AU543115B2 - 1-phenyl-2(h,3h)-indoline derivatives - Google Patents

1-phenyl-2(h,3h)-indoline derivatives

Info

Publication number: AU543115B2
Authority: AU; Australia
Prior art keywords: phenyl; indolones; treatment; aminoalkylidene; valuable
Prior art date: 1982-09-20
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Ceased

Application number

AU19252/83A

Other languages

English (en)

Other versions

AU1925283A (en

Inventor

Harry Ralph Howard

Reinhard Sarges

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Pfizer Inc

Original Assignee

PFIZER

Pfizer Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-09-20

Filing date

1983-09-19

Publication date

1985-04-04

1983-09-19 Application filed by PFIZER, Pfizer Inc filed Critical PFIZER

1984-03-29 Publication of AU1925283A publication Critical patent/AU1925283A/en

1985-04-04 Application granted granted Critical

1985-04-04 Publication of AU543115B2 publication Critical patent/AU543115B2/en

2003-09-19 Anticipated expiration legal-status Critical

Status Ceased legal-status Critical Current

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
- C07C43/225—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing halogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/38—Oxygen atoms in positions 2 and 3, e.g. isatin

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Neurology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biomedical Technology (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Neurosurgery (AREA)
Public Health (AREA)
Anesthesiology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Indole Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Dental Preparations (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AU19252/83A 1982-09-20 1983-09-19 1-phenyl-2(h,3h)-indoline derivatives Ceased AU543115B2 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US420544		1982-09-20
US06/420,544 US4476307A (en)	1982-09-20	1982-09-20	Heteroylidene indolone compounds

Publications (2)

Publication Number	Publication Date
AU1925283A AU1925283A (en)	1984-03-29
AU543115B2 true AU543115B2 (en)	1985-04-04

Family

ID=23666904

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AU19252/83A Ceased AU543115B2 (en)	1982-09-20	1983-09-19	1-phenyl-2(h,3h)-indoline derivatives

Country Status (24)

Country	Link
US (1)	US4476307A (2)
EP (1)	EP0104860B1 (2)
JP (1)	JPS5976058A (2)
KR (1)	KR860001270B1 (2)
AT (1)	ATE25972T1 (2)
AU (1)	AU543115B2 (2)
CA (1)	CA1194871A (2)
DD (1)	DD213211A5 (2)
DE (1)	DE3370325D1 (2)
DK (1)	DK157010C (2)
ES (3)	ES8503328A1 (2)
FI (1)	FI77446C (2)
GR (1)	GR79732B (2)
HU (1)	HU189747B (2)
IE (1)	IE55923B1 (2)
IL (1)	IL69758A (2)
NO (1)	NO161557C (2)
NZ (1)	NZ205638A (2)
PH (1)	PH18297A (2)
PL (3)	PL141370B1 (2)
PT (1)	PT77360B (2)
SU (1)	SU1272983A3 (2)
YU (4)	YU189283A (2)
ZA (1)	ZA836933B (2)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4879391A (en) *	1982-09-20	1989-11-07	Pfizer Inc.	1-Phenyl-2(1H,3H)-indolone psychotherapeutic agents
US4760083A (en) *	1986-04-10	1988-07-26	E. I. Dupont De Nemours & Company	3,3-disubstituted indolines
US5128352A (en) *	1989-01-10	1992-07-07	Pfizer Inc.	Anti-inflammatory 1-heteroaryl-oxindole-3-carboxamides
US5078756A (en) *	1990-01-12	1992-01-07	Major Thomas O	Apparatus and method for purification and recovery of refrigerant
US5158969A (en) *	1991-08-21	1992-10-27	Neurosearch A/S	Indole derivatives as potassium channel blockers
US5760250A (en) *	1991-11-05	1998-06-02	Zeneca Limited	Process for the preparation of 3-(α-methoxy)methylenebenzofuranones and intermediates therefor
DE19949209A1 (de) *	1999-10-13	2001-04-19	Boehringer Ingelheim Pharma	In 5-Stellung substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel
US20030225152A1 (en) *	2001-09-27	2003-12-04	Andrews Steven W.	3-(Arylamino)methylene-1, 3-dihydro-2h-indol-2-ones as kinase inhibitors
US20050101788A1 (en) *	2002-03-27	2005-05-12	Jacopo Zanon	Method for manufacture of sertindole
FR2847811B1 (fr) *	2002-11-29	2005-01-07	Oreal	Composition filtrante contenant au moins un derive du dibenzoylmethane et au moins un derive de 3-(2-azacycloalkylidene)-1,3-dihydro-indol-2-one;procede de photostabilisation
FR2847813A1 (fr) *	2002-11-29	2004-06-04	Oreal	Compositions cosmetiques photoprotectrices contenant des derives de 3-(2-azacycloalkylidene)-1,3-dihydro-indol-2-one et utilisations
MX2007014114A (es)	2005-05-10	2008-03-14	Intermune Inc	Derivados de piridona para modular el sistema de proteina cinasa activada por estres.
JP5627574B2 (ja)	2008-06-03	2014-11-19	インターミューン，インコーポレイテッド	炎症性および線維性疾患を治療するための化合物および方法
JP5390535B2 (ja)	2008-12-19	2014-01-15	日本曹達株式会社	１−ヘテロジエン誘導体および有害生物防除剤
KR101376443B1 (ko)	2009-11-12	2014-03-19	닛뽕소다 가부시키가이샤	1-헤테로디엔 유도체 및 유해 생물 방제제
AR092742A1 (es)	2012-10-02	2015-04-29	Intermune Inc	Piridinonas antifibroticas
WO2014078568A1 (en)	2012-11-14	2014-05-22	The Johns Hopkins University	Methods and compositions for treating schizophrenia
US10233195B2 (en)	2014-04-02	2019-03-19	Intermune, Inc.	Anti-fibrotic pyridinones

