ATE261435T1 - Benzofuranderivate, verfahren zu ihrer herstellung und deren verwendungen - Google Patents
Benzofuranderivate, verfahren zu ihrer herstellung und deren verwendungenInfo
- Publication number
- ATE261435T1 ATE261435T1 AT99973289T AT99973289T ATE261435T1 AT E261435 T1 ATE261435 T1 AT E261435T1 AT 99973289 T AT99973289 T AT 99973289T AT 99973289 T AT99973289 T AT 99973289T AT E261435 T1 ATE261435 T1 AT E261435T1
- Authority
- AT
- Austria
- Prior art keywords
- group
- indicates
- chem
- formula
- hydrogen atom
- Prior art date
Links
- IANQTJSKSUMEQM-UHFFFAOYSA-N 1-benzofuran Chemical class C1=CC=C2OC=CC2=C1 IANQTJSKSUMEQM-UHFFFAOYSA-N 0.000 title 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000002252 acyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 125000005915 C6-C14 aryl group Chemical group 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 210000004556 brain Anatomy 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 210000005036 nerve Anatomy 0.000 abstract 1
- 230000004770 neurodegeneration Effects 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 229940043274 prophylactic drug Drugs 0.000 abstract 1
- 230000000069 prophylactic effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229940126585 therapeutic drug Drugs 0.000 abstract 1
- 230000001988 toxicity Effects 0.000 abstract 1
- 231100000419 toxicity Toxicity 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/056—Ortho-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Furan Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Seasonings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP34535598 | 1998-12-04 | ||
| JP34536598 | 1998-12-04 | ||
| PCT/JP1999/006764 WO2000034262A1 (en) | 1998-12-04 | 1999-12-02 | Benzofuran derivatives, process for the preparation of the same and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE261435T1 true ATE261435T1 (de) | 2004-03-15 |
Family
ID=26578009
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99973289T ATE261435T1 (de) | 1998-12-04 | 1999-12-02 | Benzofuranderivate, verfahren zu ihrer herstellung und deren verwendungen |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US6479536B1 (de) |
| EP (1) | EP1136477B1 (de) |
| JP (1) | JP4778570B2 (de) |
| KR (1) | KR100660788B1 (de) |
| CN (1) | CN1297550C (de) |
| AT (1) | ATE261435T1 (de) |
| AU (1) | AU1414600A (de) |
| CA (1) | CA2352786C (de) |
| DE (1) | DE69915508T2 (de) |
| ES (1) | ES2213407T3 (de) |
| HU (1) | HU226652B1 (de) |
| NO (1) | NO327924B1 (de) |
| PT (1) | PT1136477E (de) |
| WO (1) | WO2000034262A1 (de) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000034262A1 (en) * | 1998-12-04 | 2000-06-15 | Takeda Chemical Industries, Ltd. | Benzofuran derivatives, process for the preparation of the same and uses thereof |
| WO2002028850A1 (en) * | 2000-10-05 | 2002-04-11 | Takeda Chemical Industries, Ltd. | Promoters for the proliferation and differentiation of stem cells and/or neuron precursor cells |
| ATE414070T1 (de) | 2000-12-28 | 2008-11-15 | Takeda Pharmaceutical | Verfahren zur herstellung von optisch aktiven 2,4-dihydrobenzofuranverbindungen |
| WO2003004485A1 (fr) * | 2001-07-05 | 2003-01-16 | Takeda Chemical Industries, Ltd. | Composes heterocycles a 5 chainons condenses avec un benzo, leur procede de preparation et leur utilisation |
| DE60228577D1 (de) | 2001-07-13 | 2008-10-09 | Takeda Pharmaceutical | Verfahren zur herstellung von benzofuranderivaten |
| AU2002366313A1 (en) * | 2001-12-19 | 2003-06-30 | Takeda Chemical Industries, Ltd. | Solid compositions containng compounds unstable to oxygen and method for stabilization thereof |
