ATE282031T1 - Verfahren zur herstellung von citalopram - Google Patents

Verfahren zur herstellung von citalopram

Info

Publication number: ATE282031T1
Authority: AT; Austria
Prior art keywords: producing citalopram; citalopram; producing
Prior art date: 2000-03-13

Application number

AT01913728T

Other languages

English (en)

Inventor

Hans Petersen

Original Assignee

Lundbeck & Co As H

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-03-13

Filing date

2001-03-07

Publication date

2004-11-15

2001-03-07 Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H

2004-11-15 Application granted granted Critical

2004-11-15 Publication of ATE282031T1 publication Critical patent/ATE282031T1/de

Links

WSEQXVZVJXJVFP-UHFFFAOYSA-N 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile Chemical compound O1CC2=CC(C#N)=CC=C2C1(CCCN(C)C)C1=CC=C(F)C=C1 WSEQXVZVJXJVFP-UHFFFAOYSA-N 0.000 title 1
229960001653 citalopram Drugs 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Neurology (AREA)
Pain & Pain Management (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Psychiatry (AREA)
General Chemical & Material Sciences (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Steroid Compounds (AREA)
Furan Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

AT01913728T 2000-03-13 2001-03-07 Verfahren zur herstellung von citalopram ATE282031T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DKPA200000404		2000-03-13
PCT/DK2001/000149 WO2001068628A1 (en)	2000-03-13	2001-03-07	Method for the preparation of citalopram

Publications (1)

Publication Number	Publication Date
ATE282031T1 true ATE282031T1 (de)	2004-11-15

Family

ID=8159323

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT01913728T ATE282031T1 (de)	2000-03-13	2001-03-07	Verfahren zur herstellung von citalopram

Country Status (31)

Country	Link
US (1)	US6717000B2 (de)
EP (1)	EP1265880B1 (de)
JP (1)	JP2003527384A (de)
KR (1)	KR20020080471A (de)
CN (1)	CN1423644A (de)
AR (1)	AR029893A1 (de)
AT (1)	ATE282031T1 (de)
AU (1)	AU3920301A (de)
BE (1)	BE1011598A6 (de)
BG (1)	BG107048A (de)
BR (1)	BR0109267A (de)
CA (1)	CA2402386A1 (de)
CZ (1)	CZ20023383A3 (de)
DE (1)	DE60107061D1 (de)
EA (1)	EA200200971A1 (de)
FR (1)	FR2806085B1 (de)
HR (1)	HRP20020741A2 (de)
HU (1)	HUP0300180A2 (de)
IE (1)	IES20010206A2 (de)
IL (1)	IL151489A0 (de)
IS (1)	IS6528A (de)
IT (1)	ITMI20010487A1 (de)
MX (1)	MXPA02008872A (de)
NL (1)	NL1017500C1 (de)
NO (1)	NO20024214L (de)
NZ (1)	NZ521202A (de)
PL (1)	PL360108A1 (de)
SK (1)	SK14592002A3 (de)
TR (1)	TR200202167T2 (de)
WO (1)	WO2001068628A1 (de)
ZA (1)	ZA200206898B (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL145615A0 (en) *	1999-04-14	2002-06-30	Lundbeck & Co As H	Method for the preparation of citalopram
IES20010157A2 (en)	2000-03-03	2002-03-06	Lundbeck & Co As H	Method for the preparation of citalopram
BR0109364A (pt)	2000-03-13	2002-12-24	Lundbeck & Co As H	Métodos para fabricação de citalopram através de alquilação escalonada de 5-substituìda 1- (4-fluorofenil) - 1,3- diidroisobenzofuranos e citalopram
SK14602002A3 (sk)	2000-03-13	2003-02-04	H. Lundbeck A/S	Spôsob výroby citalopramu a medziprodukty
IL151488A0 (en)	2000-03-14	2003-04-10	Lundbeck & Co As H	Method for the preparation of citalopram
AR032455A1 (es)	2000-05-12	2003-11-12	Lundbeck & Co As H	Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
AU2003223105A1 (en) *	2003-03-24	2004-10-18	Hetero Drugs Limited	Novel crystalline forms of (s)-citalopram oxalate
CN100569765C (zh)	2003-12-19	2009-12-16	杭州民生药业集团有限公司	西酞普兰中间体晶体碱

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1143703A (de)	1965-03-18
GB1526331A (en)	1976-01-14	1978-09-27	Kefalas As	Phthalanes
GB8419963D0 (en)	1984-08-06	1984-09-12	Lundbeck & Co As H	Intermediate compound and method
GB8814057D0 (en)	1988-06-14	1988-07-20	Lundbeck & Co As H	New enantiomers & their isolation
US5296507A (en)	1990-09-06	1994-03-22	H.Lundbeck A/S	Treatment of cerbrovascular disorders
DE19626659A1 (de)	1996-07-03	1998-01-08	Basf Ag	Verfahren zur Herstellung von Phthaliden
DE19627697A1 (de)	1996-07-10	1998-01-15	Basf Ag	Verfahren zur Herstellung von Phthaliden
JP3526581B2 (ja)	1997-07-08	2004-05-17	ハー・ルンドベック・アクティーゼルスカブ	シタロプラムの製造方法
UA62985C2 (en)	1997-11-10	2004-01-15	Lunnbeck As H	A method for the preparation of citalopram
CN1286687A (zh)	1997-11-11	2001-03-07	H·隆德贝克有限公司	制备西酞普兰的方法
WO2000023431A1 (en)	1998-10-20	2000-04-27	H. Lundbeck A/S	Method for the preparation of citalopram
HK1043130B (zh)	1998-12-23	2005-03-04	H‧隆德贝克有限公司	制备5-氰基2-苯并[c]呋喃酮的方法
AR022329A1 (es)	1999-01-29	2002-09-04	Lundbeck & Co As H	Metodo para la preparacion de 5-cianoftalida
IL145615A0 (en)	1999-04-14	2002-06-30	Lundbeck & Co As H	Method for the preparation of citalopram
ITMI991581A1 (it)	1999-06-25	2001-01-15	Lundbeck & Co As H	Metodo per la preparazione di citalopram
ITMI991579A1 (it)	1999-06-25	2001-01-15	Lundbeck & Co As H	Metodo per la preparazione di citalopram
GB2360281B (en)	1999-10-25	2002-01-16	Lundbeck & Co As H	Method for the preparation of citalopram
AR026063A1 (es)	1999-11-01	2002-12-26	Lundbeck & Co As H	Metodo para la preparacion de 5-carboxiftalida.
US6310222B1 (en)	1999-11-01	2001-10-30	Sumika Fine Chemicals Co., Ltd.	Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate
NZ519739A (en)	1999-12-28	2004-03-26	H	Method for the preparation of citalopram
PT1246813E (pt)	1999-12-30	2004-02-27	Lundbeck & Co As H	Metodo para a preparacao de citalopram
WO2001051477A1 (en)	2000-01-14	2001-07-19	H. Lundbeck A/S	Method for the preparation of 5-cyanophthalide
US6433196B1 (en)	2000-02-17	2002-08-13	Sumika Fine Chemicals Co., Ltd.	Production method of citalopram, intermediate therefor and production method of the intermediate
IES20010143A2 (en)	2000-02-24	2001-07-25	Lundbeck & Co As H	Method for the preparation of citalopram
NL1017415C1 (nl)	2000-02-24	2001-05-18	Lundbeck & Co As H	Werkwijze voor de bereiding van Citalopram.
IES20010157A2 (en)	2000-03-03	2002-03-06	Lundbeck & Co As H	Method for the preparation of citalopram
GB0005477D0 (en)	2000-03-07	2000-04-26	Resolution Chemicals Limited	Process for the preparation of citalopram
SK14602002A3 (sk)	2000-03-13	2003-02-04	H. Lundbeck A/S	Spôsob výroby citalopramu a medziprodukty
GB2357762B (en)	2000-03-13	2002-01-30	Lundbeck & Co As H	Crystalline base of citalopram
BR0109364A (pt)	2000-03-13	2002-12-24	Lundbeck & Co As H	Métodos para fabricação de citalopram através de alquilação escalonada de 5-substituìda 1- (4-fluorofenil) - 1,3- diidroisobenzofuranos e citalopram
IL151488A0 (en)	2000-03-14	2003-04-10	Lundbeck & Co As H	Method for the preparation of citalopram
TR200202168T2 (tr)	2000-03-16	2002-12-23	H. Lundbeck A/S	5-Siyano-1-(4-Florofenil)-1,3-Dihidroizobenzofuranların preparasyon metodu
AR032455A1 (es)	2000-05-12	2003-11-12	Lundbeck & Co As H	Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
SK3362002A3 (en)	2000-07-06	2002-08-06	Lundbeck & Co As H	Method for the preparation of citalopram
IL144816A (en)	2000-08-18	2005-09-25	Lundbeck & Co As H	Method for the preparation of citalopram
TR200201166T1 (tr)	2000-12-22	2002-10-21	H.Lundbecks A/S	Saf sitalopram hazırlanması için yöntem
JP2003519121A (ja)	2000-12-28	2003-06-17	ハー・ルンドベック・アクチエゼルスカベット	純粋なシタロプラムの製造方法

