ATE294239T1 - Streptokinasemutanten - Google Patents

Streptokinasemutanten

Info

Publication number
ATE294239T1
ATE294239T1 AT99202639T AT99202639T ATE294239T1 AT E294239 T1 ATE294239 T1 AT E294239T1 AT 99202639 T AT99202639 T AT 99202639T AT 99202639 T AT99202639 T AT 99202639T AT E294239 T1 ATE294239 T1 AT E294239T1
Authority
AT
Austria
Prior art keywords
streptokinase
mutants
present
skc
obtaining
Prior art date
Application number
AT99202639T
Other languages
English (en)
Inventor
Madrazo Isis Del Carme Torrens
Ojalvo Ariana Garcia
La Fuente Garcia Jose De Je De
Menendez Alina Seralena
Original Assignee
Ct Ingenieria Genetica Biotech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ct Ingenieria Genetica Biotech filed Critical Ct Ingenieria Genetica Biotech
Application granted granted Critical
Publication of ATE294239T1 publication Critical patent/ATE294239T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C07K14/3153—Streptokinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Superconductors And Manufacturing Methods Therefor (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
AT99202639T 1998-08-14 1999-08-13 Streptokinasemutanten ATE294239T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CU1998119A CU22732A1 (es) 1998-08-14 1998-08-14 Mutantes de estreptoquinasa

Publications (1)

Publication Number Publication Date
ATE294239T1 true ATE294239T1 (de) 2005-05-15

Family

ID=5459400

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99202639T ATE294239T1 (de) 1998-08-14 1999-08-13 Streptokinasemutanten

Country Status (7)

Country Link
US (2) US6309873B1 (de)
EP (1) EP0985729B1 (de)
AT (1) ATE294239T1 (de)
AU (1) AU769916B2 (de)
CA (1) CA2277554C (de)
CU (1) CU22732A1 (de)
DE (1) DE69924932D1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6750329B1 (en) * 1989-05-05 2004-06-15 Research Development Foundation Antibody delivery system for biological response modifiers
US6348567B1 (en) * 1995-12-06 2002-02-19 Cv Molecular Therapeutics Inc. Peptides and their use to ameliorate cell death
ZA200305980B (en) * 2001-02-12 2007-01-31 Res Dev Foundation Modified proteins, designer toxins, and methods of making thereof
NZ530582A (en) * 2001-07-17 2008-06-30 Res Dev Foundation Therapeutic agents comprising pro-apoptotic proteins, including granzyme, bax and TNF
JP2006506964A (ja) * 2002-06-12 2006-03-02 リサーチ　ディベロップメント　ファンデーション 治療剤としての免疫毒素及びその利用
NZ589557A (en) * 2008-06-04 2012-08-31 Talecris Biotherapeutics Inc Immobilised streptokinase, method and kit for preparing plasmin
HUE025670T2 (en) 2009-03-03 2016-04-28 Grifols Therapeutics Inc A method for producing plasminogen

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2238180A (en) * 1989-11-14 1991-05-22 Stc Plc Cable laying equipment
CU22277A1 (es) * 1990-05-23 1995-01-31 Cigb Procedimiento para el aislamiento y expresion de un gen codificante para estreptoquinasa,secuencia nucleotidica obtenida,adn recombinantes y microorganismos transformados
US5854049A (en) * 1995-06-09 1998-12-29 President And Fellows Of Harvard College Plasmin-resistant streptokinase

Also Published As

Publication number Publication date
EP0985729A3 (de) 2000-05-31
EP0985729B1 (de) 2005-04-27
US6309873B1 (en) 2001-10-30
AU769916B2 (en) 2004-02-12
CA2277554C (en) 2004-11-02
AU4342499A (en) 2000-03-09
EP0985729A2 (de) 2000-03-15
CU22732A1 (es) 2002-02-28
CA2277554A1 (en) 2000-02-14
US6413759B1 (en) 2002-07-02
DE69924932D1 (de) 2005-06-02

Similar Documents

Publication Publication Date Title
Takagi et al. Enhancement of the thermostability of subtilisin E by introduction of a disulfide bond engineered on the basis of structural comparison with a thermophilic serine protease.
Jeong et al. Purification and biochemical characterization of a fibrinolytic enzyme from Bacillus subtilis BK-17
JPH0829086B2 (ja) ポリクリングルプラスミノ−ゲン活性化因子
DE69637054D1 (de) Aus Bacillus stammende Transglutaminase
ATE297466T1 (de) Mutierter plasminogen-aktivator-inhibitor typ 1 und seine verwendungen
DE69924932D1 (de) Streptokinasemutanten
DE3682891D1 (de) Gewebeplasminogen-aktivator-mutant, dafuer kodierende rekombinante genetische information und verfahren zur herstellung dieser mutanten, deren verwendung und pharmazeutische zusammensetzungen.
ATE292180T1 (de) Fibrinolytisch wirksames polypeptid
ATE458817T1 (de) Klonierung und rekombinante herstellung von phospholipase aus vespidae und immunologische therapien darauf basierend
DE69943393D1 (de) Ein plasmaprotein-fragment erzeugendes enzym mit krebsmetastase-hemmender wirkung und durch dieses enzym fragmentiertes plasmaprotein-fragment
DE10199042I2 (de) Protein mit Urate-Oxidase-Aktivit{t daf}r kodierendes rekombinantes Gen Expressionsvektor Mikroorganismen und Transformanten
DE69021885D1 (de) Mutanten des menschlichen plasminogenaktivator-inhibitors 1 (pai-1), ihre herstellung und verwendung.
DK0418945T3 (da) Forgreningsenzym og dets anvendelse
DE60232733D1 (de) Alternativ gesplicter zirkulierender gewebefaktor
SE8702562L (sv) Nya fibrinolytiska enzymer
ATE194624T1 (de) Mutanten von menschlichem antithrombin iii
Sasmita et al. Purification and characterization of a fibrinolytic enzyme from tempeh bongkrek as an alternative of thrombolytic agents
US6869778B2 (en) Tissue type plasminogen activator (t-PA) variants: compositions and methods of use
JP2001505765A (ja) 組織型プラスミノーゲンアクチベーター（ｔ―ＰＡ）の変異体：組成物およびその使用方法
DE3853479D1 (de) Ausgeglichenes, konstitutives, induzierbares transkriptionssystem.
US5688664A (en) Thrombin activatable plasminogen analogues
ATE113983T1 (de) Gewebeplasminogenaktivator mit fibrin- spezifischen eigenschaften.
Takagi et al. Enhanced thermostability of the single-Cys mutant subtilisin E under oxidizing conditions
Lu et al. Expression of human plasminogen kringle 5 as fusion protein with truncated hIFNγ gene in Escherichia coli
EA200300502A1 (ru) СПОСОБЫ КРУПНОМАСШТАБНОГО ПРОИЗВОДСТВА ВЫВЕДЕННЫХ ИЗ РЕКОМБИНАНТНОЙ ДНК МОЛЕКУЛ tPA ИЛИ K2S

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties