ATE353665T1 - Glp-2 enthaltende formulierungen - Google Patents
Glp-2 enthaltende formulierungenInfo
- Publication number
- ATE353665T1 ATE353665T1 AT00988416T AT00988416T ATE353665T1 AT E353665 T1 ATE353665 T1 AT E353665T1 AT 00988416 T AT00988416 T AT 00988416T AT 00988416 T AT00988416 T AT 00988416T AT E353665 T1 ATE353665 T1 AT E353665T1
- Authority
- AT
- Austria
- Prior art keywords
- glp
- formulations containing
- containing glp
- formulations
- histidine
- Prior art date
Links
- 101800000221 Glucagon-like peptide 2 Proteins 0.000 title abstract 4
- 102400000326 Glucagon-like peptide 2 Human genes 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 3
- TWSALRJGPBVBQU-PKQQPRCHSA-N glucagon-like peptide 2 Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(O)=O)[C@@H](C)CC)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)CC)C1=CC=CC=C1 TWSALRJGPBVBQU-PKQQPRCHSA-N 0.000 title abstract 2
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 abstract 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 abstract 1
- 229930195725 Mannitol Natural products 0.000 abstract 1
- 230000001747 exhibiting effect Effects 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 229960002885 histidine Drugs 0.000 abstract 1
- 235000010355 mannitol Nutrition 0.000 abstract 1
- 239000000594 mannitol Substances 0.000 abstract 1
- 239000008363 phosphate buffer Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Inorganic Chemistry (AREA)
- Dermatology (AREA)
- Biochemistry (AREA)
- Endocrinology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9930882.7A GB9930882D0 (en) | 1999-12-30 | 1999-12-30 | GLP-2 formulations |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE353665T1 true ATE353665T1 (de) | 2007-03-15 |
Family
ID=10867197
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00988416T ATE353665T1 (de) | 1999-12-30 | 2000-12-29 | Glp-2 enthaltende formulierungen |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US7056886B2 (de) |
| EP (1) | EP1246639B1 (de) |
| JP (3) | JP5001498B2 (de) |
| AT (1) | ATE353665T1 (de) |
| AU (1) | AU782110B2 (de) |
| CA (1) | CA2395814C (de) |
| CY (1) | CY1106558T1 (de) |
| DE (1) | DE60033437T2 (de) |
| DK (1) | DK1246639T3 (de) |
| ES (1) | ES2282161T3 (de) |
| GB (1) | GB9930882D0 (de) |
| PT (1) | PT1246639E (de) |
| WO (1) | WO2001049314A2 (de) |
Families Citing this family (85)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6057287A (en) * | 1994-01-11 | 2000-05-02 | Dyax Corp. | Kallikrein-binding "Kunitz domain" proteins and analogues thereof |
| US20020025933A1 (en) * | 1996-08-30 | 2002-02-28 | Knudsen Liselotte Bjerre | GLP-2 derivatives |
| GB9930882D0 (en) * | 1999-12-30 | 2000-02-23 | Nps Allelix Corp | GLP-2 formulations |
| EP1412384B1 (de) | 2001-06-28 | 2007-12-26 | Novo Nordisk A/S | Stabile formulierung von modifiziertem glp-1 |
| EP1572720A4 (de) | 2002-05-24 | 2008-12-24 | Nps Allelix Corp | Verfahren zur enzymatischen herstellung von glp-2-(1-33)- und glp-2-(1-34)-peptiden |
| US7153829B2 (en) * | 2002-06-07 | 2006-12-26 | Dyax Corp. | Kallikrein-inhibitor therapies |
| CA2488558C (en) * | 2002-06-07 | 2013-08-20 | Dyax Corp. | Prevention and reduction of blood loss |
| ES2709103T3 (es) | 2002-08-28 | 2019-04-15 | Dyax Corp | Métodos para conservar órganos y tejidos |
| US7411039B2 (en) * | 2002-10-14 | 2008-08-12 | Novo Nordisk A/S | GLP-2 compounds, formulations, and uses thereof |
| CN1812808B (zh) * | 2003-06-03 | 2012-07-04 | 诺沃挪第克公司 | 稳定化的药物肽组合物 |
| BRPI0410972C1 (pt) * | 2003-06-03 | 2021-05-25 | Novo Nordisk As | método para aumentar a vida de armazenagem de uma composição farmacêutica, composição farmacêutica, e, método para tratamento de hiperglicemia |
| EP1633391B1 (de) * | 2003-06-03 | 2011-10-19 | Novo Nordisk A/S | Stabilisierte pharmazeutische peptid zusammensetzungen |
| KR101159559B1 (ko) | 2003-08-05 | 2012-06-26 | 노보 노르디스크 에이/에스 | 신규의 인슐린 유도체 |
| US20060247167A1 (en) * | 2003-09-01 | 2006-11-02 | Novo Nordisk A/S | Stable formulations of peptides |
| WO2005021022A2 (en) * | 2003-09-01 | 2005-03-10 | Novo Nordisk A/S | Stable formulations of peptides |
| EP1685160A1 (de) * | 2003-11-10 | 2006-08-02 | Arriva-Prometic Inc. | Trockene rekombinante humane alpha 1-antitrypsin-zusammensetzung |
| DK3300721T4 (da) | 2003-11-20 | 2025-03-03 | Novo Nordisk As | Propylenglycol-holdige peptidformuleringer hvilke er optimale til fremstilling og til anvendelse i injektionsindretninger |
| SI1704234T1 (sl) | 2003-11-21 | 2012-08-31 | Nps Pharma Inc | Proizvodnja glukagonu podobnih peptidov 2 in analogov |
| PL1789434T3 (pl) * | 2004-08-31 | 2014-07-31 | Novo Nordisk As | Zastosowanie tris(hydroksymetylo)aminometanu do stabilizacji peptydów, polipeptydów i białek |
| US7235530B2 (en) * | 2004-09-27 | 2007-06-26 | Dyax Corporation | Kallikrein inhibitors and anti-thrombolytic agents and uses thereof |
| WO2006050244A2 (en) | 2004-11-01 | 2006-05-11 | Nps Allelix Corp. | Treatment of short bowel syndrome patients with colon-in-continuity |
| CN106137952B (zh) | 2004-11-12 | 2020-11-17 | 诺和诺德公司 | 促胰岛素肽的稳定制剂 |
| CN100418983C (zh) * | 2005-05-11 | 2008-09-17 | 中国药科大学 | 人胰高血糖素相关肽-2类似物 |
| CA2622608C (en) | 2005-09-14 | 2014-08-19 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors for treating diabetes |
| WO2007033427A1 (en) * | 2005-09-23 | 2007-03-29 | Metabolic Pharmaceuticals Limited | Stabilisation of peptides with basic amino acids |
| US20090074882A1 (en) | 2005-12-28 | 2009-03-19 | Novo Nordisk A/S | Insulin compositions and method of making a composition |
| CA2643693A1 (en) * | 2006-03-10 | 2007-09-20 | Dyax Corp. | Formulations for ecallantide |
| US7879805B2 (en) | 2007-06-01 | 2011-02-01 | Acologix, Inc. | High temperature stable peptide formulation |
| WO2008152106A1 (en) | 2007-06-13 | 2008-12-18 | Novo Nordisk A/S | Pharmaceutical formulation comprising an insulin derivative |
| WO2010042145A1 (en) * | 2008-09-19 | 2010-04-15 | Nektar Therapeutics | Polymer conjugates of glp-2-like peptides |
| CA2738615A1 (en) | 2008-10-30 | 2010-05-06 | Novo Nordisk A/S | Treating diabetes melitus using insulin injections with less than daily injection frequency |
| US8637454B2 (en) * | 2009-01-06 | 2014-01-28 | Dyax Corp. | Treatment of mucositis with kallikrein inhibitors |
| WO2011041293A1 (en) | 2009-09-30 | 2011-04-07 | Takeda Pharmaceutical Company Limited | Pyrazolo [1, 5-a] pyrimidine derivatives as apoptosis signal-regulating kinase 1 inhibitors |
| US9610329B2 (en) | 2009-10-22 | 2017-04-04 | Albireo Pharma, Inc. | Stabilized glucagon solutions |
| WO2011049713A2 (en) * | 2009-10-22 | 2011-04-28 | Biodel Inc. | Stabilized glucagon solutions |
| EP2314616A1 (de) * | 2009-10-23 | 2011-04-27 | Ferring B.V. | GLP-2-Peptid-Agonisten |
| RS62853B1 (sr) | 2010-01-06 | 2022-02-28 | Takeda Pharmaceuticals Co | Proteini koji vezuju kalikrein plazme |
| SI2531501T1 (sl) | 2010-02-03 | 2014-04-30 | Takeda Pharmaceutical Company Limited | Inhibitorji kinaze-1, ki regulirajo signal apoptoze |
| JP5908478B2 (ja) | 2010-08-30 | 2016-04-26 | エヌピーエス ファーマシューティカルズ インコーポレイテッドNps Pharmaceuticals, Inc. | h「Gly2」GLP−2の固相合成 |
| JP6049625B2 (ja) | 2010-10-27 | 2016-12-21 | ノヴォ ノルディスク アー/エス | 様々な注射間隔を用いて施されるインスリン注射を使用する、真性糖尿病の治療 |
| AU2012204202A1 (en) | 2011-01-06 | 2013-07-11 | Dyax Corp. | Plasma kallikrein binding proteins |
| CA2833571A1 (en) * | 2011-04-22 | 2012-10-26 | Radius Health, Inc. | Method of drug delivery for pth, pthrp and related peptides |
| AU2012345768B2 (en) | 2011-11-30 | 2016-05-12 | Kindeva Drug Delivery L.P. | Microneedle device having a peptide therapeutic agent and an amino acid, methods of making and using the same |
