ATE338128T1 - Hiv-1 tat und/oder nef enthaltende fusionsproteine - Google Patents

Hiv-1 tat und/oder nef enthaltende fusionsproteine

Info

Publication number
ATE338128T1
ATE338128T1 AT98952625T AT98952625T ATE338128T1 AT E338128 T1 ATE338128 T1 AT E338128T1 AT 98952625 T AT98952625 T AT 98952625T AT 98952625 T AT98952625 T AT 98952625T AT E338128 T1 ATE338128 T1 AT E338128T1
Authority
AT
Austria
Prior art keywords
tat
hiv
fusion proteins
containing fusion
nef
Prior art date
Application number
AT98952625T
Other languages
English (en)
Inventor
Claudine Bruck
Stephane Andre Georges Godart
S A Biologicals
Martine Marchand
Original Assignee
Glaxosmithkline Biolog Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10819735&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE338128(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Glaxosmithkline Biolog Sa filed Critical Glaxosmithkline Biolog Sa
Application granted granted Critical
Publication of ATE338128T1 publication Critical patent/ATE338128T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16311—Human Immunodeficiency Virus, HIV concerning HIV regulatory proteins
    • C12N2740/16322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Communicable Diseases (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT98952625T 1997-09-26 1998-09-17 Hiv-1 tat und/oder nef enthaltende fusionsproteine ATE338128T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9720585.0A GB9720585D0 (en) 1997-09-26 1997-09-26 Vaccine

Publications (1)

Publication Number Publication Date
ATE338128T1 true ATE338128T1 (de) 2006-09-15

Family

ID=10819735

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98952625T ATE338128T1 (de) 1997-09-26 1998-09-17 Hiv-1 tat und/oder nef enthaltende fusionsproteine

Country Status (27)

Country Link
EP (1) EP1015596B2 (de)
JP (2) JP2001518300A (de)
KR (1) KR100554487B1 (de)
CN (1) CN1188519C (de)
AR (2) AR017147A1 (de)
AT (1) ATE338128T1 (de)
AU (1) AU746564B2 (de)
BR (1) BR9812547A (de)
CA (1) CA2305013C (de)
CO (1) CO4810339A1 (de)
CZ (1) CZ302878B6 (de)
DE (1) DE69835756T3 (de)
DK (1) DK1015596T4 (de)
ES (1) ES2272012T5 (de)
GB (1) GB9720585D0 (de)
HU (1) HUP0004896A3 (de)
IL (1) IL135102A0 (de)
NO (2) NO328824B1 (de)
NZ (1) NZ503482A (de)
PL (1) PL195243B1 (de)
PT (1) PT1015596E (de)
SA (1) SA98190877B1 (de)
SI (1) SI1015596T2 (de)
TR (1) TR200000864T2 (de)
TW (1) TW499436B (de)
WO (1) WO1999016884A1 (de)
ZA (1) ZA988789B (de)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9706957D0 (en) 1997-04-05 1997-05-21 Smithkline Beecham Plc Formulation
GB9720585D0 (en) * 1997-09-26 1997-11-26 Smithkline Beecham Biolog Vaccine
GB9820525D0 (en) 1998-09-21 1998-11-11 Allergy Therapeutics Ltd Formulation
AU3158900A (en) * 1999-02-25 2000-09-14 Smithkline Beecham Biologicals (Sa) Immunogens comprising a peptide and a carrier derived from h.influenzae protein
WO2000061617A2 (en) * 1999-04-12 2000-10-19 Modex Therapeutiques, S.A. Transiently immortalized cells for use in gene therapy
WO2001000232A2 (en) * 1999-06-29 2001-01-04 Smithkline Beecham Biologicals S.A. Use of cpg as an adjuvant for hiv vaccine
GB0000891D0 (en) 2000-01-14 2000-03-08 Allergy Therapeutics Ltd Formulation
OA12168A (en) * 2000-01-31 2006-05-08 Smithkline Beecham Biolog Vaccine for the prophylactic or therapeutic immunization against HIV.
US6472176B2 (en) 2000-12-14 2002-10-29 Genvec, Inc. Polynucleotide encoding chimeric protein and related vector, cell, and method of expression thereof
GB0110431D0 (en) * 2001-04-27 2001-06-20 Glaxosmithkline Biolog Sa Novel compounds
EP1279404A1 (de) * 2001-07-26 2003-01-29 Istituto Superiore di Sanità Verwendung von HIV-1 Fragmenten oder Derivaten zur Bestimmung oder Aktivierung von Antigen-präsentierenden Zellen, oder zur Abgabe von Cargo-Molekülen für Impfung oder für Behandlung von anderen Erkrankungen
GB0118367D0 (en) * 2001-07-27 2001-09-19 Glaxosmithkline Biolog Sa Novel use
HU230364B1 (hu) 2001-11-21 2016-03-29 The Trustees Of The University Of Pennsylvania Simian adenovírus nukleinsav és aminosav-szekvencia, azt tartalmazó vektorok, és eljárások annak alkalmazására
EP1944043A1 (de) 2001-11-21 2008-07-16 The Trustees of the University of Pennsylvania Nukleinsäure- und Aminosäuresequenzen von Affen-Adenoviren, hergeleitete Vektoren und Verwendungsverfahren.
KR100466382B1 (ko) * 2002-01-08 2005-01-14 주식회사 엘지생명과학 인간 면역 결핍 바이러스-1, -2 타입의 단백질이 융합된 재조합 콤보 단백질, 이의 생산방법, 이를 포함하는 벡터, 형질전환된 대장균 및 진단키트
GB0206359D0 (en) 2002-03-18 2002-05-01 Glaxosmithkline Biolog Sa Viral antigens
GB0206360D0 (en) 2002-03-18 2002-05-01 Glaxosmithkline Biolog Sa Viral antigens
KR20100063126A (ko) * 2002-05-16 2010-06-10 버베리안 노딕 에이/에스 Ｈｉｖ 조절/부속 단백질의 융합 단백질
GB0225788D0 (en) 2002-11-05 2002-12-11 Glaxo Group Ltd Vaccine
WO2005090968A1 (en) 2004-03-16 2005-09-29 Inist Inc. Tat-based immunomodulatory compositions and methods of their discovery and use
TW200613554A (en) 2004-06-17 2006-05-01 Wyeth Corp Plasmid having three complete transcriptional units and immunogenic compositions for inducing an immune response to HIV
GB0417494D0 (en) 2004-08-05 2004-09-08 Glaxosmithkline Biolog Sa Vaccine
GB0507003D0 (en) * 2005-04-06 2005-05-11 Molmed Spa Therapeutic
IN2014DN06624A (de) 2005-10-18 2015-07-10 Univ Colorado