| US6653346B1 (en) * | 2002-02-07 | 2003-11-25 | Galileo Pharmaceuticals, Inc. | Cytoprotective benzofuran derivatives |
| US7078541B2 (en) * | 2002-02-07 | 2006-07-18 | Galileo Pharmaceuticals, Inc. | Benzofuran derivatives |
| PL371366A1 (en) | 2002-03-01 | 2005-06-13 | Takeda Pharmaceutical Company Limited | Antidepressant |
| JP4537011B2 (ja) * | 2002-03-01 | 2010-09-01 | 武田薬品工業株式会社 | 抗うつ剤 |
| US7465815B2 (en) * | 2003-06-26 | 2008-12-16 | Takeda Pharmaceutical Company Limited | Cannabinoid receptor modulator |
| US7119214B2 (en) * | 2004-04-13 | 2006-10-10 | Cephalon France | Thio-substituted tricyclic and bicyclic aromatic methanesulfinyl derivatives |
| EP1589016A1 (de) * | 2004-04-13 | 2005-10-26 | Cephalon France | Thiosubstituierte tricyclische und bicyclische aromatische Methansulfinylderivate |
| MXPA06012621A (es) * | 2004-05-05 | 2006-12-15 | Hoffmann La Roche | Arilsulfonil benzodioxanos utiles para la modulacion del receptor 5-ht6, el receptor 5-ht2a o ambos. |
| EP1783121A4 (de) * | 2004-08-27 | 2009-08-05 | Takeda Pharmaceutical | Azoverbindungen und verfahren zu deren herstellung |
| US20060125084A1 (en) * | 2004-12-15 | 2006-06-15 | Fazzio Ronald S | Integration of micro-electro mechanical systems and active circuitry |
| PT1831159E (pt) * | 2004-12-21 | 2010-03-03 | Hoffmann La Roche | Derivados de tetralina e de indano e as suas utilizações |
| CA2591800A1 (en) * | 2004-12-21 | 2006-06-29 | F.Hoffmann-La Roche Ag | Tetralin and indane derivatives and uses thereof as 5-ht antagonists |
| ES2306275T3 (es) * | 2004-12-21 | 2008-11-01 | F. Hoffmann-La Roche Ag | Derivados de cromano y sus usos como ligandos dde receptores 5-ht. |
| BRPI0515835A (pt) * | 2004-12-21 | 2008-08-12 | Hoffmann La Roche | derivados de tetralina e de indano e seus usos |
| JP4738418B2 (ja) | 2004-12-21 | 2011-08-03 | エフ．ホフマン−ラ ロシュ アーゲー | クロマン誘導体及びｃｎｓ障害の処置におけるその使用 |
| PE20070077A1 (es) * | 2005-06-10 | 2007-02-07 | Takeda Pharmaceutical | Comprimido con recubierta con azucar |
| WO2007051735A1 (en) * | 2005-11-03 | 2007-05-10 | F. Hoffmann-La Roche Ag | Arylsulfonylchromans as 5-ht6 inhibitors indolylmaleimide derivatives as protein kinase inhibitors |
| US8067204B2 (en) | 2005-12-15 | 2011-11-29 | Seikagaku Corporation | Long-chain chondroitin sugar chain and method for producing the same and method for promoting synthesis of chondroitin |
| JP2009541248A (ja) * | 2006-06-20 | 2009-11-26 | エフ．ホフマン−ラ ロシュ アーゲー | アリールスルホンアミジルテトラリン誘導体及びそれらの使用 |
| WO2007147763A1 (en) * | 2006-06-20 | 2007-12-27 | F. Hoffmann-La Roche Ag | Arylsulfonyl naphthalene derivatives and uses thereof |
| KR101066306B1 (ko) * | 2006-06-20 | 2011-09-20 | 에프. 호프만-라 로슈 아게 | 테트랄린 및 인데인 유도체 및 이들의 용도 |
| JP2010509188A (ja) * | 2006-11-09 | 2010-03-25 | 武田薬品工業株式会社 | 医薬組成物 |
| WO2010104194A1 (en) | 2009-03-10 | 2010-09-16 | Takeda Pharmaceutical Company Limited | Benzofuran derivatives |
| WO2011062194A1 (ja) | 2009-11-18 | 2011-05-26 | 武田薬品工業株式会社 | アミノピリジン誘導体 |
| CN102712853B (zh) | 2009-12-24 | 2014-12-24 | Scg化学有限公司 | 用于减小烃的溴指数的方法 |
| CN105294662B (zh) * | 2015-09-11 | 2018-04-20 | 中山大学 | 苯并呋喃喹啉衍生物及其在制备治疗阿尔茨海默病症的药品中的应用 |
| WO2020163689A1 (en) | 2019-02-08 | 2020-08-13 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | 20-hete formation inhibitors |
| CN115260136B (zh) * | 2022-08-09 | 2023-08-15 | 嘉兴学院 | 一种苯酞类化合物及其制备方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU163046B (de) | 1970-08-25 | 1973-05-28 | ||
| US4212865A (en) | 1978-12-26 | 1980-07-15 | Riker Laboratories, Inc. | Amine derivatives of 2-nitro-3-phenylbenzofuran |
| US4881967A (en) | 1986-12-10 | 1989-11-21 | E. I. Du Pont De Nemours And Company | Heterocyclic 2,3-dihydrobenzofuran herbicides |
