ATE353665T1 - Glp-2 enthaltende formulierungen - Google Patents
Glp-2 enthaltende formulierungenInfo
- Publication number
- ATE353665T1 ATE353665T1 AT00988416T AT00988416T ATE353665T1 AT E353665 T1 ATE353665 T1 AT E353665T1 AT 00988416 T AT00988416 T AT 00988416T AT 00988416 T AT00988416 T AT 00988416T AT E353665 T1 ATE353665 T1 AT E353665T1
- Authority
- AT
- Austria
- Prior art keywords
- glp
- formulations containing
- containing glp
- formulations
- histidine
- Prior art date
Links
- 101800000221 Glucagon-like peptide 2 Proteins 0.000 title abstract 4
- 102400000326 Glucagon-like peptide 2 Human genes 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 3
- TWSALRJGPBVBQU-PKQQPRCHSA-N glucagon-like peptide 2 Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(O)=O)[C@@H](C)CC)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)CC)C1=CC=CC=C1 TWSALRJGPBVBQU-PKQQPRCHSA-N 0.000 title abstract 2
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 abstract 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 abstract 1
- 229930195725 Mannitol Natural products 0.000 abstract 1
- 230000001747 exhibiting effect Effects 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 229960002885 histidine Drugs 0.000 abstract 1
- 235000010355 mannitol Nutrition 0.000 abstract 1
- 239000000594 mannitol Substances 0.000 abstract 1
- 239000008363 phosphate buffer Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Endocrinology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Inorganic Chemistry (AREA)
- Dermatology (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9930882.7A GB9930882D0 (en) | 1999-12-30 | 1999-12-30 | GLP-2 formulations |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE353665T1 true ATE353665T1 (de) | 2007-03-15 |
Family
ID=10867197
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00988416T ATE353665T1 (de) | 1999-12-30 | 2000-12-29 | Glp-2 enthaltende formulierungen |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US7056886B2 (de) |
| EP (1) | EP1246639B1 (de) |
| JP (3) | JP5001498B2 (de) |
| AT (1) | ATE353665T1 (de) |
| AU (1) | AU782110B2 (de) |
| CA (1) | CA2395814C (de) |
| CY (1) | CY1106558T1 (de) |
| DE (1) | DE60033437T2 (de) |
| DK (1) | DK1246639T3 (de) |
| ES (1) | ES2282161T3 (de) |
| GB (1) | GB9930882D0 (de) |
| PT (1) | PT1246639E (de) |
| WO (1) | WO2001049314A2 (de) |
Families Citing this family (86)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6057287A (en) | 1994-01-11 | 2000-05-02 | Dyax Corp. | Kallikrein-binding "Kunitz domain" proteins and analogues thereof |
| US20020025933A1 (en) * | 1996-08-30 | 2002-02-28 | Knudsen Liselotte Bjerre | GLP-2 derivatives |
| GB9930882D0 (en) * | 1999-12-30 | 2000-02-23 | Nps Allelix Corp | GLP-2 formulations |
| US20030119734A1 (en) | 2001-06-28 | 2003-06-26 | Flink James M. | Stable formulation of modified GLP-1 |
| WO2003099854A2 (en) | 2002-05-24 | 2003-12-04 | Nps Allelix Corp. | Method for enzymatic production of glp-2(1-33) and glp-2-(1-34) peptides |
| DK2311432T3 (en) * | 2002-06-07 | 2015-02-02 | Dyax Corp | Modified Kunitz domain polypeptides and their use in reducing ischemia or the onset of a systemic inflammatory response associated with a surgical procedure |