2001
- 2001-03-05 NL NL1017500A patent/NL1017500C1/nl not_active IP Right Cessation
- 2001-03-05 IE IE20010206A patent/IES20010206A2/en not_active IP Right Cessation
- 2001-03-07 HR HR20020741A patent/HRP20020741A2/hr not_active Application Discontinuation
- 2001-03-07 JP JP2001567720A patent/JP2003527384A/ja not_active Withdrawn
- 2001-03-07 DE DE60107061T patent/DE60107061D1/de not_active Expired - Lifetime
- 2001-03-07 CZ CZ20023383A patent/CZ20023383A3/cs unknown
- 2001-03-07 CA CA002402386A patent/CA2402386A1/en not_active Abandoned
- 2001-03-07 BR BR0109267-7A patent/BR0109267A/pt not_active IP Right Cessation
- 2001-03-07 EP EP01913728A patent/EP1265880B1/de not_active Expired - Lifetime
- 2001-03-07 AT AT01913728T patent/ATE282031T1/de not_active IP Right Cessation
- 2001-03-07 AR ARP010101064A patent/AR029893A1/es unknown
- 2001-03-07 CN CN01806481A patent/CN1423644A/zh active Pending
- 2001-03-07 IL IL15148901A patent/IL151489A0/xx unknown
- 2001-03-07 HU HU0300180A patent/HUP0300180A2/hu unknown
- 2001-03-07 NZ NZ521202A patent/NZ521202A/en unknown
- 2001-03-07 WO PCT/DK2001/000149 patent/WO2001068628A1/en not_active Ceased
- 2001-03-07 AU AU39203/01A patent/AU3920301A/en not_active Abandoned
- 2001-03-07 TR TR2002/02167T patent/TR200202167T2/xx unknown
- 2001-03-07 SK SK1459-2002A patent/SK14592002A3/sk unknown
- 2001-03-07 EA EA200200971A patent/EA200200971A1/ru unknown
- 2001-03-07 PL PL36010801A patent/PL360108A1/xx not_active Application Discontinuation
- 2001-03-07 MX MXPA02008872A patent/MXPA02008872A/es unknown
- 2001-03-07 KR KR1020027011671A patent/KR20020080471A/ko not_active Withdrawn
- 2001-03-08 IT IT2001MI000487A patent/ITMI20010487A1/it unknown
- 2001-03-09 FR FR0103245A patent/FR2806085B1/fr not_active Expired - Fee Related
- 2001-03-13 BE BE2001/0159A patent/BE1011598A6/fr not_active IP Right Cessation
2002
- 2002-08-27 IS IS6528A patent/IS6528A/is unknown
- 2002-08-28 ZA ZA200206898A patent/ZA200206898B/en unknown
- 2002-09-02 BG BG107048A patent/BG107048A/xx unknown
- 2002-09-04 NO NO20024214A patent/NO20024214L/no not_active Application Discontinuation
- 2002-09-09 US US10/238,843 patent/US6717000B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
MXPA02008872A (es)	2003-02-10
US20030069304A1 (en)	2003-04-10
ITMI20010487A1 (it)	2002-09-08
FR2806085B1 (fr)	2005-02-25
AU3920301A (en)	2001-09-24
BG107048A (en)	2003-05-30
SK14592002A3 (sk)	2003-03-04
EP1265880B1 (de)	2004-11-10
EA200200971A1 (ru)	2003-02-27
CA2402386A1 (en)	2001-09-20
NO20024214L (no)	2002-10-31
NO20024214D0 (no)	2002-09-04
NL1017500C1 (nl)	2001-04-26
HRP20020741A2 (en)	2003-12-31
IL151489A0 (en)	2003-04-10
WO2001068628A1 (en)	2001-09-20
BE1011598A6 (fr)	2001-07-03
KR20020080471A (ko)	2002-10-23
US6717000B2 (en)	2004-04-06
TR200202167T2 (tr)	2002-12-23
CZ20023383A3 (cs)	2003-01-15
AR029893A1 (es)	2003-07-23
EP1265880A1 (de)	2002-12-18
HUP0300180A2 (en)	2003-05-28
BR0109267A (pt)	2002-12-17
ZA200206898B (en)	2004-04-20
DE60107061D1 (de)	2004-12-16
PL360108A1 (en)	2004-09-06
NZ521202A (en)	2004-11-26
FR2806085A1 (fr)	2001-09-14
CN1423644A (zh)	2003-06-11
IES20010206A2 (en)	2002-03-06
IS6528A (is)	2002-08-27
JP2003527384A (ja)	2003-09-16

