ATE25972T1 - Psychotherapeutische wirkstoffe auf basis von 1- phenyl-2(1h,3h)-indolonen. - Google Patents

Psychotherapeutische wirkstoffe auf basis von 1- phenyl-2(1h,3h)-indolonen.

Info

Publication number
ATE25972T1
ATE25972T1 AT83305484T AT83305484T ATE25972T1 AT E25972 T1 ATE25972 T1 AT E25972T1 AT 83305484 T AT83305484 T AT 83305484T AT 83305484 T AT83305484 T AT 83305484T AT E25972 T1 ATE25972 T1 AT E25972T1
Authority
AT
Austria
Prior art keywords
indolones
phenyl
treatment
psychotherapeutic
ingredients based
Prior art date
Application number
AT83305484T
Other languages
German (de)
English (en)
Inventor
Harry R Howard
Reinhard Sarges
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Application granted granted Critical
Publication of ATE25972T1 publication Critical patent/ATE25972T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/225—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/38—Oxygen atoms in positions 2 and 3, e.g. isatin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Public Health (AREA)
  • Anesthesiology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Dental Preparations (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT83305484T 1982-09-20 1983-09-19 Psychotherapeutische wirkstoffe auf basis von 1- phenyl-2(1h,3h)-indolonen. ATE25972T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/420,544 US4476307A (en) 1982-09-20 1982-09-20 Heteroylidene indolone compounds
EP83305484A EP0104860B1 (en) 1982-09-20 1983-09-19 1-phenyl-2(1h,3h)-indolone psycho-therapeutic agents

Publications (1)

Publication Number Publication Date
ATE25972T1 true ATE25972T1 (de) 1987-04-15

Family

ID=23666904

Family Applications (1)

Application Number Title Priority Date Filing Date
AT83305484T ATE25972T1 (de) 1982-09-20 1983-09-19 Psychotherapeutische wirkstoffe auf basis von 1- phenyl-2(1h,3h)-indolonen.

Country Status (24)

Country Link
US (1) US4476307A (2)
EP (1) EP0104860B1 (2)
JP (1) JPS5976058A (2)
KR (1) KR860001270B1 (2)
AT (1) ATE25972T1 (2)
AU (1) AU543115B2 (2)
CA (1) CA1194871A (2)
DD (1) DD213211A5 (2)
DE (1) DE3370325D1 (2)
DK (1) DK157010C (2)
ES (3) ES8503328A1 (2)
FI (1) FI77446C (2)
GR (1) GR79732B (2)
HU (1) HU189747B (2)
IE (1) IE55923B1 (2)
IL (1) IL69758A (2)
NO (1) NO161557C (2)
NZ (1) NZ205638A (2)
PH (1) PH18297A (2)
PL (3) PL141370B1 (2)
PT (1) PT77360B (2)
SU (1) SU1272983A3 (2)
YU (4) YU189283A (2)
ZA (1) ZA836933B (2)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4879391A (en) * 1982-09-20 1989-11-07 Pfizer Inc. 1-Phenyl-2(1H,3H)-indolone psychotherapeutic agents
US4760083A (en) * 1986-04-10 1988-07-26 E. I. Dupont De Nemours & Company 3,3-disubstituted indolines
US5128352A (en) * 1989-01-10 1992-07-07 Pfizer Inc. Anti-inflammatory 1-heteroaryl-oxindole-3-carboxamides
US5078756A (en) * 1990-01-12 1992-01-07 Major Thomas O Apparatus and method for purification and recovery of refrigerant
US5158969A (en) * 1991-08-21 1992-10-27 Neurosearch A/S Indole derivatives as potassium channel blockers
US5760250A (en) * 1991-11-05 1998-06-02 Zeneca Limited Process for the preparation of 3-(α-methoxy)methylenebenzofuranones and intermediates therefor
DE19949209A1 (de) * 1999-10-13 2001-04-19 Boehringer Ingelheim Pharma In 5-Stellung substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel
US20030225152A1 (en) * 2001-09-27 2003-12-04 Andrews Steven W. 3-(Arylamino)methylene-1, 3-dihydro-2h-indol-2-ones as kinase inhibitors
US20050101788A1 (en) * 2002-03-27 2005-05-12 Jacopo Zanon Method for manufacture of sertindole
FR2847811B1 (fr) * 2002-11-29 2005-01-07 Oreal Composition filtrante contenant au moins un derive du dibenzoylmethane et au moins un derive de 3-(2-azacycloalkylidene)-1,3-dihydro-indol-2-one;procede de photostabilisation
FR2847813A1 (fr) * 2002-11-29 2004-06-04 Oreal Compositions cosmetiques photoprotectrices contenant des derives de 3-(2-azacycloalkylidene)-1,3-dihydro-indol-2-one et utilisations
MX2007014114A (es) 2005-05-10 2008-03-14 Intermune Inc Derivados de piridona para modular el sistema de proteina cinasa activada por estres.
JP5627574B2 (ja) 2008-06-03 2014-11-19 インターミューン， インコーポレイテッド 炎症性および線維性疾患を治療するための化合物および方法
JP5390535B2 (ja) 2008-12-19 2014-01-15 日本曹達株式会社 １−ヘテロジエン誘導体および有害生物防除剤
KR101376443B1 (ko) 2009-11-12 2014-03-19 닛뽕소다 가부시키가이샤 1-헤테로디엔 유도체 및 유해 생물 방제제
AR092742A1 (es) 2012-10-02 2015-04-29 Intermune Inc Piridinonas antifibroticas
WO2014078568A1 (en) 2012-11-14 2014-05-22 The Johns Hopkins University Methods and compositions for treating schizophrenia
US10233195B2 (en) 2014-04-02 2019-03-19 Intermune, Inc. Anti-fibrotic pyridinones