| US7153829B2 (en) * | 2002-06-07 | 2006-12-26 | Dyax Corp. | Kallikrein-inhibitor therapies |
| TR201900937T4 (tr) * | 2002-08-28 | 2019-02-21 | Dyax Corp | Organların ve dokuların muhafaza edilmesine yönelik yöntem. |
| WO2004035624A2 (en) * | 2002-10-14 | 2004-04-29 | Novo Nordisk A/S | Glucagon - like peptide - 2 variants |
| CN1812808B (zh) * | 2003-06-03 | 2012-07-04 | 诺沃挪第克公司 | 稳定化的药物肽组合物 |
| JP4936884B2 (ja) * | 2003-06-03 | 2012-05-23 | ノボ・ノルデイスク・エー/エス | 安定化された薬学的ペプチド組成物 |
| WO2004105790A1 (en) * | 2003-06-03 | 2004-12-09 | Novo Nordisk A/S | Stabilized pharmaceutical peptide compositions |
| EP2107069B1 (de) | 2003-08-05 | 2013-01-16 | Novo Nordisk A/S | Neuartige Insulinderivate |
| US20060247167A1 (en) * | 2003-09-01 | 2006-11-02 | Novo Nordisk A/S | Stable formulations of peptides |
| EP1663295A2 (de) * | 2003-09-01 | 2006-06-07 | Novo Nordisk A/S | Stabilisierte peptidformulierungen |
| JP2007534633A (ja) * | 2003-11-10 | 2007-11-29 | アライバ−プロメティック インコーポレイティド | ヒト・アルファ1−抗トリプシン製剤 |
| PT1687019T (pt) | 2003-11-20 | 2018-02-26 | Novo Nordisk As | Formulações de péptidos que contêm polietileno glicol que são ótimas para produção e para utilização em dispositivos de injeção |
| HRP20120315T1 (hr) * | 2003-11-21 | 2012-05-31 | Nps Pharmaceuticals | Proizvodnja peptida 2 nalik glukagonu i analoga |
| EP1789434B1 (de) * | 2004-08-31 | 2013-11-20 | Novo Nordisk A/S | Verwendung von tris(hydroxymethyl)-aminomethan zur stabilisierung von peptiden, polypeptiden und proteinen |
| US7235530B2 (en) * | 2004-09-27 | 2007-06-26 | Dyax Corporation | Kallikrein inhibitors and anti-thrombolytic agents and uses thereof |
| US7847061B2 (en) | 2004-11-01 | 2010-12-07 | Nps Pharmaceuticals, Inc. | Treatment of short bowel syndrome patients with colon-in-continuity |
| EP2494983B1 (de) * | 2004-11-12 | 2019-04-24 | Novo Nordisk A/S | Stabile formulierung von glp-1 |
| CN100418983C (zh) * | 2005-05-11 | 2008-09-17 | 中国药科大学 | 人胰高血糖素相关肽-2类似物 |
| PL1931350T5 (pl) | 2005-09-14 | 2021-11-15 | Takeda Pharmaceutical Company Limited | Podanie inhibitorów dipeptydylo-peptydazy |
| WO2007033427A1 (en) * | 2005-09-23 | 2007-03-29 | Metabolic Pharmaceuticals Limited | Stabilisation of peptides with basic amino acids |
| US20090074882A1 (en) | 2005-12-28 | 2009-03-19 | Novo Nordisk A/S | Insulin compositions and method of making a composition |
| EP2001500A4 (de) * | 2006-03-10 | 2010-07-28 | Dyax Corp | Formulierungen für ecallantid |
| EP2150537A4 (de) * | 2007-06-01 | 2010-09-22 | Acologix Inc | Hochtemperaturstabile peptidformulierung |
| JP5552046B2 (ja) | 2007-06-13 | 2014-07-16 | ノボ・ノルデイスク・エー/エス | インスリン誘導体を含有する薬学的製剤 |
| EP2337585A1 (de) * | 2008-09-19 | 2011-06-29 | Nektar Therapeutics | Polymerkonjugate von glp-2-artigen peptiden |
| KR20110085985A (ko) | 2008-10-30 | 2011-07-27 | 노보 노르디스크 에이/에스 | 하루 한번 주사 빈도보다 적은 인슐린 주사를 사용한 진성 당뇨병의 치료 |
| US8637454B2 (en) * | 2009-01-06 | 2014-01-28 | Dyax Corp. | Treatment of mucositis with kallikrein inhibitors |
| WO2011041293A1 (en) | 2009-09-30 | 2011-04-07 | Takeda Pharmaceutical Company Limited | Pyrazolo [1, 5-a] pyrimidine derivatives as apoptosis signal-regulating kinase 1 inhibitors |
| US9610329B2 (en) | 2009-10-22 | 2017-04-04 | Albireo Pharma, Inc. | Stabilized glucagon solutions |