Legal Events

Date	Code	Title	Description
2005-05-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE69907037D1 (de)	2003-05-22	Verfahren zur herstellung von citalopram
DE69900891D1 (de)	2002-03-21	Verfahren zur herstellung von citalopram
ATE222899T1 (de)	2002-09-15	Verfahren zur herstellung von reinem citalopram
ATE235478T1 (de)	2003-04-15	Verfahren zur herstellung von citalopram
ATE281447T1 (de)	2004-11-15	Verfahren zur herstellung von citalopram
DE69904853D1 (de)	2003-02-13	Verfahren zur herstellung von citalopram
ATE386736T1 (de)	2008-03-15	Verfahren zur herstellung von benzimidazol-2-yl - chinolinonderivaten
AT7110U9 (de)	2004-11-25	Verfahren zur herstellung von amlodipinmaleat
ATE222900T1 (de)	2002-09-15	Verfahren zur herstellung von 5-cyanophthalid
ATE277920T1 (de)	2004-10-15	Verfahren zur vorbereitung von reinem citalopram
ATE232524T1 (de)	2003-02-15	Verfahren zur herstellung von citalopram
ATE331804T1 (de)	2006-07-15	Verfahren zur herstellung von ansamitocin
DE60003264D1 (de)	2003-07-17	Verfahren zur herstellung von glycerylethern
DE50102444D1 (de)	2004-07-01	Verfahren zur herstellung von isocyanatoorganosilanen
ATE316518T1 (de)	2006-02-15	Verfahren zur herstellung von (r)-2-alkyl-3- phenyl-1-propanolen
DE50111560D1 (de)	2007-01-11	Verfahren zur herstellung von guerbetalkoholen
DE60103173D1 (de)	2004-06-09	Verfahren zur herstellung von 3-amino-2-chlor-4-methylpyridin
ATE389645T1 (de)	2008-04-15	Verfahren zur herstellung von citalopram
DE50006772D1 (de)	2004-07-15	Verfahren zur herstellung von oxindolen
ATE355268T1 (de)	2006-03-15	Verfahren zur herstellung von citalopram
DE60105991D1 (de)	2004-11-04	Verfahren zur herstellung von 6-aminocapronamid
DE60107061D1 (de)	2004-12-16	Verfahren zur herstellung von citalopram
ATE232845T1 (de)	2003-03-15	Verfahren zur herstellung von cyclopropenen
DE50001895D1 (de)	2003-05-28	Verfahren zur herstellung von phosphonomethylglycin
ATE325810T1 (de)	2006-06-15	Verfahren zur herstellung von acetylamidiniophenylalanyl-cyclohexylglycyl- pyridylalaninamiden