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3506683A (en) * 1963-10-07 1970-04-14 Upjohn Co 3-(2-pyrrolidinylidene)-3h-indoles
GB1237008A (en) * 1968-12-18 1971-06-30 Pfizer Ltd Novel indoline derivatives
US3723457A (en) * 1969-09-30 1973-03-27 Eisai Co Ltd Indoline-2-one derivatives and preparation thereof
GB1374414A (en) * 1972-06-12 1974-11-20 Sterling Drug Inc 1-acyl-3-amino-alkyl-indoles and their preparation
DE2557342A1 (de) * 1975-12-19 1977-06-30 Hoechst Ag Basisch substituierte indolderivate und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
KR860001270B1 (ko) 1986-09-04
GR79732B (2) 1984-10-31
US4476307A (en) 1984-10-09
JPS6241711B2 (2) 1987-09-04
ES8505951A1 (es) 1985-06-01
ES531908A0 (es) 1985-06-01
PL250769A1 (en) 1985-07-02
DK157010B (da) 1989-10-30
FI77446C (fi) 1989-03-10
ES8505950A1 (es) 1985-06-01
PT77360B (en) 1986-05-19
YU169386A (en) 1987-10-31
EP0104860A1 (en) 1984-04-04
CA1194871A (en) 1985-10-08
IE55923B1 (en) 1991-02-27
AU1925283A (en) 1984-03-29
DD213211A5 (de) 1984-09-05
ES525737A0 (es) 1985-02-16
PL141370B1 (en) 1987-07-31
NZ205638A (en) 1986-12-05
KR840006239A (ko) 1984-11-22
NO161557C (no) 1989-08-30
YU169186A (en) 1987-10-31
ES531907A0 (es) 1985-06-01
DK157010C (da) 1990-03-26
IE832193L (en) 1984-03-20
IL69758A (en) 1986-12-31
PL243826A1 (en) 1985-04-24
JPS5976058A (ja) 1984-04-28
YU189283A (en) 1987-10-31
AU543115B2 (en) 1985-04-04
FI833335A0 (fi) 1983-09-19
HU189747B (en) 1986-07-28
YU169286A (en) 1987-10-31
ES8503328A1 (es) 1985-02-16
PT77360A (en) 1983-10-01
EP0104860B1 (en) 1987-03-18
NO161557B (no) 1989-05-22
PH18297A (en) 1985-05-24
PL141876B1 (en) 1987-09-30
SU1272983A3 (ru) 1986-11-23
DK425383D0 (da) 1983-09-19
FI833335A7 (fi) 1984-03-21
IL69758A0 (en) 1983-12-30
DK425383A (da) 1984-05-03
PL250768A1 (en) 1985-07-02
PL141609B1 (en) 1987-08-31
ZA836933B (en) 1985-05-29
FI77446B (fi) 1988-11-30
NO833367L (no) 1984-03-21
DE3370325D1 (en) 1987-04-23

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee