NO20042297L - Fremgangsmate for fremstilling av 4-(8-klor-5,6-dihydro-11H-benzo[5,6]syklohepta[1,2b]pyridin-11-yliden)-1-piperidinkarboksylsyreetylester (loratadin) - Google Patents

Fremgangsmate for fremstilling av 4-(8-klor-5,6-dihydro-11H-benzo[5,6]syklohepta[1,2b]pyridin-11-yliden)-1-piperidinkarboksylsyreetylester (loratadin)

Info

Publication number: NO20042297L
Authority: NO; Norway
Prior art keywords: chloro; loratadine; pyridin; dihydro; benzo
Prior art date: 2001-11-05

Application number

NO20042297A

Other languages

English (en)

Other versions

NO326489B1 (no

Inventor

Stefano Poli

Vincenzo Cannata

Livius Cotarca

Ivan Michieletto

Original Assignee

Zambon Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-11-05

Filing date

2004-06-04

Publication date

2004-06-04

2004-06-04 Application filed by Zambon Spa filed Critical Zambon Spa

2004-06-04 Publication of NO20042297L publication Critical patent/NO20042297L/no

2008-12-15 Publication of NO326489B1 publication Critical patent/NO326489B1/no

Links

JCCNYMKQOSZNPW-UHFFFAOYSA-N loratadine Chemical compound C1CN(C(=O)OCC)CCC1=C1C2=NC=CC=C2CCC2=CC(Cl)=CC=C21 JCCNYMKQOSZNPW-UHFFFAOYSA-N 0.000 title abstract 5
229960003088 loratadine Drugs 0.000 title abstract 4
238000000034 method Methods 0.000 title abstract 4
XCQHILUUHXSTOX-UHFFFAOYSA-N 4,4-dimethyl-2-(3-methylpyridin-2-yl)-5h-1,3-oxazole Chemical compound CC1=CC=CN=C1C1=NC(C)(C)CO1 XCQHILUUHXSTOX-UHFFFAOYSA-N 0.000 abstract 2
239000000543 intermediate Substances 0.000 abstract 2
DDGRAFHHXYIQQR-UHFFFAOYSA-N 1-chloro-3-(chloromethyl)benzene Chemical compound ClCC1=CC=CC(Cl)=C1 DDGRAFHHXYIQQR-UHFFFAOYSA-N 0.000 abstract 1
MYGXGCCFTPKWIH-UHFFFAOYSA-N 4-chloro-1-methylpiperidine Chemical compound CN1CCC(Cl)CC1 MYGXGCCFTPKWIH-UHFFFAOYSA-N 0.000 abstract 1
239000007818 Grignard reagent Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
150000004795 grignard reagents Chemical class 0.000 abstract 1
230000007062 hydrolysis Effects 0.000 abstract 1
238000006460 hydrolysis reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Plural Heterocyclic Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Hydrogenated Pyridines (AREA)

NO20042297A 2001-11-05 2004-06-04 Fremgangsmate for fremstilling av 4-(8-klor-5,6-dihydro-11H-benzo[5,6]syklohepta[1,2b]pyridin-11-yliden)-1-piperidinkarboksylsyreetylester (loratadin), fremgangsmater for fremstilling av mellomproduktforbindelser, samt mellomproduktforbindelser og anvendelse derav til fremstilling av loratadin NO326489B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT2001MI002308A ITMI20012308A1 (it)	2001-11-05	2001-11-05	Processo per la preparazione dell'estere etilico dell'acido 4-(8-cloro-5,6-diidro-11h-benzo-5,67-cicloepta-1,2-b-piridin-11-ilidene)-1-piper
PCT/EP2002/012056 WO2003040140A1 (en)	2001-11-05	2002-10-29	Process for the preparation of 4-(8-chloro-5,6-dihydro-11h-benzo(5,6)-cyclohepta-(1,2b)-pyridin-11-ylidene)-1-piperidinecarboxyli c acid ethyl ester (loratadine)

Publications (2)

Publication Number	Publication Date
NO20042297L true NO20042297L (no)	2004-06-04
NO326489B1 NO326489B1 (no)	2008-12-15

Family

ID=11448567

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20042297A NO326489B1 (no)	2001-11-05	2004-06-04	Fremgangsmate for fremstilling av 4-(8-klor-5,6-dihydro-11H-benzo[5,6]syklohepta[1,2b]pyridin-11-yliden)-1-piperidinkarboksylsyreetylester (loratadin), fremgangsmater for fremstilling av mellomproduktforbindelser, samt mellomproduktforbindelser og anvendelse derav til fremstilling av loratadin

Country Status (19)

Country	Link
US (2)	US7449583B2 (no)
EP (1)	EP1442035B1 (no)
JP (1)	JP4307262B2 (no)
CN (1)	CN100366620C (no)
AT (1)	ATE315565T1 (no)
AU (1)	AU2002340487B2 (no)
BR (1)	BR0213909A (no)
CA (1)	CA2465686C (no)
DE (1)	DE60208703T8 (no)
EA (1)	EA007740B1 (no)
ES (1)	ES2256543T3 (no)
HU (1)	HUP0402390A3 (no)
IL (1)	IL161734A0 (no)
IT (1)	ITMI20012308A1 (no)
MX (1)	MXPA04004255A (no)
NO (1)	NO326489B1 (no)
NZ (1)	NZ533287A (no)
WO (1)	WO2003040140A1 (no)
ZA (1)	ZA200404262B (no)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ITMI20012308A1 (it) *	2001-11-05	2003-05-05	Zambon Spa	Processo per la preparazione dell'estere etilico dell'acido 4-(8-cloro-5,6-diidro-11h-benzo-5,67-cicloepta-1,2-b-piridin-11-ilidene)-1-piper
WO2015084693A2 (en) *	2013-12-05	2015-06-11	Merck Sharp & Dohme Corp.	New process for preparing loratadine from a ketone intermediate
CN109897027B (zh) *	2019-04-28	2021-11-02	梯尔希（南京）药物研发有限公司	一种3-羟基地氯雷他定代谢物的合成方法
CN113135893B (zh) *	2021-06-21	2022-02-11	北京鑫开元医药科技有限公司	苯并环庚烷并吡啶化合物、其制备方法及其用途
CN115778924A (zh) *	2022-12-22	2023-03-14	河北三禾实创生物科技有限公司	一种氯雷他定制剂及其制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4731447A (en) *	1985-05-13	1988-03-15	Schering Corporation	Process for preparing piperidylidene dihydro-dibenzo(a,d)-cycloheptenes or aza-derivatives thereof
WO1996006096A1 (en) *	1994-08-23	1996-02-29	Nissan Chemical Industries, Ltd.	Pyridine derivative
WO2000005215A1 (en) *	1998-07-24	2000-02-03	Russinsky Limited	A process for preparing benzocycloheptapyridin-11-ones
AR021715A1 (es) *	1998-12-18	2002-07-31	Schering Corp	Proceso para preparar compuestos triciclicos que tienen actividad antihistaminica e intermediarios.
ITMI20012308A1 (it) *	2001-11-05	2003-05-05	Zambon Spa	Processo per la preparazione dell'estere etilico dell'acido 4-(8-cloro-5,6-diidro-11h-benzo-5,67-cicloepta-1,2-b-piridin-11-ilidene)-1-piper

2001
- 2001-11-05 IT IT2001MI002308A patent/ITMI20012308A1/it unknown
2002
- 2002-10-29 HU HU0402390A patent/HUP0402390A3/hu unknown
- 2002-10-29 EA EA200400642A patent/EA007740B1/ru not_active IP Right Cessation
- 2002-10-29 NZ NZ533287A patent/NZ533287A/en not_active IP Right Cessation
- 2002-10-29 MX MXPA04004255A patent/MXPA04004255A/es active IP Right Grant
- 2002-10-29 CA CA2465686A patent/CA2465686C/en not_active Expired - Fee Related
- 2002-10-29 CN CNB028243463A patent/CN100366620C/zh not_active Expired - Fee Related
- 2002-10-29 US US10/493,314 patent/US7449583B2/en not_active Expired - Fee Related
- 2002-10-29 IL IL16173402A patent/IL161734A0/xx not_active IP Right Cessation
- 2002-10-29 BR BR0213909-0A patent/BR0213909A/pt not_active Application Discontinuation
- 2002-10-29 AT AT02774756T patent/ATE315565T1/de not_active IP Right Cessation
- 2002-10-29 DE DE60208703T patent/DE60208703T8/de active Active
- 2002-10-29 EP EP02774756A patent/EP1442035B1/en not_active Expired - Lifetime
- 2002-10-29 AU AU2002340487A patent/AU2002340487B2/en not_active Ceased
- 2002-10-29 JP JP2003542186A patent/JP4307262B2/ja not_active Expired - Fee Related
- 2002-10-29 ES ES02774756T patent/ES2256543T3/es not_active Expired - Lifetime
- 2002-10-29 WO PCT/EP2002/012056 patent/WO2003040140A1/en not_active Ceased
2004
- 2004-05-31 ZA ZA200404262A patent/ZA200404262B/en unknown
- 2004-06-04 NO NO20042297A patent/NO326489B1/no not_active IP Right Cessation
2008
- 2008-09-09 US US12/207,170 patent/US20090005567A1/en not_active Abandoned

Also Published As

Publication number	Publication date
ZA200404262B (en)	2005-08-11
JP4307262B2 (ja)	2009-08-05
US7449583B2 (en)	2008-11-11
EP1442035B1 (en)	2006-01-11
DE60208703T2 (de)	2006-10-19
CA2465686A1 (en)	2003-05-15
HUP0402390A3 (en)	2011-03-28
DE60208703T8 (de)	2007-05-03
ATE315565T1 (de)	2006-02-15
US20090005567A1 (en)	2009-01-01
EP1442035A1 (en)	2004-08-04
EA200400642A1 (ru)	2004-12-30
CN1599736A (zh)	2005-03-23
JP2005513005A (ja)	2005-05-12
BR0213909A (pt)	2004-08-31
IL161734A0 (en)	2005-11-20
EA007740B1 (ru)	2006-12-29
ES2256543T3 (es)	2006-07-16
US20050171352A1 (en)	2005-08-04
CA2465686C (en)	2010-03-23
MXPA04004255A (es)	2005-03-31
AU2002340487B2 (en)	2007-12-13
HUP0402390A2 (en)	2006-02-28
CN100366620C (zh)	2008-02-06
NO326489B1 (no)	2008-12-15
WO2003040140A1 (en)	2003-05-15
NZ533287A (en)	2005-08-26
ITMI20012308A1 (it)	2003-05-05
DE60208703D1 (de)	2006-04-06

Legal Events

Date	Code	Title	Description
2013-05-27	MM1K	Lapsed by not paying the annual fees

Publication	Publication Date	Title
EP3045176B8 (en)	2018-12-12	Polymorphic forms of 3-(4-amino-1-oxo-1,3 dihydroisoindol-2-yl)-piperidine-2,6-dione
DE69300255D1 (de)	1995-08-17	8-Chlor-11-(1-(5-methyl-3-pyridyl)methyl-4-piperidyliden)-6,11-dihydro-5H-benzo(5,6)cyclohepta(1,2-b)-pyridin.
WO2002094180A3 (en)	2003-02-27	Pharmaceutically active isoindoline derivatives
ATE483687T1 (de)	2010-10-15	Kristalline form von 5-chloro-3-(4- methanesulfonylphenyl)-6'-methyl- ä2,3'ü bipyridinyl und herstellungsverfahren hierfür
DE60212146D1 (de)	2006-07-20	Piperidin derivate als ccr5 rezeptor antagonisten zur behandlung von hiv
DZ3123A1 (fr)	2004-09-14	Procédé amélioré pour produire des acides carboxyliques.
IL161734A0 (en)	2005-11-20	Process for the preparation of 4-(8-chloro-5,6-dihydro-11H-benzo (5,6)-cyclohepta-(1,2B)-pyridin-11-ylidene)-1-piperidinecarboxylic acid ethyl
HUP0004308A2 (hu)	2001-10-28	6,11-Dihidro-8-klór-11-(4-piperidilidén)-5H-benzo-[5,6]ciklohepta[1,2-b]piridin polimorfjai
NO20030699L (no)	2003-04-10	Fremgangsmåte for fremstilling av cilostazol
ZA200006224B (en)	2001-11-01	8-Chloro-6, 11-dihydro-11-(4-piperidylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridene oral compositions.
DE60007133D1 (de)	2004-01-22	Verfahren zur herstellung von 1-(6-methylpyridin-3-yl)-2-[(4-(methylsulfonyl)phenyl] ethanon
ATE421961T1 (de)	2009-02-15	Piperidinderivate, verfahren zu deren herstellung und pharmazeutische zusammensetzung zur behandlung von alzheimer-krankheit, die diese derivate enthält
DE60113161D1 (de)	2005-10-06	Verfahren zur herstellung von 2-(4-pyridyl)amino-6-dialkylolxaphenyl-pyrido(2,3-d)pyrimidon-7-on-derivaten
NO20063058L (no)	2006-06-30	Fremgangsmate for fremstilling av (3-okso-2,3-dihydro-1H-isoindol-1-yl)acetylguanidinderivater
DE60115428D1 (de)	2006-01-05	Benzoesäureester mit antiplasmideffekt
ATE234296T1 (de)	2003-03-15	Verfahren zur herstellung von (8-chloro-3,10- dibromo-6,11-dihydro-5h-benzo(5,6) cyclohepta(1,2-b)pyridin-11-yl)-1-piperidin
AU2013203194B9 (en)	2016-01-07	Polymorphic forms of 3-(4-amino-1-oxo-1,3 dihydro-isoindol-2-yl)-piperidine-2,6-dione
DE60029493D1 (de)	2006-08-31	Neues verfahren zur herstellung von 1-phenyl-2-(2-pyridyl)ethanamin
NO20014530D0 (no)	2001-09-18	Fremgangsmåte for fremstilling av 4, 4-dimetyl-3<beta>- hydroksy-pregna-8, 14-dien-21-karboksylsyreestere ogmellomprodukter ved fremgangsmåten
ES2087026A1 (es)	1996-07-01	Nuevo derivado de la benzo(5,6)ciclohepta- (1.2-b) piridina.