ATE279210T1 - Arzneimittel freisetzendes system enthaltend ein homeobox-peptid und ein zytotoxisches oder antineoplastisches mittel - Google Patents
Arzneimittel freisetzendes system enthaltend ein homeobox-peptid und ein zytotoxisches oder antineoplastisches mittelInfo
- Publication number
- ATE279210T1 ATE279210T1 AT99928071T AT99928071T ATE279210T1 AT E279210 T1 ATE279210 T1 AT E279210T1 AT 99928071 T AT99928071 T AT 99928071T AT 99928071 T AT99928071 T AT 99928071T AT E279210 T1 ATE279210 T1 AT E279210T1
- Authority
- AT
- Austria
- Prior art keywords
- cytotoxic
- system containing
- antineoplastic agent
- releasing system
- drug releasing
- Prior art date
Links
- 239000003814 drug Substances 0.000 title abstract 4
- 229940079593 drug Drugs 0.000 title abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 2
- 239000002246 antineoplastic agent Substances 0.000 title 1
- 229940034982 antineoplastic agent Drugs 0.000 title 1
- 231100000433 cytotoxic Toxicity 0.000 title 1
- 229940127089 cytotoxic agent Drugs 0.000 title 1
- 239000002254 cytotoxic agent Substances 0.000 title 1
- 230000001472 cytotoxic effect Effects 0.000 title 1
- 108700005087 Homeobox Genes Proteins 0.000 abstract 1
- 238000012377 drug delivery Methods 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Refuse Collection And Transfer (AREA)
- Threshing Machine Elements (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9814527.9A GB9814527D0 (en) | 1998-07-03 | 1998-07-03 | Delivery system |
| PCT/GB1999/001957 WO2000001417A1 (en) | 1998-07-03 | 1999-06-22 | Delivery system |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE279210T1 true ATE279210T1 (de) | 2004-10-15 |
Family
ID=10834959
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99928071T ATE279210T1 (de) | 1998-07-03 | 1999-06-22 | Arzneimittel freisetzendes system enthaltend ein homeobox-peptid und ein zytotoxisches oder antineoplastisches mittel |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US6472507B1 (de) |
| EP (1) | EP1093383B1 (de) |
| JP (1) | JP2002519392A (de) |
| AT (1) | ATE279210T1 (de) |
| AU (1) | AU756014B2 (de) |
| CA (1) | CA2333145C (de) |
| DE (1) | DE69921138T2 (de) |
| DK (1) | DK1093383T3 (de) |
| ES (1) | ES2230860T3 (de) |
| GB (2) | GB9814527D0 (de) |
| HU (1) | HUP0300246A3 (de) |
| IL (1) | IL140650A0 (de) |
| WO (1) | WO2000001417A1 (de) |
Families Citing this family (67)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5795909A (en) | 1996-05-22 | 1998-08-18 | Neuromedica, Inc. | DHA-pharmaceutical agent conjugates of taxanes |
| GB9814527D0 (en) | 1998-07-03 | 1998-09-02 | Cyclacel Ltd | Delivery system |
| IL142869A0 (en) | 1998-11-13 | 2002-03-10 | Cyclacel Ltd | Transport vectors |
| JP2004513059A (ja) * | 1998-12-24 | 2004-04-30 | ユセベ,ソシエテ アノニム | ペプチド産物、方法及び組成物 |
| GB9903547D0 (en) | 1999-02-16 | 1999-04-07 | Novartis Ag | Organic compounds |
| DE19933492B4 (de) * | 1999-07-16 | 2008-01-10 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Konjugat zur Vermittlung eines zell-, kompartiment- oder membranspezifischen Transports von Wirksubstanzen, Verfahren zu dessen Herstellung und dessen Verwendung |