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3506683A (en) *	1963-10-07	1970-04-14	Upjohn Co	3-(2-pyrrolidinylidene)-3h-indoles
GB1237008A (en) *	1968-12-18	1971-06-30	Pfizer Ltd	Novel indoline derivatives
US3723457A (en) *	1969-09-30	1973-03-27	Eisai Co Ltd	Indoline-2-one derivatives and preparation thereof
GB1374414A (en) *	1972-06-12	1974-11-20	Sterling Drug Inc	1-acyl-3-amino-alkyl-indoles and their preparation
DE2557342A1 (de) *	1975-12-19	1977-06-30	Hoechst Ag	Basisch substituierte indolderivate und verfahren zu ihrer herstellung

1982
- 1982-09-20 US US06/420,544 patent/US4476307A/en not_active Expired - Fee Related
1983
- 1983-09-16 CA CA000436845A patent/CA1194871A/en not_active Expired
- 1983-09-18 IL IL69758A patent/IL69758A/xx unknown
- 1983-09-19 DD DD83254923A patent/DD213211A5/de unknown
- 1983-09-19 DE DE8383305484T patent/DE3370325D1/de not_active Expired
- 1983-09-19 NZ NZ205638A patent/NZ205638A/en unknown
- 1983-09-19 KR KR1019830004396A patent/KR860001270B1/ko not_active Expired
- 1983-09-19 ZA ZA836933A patent/ZA836933B/xx unknown
- 1983-09-19 SU SU833646758A patent/SU1272983A3/ru active
- 1983-09-19 FI FI833335A patent/FI77446C/fi not_active IP Right Cessation
- 1983-09-19 ES ES525737A patent/ES8503328A1/es not_active Expired
- 1983-09-19 EP EP83305484A patent/EP0104860B1/en not_active Expired
- 1983-09-19 HU HU833235A patent/HU189747B/hu unknown
- 1983-09-19 AU AU19252/83A patent/AU543115B2/en not_active Ceased
- 1983-09-19 NO NO833367A patent/NO161557C/no unknown
- 1983-09-19 AT AT83305484T patent/ATE25972T1/de not_active IP Right Cessation
- 1983-09-19 IE IE2193/83A patent/IE55923B1/en not_active IP Right Cessation
- 1983-09-19 GR GR72470A patent/GR79732B/el unknown
- 1983-09-19 DK DK425383A patent/DK157010C/da not_active IP Right Cessation
- 1983-09-19 PT PT77360A patent/PT77360B/pt not_active IP Right Cessation
- 1983-09-20 PL PL1983250768A patent/PL141370B1/pl unknown
- 1983-09-20 YU YU01892/83A patent/YU189283A/xx unknown
- 1983-09-20 PL PL1983243826A patent/PL141609B1/pl unknown
- 1983-09-20 JP JP58174025A patent/JPS5976058A/ja active Granted
- 1983-09-20 PL PL1983250769A patent/PL141876B1/pl unknown
- 1983-09-20 PH PH29565A patent/PH18297A/en unknown
1984
- 1984-04-25 ES ES531908A patent/ES531908A0/es active Granted
- 1984-04-25 ES ES531907A patent/ES531907A0/es active Granted
1986
- 1986-10-01 YU YU01691/86A patent/YU169186A/xx unknown
- 1986-10-01 YU YU01693/86A patent/YU169386A/xx unknown
- 1986-10-01 YU YU01692/86A patent/YU169286A/xx unknown

