EA200200086A1 - Ингибиторы репликации респираторно-синцитиального вируса - Google Patents
Ингибиторы репликации респираторно-синцитиального вирусаInfo
- Publication number
- EA200200086A1 EA200200086A1 EA200200086A EA200200086A EA200200086A1 EA 200200086 A1 EA200200086 A1 EA 200200086A1 EA 200200086 A EA200200086 A EA 200200086A EA 200200086 A EA200200086 A EA 200200086A EA 200200086 A1 EA200200086 A1 EA 200200086A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- alkyl
- hydrogen
- formula
- optionally substituted
- aryl
- Prior art date
Links
- 241000700605 Viruses Species 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 230000010076 replication Effects 0.000 title 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 7
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 2
- -1 homopiperidinyl Chemical group 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- 239000000654 additive Substances 0.000 abstract 1
- 230000000996 additive effect Effects 0.000 abstract 1
- 150000001412 amines Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000002618 bicyclic heterocycle group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052751 metal Inorganic materials 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- 150000002739 metals Chemical class 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000003386 piperidinyl group Chemical group 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 125000003373 pyrazinyl group Chemical group 0.000 abstract 1
- 125000002098 pyridazinyl group Chemical group 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 125000000714 pyrimidinyl group Chemical group 0.000 abstract 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Настоящее изобретение относится к соединениям формулы (I), их пролекарствам, N-оксидам, аддитивным солям, четвертичным аминам, комплексам с металлами и стереохимически изомерным формам, где в указанной формуле -a=a-a=a- представляет собой радикал формулы -СН=СН-СН=СН-, -N=CH-CH=CH-, -CH=N-CH=CH-, -CH=CH-N=CH-,-CH=CH-CH=N-, где каждый атом водорода может быть необязательно замещен; Q представляет собой радикал формулы (b-1), (b-2), (b-3), (b-4), (b-5), (b-6), (b-7) и (b-8), где Alk представляет собой C-алкандиил; Yпредставляет собой двухвалентный радикал формулы -NR- или -CH(NRR)-; Xпредставляет собой NR, S, S(=O), S(=O), О, СН, С(=O), СН(=СН), СН(ОН), СН(СН), СН(ОСН), СН(SCH), CH(NRR), CH-NRили NR-CH; Xпредставляет собой прямую связь, СН, С(=O), NR, C-алкил-NR, NR-C-алкил; t равен 2-5; u равен 1-5; v равен 2 или 3; и при этом каждый атом водорода в Alk и в (b-3), (b-4), (b-5), (b-6), (b-7) и (b-8) может быть необязательно замещен R; при условии, что когда Rпредставляет собой гидрокси или C-алкилокси, тогда Rне может замещать атом водорода в положении α относительно атома азота; G представляет собой прямую связь или необязательно замещенный C-алкандиил; Rпредставляет собой необязательно замещенный бициклический гетероцикл; Rпредставляет собой водород, формил, C-алкилкарбонил, Het-карбонил, пирролидинил, пиперидинил, гомопиперидинил, С-циклоалкил или C-алкил, замещенный N(R)и необязательно другим заместителем; Rпредставляет собой водород, гидрокси, C-алкил, C-алкилокси, арил-С-алкил или арил-С-алкилокси; Rпредставляет собой водород, C-алкил или арил-С-алкил; R, R, Rи Rпредставляют собой водород или C-алкил; или Rи R, или Rи R, взятые вместе, образуют двухвалентный радикал формулы -(СН)-, где s равен 4 или 5; Rпредставляет собой водород, C-алкил, формил, гидрокси-C-алкил, C-алкилкарбонил или C-алкилоксикарбонил; арил представляет собой необязательно замещенный фенил; Het представляет собой пиридил, пиримидинил, пиразинил, пиридазинил, как