| US6864355B1 (en) * | 2000-05-02 | 2005-03-08 | Yale University | Inhibition of NF-κB activation by blockade of IKKβ-NEMO interactions at the NEMO binding domain |
| US7049395B2 (en) | 2000-05-02 | 2006-05-23 | Yale University | Anti-inflammatory compounds and uses thereof |
| GB0012528D0 (en) * | 2000-05-23 | 2000-07-12 | Univ Palackeho | Triterpenoid derivatives |
| FR2816845B1 (fr) | 2000-11-20 | 2006-10-20 | Centre Nat Rech Scient | Vecteurs de transport a travers un epithelium a jonctions serrees |
| US20030165873A1 (en) * | 2001-03-02 | 2003-09-04 | Come Jon H. | Three hybrid assay system |
| US20050181474A1 (en) * | 2002-01-30 | 2005-08-18 | Frank J. Giordano | Transport peptides and uses therefor |
| ES2368941T3 (es) | 2003-01-06 | 2011-11-23 | Angiochem Inc. | Angiopep-1, compuestos relacionados y utilizaciones correspondientes. |
| FR2849603B1 (fr) * | 2003-01-07 | 2006-09-08 | Centre Nat Rech Scient | Composition pour le transport intracellulaire de macromolecules ou particules biologiques |
| US20060178297A1 (en) * | 2003-01-28 | 2006-08-10 | Troy Carol M | Systems and methods for silencing expression of a gene in a cell and uses thereof |
| MXPA05011233A (es) * | 2003-04-22 | 2005-12-14 | Conseils De Rech S Et D Aplica | Vectores peptidicos. |
| AU2004240765B2 (en) * | 2003-05-20 | 2009-03-19 | Cellpep Sa | Modified antiviral peptides with increased activity and cell membrane affinity |
| US7458683B2 (en) | 2003-06-16 | 2008-12-02 | Amo Manufacturing Usa, Llc | Methods and devices for registering optical measurement datasets of an optical system |
| US7342114B2 (en) | 2003-07-01 | 2008-03-11 | California Pacific Medical Center | Podophyllotoxin derivatives |
| JP5537763B2 (ja) * | 2003-09-05 | 2014-07-02 | ザ ジェネラル ホスピタル コーポレイション | 放出システムとしてのポリアセタール薬物抱合体 |
| US20050148534A1 (en) * | 2003-09-22 | 2005-07-07 | Castellino Angelo J. | Small molecule compositions and methods for increasing drug efficiency using compositions thereof |
| US8039438B2 (en) * | 2003-10-20 | 2011-10-18 | The Regents Of The University Of California | Synthetic peptides that cause F-actin bundling and block actin depolymerization |
| US20050209147A1 (en) * | 2004-01-16 | 2005-09-22 | The Board Of Trustees Of The Leland Stanford Junior University | Peptide inhibitors of RhoA signaling |
| JP5052345B2 (ja) | 2004-09-02 | 2012-10-17 | コグノッシ, インコーポレイテッド | 改善されたアポe類似体群およびそれらの使用方法 |
| US8034762B2 (en) | 2004-09-02 | 2011-10-11 | Cognosci, Inc. | Treatment of subarachnoid hemorrhage with Apo E analogs |
| DK2730277T3 (da) | 2004-12-22 | 2020-04-06 | Nitto Denko Corp | Lægemiddelbærer og lægemiddelbærerkit til at inhibere fibrose |
| US20120269886A1 (en) | 2004-12-22 | 2012-10-25 | Nitto Denko Corporation | Therapeutic agent for pulmonary fibrosis |
| BRPI0520032A2 (pt) | 2005-02-18 | 2009-04-14 | Angiochem Inc | moléculas para transportar um composto através da barreira hematoencefálica |
| SI2233156T1 (sl) * | 2005-07-15 | 2013-09-30 | Angiochem Inc. | Uporaba polipeptidov aprotinina kot nosilce v farmacevtskih konjugatih |