Also Published As

Publication number	Publication date
KR860001270B1 (ko)	1986-09-04
GR79732B (2)	1984-10-31
US4476307A (en)	1984-10-09
JPS6241711B2 (2)	1987-09-04
ES8505951A1 (es)	1985-06-01
ES531908A0 (es)	1985-06-01
PL250769A1 (en)	1985-07-02
DK157010B (da)	1989-10-30
FI77446C (fi)	1989-03-10
ES8505950A1 (es)	1985-06-01
PT77360B (en)	1986-05-19
YU169386A (en)	1987-10-31
EP0104860A1 (en)	1984-04-04
CA1194871A (en)	1985-10-08
IE55923B1 (en)	1991-02-27
AU1925283A (en)	1984-03-29
DD213211A5 (de)	1984-09-05
ES525737A0 (es)	1985-02-16
PL141370B1 (en)	1987-07-31
NZ205638A (en)	1986-12-05
KR840006239A (ko)	1984-11-22
NO161557C (no)	1989-08-30
YU169186A (en)	1987-10-31
ES531907A0 (es)	1985-06-01
DK157010C (da)	1990-03-26
IE832193L (en)	1984-03-20
IL69758A (en)	1986-12-31
PL243826A1 (en)	1985-04-24
JPS5976058A (ja)	1984-04-28
YU189283A (en)	1987-10-31
FI833335A0 (fi)	1983-09-19
HU189747B (en)	1986-07-28
YU169286A (en)	1987-10-31
ES8503328A1 (es)	1985-02-16
ATE25972T1 (de)	1987-04-15
PT77360A (en)	1983-10-01
EP0104860B1 (en)	1987-03-18
NO161557B (no)	1989-05-22
PH18297A (en)	1985-05-24
PL141876B1 (en)	1987-09-30
SU1272983A3 (ru)	1986-11-23
DK425383D0 (da)	1983-09-19
FI833335A7 (fi)	1984-03-21
IL69758A0 (en)	1983-12-30
DK425383A (da)	1984-05-03
PL250768A1 (en)	1985-07-02
PL141609B1 (en)	1987-08-31
ZA836933B (en)	1985-05-29
FI77446B (fi)	1988-11-30
NO833367L (no)	1984-03-21
DE3370325D1 (en)	1987-04-23

Publication	Publication Date	Title
AU1925283A (en)	1984-03-29	1-phenyl-2(h,3h)-indoline derivatives
NO931635L (no)	1993-05-05	Fremgangsmaate for fremstilling av kinazolin-derivater
ES2145318T3 (es)	2000-07-01	Imidazo(4,5-c)quinolin-aminas.
IL98163A0 (en)	1992-06-21	Isoxazole-4-carboxamides and hydroxyalkylidene-cyanoacetamides,pharmaceuticals containing these compounds and their use
BG102616A (en)	1999-04-30	Substituted aza- and diazacycloheptane and cyclooctane derivatives and their application
EP0585681A3 (de)	1994-10-05	Verwendung des IL-4-Rezeptors zur Therapie, Prophylaxe und Diagnose von allergischen, viralen, parasitären und bakteriellen Erkrankungen sowie von Pilzinfektionen.
NO976048D0 (no)	1997-12-22	Farmasöytiske og diett formuleringer for profylakse og behandling av mave- og tarmforstyrrelser
NO972391L (no)	1997-05-26	2-substituerte 1,2,5-tiadiazolidin-3-on 1,1-dioksider og preparater og metoder for anvendelse derav
WO1993000094A3 (en)	1993-03-04	Use of tetrahydrobenzazepine derivatives for the treatment of portal hypertension and migraine
CA2284551A1 (en)	1998-10-08	New therapeutic combinations of mirtazapine and antipsychotic agents, for the treatment or prophylaxis of psychotic disorders
NO853698L (no)	1986-03-24	I-substituerte tetralinderivater, fremstilling og anvendel se derav.
AU641279B2 (en)	1993-09-16	Oligosaccharide derivatives
DK0833638T3 (da)	2002-05-21	Anvendelse af imidazo[1,5-a]quinoloner som neuroprotektive midler
IT1263076B (it)	1996-07-24	Uso orale e topico della n-acetil-5-metossitriptamina (melatonina) nella terapia della psoriasi volgare.
MY113450A (en)	2002-02-28	Anellated b-carbolines
SI0929566T1 (en)	2003-04-30	Process for r-epimer enrichment of 16,17-acetal derivatives of 21-acyloxy pregan-1,4-dien-11.beta.,16.alpha.,17.alpha.-triol-3,20-dione derivatives