| DK2490708T3 (da) * | 2009-10-22 | 2013-04-15 | Biodel Inc | Stabiliserede glucagon-opløsninger |
| EP2314616A1 (de) * | 2009-10-23 | 2011-04-27 | Ferring B.V. | GLP-2-Peptid-Agonisten |
| ES2688093T3 (es) | 2010-01-06 | 2018-10-30 | Dyax Corp. | Proteínas de unión a calicreína plasmática |
| WO2011097079A1 (en) | 2010-02-03 | 2011-08-11 | Takeda Pharmaceutical Company Limited | Apoptosis signal-regulating kinase 1 inhibitors |
| EP2611825B1 (de) | 2010-08-30 | 2015-09-02 | NPS Pharmaceuticals, Inc. | Festphasensynthese von h(gly2)glp-2 |
| BR112013010345A2 (pt) | 2010-10-27 | 2017-07-25 | Novo Nordisk As | tratamento de diabetes melitus usando as injeções de insulina administradas com intervalos de variação da injeção |
| IL269565B2 (en) | 2011-01-06 | 2024-06-01 | Dyax Corp | Plasma kallikrein binding proteins |
| SG194570A1 (en) * | 2011-04-22 | 2013-12-30 | Radius Health Inc | Method of drug delivery for pth, pthrp and related peptides |
| AU2012345768B2 (en) | 2011-11-30 | 2016-05-12 | Kindeva Drug Delivery L.P. | Microneedle device having a peptide therapeutic agent and an amino acid, methods of making and using the same |
| UA116217C2 (uk) | 2012-10-09 | 2018-02-26 | Санофі | Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону |
| JP2016506401A (ja) | 2012-12-21 | 2016-03-03 | サノフイ | 二重glp1/gipまたは三方glp1/gip/グルカゴンアゴニストとしてのエキセンジン−4誘導体 |
| JP2016519127A (ja) | 2013-04-30 | 2016-06-30 | ノヴォ ノルディスク アー/エス | 新規投与レジメン |
| TW201609799A (zh) | 2013-12-13 | 2016-03-16 | 賽諾菲公司 | 雙重glp-1/gip受體促效劑 |
| EP3080150B1 (de) | 2013-12-13 | 2018-08-01 | Sanofi | Exendin-4-peptidanaloga als duale glp-1/gip-rezeptoragonisten |
| TW201609796A (zh) | 2013-12-13 | 2016-03-16 | 賽諾菲公司 | 非醯化之艾塞那肽-4(exendin-4)胜肽類似物 |
| WO2015086733A1 (en) | 2013-12-13 | 2015-06-18 | Sanofi | Dual glp-1/glucagon receptor agonists |
| EP3122782A4 (de) | 2014-03-27 | 2017-09-13 | Dyax Corp. | Zusammensetzungen und verfahren zur behandlung von diabetischem makulaödem |
| RS67458B1 (sr) | 2014-03-28 | 2025-12-31 | Univ Duke | Lečenje kancera dojke pozitivnog na receptor estrogena upotrebom selektivnih modulatora receptora estrogena |
| TW201625670A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自exendin-4之雙重glp-1/升糖素受體促效劑 |
| TW201625669A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自艾塞那肽-4(Exendin-4)之肽類雙重GLP-1/升糖素受體促效劑 |
| TW201625668A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 作為胜肽性雙重glp-1/昇糖素受體激動劑之艾塞那肽-4衍生物 |
| US9932381B2 (en) | 2014-06-18 | 2018-04-03 | Sanofi | Exendin-4 derivatives as selective glucagon receptor agonists |
| CN104146969A (zh) * | 2014-07-31 | 2014-11-19 | 浙江美华鼎昌医药科技有限公司 | 注射用或输注用比伐卢定冻干粉针制剂的制备方法 |
| KR102676629B1 (ko) | 2015-04-29 | 2024-06-18 | 래디어스 파마슈티컬스, 인코포레이티드 | 암을 치료하는 방법 |
| AR105319A1 (es) | 2015-06-05 | 2017-09-27 | Sanofi Sa | Profármacos que comprenden un conjugado agonista dual de glp-1 / glucagón conector ácido hialurónico |
| TW201706291A (zh) | 2015-07-10 | 2017-02-16 | 賽諾菲公司 | 作為選擇性肽雙重glp-1/升糖素受體促效劑之新毒蜥外泌肽(exendin-4)衍生物 |
| AU2015416589B2 (en) * | 2015-12-10 | 2021-04-01 | Menicon Co., Ltd. | Peptide composition |
| BR112018011622A2 (pt) | 2015-12-11 | 2018-11-27 | Dyax Corp | método para tratar ataque de angioedema hereditário (hae) ou reduzir a taxa de ataque de hae |
| CN118078956A (zh) * | 2016-05-06 | 2024-05-28 | 免疫新炉有限公司 | 用于受控和持续释放的elp融合蛋白 |