| US9572886B2 (en) | 2005-12-22 | 2017-02-21 | Nitto Denko Corporation | Agent for treating myelofibrosis |
| WO2007113687A2 (en) * | 2006-03-30 | 2007-10-11 | Diatos S.A. | Camptothecin-cell penetrating peptide conjugates and pharmaceutical compositions containing the same |
| BRPI0709447A2 (pt) * | 2006-03-30 | 2011-07-12 | Diatos Sa | conjugado, composição farmacêutica, uso e composto |
| TWI407971B (zh) | 2007-03-30 | 2013-09-11 | Nitto Denko Corp | Cancer cells and tumor-related fibroblasts |
| US9365634B2 (en) | 2007-05-29 | 2016-06-14 | Angiochem Inc. | Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues |
| KR20100065190A (ko) | 2007-09-14 | 2010-06-15 | 닛토덴코 가부시키가이샤 | 약물 담체 |
| AR069704A1 (es) * | 2007-12-18 | 2010-02-10 | Alcon Res Ltd | Sistema de administracion de rnai de interferencia y usos del mismo |
| GB0803352D0 (en) | 2008-02-22 | 2008-04-02 | Ntnu Technology Transfer As | Oligopeptidic compounds and uses thereof |
| WO2009108340A2 (en) | 2008-02-27 | 2009-09-03 | Temple University - Of The Commonwealth System Of Higher Education | Leptin agonist and methods of use |
| ES2671024T3 (es) | 2008-02-28 | 2018-06-04 | Toray Industries, Inc. | Composición farmacéutica para administración transnasal |
| KR101919093B1 (ko) | 2008-05-23 | 2018-11-16 | 더 유니버시티 오브 브리티쉬 콜롬비아 | 리포좀 나노입자에 사용하기 위한 변형된 약물 |
| US8680263B2 (en) | 2008-09-19 | 2014-03-25 | Nektar Therapeutics | Carbohydrate-based drug delivery polymers and conjugates thereof |
| MX2011004017A (es) | 2008-10-15 | 2011-06-24 | Angiochem Inc | Conjugados de agonistas glp-1 y usos de los mismos. |
| BRPI0922689A2 (pt) | 2008-12-05 | 2018-11-06 | Angiochem Inc. | conjugados de neurotensina ou análogos de neurotensina e usos dos mesmos |
| BRPI0922611A2 (pt) | 2008-12-17 | 2018-11-06 | Angiochem Inc | inibidores de metaloproteína de matriz de membrana tipo 1 e usos dos mesmos |
| FR2941230B1 (fr) | 2009-01-19 | 2011-03-18 | Centre Nat Rech Scient | Polypeptides d'adressage specifique a des cellules-cibles d'otx2 |
| RU2011146654A (ru) | 2009-04-20 | 2013-05-27 | Ангиокем Инк. | Способы лечения рака яичников с применением конъюгированного средства |
| US8501242B2 (en) | 2009-05-29 | 2013-08-06 | University Of Florida Research Foundation | Methods and compositions for treating neoplasia |
| JP5932642B2 (ja) | 2009-07-02 | 2016-06-08 | アンジオケム インコーポレーテッド | 多量体ペプチドコンジュゲートおよびその使用 |
| GB201001602D0 (en) | 2010-02-01 | 2010-03-17 | Cytovation As | Oligopeptidic compounds and uses therof |
| JP5757497B2 (ja) * | 2010-10-06 | 2015-07-29 | 公立大学法人大阪府立大学 | シガトキシン類ctx1bおよび54−デオキシ−ctx1bを認識するモノクローナル抗体およびそれを用いるシガトキシン類検出キット |
| JP6258202B2 (ja) * | 2011-09-08 | 2018-01-10 | ウェスタン ユニバーシティ オブ ヘルス サイエンス | がん療法における標的リポソーム |
| CN103083239B (zh) * | 2012-12-26 | 2015-11-25 | 中国人民解放军第四军医大学 | 一种蟾毒灵脂质体及其制备方法和应用 |
| GB201318954D0 (en) * | 2013-10-28 | 2013-12-11 | Cupid Peptide Company Ltd | Cell transport |
| CN107530396B (zh) | 2015-05-01 | 2022-08-26 | 雅利斯塔制药公司 | 用于治疗眼科疾病的脂联素拟肽 |
| GB201507722D0 (en) | 2015-05-06 | 2015-06-17 | Norwegian Univ Sci & Tech Ntnu | Anti-bacterial agents and their use in therapy |
| JP6823055B2 (ja) | 2015-06-15 | 2021-01-27 | アンジオケム インコーポレーテッド | 軟髄膜癌腫症の治療方法 |
