ATE246807T1 - Adduktabschirmungstest - Google Patents

Adduktabschirmungstest

Info

Publication number
ATE246807T1
ATE246807T1 AT96108880T AT96108880T ATE246807T1 AT E246807 T1 ATE246807 T1 AT E246807T1 AT 96108880 T AT96108880 T AT 96108880T AT 96108880 T AT96108880 T AT 96108880T AT E246807 T1 ATE246807 T1 AT E246807T1
Authority
AT
Austria
Prior art keywords
signal
label
binding partner
adduct
alteration
Prior art date
Application number
AT96108880T
Other languages
English (en)
Inventor
Michael Becker
Norman C Nelson
Original Assignee
Gen Probe Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gen Probe Inc filed Critical Gen Probe Inc
Application granted granted Critical
Publication of ATE246807T1 publication Critical patent/ATE246807T1/de

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6816Hybridisation assays characterised by the detection means
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/13Tracers or tags
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/14Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333Saccharide [e.g., DNA, etc.]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Genetics & Genomics (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT96108880T 1995-06-07 1996-06-03 Adduktabschirmungstest ATE246807T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/478,221 US5731148A (en) 1995-06-07 1995-06-07 Adduct protection assay

Publications (1)

Publication Number Publication Date
ATE246807T1 true ATE246807T1 (de) 2003-08-15

Family

ID=23899023

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96108880T ATE246807T1 (de) 1995-06-07 1996-06-03 Adduktabschirmungstest

Country Status (11)

Country Link
US (1) US5731148A (de)
EP (1) EP0747706B1 (de)
JP (1) JP3577085B2 (de)
KR (1) KR19990022460A (de)
AT (1) ATE246807T1 (de)
AU (1) AU703605B2 (de)
CA (1) CA2222556C (de)
DE (1) DE69629333T2 (de)
DK (1) DK0747706T3 (de)
ES (1) ES2203656T3 (de)
WO (1) WO1996041197A1 (de)

