ATE246807T1 - Adduktabschirmungstest - Google Patents

Adduktabschirmungstest

Info

Publication number
ATE246807T1
ATE246807T1 AT96108880T AT96108880T ATE246807T1 AT E246807 T1 ATE246807 T1 AT E246807T1 AT 96108880 T AT96108880 T AT 96108880T AT 96108880 T AT96108880 T AT 96108880T AT E246807 T1 ATE246807 T1 AT E246807T1
Authority
AT
Austria
Prior art keywords
signal
label
binding partner
adduct
alteration
Prior art date
Application number
AT96108880T
Other languages
English (en)
Inventor
Michael Becker
Norman C Nelson
Original Assignee
Gen Probe Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gen Probe Inc filed Critical Gen Probe Inc
Application granted granted Critical
Publication of ATE246807T1 publication Critical patent/ATE246807T1/de

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6816Hybridisation assays characterised by the detection means
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/13Tracers or tags
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/14Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333Saccharide [e.g., DNA, etc.]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Genetics & Genomics (AREA)
  • General Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT96108880T 1995-06-07 1996-06-03 Adduktabschirmungstest ATE246807T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/478,221 US5731148A (en) 1995-06-07 1995-06-07 Adduct protection assay

Publications (1)

Publication Number Publication Date
ATE246807T1 true ATE246807T1 (de) 2003-08-15

Family

ID=23899023

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96108880T ATE246807T1 (de) 1995-06-07 1996-06-03 Adduktabschirmungstest

Country Status (11)

Country Link
US (1) US5731148A (de)
EP (1) EP0747706B1 (de)
JP (1) JP3577085B2 (de)
KR (1) KR19990022460A (de)
AT (1) ATE246807T1 (de)
AU (1) AU703605B2 (de)
CA (1) CA2222556C (de)
DE (1) DE69629333T2 (de)
DK (1) DK0747706T3 (de)
ES (1) ES2203656T3 (de)
WO (1) WO1996041197A1 (de)