| US20190077813A1 (en) | 2015-10-27 | 2019-03-14 | California Pacific Medical Center | Podophyllotoxin derivatives and their use |
| US10087194B2 (en) | 2015-10-27 | 2018-10-02 | California Pacific Medical Center | Podophyllotoxin derivatives and their use |
| US10538556B2 (en) | 2016-11-07 | 2020-01-21 | Colorado State University Research Foundation | Anti-HIV peptides |
| JP2020536045A (ja) | 2017-01-17 | 2020-12-10 | デイヴィッド フォレスト マイケル | Atp合成酵素のリバースモードの治療的阻害剤 |
| CA3099077A1 (en) | 2017-07-13 | 2019-01-17 | Michael David FORREST | Therapeutic modulators of the reverse mode of atp synthase |
| CN110563739A (zh) * | 2018-06-05 | 2019-12-13 | 薪火炙药(北京)科技有限公司 | 具有选择性抗肺癌作用的鬼臼毒素类化合物p-x及其制备方法和应用 |
| GB201915454D0 (en) | 2019-10-24 | 2019-12-11 | Norwegian Univ Sci & Tech Ntnu | Antibacterial bone cement and uses thereof |
| KR102397922B1 (ko) * | 2020-02-19 | 2022-05-13 | 서울대학교 산학협력단 | 신규한 종양-관련 항원 단백질 olfm4 및 이의 용도 |
| GB202006699D0 (en) | 2020-05-06 | 2020-06-17 | Therapim Pty Ltd | Dosage regimen |
| GB202008888D0 (en) | 2020-06-11 | 2020-07-29 | Norwegian Univ Of Science And Technology (Ntnu) | Peptides for sepsis treatment |
| MX2023007788A (es) | 2021-01-24 | 2023-11-17 | Michael David Forrest | Inhibidores de la atp sintasa, usos cosmeticos y terapeuticos. |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4847240A (en) * | 1978-01-16 | 1989-07-11 | The Trustees Of Boston University | Method of effecting cellular uptake of molecules |
| US5043329A (en) * | 1987-02-17 | 1991-08-27 | Board Of Regents, University Of Texas System | Methods and compositions employing unique mixtures of polar and neutral lipids for protecting the gastrointestinal tract |
| DE3836971C1 (de) * | 1988-10-31 | 1990-05-17 | Weck, Wolfgang, Dr.Med., 6990 Bad Mergentheim, De | |
| FR2662698A1 (fr) * | 1990-06-05 | 1991-12-06 | Centre Nat Rech Scient | Nouveaux facteurs de croissance neurotropes comprenant un peptide homeoboite. |
| US5888762A (en) * | 1990-06-05 | 1999-03-30 | Centre National De La Recherche Scientifique (Cnrs) | Neurotropic growth factors comprising a homeobox peptide |
| ATE154609T1 (de) | 1990-10-15 | 1997-07-15 | Tecnogen Scpa | Nicht-lineare peptide, die hydropatisch komplementär zu bekannten aminosäuresequenzen sind, verfahren zur herstellung und verwendung davon |
| WO1993022343A1 (en) * | 1992-05-01 | 1993-11-11 | The Rockfeller University | Multiple antigen peptide system having adjuvant properties and vaccines prepared therefrom |
| US5674977A (en) | 1993-02-05 | 1997-10-07 | The Ontario Cancer Institute | Branched synthetic peptide conjugate |
| US5807746A (en) | 1994-06-13 | 1998-09-15 | Vanderbilt University | Method for importing biologically active molecules into cells |
| FR2739621B1 (fr) * | 1995-10-05 | 1997-12-05 | Centre Nat Rech Scient | Peptides utilisables comme vecteurs pour l'adressage intracellulaire de molecules actives |
| US5843903A (en) * | 1995-11-27 | 1998-12-01 | The Administrators Of The Tulane Educational Fund | Targeted cytotoxic anthracycline analogs |