KR101761691B1 (ko) 2007-11-28 2017-07-26 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 유인원 ｅ 아데노바이러스 ｓａｄｖ-39, -25.2, -26, -30, -37, 및 -38
WO2009105084A2 (en) 2007-11-28 2009-08-27 The Trustees Of The University Of Pennsylvania Simian subfamily c adenoviruses sadv-40, -31, and-34 and uses thereof
EP2250255A2 (de) 2008-03-04 2010-11-17 The Trustees of the University of Pennsylvania Simian-adenoviren sadv-36, -42.1, -42.2 und -44 sowie anwendungen davon
US8986702B2 (en) 2008-05-16 2015-03-24 Taiga Biotechnologies, Inc. Antibodies and processes for preparing the same
CA2731767C (en) 2008-07-21 2016-12-06 Taiga Biotechnologies, Inc. Differentiated anucleated cells and method for preparing the same
DK2966084T3 (en) 2008-08-28 2018-08-06 Taiga Biotechnologies Inc MODULATORS OF MYC, PROCEDURES FOR USING SAME AND PROCEDURES FOR IDENTIFYING SUBSTANCES MODULATING MYC
US8940290B2 (en) 2008-10-31 2015-01-27 The Trustees Of The University Of Pennsylvania Simian adenoviruses SAdV-43, -45, -46, -47, -48, -49, and -50 and uses thereof
AU2010230073B2 (en) 2009-03-23 2016-05-26 Pin Pharma, Inc. Treatment of cancer with immunostimulatory HIV Tat derivative polypeptides
WO2010138675A1 (en) 2009-05-29 2010-12-02 The Trustees Of The University Of Pennsylvania Simian adenovirus 41 and uses thereof
AU2011332025B2 (en) 2010-11-23 2015-06-25 The Trustees Of The University Of Pennsylvania Subfamily E simian adenoviruses A1321, A1325, A1295, A1309 and A1322 and uses thereof
EP2708561A4 (de) * 2011-03-15 2014-09-24 Univ Yonsei Iacf Bio-pin
SG10201609511XA (en) 2012-05-18 2016-12-29 Univ Pennsylvania Subfamily e simian adenoviruses a1302, a1320, a1331 and a1337 and uses thereof
WO2014012090A1 (en) 2012-07-13 2014-01-16 The Broad Institute, Inc. Molecular sleds comprising a positively-charged amino acid sequence and a molecular cargo and uses thereof
AU2013292330B2 (en) 2012-07-20 2018-07-12 Htyr Acquisition Llc Enhanced reconstitution and autoreconstitution of the hematopoietic compartment
US10272115B2 (en) 2013-03-11 2019-04-30 Taiga Biotechnologies, Inc. Production and use of red blood cells
US9365825B2 (en) 2013-03-11 2016-06-14 Taiga Biotechnologies, Inc. Expansion of adult stem cells in vitro
EP3052127A1 (de) 2013-10-04 2016-08-10 PIN Pharma, Inc. Immunstimulierende hiv-tat-derivierende polypeptide zur verwendung bei der krebsbehandlung
MY186389A (en) 2014-05-13 2021-07-22 Univ Pennsylvania Compositions comprising aav expressing dual antibody constructs and uses thereof
US10272160B2 (en) * 2015-04-16 2019-04-30 The Research Foundation For The State University Of New York Nanostructures comprising cobalt porphyrin-phospholipid conjugates and polyhistidine-tags
US11207421B2 (en) 2015-04-16 2021-12-28 The Research Foundation For The State University Of New York Nanostructures comprising cobalt porphyrin-phospholipid conjugates and polyhistidine-tags
CN113786476A (zh) 2016-12-02 2021-12-14 泰加生物工艺学公司 纳米颗粒调配物
US10149898B2 (en) 2017-08-03 2018-12-11 Taiga Biotechnologies, Inc. Methods and compositions for the treatment of melanoma
CN113874033A (zh) 2019-04-08 2021-12-31 泰加生物工艺学公司 用于冷冻保存免疫细胞的组合物和方法
JP2022532608A (ja) 2019-05-14 2022-07-15 タイガ バイオテクノロジーズ，インク． Ｔ細胞疲弊を処置するための組成物および方法
CA3173793A1 (en) 2020-04-03 2021-10-07 Andrew Ferguson Infectious disease antigens and vaccines
WO2022232289A1 (en) 2021-04-27 2022-11-03 Generation Bio Co. Non-viral dna vectors expressing therapeutic antibodies and uses thereof
AU2023235112A1 (en) 2022-03-14 2024-10-17 Generation Bio Co. Heterologous prime boost vaccine compositions and methods of use

