NO20023247L - Purinderivater, fremgangsmate for deres fremstilling samt anvendelse derav - Google Patents
Purinderivater, fremgangsmate for deres fremstilling samt anvendelse deravInfo
- Publication number
- NO20023247L NO20023247L NO20023247A NO20023247A NO20023247L NO 20023247 L NO20023247 L NO 20023247L NO 20023247 A NO20023247 A NO 20023247A NO 20023247 A NO20023247 A NO 20023247A NO 20023247 L NO20023247 L NO 20023247L
- Authority
- NO
- Norway
- Prior art keywords
- purine derivatives
- processes
- preparation
- derivatives
- relates
- Prior art date
Links
- 229940083251 peripheral vasodilators purine derivative Drugs 0.000 title abstract 3
- 125000000561 purinyl group Chemical class N1=C(N=C2N=CNC2=C1)* 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 102000003903 Cyclin-dependent kinases Human genes 0.000 abstract 1
- 108090000266 Cyclin-dependent kinases Proteins 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 241000700605 Viruses Species 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000035755 proliferation Effects 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/40—Heterocyclic compounds containing purine ring systems with halogen atoms or perhalogeno-alkyl radicals directly attached in position 2 or 6
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Virology (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP00200070 | 2000-01-07 | ||
| PCT/EP2001/000150 WO2001049688A1 (en) | 2000-01-07 | 2001-01-08 | Purine derivatives, process for their preparation and use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20023247D0 NO20023247D0 (no) | 2002-07-04 |
| NO20023247L true NO20023247L (no) | 2002-09-09 |
Family
ID=8170897
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20023247A NO20023247L (no) | 2000-01-07 | 2002-07-04 | Purinderivater, fremgangsmate for deres fremstilling samt anvendelse derav |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20030187261A1 (de) |
| EP (1) | EP1244668B1 (de) |
| JP (1) | JP2003519232A (de) |
| AT (1) | ATE322494T1 (de) |
| AU (1) | AU3540101A (de) |
| CA (1) | CA2396276A1 (de) |
| CZ (1) | CZ20022353A3 (de) |
| DE (1) | DE60118521T2 (de) |
| IL (1) | IL150594A0 (de) |
| NO (1) | NO20023247L (de) |
| WO (1) | WO2001049688A1 (de) |
Families Citing this family (100)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ27399A3 (cs) * | 1999-01-26 | 2000-08-16 | Ústav Experimentální Botaniky Av Čr | Substituované dusíkaté heterocyklické deriváty, způsob jejich přípravy, tyto deriváty pro použití jako léčiva, farmaceutická kompozice a kombinovaný farmaceutický přípravek tyto deriváty obsahující a použití těchto derivátů pro výrobu léčiv |
| IL150062A0 (en) * | 1999-12-17 | 2002-12-01 | Ariad Pharma Inc | Proton pump inhibitors |
| MXPA03003774A (es) * | 2000-10-31 | 2003-07-28 | Aventis Pharm Prod Inc | Derivados de acilo y sulfonilo de 2-(trans-1, 4-diaminociclohexil)-purinas 6,9-disubstituidas y sus uso como agentes antiproliferativos. |