| US6344436B1 (en) | 1996-01-08 | 2002-02-05 | Baylor College Of Medicine | Lipophilic peptides for macromolecule delivery |
| EP0961619A4 (de) * | 1996-09-27 | 2001-09-26 | Bristol Myers Squibb Co | Hydrolisierbare prodrugs zur verabreichung von wirkstoffen gegen krebs an metastatische zellen |
| US5929042A (en) | 1997-03-03 | 1999-07-27 | The Trustees Of Columbia University In The City Of New York | Antisense compounds which prevent cell death and uses thereof |
| US6635623B1 (en) | 1997-06-13 | 2003-10-21 | Baylor College Of Medicine | Lipoproteins as nucleic acid vectors |
| WO1999005302A1 (en) * | 1997-07-24 | 1999-02-04 | The Perkin-Elmer Corporation | Conjugates of transporter peptides and nucleic acid analogs, and their use |
| US5823345A (en) * | 1997-07-24 | 1998-10-20 | Berry Plastics Corporation | Stackable receptacle assembly for pourable products |
| GB9718609D0 (en) * | 1997-09-02 | 1997-11-05 | Imp College Innovations Ltd | Fusion protein |
| US6015787A (en) * | 1997-11-04 | 2000-01-18 | New England Medical Center Hospitals, Inc. | Cell-permeable protein inhibitors of calpain |
| GB9814527D0 (en) | 1998-07-03 | 1998-09-02 | Cyclacel Ltd | Delivery system |
-
1998
- 1998-07-03 GB GBGB9814527.9A patent/GB9814527D0/en not_active Ceased
-
1999
- 1999-06-22 ES ES99928071T patent/ES2230860T3/es not_active Expired - Lifetime
- 1999-06-22 DK DK99928071T patent/DK1093383T3/da active
- 1999-06-22 IL IL14065099A patent/IL140650A0/xx not_active IP Right Cessation
- 1999-06-22 CA CA002333145A patent/CA2333145C/en not_active Expired - Fee Related
- 1999-06-22 AT AT99928071T patent/ATE279210T1/de not_active IP Right Cessation
- 1999-06-22 HU HU0300246A patent/HUP0300246A3/hu unknown
- 1999-06-22 EP EP99928071A patent/EP1093383B1/de not_active Expired - Lifetime
- 1999-06-22 DE DE69921138T patent/DE69921138T2/de not_active Expired - Fee Related
- 1999-06-22 GB GB9914577A patent/GB2340121B/en not_active Expired - Fee Related
- 1999-06-22 WO PCT/GB1999/001957 patent/WO2000001417A1/en not_active Ceased
- 1999-06-22 JP JP2000557863A patent/JP2002519392A/ja not_active Withdrawn
- 1999-06-22 AU AU45198/99A patent/AU756014B2/en not_active Ceased
- 1999-07-02 US US09/346,847 patent/US6472507B1/en not_active Expired - Fee Related
-
2002
- 2002-07-31 US US10/210,660 patent/US6992169B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ES2230860T3 (es) | 2005-05-01 |
| WO2000001417A1 (en) | 2000-01-13 |
| GB2340121A (en) | 2000-02-16 |
| IL140650A0 (en) | 2002-02-10 |
| GB9914577D0 (en) | 1999-08-25 |
| US20030119735A1 (en) | 2003-06-26 |
| DE69921138T2 (de) | 2005-11-24 |
| EP1093383B1 (de) | 2004-10-13 |
| HUP0300246A2 (en) | 2003-05-28 |
| CA2333145A1 (en) | 2000-01-13 |
| US6992169B2 (en) | 2006-01-31 |
| JP2002519392A (ja) | 2002-07-02 |
| GB2340121B (en) | 2000-09-06 |
| DK1093383T3 (da) | 2005-02-14 |
| US6472507B1 (en) | 2002-10-29 |
| GB9814527D0 (en) | 1998-09-02 |
| CA2333145C (en) | 2008-03-25 |
| HUP0300246A3 (en) | 2005-09-28 |
| AU4519899A (en) | 2000-01-24 |
| AU756014B2 (en) | 2003-01-02 |
| EP1093383A1 (de) | 2001-04-25 |
| DE69921138D1 (de) | 2004-11-18 |
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