissue dressing |
| CA2780898A1 (en) | 2009-11-13 | 2011-05-19 | University Of Maryland, College Park | Advanced functional biocompatible foam used as a hemostatic agent for compressible and non-compressible acute wounds |
| ES2691723T3 (es) | 2009-11-19 | 2018-11-28 | Ortho Regenerative Technologies Inc. | Formulaciones de quitosán fisiológicas solubles combinadas con plasma rico en plaquetas (PRP) para reparación de tejidos |
| WO2011060554A1 (en) * | 2009-11-19 | 2011-05-26 | Corporation De L'ecole Polytechnique De Montreal | Presolidified composition and method for in situ delivery of broad molecular weight range of chitosan implants with or without therapeutics for regenerative medicine and cartilage repair applications |
| WO2011060553A1 (en) * | 2009-11-19 | 2011-05-26 | Corporation De L'ecole Polytechnique De Montreal | Formulation and method for rapid preparation of isotonic and cytocompatible chitosan solutions without inducing chitosan precipitation |
| WO2011068774A2 (en) * | 2009-12-02 | 2011-06-09 | University Of Virginia Patent Foundation | Methods for regulating gelation of hydrogel solutions and uses thereof |
| US8840867B2 (en) * | 2010-05-20 | 2014-09-23 | Val-Chum Limited Partnership | Embolizing sclerosing hydrogel |
| EA024569B1 (ru) * | 2010-08-27 | 2016-09-30 | Олиго Медик Инк. | Высокобиосовместимые композиции хитозана/солей глюкозамина с двусторонним термогелеобразованием |
| TWI386224B (zh) * | 2010-09-07 | 2013-02-21 | Univ Nat Chiao Tung | 可注射性智慧凝膠及其製備方法 |
| BR112013008697A2 (pt) | 2010-09-24 | 2016-06-21 | Massachusetts Inst Technology | géis nanoestruturados capazes de liberação controlada de agentes encapsulados |
| NL2007179C2 (en) * | 2011-07-26 | 2013-01-29 | Stichting Katholieke Universiteit | Chitosan-based hydrogels containing enzyme alkaline phosphatase. |
| EP2782603A1 (en) | 2011-11-25 | 2014-10-01 | Danmarks Tekniske Universitet | Formulation of solid nano-sized particles in a gel-forming system |
| TWI473627B (zh) * | 2012-02-17 | 2015-02-21 | Taipei Veterans General Hospital | 用於幹細胞療法注射傳輸系統的雙性幾丁質奈米膠 |
| EP2922581B1 (en) | 2012-10-25 | 2017-03-15 | Mdt Int'l S.A. | Mucoadhesive compositions comprising hyaluronic acid and chitosan for topical application |
| US10245306B2 (en) | 2012-11-16 | 2019-04-02 | Isto Technologies Ii, Llc | Flexible tissue matrix and methods for joint repair |
| CA2914610C (en) | 2013-03-13 | 2022-08-02 | University Of Maryland | Advanced functional biocompatible polymer putty used as a hemostatic agent for treating damaged tissue and cells |
| AU2014324459B2 (en) | 2013-09-30 | 2018-10-11 | Bioactive Regenerative Therapeutics, Inc. | Biomimetic hybrid gel compositions and methods of use |
| US9192574B2 (en) * | 2013-10-24 | 2015-11-24 | Medtronic Xomed, Inc. | Chitosan paste wound dressing |
| US9192692B2 (en) | 2013-10-24 | 2015-11-24 | Medtronic Xomed, Inc. | Chitosan stenting paste |
| EP3082765B1 (en) * | 2013-12-19 | 2018-08-01 | Novartis AG | Drug delivery systems |
| US9522114B1 (en) | 2014-03-27 | 2016-12-20 | University Of South Florida | Enhanced targeted drug delivery system via chitosan hydrogel and chlorotoxin |
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| WO1997017038A1 (en) * | 1995-11-09 | 1997-05-15 | University Of Massachusetts | Tissue re-surfacing with hydrogel-cell compositions |
-
1997
- 1997-08-04 CA CA002212300A patent/CA2212300A1/en not_active Abandoned
-
1998
- 1998-04-06 ES ES98914751T patent/ES2205471T3/es not_active Expired - Lifetime
- 1998-04-06 AU AU69150/98A patent/AU724878B2/en not_active Expired
- 1998-04-06 DK DK98914751T patent/DK1003567T3/da active
- 1998-04-06 NZ NZ502919A patent/NZ502919A/en not_active IP Right Cessation
- 1998-04-06 WO PCT/CA1998/000326 patent/WO1999007416A1/en not_active Ceased
- 1998-04-06 AT AT98914751T patent/ATE246524T1/de active IP Right Revival
- 1998-04-06 EP EP98914751A patent/EP1003567B1/en not_active Expired - Lifetime
- 1998-04-06 DE DE69816996T patent/DE69816996T2/de not_active Expired - Lifetime
- 1998-04-06 IL IL13436898A patent/IL134368A/xx not_active IP Right Cessation
- 1998-04-06 PT PT98914751T patent/PT1003567E/pt unknown
- 1998-04-06 JP JP2000507002A patent/JP3634748B2/ja not_active Expired - Lifetime
-
1999
- 1999-02-12 US US09/250,066 patent/US6344488B1/en not_active Expired - Lifetime
-
2000
- 2000-02-04 NO NO20000593A patent/NO330580B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AU724878B2 (en) | 2000-10-05 |
| JP3634748B2 (ja) | 2005-03-30 |
| EP1003567B1 (en) | 2003-08-06 |
| IL134368A (en) | 2005-09-25 |
| ES2205471T3 (es) | 2004-05-01 |
| JP2001513367A (ja) | 2001-09-04 |
| AU6915098A (en) | 1999-03-01 |
| DK1003567T3 (da) | 2003-12-01 |
| NO20000593L (no) | 2000-03-29 |
| IL134368A0 (en) | 2001-04-30 |
| DE69816996D1 (de) | 2003-09-11 |
| NO330580B1 (no) | 2011-05-16 |
| NZ502919A (en) | 2002-04-26 |
| NO20000593D0 (no) | 2000-02-04 |
| CA2212300A1 (en) | 1999-02-04 |
| US6344488B1 (en) | 2002-02-05 |
| DE69816996T2 (de) | 2004-07-22 |
| WO1999007416A1 (en) | 1999-02-18 |
| EP1003567A1 (en) | 2000-05-31 |
| ATE246524T1 (de) | 2003-08-15 |
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