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9003010D0 (en) * 1990-02-09 1990-04-04 Glaxo Group Ltd Gene expression in yeast cells
WO1993007897A1 (en) * 1991-10-21 1993-04-29 Medimmune, Inc. Bacterial expression vectors containing dna encoding secretion signals of lipoproteins
EP0903408A3 (de) * 1992-08-21 2005-11-02 Biogen, Inc. Tat-derivate Transport-Polypeptide
WO1994016737A1 (en) * 1993-01-26 1994-08-04 Weiner David B Compositions and methods for delivery of genetic material
PL322143A1 (en) * 1995-03-08 1998-01-05 Neovacs Non-topxic immunogenes originating frommretroviral regulator protein, antibodies as such, method of preparing them and pharmaceutic compositions containing them
GB9720585D0 (en) * 1997-09-26 1997-11-26 Smithkline Beecham Biolog Vaccine

Also Published As

Publication number Publication date
TR200000864T2 (tr) 2000-08-21
AU746564B2 (en) 2002-05-02
HK1030431A1 (en) 2001-05-04
ZA988789B (en) 2000-03-29
WO1999016884A1 (en) 1999-04-08
PL339432A1 (en) 2000-12-18
KR20010024287A (ko) 2001-03-26
NZ503482A (en) 2001-09-28
AR080331A2 (es) 2012-03-28
NO328824B1 (no) 2010-05-25
AU1025599A (en) 1999-04-23
CO4810339A1 (es) 1999-06-30
SI1015596T1 (sl) 2007-02-28
EP1015596A1 (de) 2000-07-05
CZ20001091A3 (cs) 2000-09-13
CZ302878B6 (cs) 2012-01-04
DE69835756T3 (de) 2010-09-30
JP2001518300A (ja) 2001-10-16
SA98190877B1 (ar) 2006-09-10
CN1188519C (zh) 2005-02-09
NO20001508L (no) 2000-05-18
AR017147A1 (es) 2001-08-22
PL195243B1 (pl) 2007-08-31
NO20001508D0 (no) 2000-03-23
PT1015596E (pt) 2006-12-29
CA2305013C (en) 2008-04-08
DK1015596T4 (da) 2010-07-12
BR9812547A (pt) 2000-07-25
ES2272012T3 (es) 2007-04-16
NO20076467L (no) 2000-05-18
HUP0004896A1 (hu) 2001-04-28
CN1279718A (zh) 2001-01-10
DE69835756T2 (de) 2007-09-13
EP1015596B1 (de) 2006-08-30
KR100554487B1 (ko) 2006-03-03
TW499436B (en) 2002-08-21
HUP0004896A3 (en) 2003-05-28
ES2272012T5 (es) 2010-07-06
GB9720585D0 (en) 1997-11-26
DE69835756D1 (de) 2006-10-12
IL135102A0 (en) 2001-05-20
CA2305013A1 (en) 1999-04-08
JP2009213492A (ja) 2009-09-24
EP1015596B2 (de) 2010-04-14
SI1015596T2 (sl) 2010-07-30
DK1015596T3 (da) 2007-01-02

Similar Documents

Publication Publication Date Title
DE69835756D1 (de) Hiv-1 tat und/oder nef enthaltende fusionsproteine
DE69804857D1 (de) Integritätsprüfung von elektroden
DE69432788D1 (de) Elektrolytloesung und daraus hergestelltes elektrochemisches element
DE69417753D1 (de) Wegwerfbare monatsunterhose
DE69803199D1 (de) Erkennung und entfernung von makroviren
DE69422791D1 (de) Sendung und Empfang von Programminformation
PT1024358E (pt) Densitómetro
NO983364D0 (no) Konsensusproteiner
DE69814367D1 (de) Filmueberzogene tabletten von oxacarbazepin
FI952900A7 (fi) Polypeptidi ja siitä valmistettu anti-HIV-aine
DE69625317D1 (de) Stift und diesen verwendendes Koordinatenablesesystem
DE69825625D1 (de) Aminobiguanide und ihre verwendung zur desinfektion von kontaktlinsen und konservierung von pharmazeutischen zubereitungen
TR199801301A3 (tr) Insan semaforin L(H-sema-L) ve diger türlerdeki mütekabil semaforinler.
DE69819963D1 (de) Schweissgegenstand und Schweissverfahren
DE69917011D1 (de) Handgelenkprothese
DE59400650D1 (de) Knopfzelle
DE69842206D1 (de) Echounterdrücker und echounterdrückungsverfahren
EP0679051A3 (de) Kontaktierung von Betätigungs- und Anzeigemitteln.
DE69502429D1 (de) Auflösung von Gas
DE69410083D1 (de) Desoxygenierung von cis-vicinalen diolen
AU2002300390A1 (en) Fusion proteins comprising HIV-1 TAT and/or NEF proteins
NO892591D0 (no) Polyfosfitter og deres anvendelse.
KR950016325U (ko) 일회용 재떨이
FI954611L (fi) Ig-CD4-fuusioproteiineja ja niiden käyttö HIV:n tai SIV:n havaitsemiseksi
DE59812220D1 (de) Halte- und trageband

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1015596

Country of ref document: EP

UEP Publication of translation of european patent specification

Ref document number: 1015596

Country of ref document: EP