ATE272070T1 - Lösliche monovalente und multivalente mhc klasse ii fusionsproteine und deren verwendungen - Google Patents

Lösliche monovalente und multivalente mhc klasse ii fusionsproteine und deren verwendungen

Info

Publication number
ATE272070T1
ATE272070T1 AT97938386T AT97938386T ATE272070T1 AT E272070 T1 ATE272070 T1 AT E272070T1 AT 97938386 T AT97938386 T AT 97938386T AT 97938386 T AT97938386 T AT 97938386T AT E272070 T1 ATE272070 T1 AT E272070T1
Authority
AT
Austria
Prior art keywords
fusion proteins
mhc class
soluble monovalent
multivalent mhc
multivalent
Prior art date
Application number
AT97938386T
Other languages
English (en)
Inventor
Kai W Wucherpfennig
Jack L Strominger
Original Assignee
Harvard College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harvard College filed Critical Harvard College
Application granted granted Critical
Publication of ATE272070T1 publication Critical patent/ATE272070T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70539—MHC-molecules, e.g. HLA-molecules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT97938386T 1996-08-16 1997-08-15 Lösliche monovalente und multivalente mhc klasse ii fusionsproteine und deren verwendungen ATE272070T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2407796P 1996-08-16 1996-08-16
PCT/US1997/014503 WO1998006749A2 (en) 1996-08-16 1997-08-15 Soluble monovalent and multivalent mhc class ii fusion proteins, and uses therefor

Publications (1)

Publication Number Publication Date
ATE272070T1 true ATE272070T1 (de) 2004-08-15

Family

ID=21818743

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97938386T ATE272070T1 (de) 1996-08-16 1997-08-15 Lösliche monovalente und multivalente mhc klasse ii fusionsproteine und deren verwendungen

Country Status (11)