Families Citing this family (83)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5714380A (en) 1986-10-23 1998-02-03 Amoco Corporation Closed vessel for isolating target molecules and for performing amplification
JP2000514307A (ja) * 1996-07-16 2000-10-31 ジェン―プローブ・インコーポレーテッド 増加した標的特異的t▲下m▼を持つ修飾オリゴヌクレオチドを用いた核酸配列の検出および増幅のための方法
US7070925B1 (en) * 1996-07-16 2006-07-04 Gen-Probe Incorporated Method for determining the presence of an RNA analyte in a sample using a modified oligonucleotide probe
DE69840669D1 (de) 1997-04-10 2009-04-30 Stichting Katholieke Univ Pca3, pca3-gene und verfahren zu ihrer verwendung
EP0975807B1 (de) 1997-05-02 2006-09-27 Gen-Probe Incorporated Zwei-schritt hybridisierung und einfang von einem polynukleotid
US6534273B2 (en) 1997-05-02 2003-03-18 Gen-Probe Incorporated Two-step hybridization and capture of a polynucleotide
US6180340B1 (en) 1997-10-31 2001-01-30 Gen-Probe Incorporated Extended dynamic range assays
WO1999049293A2 (en) 1998-03-24 1999-09-30 Boston Probes, Inc. Methods, kits and compositions pertaining to detection complexes
AU762728B2 (en) * 1998-07-02 2003-07-03 Gen-Probe Incorporated Molecular torches
US5998175A (en) * 1998-07-24 1999-12-07 Lumigen, Inc. Methods of synthesizing and amplifying polynucleotides by ligation of multiple oligomers
WO2000047777A1 (en) 1999-02-12 2000-08-17 Gen-Probe Incorporated Protection probes
JP4824236B2 (ja) 1999-07-09 2011-11-30 ジェン−プローブ・インコーポレーテッド 核酸増幅によるhiv−1の検出
US6506887B1 (en) * 1999-07-29 2003-01-14 Somalogic, Incorporated Conditional-selex
EP1222266B1 (de) 1999-09-29 2006-03-29 Diagnocure Inc. Pca3 mrna in gutartigen und bösartigen prostatageweben
US6506567B2 (en) * 2000-01-31 2003-01-14 Fuji Photo Film Co., Ltd. Water-soluble flourescent intercalator compound
US20010046674A1 (en) * 2000-02-03 2001-11-29 Andrew Ellington Signaling aptamers that transduce molecular recognition to a differential signal
WO2002048404A2 (en) * 2000-12-14 2002-06-20 Gen-Probe Incorporated Method and kit for enhancing the association rates of polynucleotides
EP1423522A2 (de) 2001-01-23 2004-06-02 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. Hepatitis c virus-replikons und replikon- verbesserte zellen
US6780602B2 (en) * 2001-11-01 2004-08-24 Microbiosystems, Limited Partnership Taxonomic identification of pathogenic microorganisms and their toxic proteins
ATE519861T1 (de) 2002-06-14 2011-08-15 Gen Probe Inc Zusammensetzungen zum nachweis von hepatitis-b- virus
US7115374B2 (en) 2002-10-16 2006-10-03 Gen-Probe Incorporated Compositions and methods for detecting West Nile virus
EP1592809B1 (de) 2003-02-07 2013-04-10 Diagnocure Inc. Verfahren zum nachweis von prostatakrebs in einer probe
US20060257929A1 (en) * 2003-11-12 2006-11-16 Microbiosystems, Limited Partnership Method for the rapid taxonomic identification of pathogenic microorganisms and their toxic proteins
EP2251442B9 (de) 2003-12-19 2012-04-25 Gen-Probe Incorporated Zusammensetzungen, Verfahren und Kits zum Nachweis der Nukleinsäuren von HIV-1 und HIV-2
EP2806035B1 (de) 2004-02-18 2017-09-13 Chromocell Corporation Verfahren und Materialien, die Signalsonden verwenden
US7466908B1 (en) 2004-04-16 2008-12-16 Spartan Bioscience Inc. System for rapid nucleic acid amplification and detection
CA2572472C (en) 2004-07-01 2013-08-13 Gen-Probe Incorporated Methods and compositions to detect nucleic acids in a biological sample
JP4753943B2 (ja) 2004-07-13 2011-08-24 ジェン−プローブ・インコーポレーテッド A型肝炎ウイルス核酸の検出のための組成物及び方法