Families Citing this family (83)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5714380A (en) 1986-10-23 1998-02-03 Amoco Corporation Closed vessel for isolating target molecules and for performing amplification
US7070925B1 (en) 1996-07-16 2006-07-04 Gen-Probe Incorporated Method for determining the presence of an RNA analyte in a sample using a modified oligonucleotide probe
US6130038A (en) * 1996-07-16 2000-10-10 Gen-Probe Incorporated Method for amplifying target nucleic acids using modified primers
JP3981416B2 (ja) 1997-04-10 2007-09-26 ユニバーシティ メディカル センター ナイメーヘン Pca3タンパク質、pca3遺伝子、及びこれらの用途
US6534273B2 (en) 1997-05-02 2003-03-18 Gen-Probe Incorporated Two-step hybridization and capture of a polynucleotide
DK0975807T3 (da) 1997-05-02 2007-01-29 Gen Probe Inc To-trins hybridisering og indfangning af et polynukleotid
US6180340B1 (en) 1997-10-31 2001-01-30 Gen-Probe Incorporated Extended dynamic range assays
US6361942B1 (en) 1998-03-24 2002-03-26 Boston Probes, Inc. Method, kits and compositions pertaining to detection complexes
AU762728B2 (en) * 1998-07-02 2003-07-03 Gen-Probe Incorporated Molecular torches
US5998175A (en) * 1998-07-24 1999-12-07 Lumigen, Inc. Methods of synthesizing and amplifying polynucleotides by ligation of multiple oligomers
JP4772966B2 (ja) 1999-02-12 2011-09-14 ジェン−プローブ・インコーポレーテッド 保護プローブ
WO2001004361A2 (en) 1999-07-09 2001-01-18 Gen-Probe Incorporated Detection of hiv-1 by nucleic acid amplification
US6506887B1 (en) * 1999-07-29 2003-01-14 Somalogic, Incorporated Conditional-selex
PT1222266E (pt) 1999-09-29 2006-07-31 Diagnocure Inc Arn mensageiro de pca3 em tecidos benignos e malignos da prostata
US6506567B2 (en) * 2000-01-31 2003-01-14 Fuji Photo Film Co., Ltd. Water-soluble flourescent intercalator compound
IL151047A0 (en) * 2000-02-03 2003-04-10 Res Dev Foundation Signaling aptamers that transduce molecular recognition to a differential signal
AU3090102A (en) * 2000-12-14 2002-06-24 Gen Probe Inc Method and kit for enhancing the association rates of polynucleotides
WO2002059321A2 (en) 2001-01-23 2002-08-01 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa Hepatitis c virus replicons and replicon enhanced cells
US6780602B2 (en) * 2001-11-01 2004-08-24 Microbiosystems, Limited Partnership Taxonomic identification of pathogenic microorganisms and their toxic proteins
AU2003253651C1 (en) 2002-06-14 2010-06-03 Gen-Probe Incorporated Compositions and methods for detecting hepatitis B virus
US7115374B2 (en) 2002-10-16 2006-10-03 Gen-Probe Incorporated Compositions and methods for detecting West Nile virus
WO2004070056A2 (en) 2003-02-07 2004-08-19 Diagnocure Inc. Method to detect prostate cancer in a sample
US20060257929A1 (en) * 2003-11-12 2006-11-16 Microbiosystems, Limited Partnership Method for the rapid taxonomic identification of pathogenic microorganisms and their toxic proteins
EP1694871B1 (de) 2003-12-19 2010-08-25 Gen-Probe Incorporated Zusammensetzungen, verfahren und kits zum nachweis der nukleinsäuren von hiv-1 und hiv-2
KR20100063144A (ko) 2004-02-18 2010-06-10 크로모셀 코포레이션 신호 프로브를 이용하는 방법 및 물질
EP1745120A4 (de) 2004-04-16 2010-04-14 Spartan Bioscience Inc System zur schnellen nukleinsäureamplifikation und -detektion
US8034554B2 (en) 2004-07-01 2011-10-11 Gen-Probe Incorporated Methods and compositions to detect nucleic acids in a biological sample
EP2402465B1 (de) * 2004-07-13 2014-11-19 Gen-Probe Incorporated Verfahren und Kit zur Detektion von Hepatitis-A-Virus-Nukleinsäure
EP2975139B1 (de) 2004-09-30 2019-11-06 Gen-Probe Incorporated Verfahren zum nachweis und zur quantifizierung von hiv-1
AU2005333163B2 (en) 2004-11-09 2011-06-16 Gen-Probe Incorporated Compositions and methods for detecting Group A streptococci
CA2491067A1 (en) 2004-12-24 2006-06-24 Stichting Katholieke Universiteit Mrna rations in urinary sediments and/or urine as a prognostic marker for prostate cancer
AU2006244460B2 (en) 2005-05-06 2010-04-08 Gen-Probe Incorporated Compositions and assays to detect influenza virus A and B nucleic acids
ES2381279T3 (es) 2005-05-06 2012-05-24 Gen-Probe Incorporated Métodos y productos para la captura de ácido nucleico diana
US20080220432A1 (en) * 2006-11-30 2008-09-11 Chromocell Corporation Optimized host cells for protein production
EP1978111B1 (de) 2007-04-02 2013-03-27 Gen-Probe Incorporated Zusammensetzungen, Kits und zugehörige Verfahren zur Erkennung und/oder Überwachung von Pseudomonas aeruginosa
CA2691197C (en) 2007-06-21 2013-03-12 Gen-Probe Incorporated Instrument and receptacles for use in performing processes
EP2281070B1 (de) 2008-04-21 2015-01-21 Gen-Probe Incorporated Verfahren zum nachweis von chikungunya-virus
EP2806037B1 (de) 2008-05-13 2016-09-21 Gen-Probe Incorporated Inaktivierbare Target-Capture-Oligomere zur Verwendung bei der selektiven Hybridisierung und beim Fangen von Zielnukleinsäuresequenzen
WO2009158119A2 (en) 2008-05-30 2009-12-30 Gen-Probe Incorporated Compositions, kits and related methods for the detection and/or monitoring of salmonella
US8097412B2 (en) * 2008-07-12 2012-01-17 Biodiagnostics, Inc. DNA-based test for detection of annual and intermediate ryegrass
CA2638458A1 (en) * 2008-07-31 2010-01-31 Spartan Bioscience Inc. Thermal recycling by positioning relative to fixed-temperature source
CN102292457B (zh) 2008-11-25 2014-04-09 简·探针公司 检测小rna的组合物和方法及其用途
JP5793085B2 (ja) 2008-12-30 2015-10-14 ジェン−プローブ・インコーポレーテッド Listeriaを検出およびモニターするための組成物、キットおよび関連する方法
EP2391452B1 (de) 2009-01-30 2015-06-17 Gen-Probe Incorporated Systeme und verfahren zur erfassung eines signals und beaufschlagung des signalübertragungselements mit wärmeenergie
CA2756659A1 (en) 2009-02-26 2010-09-02 Gen-Probe Incorporated Assay for detection of human parvovirus nucleic acid
CN102985566B (zh) 2010-06-30 2015-06-17 简.探针公司 使用分析物和过程控制信号的单次读取确定而鉴定含分析物的样品的方法和设备
EP3301195B1 (de) 2010-07-12 2022-11-02 Gen-Probe Incorporated Zusammensetzungen und assays zur detektion der 2009 h1n1-influenza-a-virus-nukleinsäure in schweinen
CA2811333C (en) 2010-09-16 2020-05-12 Gen-Probe Incorporated Capture probes immobilizable via l-nucleotide tail
EP2625297B1 (de) 2010-10-04 2018-10-10 Gen-Probe Prodesse, Inc. Zusammensetzungen, verfahren und kits für den nachweis von adenovirus-nukleinsäuren
WO2013012708A1 (en) 2011-07-15 2013-01-24 Gen-Probe Incorporated Compositions and method for detecting human parvovirus nucleic acid and for detecting hepatitis a virus nucleic acids in single-plex or multiplex assays
DE102011120550B4 (de) 2011-12-05 2013-11-07 Gen-Probe Prodesse, Inc. Zusammensetzungen, Verfahren und Kits zur Detektion von Adenovirusnukleinsäuren
WO2014144991A1 (en) 2013-03-15 2014-09-18 Chromocell Corporation Methods and materials using signaling probes
DE102015220401B4 (de) 2014-10-20 2022-12-29 Gen-Probe Incorporated Erythrozyten-Lyselösung
CN108350407B (zh) 2015-12-11 2022-07-08 杰诺玛迪克斯公司 用于核酸扩增的管密封系统和方法
CA3232826A1 (en) 2016-04-27 2017-11-02 Gen-Probe Incorporated Blood cell lysis reagent