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP99202089 | 1999-06-28 | ||
| PCT/EP2000/005677 WO2001000615A1 (en) | 1999-06-28 | 2000-06-20 | Respiratory syncytial virus replication inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA200200086A1 true EA200200086A1 (ru) | 2002-06-27 |
| EA004746B1 EA004746B1 (ru) | 2004-08-26 |
Family
ID=8240374
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA200200086A EA004746B1 (ru) | 1999-06-28 | 2000-06-20 | Производные бензимидазола и имидазопиридина в качестве ингибиторов репликации респираторно-синцитиального вируса |
Country Status (34)
| Country | Link |
|---|---|
| US (2) | US7071192B1 (ru) |
| EP (2) | EP1196410B1 (ru) |
| JP (1) | JP2003503403A (ru) |
| KR (1) | KR100731273B1 (ru) |
| CN (1) | CN1171887C (ru) |
| AR (1) | AR024495A1 (ru) |
| AT (2) | ATE259796T1 (ru) |
| AU (1) | AU774829B2 (ru) |
| BG (1) | BG65373B1 (ru) |
| BR (1) | BR0011997A (ru) |
| CA (1) | CA2376785A1 (ru) |
| CZ (1) | CZ20014573A3 (ru) |
| DE (2) | DE60008382T2 (ru) |
| DK (1) | DK1196410T3 (ru) |
| EA (1) | EA004746B1 (ru) |
| EE (1) | EE04592B1 (ru) |
| ES (2) | ES2283716T3 (ru) |
| HK (1) | HK1045998B (ru) |
| HR (2) | HRP20080390A2 (ru) |
| HU (1) | HUP0201789A3 (ru) |
| IL (2) | IL147328A0 (ru) |
| MX (1) | MXPA02000117A (ru) |
| MY (1) | MY129810A (ru) |
| NO (1) | NO321599B1 (ru) |
| NZ (1) | NZ515392A (ru) |
| PL (1) | PL200694B1 (ru) |
| PT (1) | PT1196410E (ru) |
| SI (1) | SI1196410T1 (ru) |
| SK (1) | SK18952001A3 (ru) |
| TR (2) | TR200500707T2 (ru) |
| TW (1) | TWI267513B (ru) |
| UA (1) | UA75866C2 (ru) |
| WO (1) | WO2001000615A1 (ru) |
| ZA (1) | ZA200110473B (ru) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6495580B1 (en) | 1998-01-29 | 2002-12-17 | Viropharma Incorporated | Compounds, compositions and methods for treating or preventing pneumovirus infection and associated diseases |
| US20040010004A1 (en) | 2000-01-17 | 2004-01-15 | Naoki Tsuchiya | Benzimidazole derivatives |
| AU758789B2 (en) | 1998-07-15 | 2003-03-27 | Teijin Limited | Thiobenzimidazole derivatives |
| CN100415723C (zh) * | 2000-01-17 | 2008-09-03 | 帝人株式会社 | 苯并咪唑衍生物 |
| US6489338B2 (en) | 2000-06-13 | 2002-12-03 | Bristol-Myers Squibb Company | Imidazopyridine and imidazopyrimidine antiviral agents |
| PE20020506A1 (es) | 2000-08-22 | 2002-07-09 | Glaxo Group Ltd | Derivados de pirazol fusionados como inhibidores de la proteina cinasa |
| US6506738B1 (en) | 2000-09-27 | 2003-01-14 | Bristol-Myers Squibb Company | Benzimidazolone antiviral agents |
| EP1341788B1 (en) | 2000-12-15 | 2005-08-10 | Glaxo Group Limited | Pyrazolopyridines |
| DE60112330T2 (de) | 2000-12-15 | 2006-04-13 | Glaxo Group Ltd., Greenford | Pyrazolopyridinderivate |
| US6774134B2 (en) | 2000-12-20 | 2004-08-10 | Bristol-Myers Squibb Company | Heterocyclic substituted 2-methyl-benzimidazole antiviral agents |
| EP1366048B1 (en) | 2001-03-08 | 2004-08-25 | SmithKline Beecham Corporation | Pyrazolopyridine derivatives |
| US7034030B2 (en) | 2001-03-30 | 2006-04-25 | Smithkline Beecham Corporation | Pyralopyridines, process for their preparation and use as therapeutic compounds |
| JP4219171B2 (ja) | 2001-04-10 | 2009-02-04 | スミスクライン ビーチャム コーポレーション | 抗ウイルス性ピラゾロピリジン化合物 |
| ATE296826T1 (de) | 2001-04-27 | 2005-06-15 | Smithkline Beecham Corp | Pyrazolo(1,5)pyridinderivate |
| US7030150B2 (en) | 2001-05-11 | 2006-04-18 | Trimeris, Inc. | Benzimidazole compounds and antiviral uses thereof |
| WO2003000689A1 (en) | 2001-06-21 | 2003-01-03 | Smithkline Beecham Corporation | Imidazo`1,2-a!pyridine derivatives for the prophylaxis and treatment of herpes viral infections |
| ES2262893T3 (es) * | 2001-10-05 | 2006-12-01 | Smithkline Beecham Corporation | Derivados de imidazo-piridina para su uso en el tratamiento de infeccion virica por herpes. |
| US6919331B2 (en) | 2001-12-10 | 2005-07-19 | Bristol-Myers Squibb Company | Substituted 2-methyl-benzimidazole respiratory syncytial virus antiviral agents |
| JP2005516916A (ja) | 2001-12-11 | 2005-06-09 | スミスクライン ビーチャム コーポレーション | 抗ヘルペス薬としてのピラゾロ−ピリジン誘導体 |
| US7244847B2 (en) * | 2002-02-06 | 2007-07-17 | Isis Pharmaceuticals, Inc. | Benzimidazole compounds |
| US8119672B2 (en) | 2002-08-09 | 2012-02-21 | Microdose Therapeutx, Inc. | Compounds, compositions and methods for treating or preventing pneumovirus infection and associated diseases |
| CA2495266A1 (en) | 2002-08-09 | 2004-02-19 | Viropharma Incorporated | Compounds, compositions and methods for treating or preventing pneumovirus infection and associated diseases |
| US7153863B2 (en) | 2002-10-03 | 2006-12-26 | Smithkline Beecham Corporation | Therapeutic compounds based on pyrazolopyridline derivatives |
| WO2005042530A1 (en) | 2003-10-30 | 2005-05-12 | Boehringer Ingelheim (Canada) Ltd. | Rsv polymerase inhibitors |
| AR046959A1 (es) * | 2003-12-18 | 2006-01-04 | Tibotec Pharm Ltd | Morfolinilo que contiene bencimidazoles como inhibidores de la replicacion del virus sincitial respiratorio |
| EP1697343B1 (en) | 2003-12-18 | 2009-07-01 | Tibotec Pharmaceuticals Ltd. | Aminobenzimidazoles and benzimidazoles as inhibitors of respiratory syncytial virus replication |
| DE602004021135D1 (de) * | 2003-12-18 | 2009-06-25 | Tibotec Pharm Ltd | Aminobenzimidazolderivate als inhibitoren der replikation des respiratory syncytial virus |
| CN1894236B (zh) * | 2003-12-18 | 2011-08-17 | 泰博特克药品有限公司 | 作为呼吸道合胞病毒复制抑制剂的氨基-苯并咪唑类衍生物 |
| ATE501135T1 (de) * | 2003-12-18 | 2011-03-15 | Tibotec Pharm Ltd | Piperidinamino-benzimidazol-derivate al respiratorisches syncytialvirus replikation inhibitoren |
| RU2369606C2 (ru) * | 2003-12-18 | 2009-10-10 | Тиботек Фармасьютикалз Лтд. | Производные 5- или 6-замещенных бензимидазолов в качестве ингибиторов репликации респираторного синцитиального вируса |
| ES2574670T3 (es) * | 2005-03-17 | 2016-06-21 | Janssen Sciences Ireland Uc | 1,3-Dihidro-bencimidazol-2-ilidenoaminas como inhibidores de replicación del virus sincicial respiratorio |
