ATE342888T1 - Verfahren zur herstellung von distamycin und derivaten unter iterativer verwendung von 1- methyl-4-formylamino-2-pyrrolcarbonsäurechlorid als zwischenverbinung - Google Patents
Verfahren zur herstellung von distamycin und derivaten unter iterativer verwendung von 1- methyl-4-formylamino-2-pyrrolcarbonsäurechlorid als zwischenverbinungInfo
- Publication number
- ATE342888T1 ATE342888T1 AT04735232T AT04735232T ATE342888T1 AT E342888 T1 ATE342888 T1 AT E342888T1 AT 04735232 T AT04735232 T AT 04735232T AT 04735232 T AT04735232 T AT 04735232T AT E342888 T1 ATE342888 T1 AT E342888T1
- Authority
- AT
- Austria
- Prior art keywords
- distamycin
- iteratively
- methyl
- formylamino
- pyrrol
- Prior art date
Links
- UPBAOYRENQEPJO-UHFFFAOYSA-N n-[5-[[5-[(3-amino-3-iminopropyl)carbamoyl]-1-methylpyrrol-3-yl]carbamoyl]-1-methylpyrrol-3-yl]-4-formamido-1-methylpyrrole-2-carboxamide Chemical compound CN1C=C(NC=O)C=C1C(=O)NC1=CN(C)C(C(=O)NC2=CN(C)C(C(=O)NCCC(N)=N)=C2)=C1 UPBAOYRENQEPJO-UHFFFAOYSA-N 0.000 title abstract 2
- 108010042747 stallimycin Proteins 0.000 title abstract 2
- YGYAWVDWMABLBF-UHFFFAOYSA-N Phosgene Chemical compound ClC(Cl)=O YGYAWVDWMABLBF-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 abstract 2
- QHKDIOCTRDVFNB-UHFFFAOYSA-N 3-amino-1h-pyrrole-2-carboxamide Chemical compound NC(=O)C=1NC=CC=1N QHKDIOCTRDVFNB-UHFFFAOYSA-N 0.000 abstract 1
- 239000000039 congener Substances 0.000 abstract 1
- 238000005516 engineering process Methods 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 238000006257 total synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyrrole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polyamides (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT001111A ITMI20031111A1 (it) | 2003-06-03 | 2003-06-03 | Processo per la sintesi della distramicina e analoghi poli-4-(1-metilpirrolo)-2-carbossiammidici. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE342888T1 true ATE342888T1 (de) | 2006-11-15 |
Family
ID=30131134
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04735232T ATE342888T1 (de) | 2003-06-03 | 2004-05-28 | Verfahren zur herstellung von distamycin und derivaten unter iterativer verwendung von 1- methyl-4-formylamino-2-pyrrolcarbonsäurechlorid als zwischenverbinung |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US7449547B2 (de) |
| EP (1) | EP1641753B1 (de) |
| AT (1) | ATE342888T1 (de) |
| DE (1) | DE602004002875D1 (de) |
| IT (1) | ITMI20031111A1 (de) |
| WO (1) | WO2004106301A1 (de) |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1263089B (it) * | 1993-04-26 | 1996-07-24 | Menarini Farma Ind | Composti pirrol-amidinici, processi di preparazione e composizioni farmaceutiche che li contengono. |
-
2003
- 2003-06-03 IT IT001111A patent/ITMI20031111A1/it unknown
-
2004
- 2004-05-28 EP EP04735232A patent/EP1641753B1/de not_active Expired - Lifetime
- 2004-05-28 AT AT04735232T patent/ATE342888T1/de not_active IP Right Cessation
- 2004-05-28 DE DE602004002875T patent/DE602004002875D1/de not_active Expired - Lifetime
- 2004-05-28 US US10/557,424 patent/US7449547B2/en not_active Expired - Fee Related
- 2004-05-28 WO PCT/EP2004/005821 patent/WO2004106301A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| WO2004106301A1 (en) | 2004-12-09 |
| US7449547B2 (en) | 2008-11-11 |
| US20070060523A1 (en) | 2007-03-15 |
| EP1641753A1 (de) | 2006-04-05 |
| EP1641753B1 (de) | 2006-10-18 |
| DE602004002875D1 (de) | 2006-11-30 |
| ITMI20031111A1 (it) | 2004-12-04 |
| ITMI20031111A0 (it) | 2003-06-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |