ATE466094T1 - Verfahren zur herstellung von oligosacchariden - Google Patents

Verfahren zur herstellung von oligosacchariden

Info

Publication number
ATE466094T1
ATE466094T1 AT05111263T AT05111263T ATE466094T1 AT E466094 T1 ATE466094 T1 AT E466094T1 AT 05111263 T AT05111263 T AT 05111263T AT 05111263 T AT05111263 T AT 05111263T AT E466094 T1 ATE466094 T1 AT E466094T1
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AT
Austria
Prior art keywords
cell
intermediates
degrading
culturing
modification
Prior art date
Application number
AT05111263T
Other languages
English (en)
Inventor
Eric Samain
Original Assignee
Centre Nat Rech Scient
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9547804&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE466094(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Centre Nat Rech Scient filed Critical Centre Nat Rech Scient
Application granted granted Critical
Publication of ATE466094T1 publication Critical patent/ATE466094T1/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/18—Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Emergency Medicine (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Virology (AREA)
AT05111263T 1999-07-07 2000-07-07 Verfahren zur herstellung von oligosacchariden ATE466094T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9908772A FR2796082B1 (fr) 1999-07-07 1999-07-07 Procede de production d'oligosaccharides

Publications (1)

Publication Number Publication Date
ATE466094T1 true ATE466094T1 (de) 2010-05-15

Family

ID=9547804

Family Applications (2)

Application Number Title Priority Date Filing Date
AT05111263T ATE466094T1 (de) 1999-07-07 2000-07-07 Verfahren zur herstellung von oligosacchariden
AT00949678T ATE318324T1 (de) 1999-07-07 2000-07-07 Verfahren zur herstellung von oligosaccharide

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT00949678T ATE318324T1 (de) 1999-07-07 2000-07-07 Verfahren zur herstellung von oligosaccharide

Country Status (11)

Country Link
US (2) US7521212B1 (de)
EP (2) EP1637611B1 (de)
JP (1) JP5058420B2 (de)
AT (2) ATE466094T1 (de)
AU (1) AU780290B2 (de)
CA (1) CA2378562C (de)
DE (2) DE60044310D1 (de)
FR (1) FR2796082B1 (de)
MX (1) MXPA02000240A (de)
NZ (1) NZ516808A (de)
WO (1) WO2001004341A1 (de)

Families Citing this family (123)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE456664T1 (de) * 2001-04-02 2010-02-15 Glycomedics Inc Verfahren zur herstellung von oligosaccharidketten
FI20021989A0 (fi) * 2002-11-06 2002-11-06 Halina Miller-Podraza Korkean affiniteetin Helicobacter pylori-reseptorit ja niiden käyttö
US7820422B2 (en) 2005-06-16 2010-10-26 Centre National De La Recherche Scientifique (Cnrs) Efficient production of oligosaccharides using metabolically engineered microorganisms
WO2008002230A1 (en) * 2006-03-04 2008-01-03 Nilsson Kurt G I Production of glycoside oligosaccharides
PL1991690T3 (pl) 2006-03-09 2014-07-31 Centre Nat Rech Scient Sposób wytwarzania sialilowanych oligosacharydów
EP1911850A1 (de) * 2006-10-09 2008-04-16 Centre National De La Recherche Scientifique (Cnrs) Verfahren zur Herstellung von 6-thio-sialierten Glykoproteinen und Glycokonjugaten
WO2010111530A1 (en) 2009-03-25 2010-09-30 Seneb Biosciences, Inc. Glycolipids as treatment for disease
BR112012020791A2 (pt) 2010-02-19 2016-05-03 Glycom As produção de 6'-o-sialillactose e intermediários
JP5998130B2 (ja) 2010-07-12 2016-09-28 ユニヴェルシテイト ヘントＵｎｉｖｅｒｓｉｔｅｉｔ Ｇｅｎｔ 付加価値バイオ生成物の生成のための代謝操作された生物
RU2460800C2 (ru) * 2010-08-04 2012-09-10 Государственное научное учреждение Всероссийский научно-исследовательский институт сельскохозяйственной микробиологии Российской академии сельскохозяйственных наук (ГНУ ВНИИСХМ Россельхозакадемии) Способ ферментативного получения пента-n-ацетилхитопентаозы
EP2675899A4 (de) 2011-02-16 2014-09-10 Glycosyn LLC Biosynthese menschlicher milch-oligosaccharide in manipulierten bakterien
JP6129821B2 (ja) 2011-05-13 2017-05-17 グリコシン リミテッド ライアビリティー カンパニー プレバイオティクスとしての、精製された２’−フコシルラクトース、３−フコシルラクトース、およびラクトジフコテトラオースの使用
DK2722394T3 (en) 2011-06-07 2018-06-18 Hero Ag OBJECTIVES OF OLIGOSACCHARIDES BY A BIOTECHNOLOGICAL PROCEDURE
NL2007268C2 (en) 2011-08-16 2013-02-19 Friesland Brands Bv Nutritional compositions comprising human milk oligosaccharides and uses thereof.
BR112014005400B1 (pt) 2011-09-08 2019-10-01 Novozymes Bioag A/S Método para aumentar o crescimento e/ou rendimento de soja
UA116193C2 (uk) 2011-09-14 2018-02-26 Новозаймс Біоаг А/С Композиція для обробки рослини або насінини рослини та спосіб стимулювання росту рослин
CA2849899A1 (en) 2011-09-23 2013-03-28 Novozymes Bioag A/S Chitooligosaccharides and methods for use in enhancing soybean growth
US9055746B2 (en) 2011-09-23 2015-06-16 Novozymes Bioag A/S Chitooligosaccharides and methods for use in enhancing plant growth
IN2014CN02911A (de) 2011-09-23 2015-07-03 Novozymes Bioag As
WO2013044214A1 (en) 2011-09-23 2013-03-28 Novozymes Biologicals Holdings A/S Combinations of lipo-chitooligosaccharides and methods for use in enhancing plant growth
US20150225758A1 (en) * 2011-11-08 2015-08-13 University Of Georgia Research Foundation, Inc. Genetically modified cells and methods for making activated sugar-nucleotides
CN103155816A (zh) * 2011-12-09 2013-06-19 青岛天力建筑加固工程有限公司 一种使单体树木便于靠接成整棵大树的模具
RU2517620C2 (ru) * 2012-02-17 2014-05-27 Государственное научное учреждение Всероссийский научно-исследовательский институт сельскохозяйственной микробиологии Российской академии сельскохозяйственных наук (ГНУ ВНИИСХМ Россельхозакадемии) Способ ферментативного получения пента-n-ацетилхитопентаозы и гекса-n-ацетилхитогексаозы
EP2859112A4 (de) 2012-06-08 2015-10-28 Glycom As Verfahren zur herstellung von oligosacchariden und oligosaccharidglykosiden durch fermentation
US9816122B2 (en) 2012-09-25 2017-11-14 Glycom A/S Glycoconjugate synthesis
DK2728009T3 (da) * 2012-10-31 2017-11-06 Jennewein Biotechnologie Gmbh Fremgangsmåde til fremstilling af monosaccharider
WO2014086373A1 (en) 2012-12-07 2014-06-12 Glycom A/S Crystallisation of human milk oligosaccharides (hmo)
EP3467100B1 (de) * 2013-03-14 2022-09-21 Glycosyn LLC Mikroorganismen und verfahren zur herstellung sialylierter und n-acetylglucosamin-haltiger oligosaccharide
DK2999358T3 (en) 2013-05-22 2021-10-11 Glycom As Synthetic mixture of oligosaccharides for the treating a microbiota of a mammal
CN111172220B (zh) 2013-09-06 2023-08-04 格礼卡姆股份公司 寡糖的发酵生产
EP3041947A4 (de) 2013-09-06 2017-07-26 Glycom A/S Fermentative herstellung von oligosacchariden
PL2896628T3 (pl) 2014-01-20 2019-03-29 Jennewein Biotechnologie Gmbh Sposób wydajnego oczyszczania obojętnych oligosacharydów ludzkiego mleka (HMO) z fermentacji mikrobiologicznej
DK2927316T3 (en) * 2014-03-31 2019-03-04 Jennewein Biotechnologie Gmbh Total fermentation of oligosaccharides
MX2016014807A (es) 2014-05-15 2017-05-10 Glycosyn LLC Singenes de alfa(1,2)fucosiltransferasa para su utilizacion en la produccion de oligosacaridos fucosilados.
ES2968677T3 (es) 2014-06-11 2024-05-13 Glycom As Separación de 2’-O-fucosil-lactosa de caldo de fermentación
US11926858B2 (en) 2014-06-27 2024-03-12 Glycom A/S Oligosaccharide production
WO2015197082A1 (en) 2014-06-27 2015-12-30 Glycom A/S Oligosaccharide production
KR20170028438A (ko) * 2014-07-14 2017-03-13 바스프 에스이 Ｌｎｔ, ｌｎｎｔ 및 이들의 푸코실화 유도체의 생명공학적 생산
US9616114B1 (en) 2014-09-18 2017-04-11 David Gordon Bermudes Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity
CN107108677B (zh) 2014-10-24 2020-08-07 格礼卡姆股份公司 Hmo的混合物
US11040049B2 (en) 2014-10-29 2021-06-22 Glycom A/S Composition comprising HMSs/HMOs and use thereof
US20160346303A1 (en) 2014-10-29 2016-12-01 Glycom A/S Synthetic composition and method for treating irritable bowel syndrome
US11040050B2 (en) 2014-10-29 2021-06-22 Glycom A/S Composition comprising HMSs/HMOs and use thereof
US20170258820A1 (en) 2014-10-29 2017-09-14 Glycom A/S Synthetic composition and method for promoting mucosal healing
US10500221B2 (en) 2014-12-05 2019-12-10 Glycom A/S Crystalline difucosyllactose
US10835544B2 (en) 2014-12-08 2020-11-17 Glycom A/S Synthetic composition for regulating satiety
CN107106584A (zh) 2014-12-08 2017-08-29 格礼卡姆股份公司 用于治疗代谢障碍的合成组合物
US10987368B2 (en) 2014-12-08 2021-04-27 Glycom A/S Synthetic composition for preventing or treating CVD
US10881674B2 (en) 2014-12-08 2021-01-05 Glycom A/S Synthetic composition for treating metabolic disorders
ES2933616T3 (es) 2014-12-16 2023-02-10 Glycom As Separación de 2'-FL de un caldo de fermentación
WO2016157108A1 (en) 2015-03-31 2016-10-06 Glycom A/S Mixtures of human milk oligosaccharides comprising 3 '-o-sialyllactose
FR3035799B1 (fr) 2015-05-06 2017-05-05 Elicityl Support pour la purification de liquides biologiques
FR3035794B1 (fr) 2015-05-06 2017-05-05 Elicityl Procede pour la purification du sang total ou d'un produit issu du sang
US10676723B2 (en) 2015-05-11 2020-06-09 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
WO2016199071A1 (en) 2015-06-09 2016-12-15 Glycom A/S TERNARY MIXTURES OF 6'-SL, LNnT and LST c
EP3141610A1 (de) * 2015-09-12 2017-03-15 Jennewein Biotechnologie GmbH Herstellung von menschlichen milch-oligosacchariden in mikrobiellen wirten mit gentechnisch verändertem import/export-system
ES2886951T3 (es) 2015-09-14 2021-12-21 Glycom As Composición para su uso en la modulación de la microbiota
WO2017071715A1 (en) 2015-10-28 2017-05-04 Glycom A/S Synthetic composition and method for modulating brain function and behaviour
US10780103B2 (en) 2015-10-28 2020-09-22 Glycom A/S Synthetic composition and method for modulating emotion and mood disorders
EP3377071B1 (de) 2015-11-17 2024-01-10 Glycom A/S Humane milch-oligosaccharide zur behandlung von komplikationen im zusammenhang mit antibiotika
CN108541221B (zh) 2015-12-15 2023-02-28 格礼卡姆股份公司 Hmo的混合物
ES3011213T3 (en) 2015-12-18 2025-04-07 Glycom As Fermentative production of oligosaccharides
US10857168B2 (en) 2016-02-24 2020-12-08 Glycom A/S Synthetic composition for microbiota modulation
ES2991621T3 (es) 2016-03-07 2024-12-04 Glycom As Separación de oligosacáridos de caldo de fermentación
US11312741B2 (en) 2016-04-19 2022-04-26 Glycom A/S Separation of oligosaccharides from fermentation broth
ES2938355T3 (es) 2016-05-05 2023-04-10 Glycom As Composición que comprende HMOS para el tratamiento de la diarrea no infecciosa
WO2017190755A1 (en) 2016-05-05 2017-11-09 Glycom A/S Composition comprising hmos for use in the treatment of mast cell mediated visceral hypersensitivity and/or pain
US11224605B2 (en) 2016-05-19 2022-01-18 Glycom A/S Synthetic composition
US11419884B2 (en) 2016-06-24 2022-08-23 Glycom A/S Compositions comprising HMOS, their production and use for the prevention and/or treatment of viral and/or bacterial infections
ES2856749T3 (es) * 2016-10-29 2021-09-28 Chr Hansen Hmo Gmbh Proceso para la producción de oligosacáridos fucosilados
US10407516B2 (en) 2016-10-31 2019-09-10 Glycom A/S Crystalline HMO
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
EP3589139A4 (de) 2017-03-01 2020-12-23 Glycom A/S Synthetische zusammensetzung zur mikrobiotamodulation
WO2018207110A1 (en) 2017-05-09 2018-11-15 Glycom A/S Synthetic composition for microbiota modulation
US11541068B2 (en) 2017-05-24 2023-01-03 Glycom A/S HMO compositions and methods for reducing autism spectrum disorder symptoms
EP3630123A4 (de) 2017-05-24 2020-10-28 Glycom A/S Synthetische zusammensetzung mit einem oder mehreren menschlichen milcholigosacchariden (hmos)
EP3645545A4 (de) * 2017-06-30 2021-05-05 Glycom A/S Reinigung von oligosacchariden
CN119655445A (zh) 2017-07-12 2025-03-21 格礼卡姆股份公司 包含中性单糖或寡糖和酸性非碳水化合物组分的无定形混合物
EP3438122A1 (de) 2017-08-01 2019-02-06 OligoScience Biotechnology GmbH Mikroorganismus zur herstellung menschlicher milcholigosaccharide
EP3672600A4 (de) 2017-08-21 2021-05-19 Glycom A/S Synthetische zusammensetzung zur verminderung von allergiesymptomen
EP3450443A1 (de) 2017-08-29 2019-03-06 Jennewein Biotechnologie GmbH Verfahren zur reinigung sialylierter oligosaccharide
EP3456836A1 (de) 2017-09-13 2019-03-20 Glycom A/S Abtrennung von sialylierten oligosacchariden aus der fermentationsbrühe
KR20260033622A (ko) 2017-10-04 2026-03-10 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 면역조절성 올리고사카라이드
GB201717555D0 (en) 2017-10-25 2017-12-06 Nonwovens Innovation & Res Institute Ltd Blood filter
WO2019087140A1 (en) 2017-11-02 2019-05-09 Glycom A/S One or more hmos for reducing or preventing fatigue and/or improving focus or concentration
US11452736B2 (en) 2017-11-30 2022-09-27 Glycom A/S Mixture of HMOs for treating wheat sensitivity
US11602545B2 (en) 2017-12-05 2023-03-14 Glycom A/S Human milk oligosaccharides for treating migraine
EP3743078A4 (de) 2017-12-22 2022-01-19 Glycom A/S ZUSAMMENSETZUNG MIT HMOs ZUR VERHINDERUNG ODER VERMINDERUNG DER NOZIZEPTION
CN108504678A (zh) * 2018-04-12 2018-09-07 江南大学 一种提高重组枯草芽孢杆菌几丁寡糖产量的方法
CN112074196A (zh) 2018-05-07 2020-12-11 詹尼温生物技术有限责任公司 从微生物发酵获得的碳水化合物中纯化乳-N-新四糖(LNnT)的简单方法
US11554131B2 (en) 2018-05-31 2023-01-17 Glycom A/S Mixture of HMOs for treating autoimmune diseases
PL3620510T5 (pl) 2018-09-06 2026-07-20 Chr. Hansen HMO GmbH Fermentacyjne wytwarzanie oligosacharydów przez całkowitą fermentację z wykorzystaniem mieszanego surowca
BR112021010116A2 (pt) * 2018-12-04 2021-08-31 Glycom A/S Síntese do oligossacarídeo fucosilado lnfp-v
PT3897902T (pt) 2018-12-19 2023-12-06 Glycom As Separação de oligossacáridos
JP2022513524A (ja) 2018-12-19 2022-02-08 グリコム・アクティーゼルスカブ 低ｆｏｄｍａｐ食を使用してヒトを治療するための組成物および方法
EP3702468A1 (de) 2019-03-01 2020-09-02 Jennewein Biotechnologie GmbH Fermentative produktion von kohlenhydraten durch mikrobielle zellen, die ein gemischtes ausgangsmaterial verwenden
EP3741770A1 (de) 2019-05-21 2020-11-25 Jennewein Biotechnologie GmbH Reinigung von oligosacchariden aus einem fermentationsmedium mittels filtration
WO2021094133A2 (en) 2019-11-13 2021-05-20 Basf Se Enzymatic hydrolysis of 2',3-difucosyllactose
EP4065128A4 (de) 2019-11-29 2023-12-20 Glycom A/S Mischung von hmos zur verbesserung der mikrobiota von schwangeren frauen
AU2020409590A1 (en) 2019-12-18 2022-05-19 Inbiose N.V. Production of sialylated oligosaccharide in host cells
WO2021124234A1 (en) * 2019-12-19 2021-06-24 Glycom A/S Separation of sialylated oligosaccharides from fermentation broth
EP4077699A1 (de) 2019-12-19 2022-10-26 Basf Se Erhöhung der raum-zeit-ausbeute, der kohlenstoffkonversionseffizienz und kohlenstoffsubstratflexibilität bei der herstellung von feinchemikalien
US20230098432A1 (en) * 2020-02-24 2023-03-30 Carbocode S.A. Synthesis of glycosyl fluorides
CN115279778B (zh) 2020-03-12 2025-06-24 格礼卡姆股份公司 2’-fl的结晶
FR3110176B1 (fr) 2020-05-12 2022-05-13 Institut Nat Des Sciences Appliquees De Toulouse Souche et procédé de production d’oligosaccharides
WO2022013143A1 (en) 2020-07-13 2022-01-20 Glycom A/S Oligosaccharide production
US12077788B2 (en) * 2020-08-10 2024-09-03 Inbiose N.V. Production of a mixture of neutral non-fucosylated oligosaccharides by a cell
ES2966260T3 (es) 2020-08-10 2024-04-19 Inbiose Nv Producción de una mezcla de oligosacáridos neutros no fucosilados por una célula
CN116171328A (zh) * 2020-08-10 2023-05-26 因比奥斯公司 藉由细胞培养或微生物发酵产生的不同寡糖的纯化混合物的制造方法
WO2022118269A1 (en) 2020-12-04 2022-06-09 Glycom A/S Human milk oligosaccharides for use in supporting maturation or improvement of sleeping patterns
WO2022189361A1 (en) 2021-03-08 2022-09-15 Universiteit Gent Conjugates including multiple saccharidic chains on a linear protein and uses in mammals feed
DK181061B1 (en) 2021-03-12 2022-10-31 Glycom As Purification of sialooligosaccharides
WO2022223430A1 (en) 2021-04-19 2022-10-27 Dsm Ip Assets B.V. A composition of enzymes and human milk oligosaccharides
US12534701B2 (en) 2021-05-17 2026-01-27 Dsm Ip Assets B.V. Microbial strain expressing an invertase/sucrose hydrolase
EP4355465A1 (de) 2021-06-15 2024-04-24 DSM IP Assets B.V. Trennung von menschlichen milcholigosacchariden aus einer fermentationsbrühe
BE1029434B1 (nl) 2021-06-15 2023-07-31 Dsm Ip Assets Bv Scheiding van moedermelkoligosachariden uit een fermentatiebouillon
WO2022263424A1 (en) 2021-06-15 2022-12-22 Dsm Ip Assets B.V. Separation of human milk oligosaccharides from a fermentation broth
BE1029436B1 (nl) 2021-06-15 2023-07-31 Dsm Ip Assets Bv Scheiding van moedermelkoligosachariden uit een fermentatiebouillon
CN115873051B (zh) * 2022-05-17 2024-06-25 山东恒鲁生物科技有限公司 三糖的新晶型
US20250376707A1 (en) 2022-06-14 2025-12-11 Dsm Ip Assets B.V. Separation of human milk oligosaccharides from a fermentation broth
DK202200588A1 (en) 2022-06-20 2024-02-23 Dsm Ip Assets Bv Mixture of fucosylated HMOs
KR20260057080A (ko) 2023-08-25 2026-04-27 시에이치알. 한센 에이/에스 변경된 기질 특이성을 갖는 n-아세틸글루코사미닐트랜스퍼라제 효소 및 발효 올리고당 생산에서의 이들의 용도

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI883076A7 (fi) * 1987-10-29 1989-04-30 Soc Gen Pour Les Techniques Valmistusmenetelmä, jossa yhdistetään hyvin fruktoosipitoisia oligosidejä ja glukonihappoa käymisen avulla.
US5079353A (en) * 1987-12-02 1992-01-07 Chembiomed, Ltd. Sialic acid glycosides, antigens, immunoadsorbents, and methods for their preparation
JPH02273192A (ja) * 1989-04-13 1990-11-07 Meito Sangyo Kk イソマルチユロースの製造方法
CN1129953A (zh) * 1993-07-15 1996-08-28 尼奥斯药品公司 糖组分的合成方法
EP0723010A4 (de) 1994-05-19 2000-09-27 Bio Polymer Res Co Ltd Mit einem auf den zuckermetabolismus bezogenem gen transformiertes cellulose produzierendes bakterium
US5545553A (en) * 1994-09-26 1996-08-13 The Rockefeller University Glycosyltransferases for biosynthesis of oligosaccharides, and genes encoding them
WO1998012343A1 (en) 1996-09-17 1998-03-26 Kyowa Hakko Kogyo Co., Ltd. Processes for producing sugar nucleotides and complex carbohydrates
US5945314A (en) * 1997-03-31 1999-08-31 Abbott Laboratories Process for synthesizing oligosaccharides
DE19735994A1 (de) * 1997-08-19 1999-02-25 Piepersberg Wolfgang Prof Dr Verfahren zur enzymatischen Synthese von Guanosindiphosphat-6-desoxyhexosen und deren Verwendung zur Herstellung von Oligosacchariden
CA2351022A1 (en) * 1998-11-18 2000-05-25 Neose Technologies, Inc. Low cost manufacture of oligosaccharides
WO2000070060A1 (en) * 1999-05-18 2000-11-23 University Of Iowa Research Foundation Production of complex carbohydrates
JP2001546898A (en) 1999-12-21 2003-06-10 Kyowa Hakko Kogyo Kk MODIFIED alpha -1,2-FUCOSYLTRANSFERASE GENE AND PROCESS FOR PRODUCING alpha -1,2-FUCOSYLTRANSFERASE AND FUCOSE-CONTAINING SUGAR CHAIN
AU2001246894A1 (en) 2000-04-11 2001-10-23 Kyowa Hakko Kogyo Co. Ltd. Alpha1,2-fucosyltransferase and process for producing fucose-containing complex carbohydrate

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AU6296100A (en) 2001-01-30
EP1194584A1 (de) 2002-04-10
CA2378562A1 (fr) 2001-01-18
DE60026142D1 (de) 2006-04-27
DE60026142T2 (de) 2006-11-23
FR2796082A1 (fr) 2001-01-12
ATE318324T1 (de) 2006-03-15
DE60044310D1 (de) 2010-06-10
FR2796082B1 (fr) 2003-06-27
MXPA02000240A (es) 2002-06-21
EP1637611A1 (de) 2006-03-22
AU780290B2 (en) 2005-03-17
WO2001004341A1 (fr) 2001-01-18
US20090082307A1 (en) 2009-03-26
EP1637611B1 (de) 2010-04-28
CA2378562C (fr) 2013-11-26
US8586332B2 (en) 2013-11-19
JP2003504072A (ja) 2003-02-04
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JP5058420B2 (ja) 2012-10-24
NZ516808A (en) 2004-07-30

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