Country Link
EP (1) EP0935607B1 (de)
JP (1) JP2000516470A (de)
AT (1) ATE272070T1 (de)
AU (1) AU730457B2 (de)
CA (1) CA2263195A1 (de)
DE (1) DE69730038T2 (de)
DK (1) DK0935607T3 (de)
ES (1) ES2221065T3 (de)
NZ (1) NZ333915A (de)
PT (1) PT935607E (de)
WO (1) WO1998006749A2 (de)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6458354B1 (en) 1996-03-28 2002-10-01 The Johns Hopkins University Molecular complexes which modify immune responses
NZ331688A (en) 1996-03-28 2000-02-28 Univ Johns Hopkins Soluble divalent and multivalent heterodimeric analogs of proteins
US6268411B1 (en) 1997-09-11 2001-07-31 The Johns Hopkins University Use of multivalent chimeric peptide-loaded, MHC/ig molecules to detect, activate or suppress antigen-specific T cell-dependent immune responses
JP2002504342A (ja) * 1998-02-19 2002-02-12 プレジデント アンド フェローズ オブ ハーバード カレッジ 一価ｍｈｃ結合ドメイン融合タンパク質および接合体、多価ｍｈｃ結合ドメイン融合タンパク質および接合体、ならびに多量体ｍｈｃ結合ドメイン融合タンパク質および接合体、そしてそれらのための使用
FR2778669B1 (fr) * 1998-05-14 2002-06-14 Centre Nat Rech Scient Procede d'expression d'un complexe forme d'au moins un produit du complexe majeur d'histocompatibilite et d'un peptide chez un phage, phages et complexes ainsi obtenus et leurs applications
WO1999060120A2 (en) * 1998-05-19 1999-11-25 Avidex Limited Soluble t cell receptor
FR2796953B1 (fr) * 1999-07-29 2003-10-10 Centre Nat Rech Scient Proteines recombinantes, et complexes moleculaires derives de ces proteines, analogues a des molecules impliquees dans les reponses immunitaires
US7521202B2 (en) 1999-12-17 2009-04-21 The Board Of Regents Of The University Of Oklahoma Method and apparatus for the production of soluble MHC antigens and uses thereof
US7541429B2 (en) 2000-10-10 2009-06-02 The Board Of Regents Of The University Of Oklahoma Comparative ligand mapping from MHC positive cells
US20070026433A1 (en) 2001-03-09 2007-02-01 Hildebrand William H Epitope testing using soluble HLA
EP1353950A2 (de) * 2000-12-18 2003-10-22 William H. Hildebrand Verfahren und vorrichtung zur herstellung von antigene und deren verwendungen
US7094555B2 (en) 2001-04-05 2006-08-22 Benaroya Research Institute At Virginia Mason Methods of MHC class II epitope mapping, detection of autoimmune T cells and antigens, and autoimmune treatment
GB2392158B (en) * 2002-08-21 2005-02-16 Proimmune Ltd Chimeric MHC protein and oligomer thereof
EP1400534B1 (de) * 2002-09-10 2015-10-28 Affimed GmbH Menschlicher CD3-spezifischer Antikörper mit immunosupressiven Eigenschaften
DE602004030451D1 (de) 2003-07-15 2011-01-20 Chugai Pharmaceutical Co Ltd Produktion von igm durch transformierte zellen und verfahren zur quantifizierung dieser igm-produktion
EP1688432B1 (de) 2003-10-09 2011-08-03 Chugai Seiyaku Kabushiki Kaisha Stabilisierte lösung mit hoher igm-konzentration
GB2409456B (en) * 2003-10-30 2006-01-04 Proimmune Ltd Oligomeric receptor ligand pair member complexes
WO2008116468A2 (en) 2007-03-26 2008-10-02 Dako Denmark A/S Mhc peptide complexes and uses thereof in infectious diseases
EP3620465B1 (de) 2007-07-03 2025-02-19 Dako Denmark A/S Verbesserte verfahren zur herstellung, markierung und verwendung von mhc-multimeren
US10611818B2 (en) 2007-09-27 2020-04-07 Agilent Technologies, Inc. MHC multimers in tuberculosis diagnostics, vaccine and therapeutics
DK2254592T3 (da) 2008-02-28 2019-09-09 Dako Denmark As MHC-multimerer til Borrelia-diagnostik og sygdom
WO2010009735A2 (en) 2008-07-23 2010-01-28 Dako Denmark A/S Combinatorial analysis and repair
GB0817244D0 (en) 2008-09-20 2008-10-29 Univ Cardiff Use of a protein kinase inhibitor to detect immune cells, such as T cells
WO2010037402A1 (en) 2008-10-02 2010-04-08 Dako Denmark A/S Molecular vaccines for infectious disease
US11992518B2 (en) 2008-10-02 2024-05-28 Agilent Technologies, Inc. Molecular vaccines for infectious disease
GB201002730D0 (en) * 2010-02-18 2010-04-07 Uni I Oslo Product
US9511151B2 (en) 2010-11-12 2016-12-06 Uti Limited Partnership Compositions and methods for the prevention and treatment of cancer
JP6364352B2 (ja) * 2012-01-06 2018-07-25 オレゴン ヘルス アンド サイエンス ユニバーシティ 部分的ｍｈｃコンストラクト及びその使用方法
ES3011307T3 (en) 2012-02-23 2025-04-07 Juno Therapeutics Gmbh Chromatographic isolation of cells and other complex biological materials
US10988516B2 (en) 2012-03-26 2021-04-27 Uti Limited Partnership Methods and compositions for treating inflammation
US9603948B2 (en) 2012-10-11 2017-03-28 Uti Limited Partnership Methods and compositions for treating multiple sclerosis and related disorders
GB201309469D0 (en) 2013-05-28 2013-07-10 Imcyse Sa Detection of CD4+ T lymphocytes
EP3052526A4 (de) 2013-10-03 2017-04-19 Oregon Health & Science University Rekombinante polypeptide mit mhc-klasse-ii-1-domänen
AU2014343379B2 (en) 2013-11-04 2019-02-14 Uti Limited Partnership Methods and compositions for sustained immunotherapy
US10857219B2 (en) 2014-03-28 2020-12-08 The Board Of Regents Of The University Of Oklahoma Compositions comprising soluble HLA/M. tuberculosis-specific ligand complexes and methods of production and use thereof
EA035419B9 (ru) 2014-05-29 2020-08-07 Мэкроудженикс, Инк. Триспецифичные связывающие молекулы и способы их применения
WO2015188839A2 (en) 2014-06-13 2015-12-17 Immudex Aps General detection and isolation of specific cells by binding of labeled molecules
EP3291832B1 (de) 2015-05-06 2025-09-03 UTI Limited Partnership Nanopartikelzusammensetzungen zur verzögerten therapie
BR112018006817A2 (pt) 2015-10-08 2018-10-23 Macrogenics Inc método de tratamento do câncer
EP3365453A2 (de) 2015-10-22 2018-08-29 Juno Therapeutics GmbH Verfahren, kits, mittel und vorrichtungen zur transduktion
MX2018004875A (es) 2015-10-22 2018-08-01 Juno Therapeutics Gmbh Metodos para cultivar celulas y kits y aparatos para ello.
US20180127481A1 (en) * 2016-11-09 2018-05-10 Uti Limited Partnership RECOMBINANT pMHC CLASS II MOLECULES
JP7339160B2 (ja) 2017-04-27 2023-09-05 ジュノ セラピューティクス ゲーエムベーハー オリゴマー粒子試薬およびその使用方法
CA3083748A1 (en) 2017-11-29 2019-06-06 Uti Limited Partnership Methods of treating autoimmune disease
WO2020018715A1 (en) * 2018-07-17 2020-01-23 Massachusetts Institute Of Technology Soluble multimeric immunoglobulin-scaffold based fusion proteins and uses thereof
SG11202104355SA (en) 2018-10-31 2021-05-28 Juno Therapeutics Gmbh Methods for selection and stimulation of cells and apparatus for same
WO2020127222A2 (en) 2018-12-17 2020-06-25 Immudex Aps Panel comprising borrelia mhc multimers
GB201909509D0 (en) * 2019-07-02 2019-08-14 Immunocore Ltd Peptide-MHC complexes
RU2753282C2 (ru) * 2019-09-19 2021-08-12 Закрытое Акционерное Общество "Биокад" ИММУНОЦИТОКИН, ВКЛЮЧАЮЩИЙ ГЕТЕРОДИМЕРНЫЙ БЕЛКОВЫЙ КОМПЛЕКС НА ОСНОВЕ IL-15/IL-15Rα, И ЕГО ПРИМЕНЕНИЕ
CN112816595A (zh) * 2021-01-06 2021-05-18 海默斯（重庆）医学生物技术有限公司 一种重组角蛋白液体制剂及其纯度检测方法
WO2022216974A1 (en) * 2021-04-07 2022-10-13 Repertoire Immune Medicines, Inc. Peptide-mhc-immunoglobulin multimers and methods of use thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3220593A (en) * 1991-11-19 1993-06-15 Anergen, Inc. Soluble mhc molecules and their uses
WO1996004314A1 (en) * 1994-07-29 1996-02-15 Dade International, Inc. Mhc complexes and uses thereof