| CA2612263C (en) * | 2005-06-20 | 2015-04-14 | Tibotec Pharmaceuticals Ltd. | 1-(2-amino-3-(substituted alkyl)-3h-benzimidazolylmethyl)-3-subtituted-1,3-dihydro-benzoimidazol-2-ones with activity on respiratory syncytial virus |
| BRPI0611744B8 (pt) | 2005-06-20 | 2021-05-25 | Janssen R & D Ireland | benzimidazóis heterociclilaminoalquila substituída, seu processo de preparação e composição farmacêutica |
| ES2392863T3 (es) * | 2005-06-20 | 2012-12-14 | Janssen R&D Ireland | Bencimidazoles 2-sustituidos |
| CL2008001003A1 (es) | 2007-04-11 | 2008-10-17 | Actelion Pharmaceuticals Ltd | Compuestos derivados de oxazolidinona; composicion farmaceutica que comprende a dichos compuestos; y su uso para preparar un medicamento para tratar una infeccion bacteriana. |
| US20110190336A1 (en) * | 2008-10-16 | 2011-08-04 | Cara Therapeutics, Inc. | Azabenzimidazolones |
| JP5487692B2 (ja) | 2009-04-10 | 2014-05-07 | 国立大学法人京都大学 | 複素環骨格を有する化合物および該化合物を不斉触媒として用いる光学活性化合物の製造方法 |
| KR20120049852A (ko) * | 2009-06-30 | 2012-05-17 | 시가 테크놀로지스, 인크. | 뎅기 바이러스 감염의 치료 및 예방 |
| US8993604B2 (en) | 2009-06-30 | 2015-03-31 | Siga Technologies, Inc. | Treatment and prevention of dengue virus infections |
| EP2733141B1 (en) | 2011-07-15 | 2019-01-09 | Shionogi & Co., Ltd. | Azabenzimidazole derivative having ampk-activating activity |
| AU2013305759C1 (en) * | 2012-08-23 | 2018-01-18 | Janssen Biopharma, Inc. | Compounds for the treatment of paramoxyvirus viral infections |
| JP2016079168A (ja) | 2014-10-17 | 2016-05-16 | 塩野義製薬株式会社 | ９員縮合環誘導体 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1140119A (en) | 1978-04-03 | 1983-01-25 | Joseph Torremans | N-heterocyclyl-4-piperidinamines |
| US4556660A (en) | 1982-07-12 | 1985-12-03 | Janssen Pharmaceutica N.V. | N-(Bicyclic heterocyclyl)-4-piperidinamines |
| US4634704A (en) | 1983-10-06 | 1987-01-06 | Janssen Pharmaceutica, N.V. | Anti-allergic five membered heterocyclic ring containing N-(bicyclic heterocycyl)-4-piperidinamines |
| EP0144101B1 (en) | 1983-11-30 | 1991-02-06 | Janssen Pharmaceutica N.V. | Bicyclic heterocyclyl containing n-(bicyclic heterocyclyl)-4-piperidinamines |
| US4695569A (en) | 1983-11-30 | 1987-09-22 | Janssen Pharmaceutica N.V. | Bicyclic heterocyclyl containing N-(bicyclic heterocyclyl)-4-piperidinamines |
| US4588722A (en) | 1984-01-09 | 1986-05-13 | Janssen Pharmaceutica N.V. | N-(4-piperidinyl) bicyclic condensed 2-imidazolamine derivatives |
| PH23995A (en) | 1984-01-09 | 1990-02-09 | Janssen Pharmaceutica Nv | 4((bicycle heterocyclyl)-methyl and hetero)piperidines |
| EG17993A (en) | 1986-02-03 | 1991-08-30 | Janssen Pharmaceutica Nv | Anti-histaminic compositions containing n-heterocyclyl-4-piperidinanines |
| US4897401A (en) | 1987-06-19 | 1990-01-30 | Janssen Pharmaceutical N.V. | N-(4-piperidinyl) bicyclic condensed 2-imidazolamine derivatives useful in treating allergic diseases |
| CA1317939C (en) | 1987-07-01 | 1993-05-18 | Janssen Pharmaceutica Naamloze Vennootschap | ¬(bicyclic heterocyclyl)methyl and -hetero| substituted hexahydro-1h-azepines and pyrrolidines |
| GB8716313D0 (en) * | 1987-07-10 | 1987-08-19 | Janssen Pharmaceutica Nv | 2-(heterocyclylalkyl)imidazopyridines |