| CZ294535B6 (cs) * | 2001-08-02 | 2005-01-12 | Ústav Experimentální Botaniky Avčr | Heterocyklické sloučeniny na bázi N6-substituovaného adeninu, způsoby jejich přípravy, jejich použití pro přípravu léčiv, kosmetických přípravků a růstových regulátorů, farmaceutické přípravky, kosmetické přípravky a růstové regulátory tyto sloučeniny obsahující |
| GB0119249D0 (en) | 2001-08-07 | 2001-10-03 | Novartis Ag | Organic compounds |
| US7323469B2 (en) | 2001-08-07 | 2008-01-29 | Novartis Ag | 7H-pyrrolo[2,3-d]pyrimidine derivatives |
| ES2279903T3 (es) | 2001-12-18 | 2007-09-01 | Cv Therapeutics, Inc. | Antagonistas del receptor a2a de adenosina. |
| EP1485390B1 (de) | 2002-03-07 | 2008-10-08 | F. Hoffman-la Roche AG | Bicyclische pyridin- und pyrimidininhibitoren von p38-kinase |
| ES2347544T3 (es) | 2002-03-13 | 2010-11-02 | Janssen Pharmaceutica Nv | Inhibidores de histona-desacetilasas. |
| EP1352910A1 (de) * | 2002-04-10 | 2003-10-15 | Grünenthal GmbH | Neue Analoga von Nitrobenzylthioinosine |
| WO2004013141A1 (en) | 2002-08-06 | 2004-02-12 | Astrazeneca Ab | Condensed pyridines and pyrimidines with tie2 (tek) activity |
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| EP1620437B1 (de) | 2003-04-29 | 2009-06-17 | Pfizer Limited | 5,7-diaminopyrazolo¬4,3-d pyrimidine zur verwendung in der behandlung von bluthochdruck |
| EP2145888A1 (de) | 2003-09-18 | 2010-01-20 | Conforma Therapeutics Corporation | Deazapurinderivate als HSP90-Inhibitoren |
| EP1668011B1 (de) * | 2003-09-25 | 2011-03-02 | Janssen Pharmaceutica NV | Die replikation von hiv hemmende purinderivate |
| US7572799B2 (en) | 2003-11-24 | 2009-08-11 | Pfizer Inc | Pyrazolo[4,3-d]pyrimidines as Phosphodiesterase Inhibitors |
| GB0327323D0 (en) * | 2003-11-24 | 2003-12-31 | Pfizer Ltd | Novel pharmaceuticals |
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| HRP20060254A2 (en) * | 2003-12-30 | 2006-10-31 | Gilead Sciences | Phosphonates, monophosphonamidates, bisphosphonamidates for the treatment of viral diseases |
| CN1938307B (zh) | 2004-03-26 | 2010-06-16 | 大日本住友制药株式会社 | 9-取代的8-氧代腺嘌呤 |
| ES2317209T3 (es) * | 2004-04-07 | 2009-04-16 | Pfizer Inc. | Pirazolo(4,3-) pirimidinas. |
| ES2294400T3 (es) * | 2004-06-29 | 2008-04-01 | Grunenthal Gmbh | Nuevos analogos de notrobenciltioinosina. |
| BRPI0512676B8 (pt) | 2004-07-28 | 2021-05-25 | Janssen Pharmaceutica Nv | derivados de indolil alquil amina substituídos como inibidores de histona desacetilase, composição farmacêutica que os compreende, seus processos de preparação e uso |
| US7521446B2 (en) * | 2005-01-13 | 2009-04-21 | Signal Pharmaceuticals, Llc | Haloaryl substituted aminopurines, compositions thereof, and methods of treatment therewith |
| US7723340B2 (en) * | 2005-01-13 | 2010-05-25 | Signal Pharmaceuticals, Llc | Haloaryl substituted aminopurines, compositions thereof, and methods of treatment therewith |
| US7759342B2 (en) | 2005-01-13 | 2010-07-20 | Signal Pharmaceuticals, Llc | Methods of treatment and prevention using haloaryl substituted aminopurines |
| EP1846408B1 (de) * | 2005-01-14 | 2013-03-20 | Janssen Pharmaceutica NV | 5-gliedrige annelierte heterocyclische pyrimidine als kinaseinhibitoren |
| EP1844048B1 (de) | 2005-01-14 | 2010-05-26 | Janssen Pharmaceutica N.V. | Pyrazolopyrimidine als zellzyklus-kinasehemmer |
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| US7534796B2 (en) | 2005-02-18 | 2009-05-19 | Wyeth | Imidazo[4,5-b]pyridine antagonists of gonadotropin releasing hormone receptor |
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| MX2007011903A (es) | 2005-03-30 | 2007-12-05 | Conforma Therapeutics Corp | Alquinil pirrolopirimidinas y analogos relacionados como inhibidores de hsp90. |
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| US8846697B2 (en) | 2006-05-31 | 2014-09-30 | The Regents Of The University Of California | Purine analogs |
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| TW202241889A (zh) | 2020-12-23 | 2022-11-01 | 美商雅捷可斯治療公司 | 作為jak2抑制劑之6-雜芳基氧基苯并咪唑及氮雜苯并咪唑 |
| EP4430042B1 (de) | 2021-11-09 | 2026-02-18 | Ajax Therapeutics, Inc. | 6-heteroaryloxybenzimidazole und azabenzimidazole als jak2-inhibitoren |
| WO2023086320A1 (en) | 2021-11-09 | 2023-05-19 | Ajax Therapeutics, Inc. | Forms and compositions of inhibitors of jak2 |
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|---|---|---|---|---|
| US3506643A (en) * | 1966-12-09 | 1970-04-14 | Max Thiel | N**6-aralkyl-adenosine derivatives |
| NL6717061A (de) * | 1966-12-21 | 1968-06-24 | ||
| DE1670265A1 (de) * | 1967-08-25 | 1971-01-28 | Boehringer Mannheim Gmbh | 2-Amino-Adenosinderivate und Verfahren zu deren Herstellung |
| AT293627B (de) * | 1968-09-10 | 1971-10-25 | Boehringer Mannheim Gmbh | Verfahren zur Herstellung von neuen in 6-Stellung substituierten Purinribonucleosid-3':5'-cyclophosphaten |
| BE789773A (fr) * | 1971-10-08 | 1973-04-06 | Schering Ag | Adenosines n6 -substituees et leur procede de |
| DE2401254A1 (de) * | 1974-01-11 | 1975-11-27 | Boehringer Mannheim Gmbh | Neue derivate von n hoch 6-substituierten adeninen |
| CS233665B1 (en) * | 1983-01-06 | 1985-03-14 | Antonin Holy | Processing of isomere o-phosphonylmethylderivative of anantiomere racemic vicinal diene |
| CS263952B1 (en) * | 1985-04-25 | 1989-05-12 | Holy Antonin | Remedy with antiviral effect |
| JPS61256346A (ja) * | 1985-05-10 | 1986-11-13 | Konishiroku Photo Ind Co Ltd | ハロゲン化銀写真感光材料 |
| CS264222B1 (en) * | 1986-07-18 | 1989-06-13 | Holy Antonin | N-phosphonylmethoxyalkylderivatives of bases of pytimidine and purine and method of use them |
| JPS63165398A (ja) * | 1986-12-15 | 1988-07-08 | サンド・アクチエンゲゼルシャフト | 新規フラヌロン酸誘導体、それらの製造方法およびそれらの用途 |
| US4918075A (en) * | 1988-12-20 | 1990-04-17 | E. R. Squibb & Sons, Inc. | Purinyl and pyrimidinyl cyclobutanes and their use as antiviral agents |
| US5302585A (en) * | 1990-04-20 | 1994-04-12 | Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic | Use of chiral 2-(phosphonomethoxy)propyl guanines as antiviral agents |
| WO1992001698A1 (en) * | 1990-07-19 | 1992-02-06 | Beecham Group Plc | Antiviral phosphono-alken derivatives of purines |
| US5208221A (en) * | 1990-11-29 | 1993-05-04 | Bristol-Myers Squibb Company | Antiviral (phosphonomethoxy) methoxy purine/pyrimidine derivatives |
| US5124051A (en) * | 1990-11-29 | 1992-06-23 | Solarchem Enterprises Inc. | Process for treatment of contaminated waste water or groundwater |