| IE68675B1 (en) | 1990-11-01 | 1996-07-10 | Takeda Chemical Industries Ltd | Aminocoumaran derivatives their production and use |
| WO1992012144A1 (en) * | 1990-12-28 | 1992-07-23 | Teijin Limited | Condensed benzoxa ring compound, production thereof, and pharmaceutical composition containing the same |
| EP0539709A1 (de) * | 1991-09-18 | 1993-05-05 | FUJIREBIO Inc. | 3,5-Dihydroxyheptansäurederivate und deren Lactone als HMG-CoA-Reduktase-Inhibitoren |
| JP3168728B2 (ja) * | 1991-09-18 | 2001-05-21 | 富士レビオ株式会社 | ３，５−ジヒドロキシヘプタン酸誘導体 |
| GB9408577D0 (en) * | 1994-04-29 | 1994-06-22 | Fujisawa Pharmaceutical Co | New compound |
| DK0685475T3 (da) | 1994-05-31 | 1999-08-30 | Bayer Ag | Amino-benzofuryl- og thienylderivater |
| GB9522007D0 (en) * | 1995-10-27 | 1996-01-03 | Fujisawa Pharmaceutical Co | New compound |
| AU4031697A (en) | 1996-08-29 | 1998-03-19 | Takeda Chemical Industries Ltd. | Cyclic ether compounds as sodium channel modulators |
| EP0988289A2 (de) | 1997-06-05 | 2000-03-29 | Takeda Pharmaceutical Company Limited | Benzofurane und benzothiophene als unterdrücker der neurodegeneration |
| WO2000034262A1 (en) * | 1998-12-04 | 2000-06-15 | Takeda Chemical Industries, Ltd. | Benzofuran derivatives, process for the preparation of the same and uses thereof |
-
1999
- 1999-12-02 WO PCT/JP1999/006764 patent/WO2000034262A1/ja not_active Ceased
- 1999-12-02 CN CNB998156825A patent/CN1297550C/zh not_active Expired - Fee Related
- 1999-12-02 KR KR1020017006999A patent/KR100660788B1/ko not_active Expired - Fee Related
- 1999-12-02 EP EP99973289A patent/EP1136477B1/de not_active Expired - Lifetime
- 1999-12-02 PT PT99973289T patent/PT1136477E/pt unknown
- 1999-12-02 US US09/857,293 patent/US6479536B1/en not_active Expired - Lifetime
- 1999-12-02 ES ES99973289T patent/ES2213407T3/es not_active Expired - Lifetime
- 1999-12-02 CA CA002352786A patent/CA2352786C/en not_active Expired - Fee Related
- 1999-12-02 HU HU0105480A patent/HU226652B1/hu not_active IP Right Cessation
- 1999-12-02 DE DE69915508T patent/DE69915508T2/de not_active Expired - Lifetime
- 1999-12-02 AU AU14146/00A patent/AU1414600A/en not_active Abandoned
- 1999-12-02 AT AT99973289T patent/ATE261435T1/de active
-
2001
- 2001-06-01 NO NO20012726A patent/NO327924B1/no not_active IP Right Cessation
-
2002
- 2002-04-11 US US10/120,102 patent/US7101867B2/en not_active Expired - Fee Related
-
2005
- 2005-03-17 US US11/081,615 patent/US7456162B2/en not_active Expired - Fee Related
-
2009
- 2009-04-08 JP JP2009094172A patent/JP4778570B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1136477B1 (de) | 2004-03-10 |
| EP1136477A1 (de) | 2001-09-26 |
| US7456162B2 (en) | 2008-11-25 |
| US20020160996A1 (en) | 2002-10-31 |
| HUP0105480A3 (en) | 2003-07-28 |
| WO2000034262A1 (en) | 2000-06-15 |
| HUP0105480A2 (hu) | 2002-11-28 |
| US7101867B2 (en) | 2006-09-05 |
| CN1297550C (zh) | 2007-01-31 |
| CN1333764A (zh) | 2002-01-30 |
| HU226652B1 (en) | 2009-05-28 |
| PT1136477E (pt) | 2004-08-31 |
| KR100660788B1 (ko) | 2007-02-28 |
| JP2009185049A (ja) | 2009-08-20 |
| DE69915508D1 (de) | 2004-04-15 |
| US6479536B1 (en) | 2002-11-12 |
| NO20012726L (no) | 2001-07-31 |
| NO327924B1 (no) | 2009-10-19 |
| KR20010081113A (ko) | 2001-08-27 |
| NO20012726D0 (no) | 2001-06-01 |
| ES2213407T3 (es) | 2004-08-16 |
| DE69915508T2 (de) | 2005-01-27 |
| CA2352786A1 (en) | 2000-06-15 |
| AU1414600A (en) | 2000-06-26 |
| EP1136477A4 (de) | 2002-04-10 |
| CA2352786C (en) | 2009-02-03 |
| JP4778570B2 (ja) | 2011-09-21 |
| US20050187238A1 (en) | 2005-08-25 |
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