DK2975139T3 (da) 2004-09-30 2019-12-09 Gen Probe Inc Assay til at detektere og kvantificere hiv-1
WO2006137939A2 (en) 2004-11-09 2006-12-28 Gen-Probe Incorporated Compositions and methods for detecting group a streptococci
CA2491067A1 (en) 2004-12-24 2006-06-24 Stichting Katholieke Universiteit Mrna rations in urinary sediments and/or urine as a prognostic marker for prostate cancer
EP2471805A3 (de) 2005-05-06 2013-01-16 Gen-Probe Incorporated Zusammensetzungen und Verfahren zur spezifischen Detektion von Nukleinsäuren der Viren Influenza A oder B
ATE551433T1 (de) 2005-05-06 2012-04-15 Gen Probe Inc Verfahren und produkte zum erfassen von nukleinsäurezielen
JP2010511385A (ja) * 2006-11-30 2010-04-15 クロモセル コーポレイション タンパク質産生のための至適化された宿主細胞
EP1978111B1 (de) 2007-04-02 2013-03-27 Gen-Probe Incorporated Zusammensetzungen, Kits und zugehörige Verfahren zur Erkennung und/oder Überwachung von Pseudomonas aeruginosa
US9458451B2 (en) 2007-06-21 2016-10-04 Gen-Probe Incorporated Multi-channel optical measurement instrument
EP3957754B1 (de) 2008-04-21 2026-01-28 Gen-Probe Incorporated Verfahren zur erkennung des chikungunya-virus
US10316352B2 (en) * 2008-05-13 2019-06-11 Gen-Probe Incorporated Methods of capturing a target nucleic acid for amplification and detection using an inactivatable target capture oligomer
AU2009262870B2 (en) 2008-05-30 2014-03-20 Gen-Probe Incorporated Compositions, kits and related methods for the detection and/or monitoring of Salmonella
US8097412B2 (en) * 2008-07-12 2012-01-17 Biodiagnostics, Inc. DNA-based test for detection of annual and intermediate ryegrass
CA2638458A1 (en) * 2008-07-31 2010-01-31 Spartan Bioscience Inc. Thermal recycling by positioning relative to fixed-temperature source
CN102292457B (zh) * 2008-11-25 2014-04-09 简·探针公司 检测小rna的组合物和方法及其用途
EP2910647A1 (de) 2008-12-30 2015-08-26 Gen-Probe Incorporated Zusammensetzungen, Kits und damit verbundene Verfahren zum Nachweis und/oder Überwachen von Listerien
EP2391452B1 (de) 2009-01-30 2015-06-17 Gen-Probe Incorporated Systeme und verfahren zur erfassung eines signals und beaufschlagung des signalübertragungselements mit wärmeenergie
EP3257859B1 (de) 2009-02-26 2020-09-23 Gen-Probe Incorporated Assay zum nachweisen menschlicher parvoviren-nukleinsäure
WO2012003289A1 (en) 2010-06-30 2012-01-05 Gen-Probe Incorporated Method and apparatus for identifying analyte-containing samples using single-read determination of analyte and process control signals
EP2593569B1 (de) 2010-07-12 2018-01-03 Gen-Probe Incorporated Zusammensetzungen und tests für den nachweis von nukleinsäuren des saisonalen h1 influenza a virus
EP2616555B1 (de) 2010-09-16 2017-11-08 Gen-Probe Incorporated Über l-nukleotidenden immobilisierbare fängersonden
EP2625297B1 (de) 2010-10-04 2018-10-10 Gen-Probe Prodesse, Inc. Zusammensetzungen, verfahren und kits für den nachweis von adenovirus-nukleinsäuren
EP3009522B1 (de) 2011-07-15 2019-09-04 Gen-Probe Incorporated Verfahren zum nachweis von hepatitis-a-virus-nukleinsäuren bei single-plex- oder multiplextests
DE102011120550B4 (de) 2011-12-05 2013-11-07 Gen-Probe Prodesse, Inc. Zusammensetzungen, Verfahren und Kits zur Detektion von Adenovirusnukleinsäuren
EP2971131A4 (de) 2013-03-15 2016-11-23 Chromocell Corp Verfahren und materialien unter verwendung von signalsonden
US10093989B2 (en) 2014-10-20 2018-10-09 Gen-Probe Incorporated Red blood cell lysis solution
CN108350407B (zh) 2015-12-11 2022-07-08 杰诺玛迪克斯公司 用于核酸扩增的管密封系统和方法
EP3448998B1 (de) 2016-04-27 2020-06-03 Gen-Probe Incorporated Reagens für blutzelllyse