EP3601617B3 (de) 2017-03-24 2024-03-20 Gen-Probe Incorporated Zusammensetzungen und verfahren zum nachweis oder zur quantifizierung des parainfluenzavirus
EP4219770A3 (de) 2017-03-24 2023-08-16 Gen-Probe Incorporated Zusammensetzungen und verfahren zum nachweis von rsv b in proben
FI3601618T3 (fi) 2017-03-25 2024-10-24 Gen Probe Inc Koostumuksia, menetelmiä ja tarvikepakkauksia adenoviruksen, metapneumoviruksen ja/tai rinoviruksen nukleiinihappojen havaitsemiseksi
CN111032209A (zh) 2017-07-10 2020-04-17 简·探针公司 分析系统和方法
WO2019032809A1 (en) 2017-08-11 2019-02-14 Gen-Probe Incorporated COMPOSITIONS AND METHODS FOR DETECTING STAPHYLOCOCCUS AUREUS
JP2021506274A (ja) 2017-12-15 2021-02-22 ジェン−プローブ・インコーポレーテッド 毒素産生Clostridium difficileを検出するための組成物および方法
AU2019212931A1 (en) 2018-01-29 2020-08-27 Gen-Probe Incorporated Analytical systems and methods
GB2597566B (en) 2018-06-13 2023-02-01 Gen Probe Inc Compositions and methods for detecting group B streptococcus nucleic acid
JP7470095B2 (ja) 2018-07-10 2024-04-17 ジェン-プローブ・インコーポレーテッド 核酸を検出および定量するための方法およびシステム
EP3830302B1 (de) 2018-08-01 2022-10-05 Gen-Probe Incorporated Zusammensetzungen und verfahren zum nachweis von nukleinsäuren des epstein-barr-virus
AU2019319203B8 (en) 2018-08-08 2025-10-09 Gen-Probe Incorporated Compositions, methods and kits for detecting Mycoplasma genitalium
JP7579779B2 (ja) 2018-08-21 2024-11-08 ジェン-プローブ・インコーポレーテッド ヒトサイトメガロウイルスを増幅、検出、または定量化するための組成物および方法
EP3856934A2 (de) 2018-09-27 2021-08-04 Gen-Probe Incorporated Zusammensetzungen und verfahren zur detektion von bordetella-pertussis- und bordetella-parapertussis-nukleinsäure
EP3861141B1 (de) 2018-10-01 2026-03-11 Gen-Probe Incorporated Zusammensetzungen und verfahren zur amplifikation oder zum nachweis von varicella-zoster-virus
CA3116895A1 (en) 2018-10-22 2020-04-30 Gen-Probe Incorporated Compositions and methods for amplifying, detecting or quantifying human polyomavirus bk virus
EP4389916A3 (de) 2019-03-22 2024-10-16 Gen-Probe Incorporated Zusammensetzungen und verfahren zum nachweis von gruppe-a-streptococcus
CA3176703C (en) 2019-05-03 2025-10-14 Gen-Probe Incorporated RECEPTACLE TRANSPORT SYSTEM FOR ANALYTICAL SYSTEM
CA3152309A1 (en) 2019-08-23 2021-03-04 Gen-Probe Incorporated Compositions, methods and kits for detecting treponema pallidum
US20220333162A1 (en) 2019-09-05 2022-10-20 Gen-Probe Incorporated Detection of chlamydia trachomatis nucleic acid variants
EP4582563A3 (de) 2020-03-04 2025-10-08 Gen-Probe Incorporated Zusammensetzungen und verfahren zum nachweis von sars-cov-2-nukleinsäure
AU2021365165B2 (en) 2020-10-21 2026-03-05 Gen-Probe Incorporated Fluid container management system
WO2023010008A1 (en) 2021-07-27 2023-02-02 Gen-Probe Incorporated Compositions and methods for detecting gastrointestinal pathogens
WO2023175434A1 (en) 2022-03-15 2023-09-21 Diagenode S.A. Detection of methylation status of a dna sample
WO2024054924A1 (en) 2022-09-08 2024-03-14 Gen-Probe Incorporated Method of detecting nucleic acid analytes using dual-specificity primers
EP4638804A2 (de) 2022-12-19 2025-10-29 Gen-Probe Incorporated Zusammensetzungen und verfahren zum nachweis von gastrointestinalen pathogenen
WO2024192338A1 (en) 2023-03-16 2024-09-19 Gen-Probe Incorporated Compositions and methods for detecting gastrointestinal parasites
KR20240153658A (ko) 2023-04-17 2024-10-24 김보라 슬라이딩 강대상
WO2026050332A1 (en) 2024-08-29 2026-03-05 Gen-Probe Incorporated Methods and compositions for amplifying and/or detecting rotavirus nucleic acids