| EP3296746A1 (de) * | 2016-09-20 | 2018-03-21 | Université de Bourgogne | In-vitro-verfahren zur diagnose eines frühstadiums von darmischämie |
| TWI591177B (zh) | 2016-10-27 | 2017-07-11 | 中化合成生技股份有限公司 | 一種胰高血糖素胜肽-2(glp-2)類似物的製備方法 |
| KR102881465B1 (ko) | 2017-01-05 | 2025-11-04 | 래디어스 파마슈티컬스, 인코포레이티드 | Rad1901-2hcl의 다형 형태 |
| WO2018142363A1 (en) * | 2017-02-06 | 2018-08-09 | Orbicular Pharmaceutical Technologies Private Limited | Ready to use compositions of glp-2 analogues through self-administrable devices |
| CA3090767A1 (en) | 2017-02-27 | 2018-08-30 | Urigen N.A. | Treatment of lower urinary tract epithelium with glucagon like peptide 2 |
| ES2894629T3 (es) | 2017-06-16 | 2022-02-15 | Zealand Pharma As | Pautas posológicas para la administración de análogos del péptido 2 similar al glucagón (GLP-2) |
| HUE066356T2 (hu) | 2017-08-24 | 2024-07-28 | Novo Nordisk As | GLP-1 készítmények és alkalmazásaik |
| FR3072875B1 (fr) * | 2017-10-31 | 2020-11-06 | Adocia | Composition comprenant un agoniste du recepteur du glp-2 et un co-polyaminoacide porteur de charges carboxylates et de radicaux hydrophobes |
| WO2019086559A1 (fr) | 2017-10-31 | 2019-05-09 | Adocia | Composition comprenant un agoniste du recepteur du glp-2 et un co-polyaminoacide porteur de charges carboxylates et de radicaux hydrophobes |
| FR3079414B1 (fr) * | 2018-03-27 | 2020-05-01 | Adocia | Composition comprenant un agoniste du recepteur du glp-2 et un co-polyaminoacide porteur de charges carboxylates et de radicaux hydrophobes |
| US10335464B1 (en) | 2018-06-26 | 2019-07-02 | Novo Nordisk A/S | Device for titrating basal insulin |
| CN112423844B (zh) | 2018-07-04 | 2024-08-13 | 雷迪厄斯制药公司 | Rad1901-2hcl的多晶型形式 |
| EP3628682A1 (de) | 2018-09-28 | 2020-04-01 | Zealand Pharma A/S | Formulierungen von analoga des glucagon-like-peptid-2 (glp-2) |
| EP3628683A1 (de) * | 2018-09-28 | 2020-04-01 | Zealand Pharma A/S | Formulierungen von analoga des glucagon-like-peptid-2 (glp-2) |
| IL281938B2 (en) | 2018-10-26 | 2024-04-01 | Novo Nordisk As | Stable semaglutide compositions and uses thereof |
| JOP20210218A1 (ar) | 2019-02-12 | 2023-01-30 | Radius Pharmaceuticals Inc | عمليات ومركبات |
| SG11202111312UA (en) | 2019-06-14 | 2021-12-30 | Zealand Pharma As | Pharmaceutical parenteral composition of dual glp1/2 agonist |
| US12343383B2 (en) | 2019-07-12 | 2025-07-01 | Novo Nordisk A/S | High concentration insulin formulation |
| CN121197633A (zh) | 2019-12-13 | 2025-12-26 | 比特比德科有限责任公司 | 用于将治疗剂递送至胃肠道的可摄取装置 |
| CA3167336A1 (en) | 2020-01-13 | 2021-07-22 | Takeda Pharmaceutical Company Limited | Plasma kallikrein inhibitors and uses thereof for treating pediatric hereditary angioedema attack |
| PE20221575A1 (es) * | 2020-02-18 | 2022-10-06 | Novo Nordisk As | Formulaciones farmaceuticas |
| CA3179472A1 (en) * | 2020-05-22 | 2021-11-25 | Sung Hee Hong | Liquid formulation of long-acting conjugate of glp-2 |
| KR20230038187A (ko) | 2020-06-09 | 2023-03-17 | 벡티브바이오 에이지 | 아프라글루타이드의 제조, 제형화 및 투여 |
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| JPS63307827A (ja) * | 1987-06-08 | 1988-12-15 | Kitasato Inst:The | 安定化された生ウイルスワクチンおよびその製造法 |
| US5997856A (en) * | 1988-10-05 | 1999-12-07 | Chiron Corporation | Method and compositions for solubilization and stabilization of polypeptides, especially proteins |
| US5652216A (en) * | 1994-05-26 | 1997-07-29 | Novo Nordisk A/S | Pharmaceutical preparation |
| CA2226575C (en) * | 1995-07-27 | 2011-10-18 | Genentech, Inc. | Stabile isotonic lyophilized protein formulation |
| US5912229A (en) * | 1996-03-01 | 1999-06-15 | Novo Nordisk Als | Use of a pharmaceutical composition comprising an appetite-suppressing peptide |
| EP0906338B1 (de) * | 1996-04-12 | 2002-11-06 | 1149336 Ontario Inc. | Analoge des glucagon ähnlichen peptides -2 |
| TW518219B (en) * | 1996-04-26 | 2003-01-21 | Chugai Pharmaceutical Co Ltd | Erythropoietin solution preparation |
| US5994500A (en) | 1996-07-19 | 1999-11-30 | 1149336 Ontario Inc. | Antagonists of intestinotrophic GLP-2 peptides |
| US5952301A (en) * | 1996-12-10 | 1999-09-14 | 1149336 Ontario Inc. | Compositions and methods for enhancing intestinal function |
| ATE358682T1 (de) * | 1996-12-13 | 2007-04-15 | Allelix Biopharma | Klonierte rezeptoren des glukagon-ähnlichen peptids-2 |
| JP2002504527A (ja) * | 1998-02-27 | 2002-02-12 | ノボ ノルディスク アクティーゼルスカブ | 部分的に組織化したミセル様凝集物を形成する25%を越えるヘリックス成分を有するglp−2誘導体 |
| GB9930882D0 (en) * | 1999-12-30 | 2000-02-23 | Nps Allelix Corp | GLP-2 formulations |
-
1999
- 1999-12-30 GB GBGB9930882.7A patent/GB9930882D0/en not_active Ceased
-
2000
- 2000-12-29 JP JP2001549681A patent/JP5001498B2/ja not_active Expired - Lifetime
- 2000-12-29 AT AT00988416T patent/ATE353665T1/de active
- 2000-12-29 DK DK00988416T patent/DK1246639T3/da active
- 2000-12-29 AU AU24626/01A patent/AU782110B2/en not_active Expired
- 2000-12-29 US US09/750,022 patent/US7056886B2/en not_active Expired - Lifetime
- 2000-12-29 CA CA2395814A patent/CA2395814C/en not_active Expired - Lifetime
- 2000-12-29 DE DE60033437T patent/DE60033437T2/de not_active Expired - Lifetime
- 2000-12-29 EP EP00988416A patent/EP1246639B1/de not_active Expired - Lifetime
- 2000-12-29 ES ES00988416T patent/ES2282161T3/es not_active Expired - Lifetime
- 2000-12-29 PT PT00988416T patent/PT1246639E/pt unknown
- 2000-12-29 WO PCT/US2000/035512 patent/WO2001049314A2/en not_active Ceased
-
2007
- 2007-05-04 CY CY20071100588T patent/CY1106558T1/el unknown
-
2012
- 2012-02-10 JP JP2012027323A patent/JP5604463B2/ja not_active Expired - Lifetime
-
2014
- 2014-05-07 JP JP2014095701A patent/JP5934739B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CA2395814A1 (en) | 2001-07-12 |
| US20010027180A1 (en) | 2001-10-04 |
| CA2395814C (en) | 2011-09-20 |
| EP1246639A2 (de) | 2002-10-09 |
| JP2014159463A (ja) | 2014-09-04 |
| ES2282161T3 (es) | 2007-10-16 |
| CY1106558T1 (el) | 2012-01-25 |
| WO2001049314A2 (en) | 2001-07-12 |
| GB9930882D0 (en) | 2000-02-23 |
| JP5604463B2 (ja) | 2014-10-08 |
| JP2003519195A (ja) | 2003-06-17 |
| PT1246639E (pt) | 2007-05-31 |
| AU782110B2 (en) | 2005-07-07 |
| US7056886B2 (en) | 2006-06-06 |
| JP5934739B2 (ja) | 2016-06-15 |
| WO2001049314A3 (en) | 2002-01-03 |
| EP1246639B1 (de) | 2007-02-14 |
| JP5001498B2 (ja) | 2012-08-15 |
| AU2462601A (en) | 2001-07-16 |
| DE60033437D1 (de) | 2007-03-29 |
| JP2012116861A (ja) | 2012-06-21 |
| DE60033437T2 (de) | 2007-11-29 |
| DK1246639T3 (da) | 2007-06-11 |
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