ATE297413T1 - Hyaluronsäureamide und ihre derivate und ein verfahren zu deren herstellung - Google Patents

Hyaluronsäureamide und ihre derivate und ein verfahren zu deren herstellung

Info

Publication number: ATE297413T1
Authority: AT; Austria
Prior art keywords: group; hyaluronic acid; arylaliphatic; cycloaliphatic; aliphatic
Prior art date: 1998-07-06

Application number

AT99929619T

Other languages

English (en)

Inventor

Davide Bellini

Alessandra Topai

Original Assignee

Fidia Farmaceutici

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-07-06

Filing date

1999-07-06

Publication date

2005-06-15

1999-07-06 Application filed by Fidia Farmaceutici filed Critical Fidia Farmaceutici

2005-06-15 Application granted granted Critical

2005-06-15 Publication of ATE297413T1 publication Critical patent/ATE297413T1/de

Links

KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 title abstract 5
229920002674 hyaluronan Polymers 0.000 title abstract 4
229960003160 hyaluronic acid Drugs 0.000 title abstract 4
125000001931 aliphatic group Chemical group 0.000 abstract 5
125000003118 aryl group Chemical group 0.000 abstract 5
125000000623 heterocyclic group Chemical group 0.000 abstract 3
125000002252 acyl group Chemical group 0.000 abstract 2
230000001476 alcoholic effect Effects 0.000 abstract 2
150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 2
125000003368 amide group Chemical group 0.000 abstract 1
150000001408 amides Chemical class 0.000 abstract 1
125000003277 amino group Chemical group 0.000 abstract 1
230000003252 repetitive effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/043—Mixtures of macromolecular materials
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/20—Polysaccharides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/34—Macromolecular materials
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/042—Polysaccharides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Dermatology (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Surgery (AREA)
Bioinformatics & Cheminformatics (AREA)
Transplantation (AREA)
Molecular Biology (AREA)
Oral & Maxillofacial Surgery (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Vascular Medicine (AREA)
Heart & Thoracic Surgery (AREA)
Biochemistry (AREA)
Materials Engineering (AREA)
Polymers & Plastics (AREA)
Ophthalmology & Optometry (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Materials For Medical Uses (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Coloring Foods And Improving Nutritive Qualities (AREA)
External Artificial Organs (AREA)

AT99929619T 1998-07-06 1999-07-06 Hyaluronsäureamide und ihre derivate und ein verfahren zu deren herstellung ATE297413T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT98PD000169A ITPD980169A1 (it)	1998-07-06	1998-07-06	Ammidi dell'acido ialuronico e dei suoi derivati e processo per la loro preparazione.
PCT/IB1999/001254 WO2000001733A1 (en)	1998-07-06	1999-07-06	Amides of hyaluronic acid and the derivatives thereof and a process for their preparation

Publications (1)

Publication Number	Publication Date
ATE297413T1 true ATE297413T1 (de)	2005-06-15

Family

ID=11392271

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99929619T ATE297413T1 (de)	1998-07-06	1999-07-06	Hyaluronsäureamide und ihre derivate und ein verfahren zu deren herstellung

Country Status (14)

Country	Link
US (2)	US7884087B1 (de)
EP (2)	EP1589036A1 (de)
JP (3)	JP2002519481A (de)
AT (1)	ATE297413T1 (de)
AU (1)	AU761986B2 (de)
CA (1)	CA2339066C (de)
DE (1)	DE69925733T2 (de)
DK (1)	DK1095064T3 (de)
ES (1)	ES2244198T3 (de)
IL (2)	IL140604A0 (de)
IT (1)	ITPD980169A1 (de)
PT (1)	PT1095064E (de)
SI (1)	SI1095064T1 (de)
WO (1)	WO2000001733A1 (de)

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1998
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- 1999-07-06 ES ES99929619T patent/ES2244198T3/es not_active Expired - Lifetime
- 1999-07-06 US US10/220,853 patent/US7884087B1/en not_active Expired - Fee Related
- 1999-07-06 EP EP05011126A patent/EP1589036A1/de not_active Withdrawn
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- 1999-07-06 EP EP99929619A patent/EP1095064B1/de not_active Expired - Lifetime
- 1999-07-06 JP JP2000558133A patent/JP2002519481A/ja active Pending
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- 1999-07-06 AT AT99929619T patent/ATE297413T1/de active
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WO2000001733A1 (en)	2000-01-13
JP2007031721A (ja)	2007-02-08
JP2002519481A (ja)	2002-07-02
EP1589036A1 (de)	2005-10-26
DE69925733D1 (de)	2005-07-14
DK1095064T3 (da)	2005-10-03
ITPD980169A1 (it)	2000-01-06
JP2011174079A (ja)	2011-09-08
AU761986B2 (en)	2003-06-12
IL140604A0 (en)	2002-02-10
CA2339066A1 (en)	2000-01-13
US7884087B1 (en)	2011-02-08
DE69925733T2 (de)	2006-03-16
JP4791921B2 (ja)	2011-10-12
EP1095064A1 (de)	2001-05-02
IL140604A (en)	2010-06-16
AU4639799A (en)	2000-01-24
US20100158796A1 (en)	2010-06-24
CA2339066C (en)	2012-04-03
SI1095064T1 (sl)	2005-12-31
PT1095064E (pt)	2005-10-31
US8575129B2 (en)	2013-11-05
EP1095064B1 (de)	2005-06-08
ES2244198T3 (es)	2005-12-01

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