| US5276143A (en) * | 1990-12-21 | 1994-01-04 | E. I. Du Pont De Nemours And Company | Dideoxyfructonucleosides and deoxyfructonucleotides |
| CZ284678B6 (cs) * | 1991-05-20 | 1999-01-13 | Ústav Organické Chemie A Biochemie Avčr | Di(2-propyl)estery 1-fluor-2-fosfonomethoxy-3-p -toluensulfonyloxypropanů, způsob jejich přípravy a použití |
| US5849905A (en) * | 1994-11-23 | 1998-12-15 | Centre National De La Recherche Scientifique | Biologically active phosphotriester-type nucleosides and methods for preparing same |
| PT874846E (pt) * | 1995-11-01 | 2003-08-29 | Novartis Ag | Derivados de purina e processos para a sua preparacao |
| FR2741881B1 (fr) * | 1995-12-01 | 1999-07-30 | Centre Nat Rech Scient | Nouveaux derives de purine possedant notamment des prorietes anti-proliferatives et leurs applications biologiques |
| KR100298523B1 (ko) * | 1996-06-06 | 2001-09-06 | 오쓰카 요시미쓰 | 아미드유도체 |
| US5866702A (en) * | 1996-08-02 | 1999-02-02 | Cv Therapeutics, Incorporation | Purine inhibitors of cyclin dependent kinase 2 |
| JP2001516694A (ja) * | 1997-08-07 | 2001-10-02 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | プロテインキナーゼ、gプロテイン及びポリメラーゼのプリン阻害剤 |
| US6479487B1 (en) * | 1998-02-26 | 2002-11-12 | Aventis Pharmaceuticals Inc. | 6, 9-disubstituted 2-[trans-(4-aminocyclohexyl)amino] purines |
| PL344021A1 (en) * | 1998-02-26 | 2001-09-24 | Aventis Pharma Inc | 6,9-disubstituted 2-[trans-(4- aminocyclohexyl) amino]purines |
| CZ294535B6 (cs) * | 2001-08-02 | 2005-01-12 | Ústav Experimentální Botaniky Avčr | Heterocyklické sloučeniny na bázi N6-substituovaného adeninu, způsoby jejich přípravy, jejich použití pro přípravu léčiv, kosmetických přípravků a růstových regulátorů, farmaceutické přípravky, kosmetické přípravky a růstové regulátory tyto sloučeniny obsahující |
-
2001
- 2001-01-08 JP JP2001550228A patent/JP2003519232A/ja active Pending
- 2001-01-08 WO PCT/EP2001/000150 patent/WO2001049688A1/en not_active Ceased
- 2001-01-08 IL IL15059401A patent/IL150594A0/xx unknown
- 2001-01-08 US US10/169,592 patent/US20030187261A1/en not_active Abandoned
- 2001-01-08 CZ CZ20022353A patent/CZ20022353A3/cs unknown
- 2001-01-08 DE DE60118521T patent/DE60118521T2/de not_active Expired - Lifetime
- 2001-01-08 AT AT01907418T patent/ATE322494T1/de not_active IP Right Cessation
- 2001-01-08 CA CA002396276A patent/CA2396276A1/en not_active Abandoned
- 2001-01-08 AU AU35401/01A patent/AU3540101A/en not_active Abandoned
- 2001-01-08 EP EP01907418A patent/EP1244668B1/de not_active Expired - Lifetime
-
2002
- 2002-07-04 NO NO20023247A patent/NO20023247L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2003519232A (ja) | 2003-06-17 |
| EP1244668B1 (de) | 2006-04-05 |
| US20030187261A1 (en) | 2003-10-02 |
| ATE322494T1 (de) | 2006-04-15 |
| IL150594A0 (en) | 2003-02-12 |
| WO2001049688A8 (en) | 2001-10-04 |
| DE60118521T2 (de) | 2006-10-12 |
| NO20023247D0 (no) | 2002-07-04 |
| CZ20022353A3 (cs) | 2003-02-12 |
| AU3540101A (en) | 2001-07-16 |
| CA2396276A1 (en) | 2001-07-12 |
| WO2001049688A1 (en) | 2001-07-12 |
| EP1244668A1 (de) | 2002-10-02 |
| DE60118521D1 (de) | 2006-05-18 |
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