Family Cites Families (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL6515469A (de) * 1965-01-22 1966-07-25
US3817837A (en) * 1971-05-14 1974-06-18 Syva Corp Enzyme amplification assay
US4190496A (en) * 1971-05-14 1980-02-26 Syva Company Homogeneous enzyme assay for antibodies
US4199559A (en) * 1974-08-12 1980-04-22 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4383031A (en) * 1975-04-28 1983-05-10 Miles Laboratories, Inc. Homogeneous chemiluminescent specific binding assay
US4174384A (en) * 1975-06-30 1979-11-13 Syva Company Fluorescence quenching with immunological pairs in immunoassays
FR2422956A1 (fr) * 1978-04-13 1979-11-09 Pasteur Institut Procede de detection et de caracterisation d'un acide nucleique ou d'une sequence de celui-ci, et reactif enzymatique pour la mise en oeuvre de ce procede
US4318707A (en) * 1978-11-24 1982-03-09 Syva Company Macromolecular fluorescent quencher particle in specific receptor assays
CA1185177A (en) * 1981-07-17 1985-04-09 Larry E. Morrison Non-radiative energy transfer immunochemical technique
CA1190838A (en) * 1981-07-17 1985-07-23 Cavit Akin Homogeneous nucleic acid hybridization diagnostics by non-radiative energy transfer
US4668640A (en) * 1981-12-11 1987-05-26 Abbott Laboratories Fluorescence polarization immunoassay utilizing substituted carboxyfluoresceins
EP0082636B2 (de) * 1981-12-11 2006-10-18 The Welsh National School of Medicine Lumineszierende Markierungssubstanzen und -verfahren
US4462931A (en) * 1982-06-16 1984-07-31 American Cyanamid Company Enhanced aqueous chemiluminescent systems
US4508642A (en) * 1983-04-21 1985-04-02 World Victor B Method of obtaining greater lifetime duration from chemiluminescent systems
US4640898A (en) * 1983-08-01 1987-02-03 University Of Health Sciences/The Chicago Medical School Homogeneous fluorescence ligang binding assay based upon preferential alteration of the respective intensities of bound and free label by solvent components
US4816419A (en) * 1983-08-01 1989-03-28 University Of Health Sciences/The Chicago Medical School Fluorescence ligand binding assay using charge-matched dye and solvent components
US4582789A (en) * 1984-03-21 1986-04-15 Cetus Corporation Process for labeling nucleic acids using psoralen derivatives
AU580042B2 (en) * 1984-03-22 1988-12-22 Bresatec Limited Non-radioactive biological probes
CA1260372A (en) * 1984-04-27 1989-09-26 Elazar Rabbani Hybridization method for the detection of genetic materials
US4670379A (en) * 1984-12-19 1987-06-02 E. I. Du Pont De Nemours And Company Polynucleotide hydridization assays employing catalyzed luminescence
DE3568063D1 (en) * 1985-01-10 1989-03-09 Molecular Diagnostics Inc Photochemical method of labelling nucleic acids for detection in hybridization assays
US4655969A (en) * 1985-04-03 1987-04-07 Richter Herbert P Chemiluminescent systems
JP2509574B2 (ja) * 1985-08-15 1996-06-19 アモコ・コーポレーション 標識付けした核酸
JPS6261969A (ja) * 1985-09-06 1987-03-18 アモコ・コーポレーション アクリジニウムエステルの合成法
DE3545398A1 (de) * 1985-12-20 1987-06-25 Boehringer Mannheim Gmbh Verfahren zur steigerung der quanten-ausbeute bei der oxidation von luminol durch peroxide in gegenwart von peroxidase
US4698183A (en) * 1986-02-04 1987-10-06 American Cyanamid Company High light output-short duration chemiluminescent compositions
DE3628573C2 (de) * 1986-08-22 1994-10-13 Hoechst Ag Chemilumineszierende Acridinderivate, Verfahren zu deren Herstellung und ihre Verwendung in Lumineszenzimmunoassays
US5110932A (en) * 1986-10-06 1992-05-05 Ciba Corning Diagnostics Corp. Polysubstituted aryl acridinium esters
US4918192A (en) * 1986-10-06 1990-04-17 Ciba Corning Diagnostics Corp. Polysubstituted aryl acridinium esters
US4745181A (en) * 1986-10-06 1988-05-17 Ciba Corning Diagnostics Corp. Polysubstituted aryl acridinium esters
ATE111083T1 (de) * 1986-10-22 1994-09-15 Abbott Lab Chemilumineszierende acridinium- und phenantridiniumsalze.
JPS63107898A (ja) * 1986-10-23 1988-05-12 Natl Inst For Res In Inorg Mater プラズマを用いるダイヤモンドの合成法
US4927769A (en) * 1987-07-08 1990-05-22 Ciba Corning Diagnostics Corp. Method for enhancement of chemiluminescence
PT88550A (pt) * 1987-09-21 1989-07-31 Ml Tecnology Ventures Lp Processo para a preparacao de reagentes de ligacao nao nucleotidicos para sondas nucleotidicas
JP3787352B2 (ja) * 1987-09-21 2006-06-21 ジェン−プローブ・インコーポレイテッド ハイブリダイゼーション保護検定
US5283174A (en) * 1987-09-21 1994-02-01 Gen-Probe, Incorporated Homogenous protection assay
US5185439A (en) * 1987-10-05 1993-02-09 Gen-Probe Incorporated Acridinium ester labelling and purification of nucleotide probes
US4883898A (en) * 1987-12-10 1989-11-28 University Of Chicago Chemiluminescent compounds
NL8703075A (nl) * 1987-12-18 1989-07-17 Nederlanden Staat Acridiniumverbindingen als chemiluminescentie-merkstof.
US5338847A (en) * 1987-12-31 1994-08-16 London Diagnostics, Inc. Hydrolytically stable chemiluminescent labels and their conjugates, and assays therefrom by adduct formation
US5321136A (en) * 1987-12-31 1994-06-14 London Diagnostics, Inc. Peri substituted fused ring chemiluminescent labels and their conjugates, and assays therefrom
NZ227506A (en) * 1987-12-31 1992-06-25 London Diagnostics Inc Specific binding assays using chemiluminescent compounds
US5283334A (en) * 1987-12-31 1994-02-01 London Diagnostics, Inc. Side-chain functional chemiluminescent labels and their conjugates, and assays therefrom
DE3844954C2 (de) * 1988-02-20 1998-07-16 Hoechst Ag Spezielle chemilumineszierende Acridinderivate und ihre Verwendung in Lumineszenzimmunoassays
US4950613A (en) * 1988-02-26 1990-08-21 Gen-Probe Incorporated Proteted chemiluminescent labels
AU634716B2 (en) * 1988-08-01 1993-03-04 Ciba Corning Diagnostics Corp. Method for detection of an analyte using acridinium esters and liposomes
CA1339491C (en) * 1988-09-26 1997-10-07 Say-Jong Law Nucleophilic polysubstituted aryl acridinium ester and uses thereof
US5241070A (en) * 1988-09-26 1993-08-31 Ciba Corning Diagnostics Corp. Nucleophilic polysubstituted aryl acridinium esters and uses thereof
US5093270A (en) * 1989-05-24 1992-03-03 Ciba Corning Diagnostics Corp. Method for enhancing signal release from liposomes using water-miscible alcohols
GB2233451B (en) * 1989-06-27 1993-09-15 Tropix Inc Chemiluminescence enhancement
JPH0335147A (ja) * 1989-07-03 1991-02-15 Doujin Kagaku Kenkyusho:Kk 化学発光の検出
JPH06509542A (ja) * 1990-10-26 1994-10-27 ジンタ・インコーポレイテッド オリゴマーを合成するための改良法
WO1992009580A1 (en) * 1990-11-21 1992-06-11 Beckman Instruments, Inc. Chemiluminescent compounds
EP0492570B1 (de) * 1990-12-24 2001-05-02 Enzo Diagnostics, Inc. Verfahren zum Nachweis eines Zielpolynukleotids in einer Probe unter Verwendung eines Reagenz, das den Hintergrund verringert, und eine dieses Reagenz enthaltende Zusammensetzung und Kit
JPH0579985A (ja) * 1991-09-24 1993-03-30 Kyoto Daiichi Kagaku:Kk 化学発光増強剤及び増強方法
JPH05255264A (ja) * 1992-03-13 1993-10-05 Sanyo Chem Ind Ltd 標識剤および標識されたリガンドの製法
CA2135074A1 (en) * 1992-05-06 1993-11-11 Sherrol H. Mcdonough Nucleic acid amplification oligonucleotides and probes to human hepatitis b virus
JP3248628B2 (ja) * 1992-06-25 2002-01-21 国際試薬株式会社 化学発光性化合物およびこれを用いるアッセイ法
CA2140661A1 (en) * 1992-07-20 1994-02-03 Sharat Singh Novel chemiluminescent compounds and methods of use
JP3207933B2 (ja) * 1992-09-09 2001-09-10 株式会社ヤトロン アクリジニウム誘導体の発光方法及びそれを用いた検査対象物質の検出方法
EP0602524A1 (de) * 1992-12-15 1994-06-22 Hoechst Aktiengesellschaft Chemilumineszenzmarkierte Gensonden und ihre Verwendung in Gensondentesten
JP3584379B2 (ja) * 1993-02-04 2004-11-04 持田製薬株式会社 アクリジニウム化合物およびアクリジニウム化合物複合体
WO1994023069A1 (en) * 1993-03-26 1994-10-13 Gen-Probe Incorporated Detection of human immunodeficiency virus type 1
US5491072A (en) * 1993-05-17 1996-02-13 Lumigen, Inc. N-alkylacridan carboxyl derivatives useful for chemiluminescent detection
WO1995003427A2 (en) * 1993-07-19 1995-02-02 Gen-Probe Incorporated Oligonucleotide screening assay
JPH07330838A (ja) * 1994-06-10 1995-12-19 Nippon Oil & Fats Co Ltd アクリダン基含有高分子および化学発光方法
JP3694044B2 (ja) * 1994-06-22 2005-09-14 株式会社三菱化学ヤトロン アクリジニウム誘導体の発光方法及びその方法を用いた検査対象物質の検出方法
ATE340866T1 (de) * 1994-10-28 2006-10-15 Gen Probe Inc Zusammensetzungen und verfahren für die gleichzeitige detektion und quantifizierung von einer mehrheit spezifischer nuklein säure sequenzen

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DE69629333T2 (de) 2004-06-24
WO1996041197A1 (en) 1996-12-19
EP0747706B1 (de) 2003-08-06
KR19990022460A (ko) 1999-03-25
EP0747706A1 (de) 1996-12-11
ES2203656T3 (es) 2004-04-16
JP3577085B2 (ja) 2004-10-13
US5731148A (en) 1998-03-24
DK0747706T3 (da) 2003-11-24
AU703605B2 (en) 1999-03-25
DE69629333D1 (de) 2003-09-11
CA2222556C (en) 2002-06-11
CA2222556A1 (en) 1996-12-19
AU6024496A (en) 1996-12-30

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