US10844425B2 (en) 2017-03-24 2020-11-24 Gen-Probe Incorporated Compositions and methods for detecting or quantifying parainfluenza virus
AU2018237331B2 (en) 2017-03-24 2022-02-03 Gen-Probe Incorporated Compositions and methods for detection of viral pathogens in samples
JP6956800B2 (ja) 2017-03-25 2021-11-02 ジェン−プローブ・インコーポレーテッド アデノウイルス、メタニューモウイルス、および/またはライノウイルス核酸を検出するための組成物、方法、およびキット
JP6997287B2 (ja) 2017-07-10 2022-02-03 ジェン-プローブ・インコーポレーテッド 試料割り当てパラメータを使用した核酸増幅のための分析システムおよび方法
US11859257B2 (en) 2017-08-11 2024-01-02 Gen-Probe Incorporated Compositions and methods for detecting Staphylococcus aureus
EP3724354A1 (de) 2017-12-15 2020-10-21 Gen-Probe Incorporated Zusammensetzungen und verfahren zum nachweis von toxigenem clostridium difficile
EP3746225B1 (de) 2018-01-29 2024-10-30 Gen-Probe Incorporated Analytische systeme und verfahren
AU2019286648B2 (en) 2018-06-13 2023-11-23 Gen-Probe Incorporated Compositions and methods for detecting group B Streptococcus nucleic acid
JP7470095B2 (ja) 2018-07-10 2024-04-17 ジェン-プローブ・インコーポレーテッド 核酸を検出および定量するための方法およびシステム
WO2020028631A1 (en) 2018-08-01 2020-02-06 Gen-Probe Incorporated Compositions and methods for detecting nucleic acids of epstein-barr virus
US12460254B2 (en) 2018-08-08 2025-11-04 Gen-Probe Incorporated Compositions, methods and kits for detecting Mycoplasma genitalium
AU2019326462C1 (en) 2018-08-21 2026-02-12 Gen-Probe Incorporated Compositions and methods for amplifying, detecting or quantifying human cytomegalovirus
CA3112651A1 (en) 2018-09-27 2020-04-02 Gen-Probe Incorporated Compositions and methods for detecting bordetella pertussis and bordetella parapertussis nucleic acid
JP7432610B2 (ja) 2018-10-01 2024-02-16 ジェン-プローブ・インコーポレーテッド 水痘帯状疱疹ウイルスを増幅または検出するための組成物および方法
CA3116895A1 (en) 2018-10-22 2020-04-30 Gen-Probe Incorporated Compositions and methods for amplifying, detecting or quantifying human polyomavirus bk virus
EP3942078A1 (de) 2019-03-22 2022-01-26 Gen-Probe Incorporated Zusammensetzungen und verfahren zur detektion von gruppe-a-streptococcus
WO2020226969A2 (en) 2019-05-03 2020-11-12 Gen-Probe Incorporated Receptacle transport system for an analytical system
AU2020335996A1 (en) 2019-08-23 2022-03-31 Gen-Probe Incorporated Compositions, methods and kits for detecting Treponema pallidum
EP4025715A1 (de) 2019-09-05 2022-07-13 Gen-Probe Incorporated Nachweis von chlamydia-trachomatis-nukleinsäurevarianten
US20230117369A1 (en) 2020-03-04 2023-04-20 Gen-Probe Incorporated Compositions and methods for detecting sars-cov-2 nucleaic acid
CA3177256A1 (en) 2020-10-21 2022-04-28 Gen-Probe Incorporated Fluid container management system
CA3226812A1 (en) 2021-07-27 2023-02-02 Gen-Probe Incorporated Compositions and methods for detecting gastrointestinal pathogens
WO2023175434A1 (en) 2022-03-15 2023-09-21 Diagenode S.A. Detection of methylation status of a dna sample
WO2024054924A1 (en) 2022-09-08 2024-03-14 Gen-Probe Incorporated Method of detecting nucleic acid analytes using dual-specificity primers
WO2024137379A2 (en) 2022-12-19 2024-06-27 Gen-Probe Incorporated Compositions and methods for detecting gastrointestinal pathogens
WO2024192338A1 (en) 2023-03-16 2024-09-19 Gen-Probe Incorporated Compositions and methods for detecting gastrointestinal parasites
KR20240153658A (ko) 2023-04-17 2024-10-24 김보라 슬라이딩 강대상
WO2026050332A1 (en) 2024-08-29 2026-03-05 Gen-Probe Incorporated Methods and compositions for amplifying and/or detecting rotavirus nucleic acids

Family Cites Families (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL6515469A (de) * 1965-01-22 1966-07-25
US3817837A (en) * 1971-05-14 1974-06-18 Syva Corp Enzyme amplification assay
US4190496A (en) * 1971-05-14 1980-02-26 Syva Company Homogeneous enzyme assay for antibodies
US4199559A (en) * 1974-08-12 1980-04-22 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4383031A (en) * 1975-04-28 1983-05-10 Miles Laboratories, Inc. Homogeneous chemiluminescent specific binding assay
US4174384A (en) * 1975-06-30 1979-11-13 Syva Company Fluorescence quenching with immunological pairs in immunoassays
FR2422956A1 (fr) * 1978-04-13 1979-11-09 Pasteur Institut Procede de detection et de caracterisation d'un acide nucleique ou d'une sequence de celui-ci, et reactif enzymatique pour la mise en oeuvre de ce procede
US4318707A (en) * 1978-11-24 1982-03-09 Syva Company Macromolecular fluorescent quencher particle in specific receptor assays
CA1190838A (en) * 1981-07-17 1985-07-23 Cavit Akin Homogeneous nucleic acid hybridization diagnostics by non-radiative energy transfer
CA1185177A (en) * 1981-07-17 1985-04-09 Larry E. Morrison Non-radiative energy transfer immunochemical technique
US4668640A (en) * 1981-12-11 1987-05-26 Abbott Laboratories Fluorescence polarization immunoassay utilizing substituted carboxyfluoresceins
DE3279029D1 (en) * 1981-12-11 1988-10-20 Welsh Nat School Med Luminescent labelling materials and procedures
US4462931A (en) * 1982-06-16 1984-07-31 American Cyanamid Company Enhanced aqueous chemiluminescent systems
US4508642A (en) * 1983-04-21 1985-04-02 World Victor B Method of obtaining greater lifetime duration from chemiluminescent systems
US4816419A (en) * 1983-08-01 1989-03-28 University Of Health Sciences/The Chicago Medical School Fluorescence ligand binding assay using charge-matched dye and solvent components
US4640898A (en) * 1983-08-01 1987-02-03 University Of Health Sciences/The Chicago Medical School Homogeneous fluorescence ligang binding assay based upon preferential alteration of the respective intensities of bound and free label by solvent components
US4582789A (en) * 1984-03-21 1986-04-15 Cetus Corporation Process for labeling nucleic acids using psoralen derivatives
AU580042B2 (en) * 1984-03-22 1988-12-22 Bresatec Limited Non-radioactive biological probes
CA1260372A (en) * 1984-04-27 1989-09-26 Elazar Rabbani Hybridization method for the detection of genetic materials
US4670379A (en) * 1984-12-19 1987-06-02 E. I. Du Pont De Nemours And Company Polynucleotide hydridization assays employing catalyzed luminescence
ATE40572T1 (de) * 1985-01-10 1989-02-15 Molecular Diagnostics Inc Photochemisches verfahren zum markieren von nucleinsaeuren zum nachweis in hybridisationsproben.
US4655969A (en) * 1985-04-03 1987-04-07 Richter Herbert P Chemiluminescent systems
JP2509574B2 (ja) * 1985-08-15 1996-06-19 アモコ・コーポレーション 標識付けした核酸
