ATE255904T1 - Fibrin-/fibrinogen-abbau und gerinsel-auflösung durch eine fibrinolytische matrix- metallproteinase - Google Patents

Fibrin-/fibrinogen-abbau und gerinsel-auflösung durch eine fibrinolytische matrix- metallproteinase

Info

Publication number
ATE255904T1
ATE255904T1 AT96918996T AT96918996T ATE255904T1 AT E255904 T1 ATE255904 T1 AT E255904T1 AT 96918996 T AT96918996 T AT 96918996T AT 96918996 T AT96918996 T AT 96918996T AT E255904 T1 ATE255904 T1 AT E255904T1
Authority
AT
Austria
Prior art keywords
fibrinolytic
fibrin
metalproteinase
metalloproteinase
clot dissolution
Prior art date
Application number
AT96918996T
Other languages
English (en)
Inventor
Alessandra Bini
Original Assignee
New York Blood Ct Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by New York Blood Ct Inc filed Critical New York Blood Ct Inc
Application granted granted Critical
Publication of ATE255904T1 publication Critical patent/ATE255904T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
  • Peptides Or Proteins (AREA)
AT96918996T 1995-05-17 1996-05-17 Fibrin-/fibrinogen-abbau und gerinsel-auflösung durch eine fibrinolytische matrix- metallproteinase ATE255904T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/446,887 US5830468A (en) 1995-05-17 1995-05-17 Fibrin(ogen) degradation by fibrinolytic matrix metalloproteinase
PCT/US1996/007188 WO1996036227A1 (en) 1995-05-17 1996-05-17 Fibrin(ogen) degradation and clot lysis by fibrinolytic matrix metalloproteinase

Publications (1)

Publication Number Publication Date
ATE255904T1 true ATE255904T1 (de) 2003-12-15

Family

ID=23774197

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96918996T ATE255904T1 (de) 1995-05-17 1996-05-17 Fibrin-/fibrinogen-abbau und gerinsel-auflösung durch eine fibrinolytische matrix- metallproteinase

Country Status (9)

Country Link
US (2) US5830468A (de)
EP (1) EP0771146B1 (de)
JP (1) JPH10506925A (de)
AT (1) ATE255904T1 (de)
AU (1) AU6145396A (de)
CA (1) CA2194692A1 (de)
DE (1) DE69631014T2 (de)
ES (1) ES2212802T3 (de)
WO (1) WO1996036227A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5817768A (en) * 1995-06-07 1998-10-06 The New York Blood Center, Inc. Monospecific antibodies against a subunit of fibrinogen
US6953788B1 (en) 1996-09-19 2005-10-11 Aventis Pharmaceuticals Inc. 3-mercaptoacetylamino-1,5-substituted-2-oxo-azepan derivatives useful as inhibitors of matrix metalloproteinase
WO2000063700A1 (en) * 1999-04-16 2000-10-26 The New York Blood Center, Inc. Monoclonal antibodies reactive with fibrin(ogen) degradation products generated by matrix metalloproteinases
US7632494B2 (en) * 1999-09-24 2009-12-15 Proteon Therapeutics, Inc. Methods for enlarging the diameter of a biological conduit in a human subject
US7063838B1 (en) * 1999-09-24 2006-06-20 Proteon Therapeutics Llc Methods for treating an artery or vein in a human subject
AU7612100A (en) * 1999-09-24 2001-04-24 Johns Hopkins University, The Systems and methods for opening obstructed biological conduits
US6261820B1 (en) * 1999-10-01 2001-07-17 Amgen Inc. Fibronolytically active polypeptide
US6440414B1 (en) * 1999-10-01 2002-08-27 Amgen Inc. Pharmaceutical compositions of fibrinolytic agent
RS20050031A (sr) * 1999-12-17 2007-06-04 Amgen Inc., Postupak za tretman okluzija prepariranog katetera upotrebom fibrinolitičkih metaloproteinaza
US7033776B2 (en) * 1999-12-17 2006-04-25 Amgen Inc. Method for treatment of indwelling catheter occlusion using fibrinolytic metalloproteinases
US6455269B1 (en) * 1999-12-17 2002-09-24 Amgen, Inc. Method for localized administration of fibrinolytic metalloproteinases
US6600057B2 (en) 2000-12-29 2003-07-29 Kimberly-Clark Worldwide, Inc. Matrix metalloproteinase inhibitors
US7041787B2 (en) * 2000-12-29 2006-05-09 Kimberly-Clark Worldwide, Inc. Design and use of advanced zinc chelating peptides to regulate matrix metalloproteinases
BR0211888A (pt) 2001-08-13 2004-08-24 Univ Florida Res Foudantion In Materiais e métodos para promoção de reparo de tecido nervoso
US20030119073A1 (en) * 2001-12-21 2003-06-26 Stephen Quirk Sensors and methods of detection for proteinase enzymes
ES2335167B1 (es) * 2007-02-26 2011-01-24 Proyecto De Biomedicina Cima, S.L. Uso de la metaloproteinasa de matriz-10 (mmp10) para tratamientos tromboliticos.
ES2313841B1 (es) * 2007-06-26 2010-01-12 Proyecto De Biomedicina Cima, S.L. Composiciones para tratamiento anti-fibrinolitico.
EP2852403B1 (de) 2012-04-30 2018-03-07 Elastomics AB Verfahren zur modifizierung von gewebe
JP7138702B2 (ja) 2017-09-22 2022-09-16 ベクトン・ディキンソン・アンド・カンパニー カテーテルロック溶液としての使用のための４％クエン酸三ナトリウム溶液

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS54157816A (en) * 1978-05-27 1979-12-13 Unitika Ltd Fixing of bioactive substance to solid surface
US4610879A (en) * 1984-01-06 1986-09-09 University Of Southern California Fibrinolytic enzyme from snake vernom
US4813538A (en) * 1987-03-19 1989-03-21 Blackman Seymour N Re-usable sterile parenteral fluid medication administration kit
US5130143A (en) * 1988-11-04 1992-07-14 The Research Foundation Of State University Of New York Use of a low affinity-heparin fraction in conjunction with t-pa for thrombolytic therapy
SE462829B (sv) * 1989-01-10 1990-09-10 Kabigen Ab Trombolytiskt aktiva kompositioner innehaallande en modifierad plasminogenaktivator av vaevnadstyp samt en normal human t-pa, streptokinas eller humant urokinas
US5260059A (en) * 1989-04-14 1993-11-09 The State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon Health Sciences University Treatment of open-angle glaucoma by modulation matrix metalloproteinases and their inhibitor
US5185001A (en) * 1990-01-18 1993-02-09 The Research Foundation Of State University Of New York Method of preparing autologous plasma fibrin and application apparatus therefor
US5260060A (en) * 1991-08-09 1993-11-09 University Of Southern California Fibrinolytic enzymes
US5324634A (en) * 1992-03-31 1994-06-28 The Research Foundation Of State University Of New York Diagnostic tests measuring gelatinase/inhibitor complexes for detection of aggressive and metastatic cancer

Also Published As

Publication number Publication date
US5922322A (en) 1999-07-13
EP0771146A1 (de) 1997-05-07
DE69631014D1 (de) 2004-01-22
EP0771146A4 (de) 2002-08-07
JPH10506925A (ja) 1998-07-07
AU6145396A (en) 1996-11-29
CA2194692A1 (en) 1996-11-21
DE69631014T2 (de) 2004-09-16
ES2212802T3 (es) 2004-08-01
WO1996036227A1 (en) 1996-11-21
US5830468A (en) 1998-11-03
EP0771146B1 (de) 2003-12-10

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