Also Published As

Publication number Publication date
DE69730038D1 (de) 2004-09-02
WO1998006749A2 (en) 1998-02-19
EP0935607B1 (de) 2004-07-28
PT935607E (pt) 2004-12-31
JP2000516470A (ja) 2000-12-12
AU730457B2 (en) 2001-03-08
ES2221065T3 (es) 2004-12-16
CA2263195A1 (en) 1998-02-19
AU4072397A (en) 1998-03-06
DE69730038T2 (de) 2004-11-25
DK0935607T3 (da) 2004-12-06
WO1998006749A3 (en) 1998-06-11
EP0935607A2 (de) 1999-08-18
NZ333915A (en) 2000-11-24

Similar Documents

Publication Publication Date Title
ATE272070T1 (de) Lösliche monovalente und multivalente mhc klasse ii fusionsproteine und deren verwendungen
CY1107706T1 (el) Πεπτιδια ανταγωνιστες καρκινοεμβρυονικου αντιγονου (cea)
ATE328068T1 (de) Papillomavirus vakzine
TR199801722T2 (xx) Peptit imm�nojenler.
DK1053256T3 (da) Antistoffer mod Dødsreceptor 4 (DR4) og anvendelser deraf
CA2045869A1 (en) Fusion proteins with immunoglobulin portions, the preparation and use thereof
DE69824013D1 (de) Impfstoff gegen hpv
DK0975333T3 (da) Alginatgel med langvarig frigörelse
ATE229978T1 (de) Helicobacter proteine und impstoffe
ATE405647T1 (de) Rekombinantes gelatin in impstoffen
ATE339507T1 (de) Erythropoietin-analog-menschliches serum-albumin fusionsprotein
ATE210127T1 (de) 6-substituierte mycophenolsäurederivate mit immun suppressiver wirkung
DK0960127T3 (da) Isoleret dimert fibroblastaktiverende protein-alfa og anvendelser deraf
DE59101397D1 (de) O-glycosyliertes ifn-alpha.
DE69930630D1 (de) B2microglobulin fusionsproteine und varianten mit hoher affinität
BG102362A (en) New derivatives of amino acids, their preparation and application
AR016389A1 (es) Composicion cosmetica que contiene una dispersion acuosa de polimero y una emulsion de silicona disilanol y procedimiento.
DE69532106D1 (de) Maltose Phospharylase, Trehalose Phophorylase, Plesiomonasstamm, und Herstellung von Trehalose
DE69127821D1 (de) Herstellung von siliciumnitrid mit verdichtungshilfsmittel, und resultate
TR200001102T2 (tr) İkameli tetrahidropirimidinen türevleri, üretimleri ve kullanımları.
DK1040191T3 (da) RANTES-mutanter og terapeutiske anvendelser heraf
TR199800575T1 (en) Kemokin �-8'in k�sa formlar�.
ATE341339T1 (de) Zusammensetzungen von rekombinanten papillomavirus vakzinen
DE3751834D1 (de) Selbstantigen der primären lebercirrhose
DE59709066D1 (de) Mittel zur dauerhaften Verformung von menschlichen Haaren

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 0935607

Country of ref document: EP

REN Ceased due to non-payment of the annual fee