| US5597824A (en) | 1987-11-03 | 1997-01-28 | Abbott Laboratories | Analogs of oxetanyl purines and pyrimidines |
| IE904378A1 (en) | 1989-12-20 | 1991-07-03 | Abbott Lab | Analogs of oxetanyl purines and pyrimidines |
| KR100190299B1 (ko) | 1990-07-19 | 1999-06-01 | 디르크 반테 | 신규한 옥사졸릴 유도체 |
| NZ238863A (en) | 1990-07-19 | 1993-03-26 | Janssen Pharmaceutica Nv | Substituted thiazolyl and pyridinyl derivatives |
| US5567824A (en) * | 1994-05-24 | 1996-10-22 | Merck & Co., Inc. | Palladium catalyzed ring closure of triazolyltryptamine |
| US5693661A (en) * | 1995-06-07 | 1997-12-02 | Eli Lilly And Company | Anti-viral compounds |
| PE107598A1 (es) * | 1996-09-11 | 1999-01-29 | Ucb Sa | Cetirizina util para el tratamiento de enfermedades de tipo virico |
| AU6031898A (en) * | 1997-01-22 | 1998-08-07 | Eli Lilly And Company | Anti-viral compounds |
| CA2293508A1 (en) * | 1997-06-04 | 1998-12-10 | Louis Nickolaus Jungheim | Anti-viral compounds |
| IL138228A0 (en) | 1998-03-06 | 2001-10-31 | Janssen Pharmaceutica Nv | Glycine transport inhibitors |
| AU741946B2 (en) | 1998-07-20 | 2001-12-13 | Bristol-Myers Squibb Company | Substituted benzimidazole antiviral agents |
-
2000
- 2000-06-20 EE EEP200100694A patent/EE04592B1/xx not_active IP Right Cessation
- 2000-06-20 MX MXPA02000117A patent/MXPA02000117A/es active IP Right Grant
- 2000-06-20 SI SI200030358T patent/SI1196410T1/xx unknown
- 2000-06-20 TR TR2005/00707T patent/TR200500707T2/xx unknown
- 2000-06-20 EP EP00936899A patent/EP1196410B1/en not_active Expired - Lifetime
- 2000-06-20 HK HK02107623.8A patent/HK1045998B/zh not_active IP Right Cessation
- 2000-06-20 US US10/019,376 patent/US7071192B1/en not_active Expired - Fee Related
- 2000-06-20 AT AT00936899T patent/ATE259796T1/de not_active IP Right Cessation
- 2000-06-20 PL PL352385A patent/PL200694B1/pl not_active IP Right Cessation
- 2000-06-20 BR BR0011997-0A patent/BR0011997A/pt not_active Application Discontinuation
- 2000-06-20 DE DE60008382T patent/DE60008382T2/de not_active Expired - Fee Related
- 2000-06-20 AU AU52222/00A patent/AU774829B2/en not_active Ceased
- 2000-06-20 SK SK1895-2001A patent/SK18952001A3/sk unknown
- 2000-06-20 KR KR1020017015284A patent/KR100731273B1/ko not_active Expired - Fee Related
- 2000-06-20 CA CA002376785A patent/CA2376785A1/en not_active Abandoned
- 2000-06-20 ES ES03102464T patent/ES2283716T3/es not_active Expired - Lifetime
- 2000-06-20 ES ES00936899T patent/ES2215670T3/es not_active Expired - Lifetime
- 2000-06-20 DE DE60033859T patent/DE60033859T2/de not_active Expired - Fee Related
- 2000-06-20 IL IL14732800A patent/IL147328A0/xx active IP Right Grant
- 2000-06-20 EP EP03102464A patent/EP1400519B1/en not_active Expired - Lifetime
- 2000-06-20 UA UA2002010361A patent/UA75866C2/uk unknown
- 2000-06-20 TR TR2001/03805T patent/TR200103805T2/xx unknown
- 2000-06-20 HU HU0201789A patent/HUP0201789A3/hu unknown
- 2000-06-20 CN CNB008095302A patent/CN1171887C/zh not_active Expired - Fee Related
- 2000-06-20 CZ CZ20014573A patent/CZ20014573A3/cs unknown
- 2000-06-20 AT AT03102464T patent/ATE356121T1/de not_active IP Right Cessation
- 2000-06-20 NZ NZ515392A patent/NZ515392A/xx unknown
- 2000-06-20 WO PCT/EP2000/005677 patent/WO2001000615A1/en not_active Ceased
- 2000-06-20 DK DK00936899T patent/DK1196410T3/da active
- 2000-06-20 JP JP2001507023A patent/JP2003503403A/ja not_active Withdrawn
- 2000-06-20 EA EA200200086A patent/EA004746B1/ru not_active IP Right Cessation
- 2000-06-20 HR HR20080390A patent/HRP20080390A2/xx not_active Application Discontinuation
- 2000-06-20 PT PT00936899T patent/PT1196410E/pt unknown
- 2000-06-20 HR HR20010934A patent/HRP20010934A2/hr not_active Application Discontinuation
- 2000-06-26 TW TW089112479A patent/TWI267513B/zh not_active IP Right Cessation
- 2000-06-27 MY MYPI20002914A patent/MY129810A/en unknown
- 2000-06-27 AR ARP000103222A patent/AR024495A1/es unknown
-
2001
- 2001-12-20 ZA ZA200110473A patent/ZA200110473B/xx unknown
- 2001-12-26 IL IL147328A patent/IL147328A/en not_active IP Right Cessation
- 2001-12-27 NO NO20016370A patent/NO321599B1/no unknown
-
2002
- 2002-01-08 BG BG106288A patent/BG65373B1/bg unknown
-
2005
- 2005-10-11 US US11/247,392 patent/US7407969B2/en not_active Expired - Fee Related
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EA200200086A1 (ru) | Ингибиторы репликации респираторно-синцитиального вируса | |
| EA200200088A1 (ru) | Ингибиторы репликации респираторно-синцитиального вируса | |
| MY135747A (en) | Respiratory syncytial virus replication inhibitors | |
| RU2441869C2 (ru) | Противовирусные соединения | |
| MY108261A (en) | Water soluble camptothecin derivatives | |
| CA2138298A1 (en) | Pyridopyrimidinone Antianginal Agents | |
| CA2416274A1 (en) | N-phenyl-2-pyrimidine-amine derivatives | |
| EG19650A (en) | Derivatives of indol and their use for treatment of megraine | |
| DK1389617T3 (da) | Heterocyclisk forbindelse og antitumormiddel indeholdende denne som den aktive bestanddel | |
| RU2015153094A (ru) | Арилхиназолины | |
| AR041739A1 (es) | Compuestos derivados -3,4-dihidro-1h-pirimido[4,5-d]pirimidin-2-ona y con actividad antiproliferativa. | |
| AR039659A1 (es) | Inhibidores de metaloproteinasa de heteroariloxi-aril-espiro-pirimidina-2,4,6-triona n-sustituida metaloproteinasa | |
| MY118904A (en) | 4-oxo-1, 4-dihydro-3-quinolinecarboxamides as antiviral agents | |
| EA200601177A1 (ru) | Пиридо- и пиримидопиримидиновые производные в качестве антипролиферативных агентов | |
| EA200100710A1 (ru) | 4-(аминометил)пиперидинбензамиды для лечения желудочно-кишечных расстройств | |
| TR200000918T2 (tr) | Halojen ikameli tetrasiklik tetrahidrofuran türevleri. | |
| AR044821A1 (es) | 4-(aminometil)-piperidin benzamidas como antagonistas de 5ht4 | |
| JPWO2020150474A5 (ru) | ||
| MX2007006173A (es) | Nuevos derivados de piridotienopirimidina. | |
| PA8519601A1 (es) | Compuestos para tratar el desacomodamiento fundico | |
| RU2012108930A (ru) | Способы и композиции для лечения лейкоза | |
| WO2004007498A3 (en) | 3-phenyl analogs of toxoflavine as kinase inhibitors | |
| DK1791811T3 (da) | Aminoalkoholderivater | |
| TW330147B (en) | Halogenobenzimidazoles, their preparation processes and their use | |
| IL81258A0 (en) | Dihydropyridinelactols,their preparation and pharmaceutical compositions containing them |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM |
|
| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): RU |