JPS6261969A (ja) * 1985-09-06 1987-03-18 アモコ・コーポレーション アクリジニウムエステルの合成法
DE3545398A1 (de) * 1985-12-20 1987-06-25 Boehringer Mannheim Gmbh Verfahren zur steigerung der quanten-ausbeute bei der oxidation von luminol durch peroxide in gegenwart von peroxidase
US4698183A (en) * 1986-02-04 1987-10-06 American Cyanamid Company High light output-short duration chemiluminescent compositions
DE3628573C2 (de) * 1986-08-22 1994-10-13 Hoechst Ag Chemilumineszierende Acridinderivate, Verfahren zu deren Herstellung und ihre Verwendung in Lumineszenzimmunoassays
US5110932A (en) * 1986-10-06 1992-05-05 Ciba Corning Diagnostics Corp. Polysubstituted aryl acridinium esters
US4918192A (en) * 1986-10-06 1990-04-17 Ciba Corning Diagnostics Corp. Polysubstituted aryl acridinium esters
US4745181A (en) * 1986-10-06 1988-05-17 Ciba Corning Diagnostics Corp. Polysubstituted aryl acridinium esters
DE3750503T2 (de) * 1986-10-22 1995-02-09 Abbott Lab Chemilumineszierende Acridinium- und Phenantridiniumsalze.
JPS63107898A (ja) * 1986-10-23 1988-05-12 Natl Inst For Res In Inorg Mater プラズマを用いるダイヤモンドの合成法
US4927769A (en) * 1987-07-08 1990-05-22 Ciba Corning Diagnostics Corp. Method for enhancement of chemiluminescence
JP3012244B2 (ja) * 1987-09-21 2000-02-21 ジェン―プローブ インコーポレイテッド ヌクレオチドプローブ用非ヌクレオチド連結試薬
DE3854029T2 (de) * 1987-09-21 1995-10-26 Gen Probe Inc Homogener Abschirmungstest.
US5283174A (en) * 1987-09-21 1994-02-01 Gen-Probe, Incorporated Homogenous protection assay
US5185439A (en) * 1987-10-05 1993-02-09 Gen-Probe Incorporated Acridinium ester labelling and purification of nucleotide probes
US4883898A (en) * 1987-12-10 1989-11-28 University Of Chicago Chemiluminescent compounds
NL8703075A (nl) * 1987-12-18 1989-07-17 Nederlanden Staat Acridiniumverbindingen als chemiluminescentie-merkstof.
NZ227506A (en) * 1987-12-31 1992-06-25 London Diagnostics Inc Specific binding assays using chemiluminescent compounds
US5338847A (en) * 1987-12-31 1994-08-16 London Diagnostics, Inc. Hydrolytically stable chemiluminescent labels and their conjugates, and assays therefrom by adduct formation
US5290936A (en) * 1987-12-31 1994-03-01 London Diagnostics, Inc. Nitro substituted chemiluminescent labels and their conjugates, and assays therefrom
US5321136A (en) * 1987-12-31 1994-06-14 London Diagnostics, Inc. Peri substituted fused ring chemiluminescent labels and their conjugates, and assays therefrom
DE3844954C2 (de) * 1988-02-20 1998-07-16 Hoechst Ag Spezielle chemilumineszierende Acridinderivate und ihre Verwendung in Lumineszenzimmunoassays
US4950613A (en) * 1988-02-26 1990-08-21 Gen-Probe Incorporated Proteted chemiluminescent labels
AU634716B2 (en) * 1988-08-01 1993-03-04 Ciba Corning Diagnostics Corp. Method for detection of an analyte using acridinium esters and liposomes
US5241070A (en) * 1988-09-26 1993-08-31 Ciba Corning Diagnostics Corp. Nucleophilic polysubstituted aryl acridinium esters and uses thereof
CA1339491C (en) * 1988-09-26 1997-10-07 Say-Jong Law Nucleophilic polysubstituted aryl acridinium ester and uses thereof
US5093270A (en) * 1989-05-24 1992-03-03 Ciba Corning Diagnostics Corp. Method for enhancing signal release from liposomes using water-miscible alcohols
GB2233451B (en) * 1989-06-27 1993-09-15 Tropix Inc Chemiluminescence enhancement
JPH0335147A (ja) * 1989-07-03 1991-02-15 Doujin Kagaku Kenkyusho:Kk 化学発光の検出
EP0592434B1 (de) * 1990-10-26 1998-10-07 Genta Incorporated Verbessertes verfahren zur synthese von oligomeren
EP0511366A1 (de) * 1990-11-21 1992-11-04 Beckman Instruments, Inc. Chemilumineszierende derivate
DE69132765T2 (de) * 1990-12-24 2002-02-21 Enzo Diagnostics, Inc. Verfahren zum Nachweis eines Zielpolynukleotids in einer Probe unter Verwendung eines Reagenz, das den Hintergrund verringert, und eine dieses Reagenz enthaltende Zusammensetzung und Kit.
JPH0579985A (ja) * 1991-09-24 1993-03-30 Kyoto Daiichi Kagaku:Kk 化学発光増強剤及び増強方法
JPH05255264A (ja) * 1992-03-13 1993-10-05 Sanyo Chem Ind Ltd 標識剤および標識されたリガンドの製法
KR950701392A (ko) * 1992-05-06 1995-03-23 다니엘 엘. 카시안 인체 B형 간염 바이러스에 대한 핵산 증폭 올리고뉴클레오티드 및 프로브(Nucleic Acide Amplification Oligonucleotides and Probes to Human Hepatitis B Birus)
JP3248628B2 (ja) * 1992-06-25 2002-01-21 国際試薬株式会社 化学発光性化合物およびこれを用いるアッセイ法
WO1994002486A1 (en) * 1992-07-20 1994-02-03 Syntex (U.S.A.) Inc. Novel chemiluminescent compounds and methods of use
JP3207933B2 (ja) * 1992-09-09 2001-09-10 株式会社ヤトロン アクリジニウム誘導体の発光方法及びそれを用いた検査対象物質の検出方法
EP0602524A1 (de) * 1992-12-15 1994-06-22 Hoechst Aktiengesellschaft Chemilumineszenzmarkierte Gensonden und ihre Verwendung in Gensondentesten
JP3584379B2 (ja) * 1993-02-04 2004-11-04 持田製薬株式会社 アクリジニウム化合物およびアクリジニウム化合物複合体
KR100325554B1 (ko) * 1993-03-26 2002-11-02 젠-프로브 인코포레이티드 사람의면역결핍 바이러스타입1의검출
US5491072A (en) * 1993-05-17 1996-02-13 Lumigen, Inc. N-alkylacridan carboxyl derivatives useful for chemiluminescent detection
JP3789471B2 (ja) * 1993-07-19 2006-06-21 ジェン−プローブ・インコーポレイテッド オリゴヌクレオチドスクリーニングアッセイ
JPH07330838A (ja) * 1994-06-10 1995-12-19 Nippon Oil & Fats Co Ltd アクリダン基含有高分子および化学発光方法
JP3694044B2 (ja) * 1994-06-22 2005-09-14 株式会社三菱化学ヤトロン アクリジニウム誘導体の発光方法及びその方法を用いた検査対象物質の検出方法
DE69535240T2 (de) * 1994-10-28 2007-06-06 Gen-Probe Inc., San Diego Zusammensetzungen und Verfahren für die gleichzeitige Detektion und Quantifizierung von einer Mehrheit spezifischer Nuklein Säure Sequenzen

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US5731148A (en) 1998-03-24
WO1996041197A1 (en) 1996-12-19
AU703605B2 (en) 1999-03-25
JP2002515118A (ja) 2002-05-21
DE69629333T2 (de) 2004-06-24
DE69629333D1 (de) 2003-09-11
AU6024496A (en) 1996-12-30
ES2203656T3 (es) 2004-04-16
JP3577085B2 (ja) 2004-10-13
EP0747706A1 (de) 1996-12-11
KR19990022460A (ko) 1999-03-25
DK0747706T3 (da) 2003-11-24
CA2222556A1 (en) 1996-12-19
CA2222556C (en) 2002-06-11
EP0747706B1 (de) 2003-08-06

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