| UA116217C2 (uk) | 2012-10-09 | 2018-02-26 | Санофі | Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону |
| SG10201705097PA (en) | 2012-12-21 | 2017-07-28 | Sanofi Sa | Functionalized exendin-4 derivatives |
| WO2014177623A1 (en) | 2013-04-30 | 2014-11-06 | Novo Nordisk A/S | Novel administration regime |
| EP3080149A1 (de) | 2013-12-13 | 2016-10-19 | Sanofi | Duale glp-1-/glucagon-rezeptoragonisten |
| WO2015086729A1 (en) | 2013-12-13 | 2015-06-18 | Sanofi | Dual glp-1/gip receptor agonists |
| WO2015086730A1 (en) | 2013-12-13 | 2015-06-18 | Sanofi | Non-acylated exendin-4 peptide analogues |
| TW201609795A (zh) | 2013-12-13 | 2016-03-16 | 賽諾菲公司 | 作為雙重glp-1/gip受體促效劑的艾塞那肽-4(exendin-4)胜肽類似物 |
| AU2015235967B2 (en) | 2014-03-27 | 2020-10-22 | Takeda Pharmaceutical Company Limited | Compositions and methods for treatment of diabetic macular edema |
| EP4035664A3 (de) | 2014-03-28 | 2022-11-30 | Duke University | Behandlung von krebs unter verwendung von selektiven östrogenrezeptormodulatoren |
| TW201625668A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 作為胜肽性雙重glp-1/昇糖素受體激動劑之艾塞那肽-4衍生物 |
| TW201625669A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自艾塞那肽-4(Exendin-4)之肽類雙重GLP-1/升糖素受體促效劑 |
| TW201625670A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自exendin-4之雙重glp-1/升糖素受體促效劑 |
| US9932381B2 (en) | 2014-06-18 | 2018-04-03 | Sanofi | Exendin-4 derivatives as selective glucagon receptor agonists |
| CN104146969A (zh) * | 2014-07-31 | 2014-11-19 | 浙江美华鼎昌医药科技有限公司 | 注射用或输注用比伐卢定冻干粉针制剂的制备方法 |
| MX393599B (es) | 2015-04-29 | 2025-03-19 | Radius Pharmaceuticals Inc | Rad1901 para usarse en el tratamiento de cancer en sujetos con cancer positivo a receptor de estrogeno alfa resistente a farmaco |
| AR105319A1 (es) | 2015-06-05 | 2017-09-27 | Sanofi Sa | Profármacos que comprenden un conjugado agonista dual de glp-1 / glucagón conector ácido hialurónico |
| AR105284A1 (es) | 2015-07-10 | 2017-09-20 | Sanofi Sa | Derivados de exendina-4 como agonistas peptídicos duales específicos de los receptores de glp-1 / glucagón |
| EP3388089B1 (de) * | 2015-12-10 | 2022-05-18 | Menicon Co., Ltd. | Peptidzusammensetzung |
| CN116077648A (zh) | 2015-12-11 | 2023-05-09 | 武田药品工业株式会社 | 血浆激肽释放酶抑制剂及其治疗遗传性血管性水肿发作的用途 |
| EP3296746A1 (de) * | 2016-09-20 | 2018-03-21 | Université de Bourgogne | In-vitro-verfahren zur diagnose eines frühstadiums von darmischämie |
| TWI591177B (zh) | 2016-10-27 | 2017-07-11 | 中化合成生技股份有限公司 | 一種胰高血糖素胜肽-2(glp-2)類似物的製備方法 |
| DK3565542T3 (da) | 2017-01-05 | 2024-07-01 | Radius Pharmaceuticals Inc | Polymorphic forms of rad1901-2hcl |
| WO2018142363A1 (en) * | 2017-02-06 | 2018-08-09 | Orbicular Pharmaceutical Technologies Private Limited | Ready to use compositions of glp-2 analogues through self-administrable devices |
| CA3090767A1 (en) | 2017-02-27 | 2018-08-30 | Urigen N.A. | Treatment of lower urinary tract epithelium with glucagon like peptide 2 |
| DK3881861T3 (da) | 2017-06-16 | 2024-09-09 | Zealand Pharma As | Doseringsregimer for indgivelse af glukagonlignende peptid-2- (GLP-2)-analoger |
| TWI847306B (zh) | 2017-08-24 | 2024-07-01 | 丹麥商諾佛 儂迪克股份有限公司 | Glp-1組成物及其用途 |
| WO2019086559A1 (fr) | 2017-10-31 | 2019-05-09 | Adocia | Composition comprenant un agoniste du recepteur du glp-2 et un co-polyaminoacide porteur de charges carboxylates et de radicaux hydrophobes |
| FR3072875B1 (fr) * | 2017-10-31 | 2020-11-06 | Adocia | Composition comprenant un agoniste du recepteur du glp-2 et un co-polyaminoacide porteur de charges carboxylates et de radicaux hydrophobes |
| FR3079414B1 (fr) * | 2018-03-27 | 2020-05-01 | Adocia | Composition comprenant un agoniste du recepteur du glp-2 et un co-polyaminoacide porteur de charges carboxylates et de radicaux hydrophobes |
| US10335464B1 (en) | 2018-06-26 | 2019-07-02 | Novo Nordisk A/S | Device for titrating basal insulin |
| KR102792490B1 (ko) | 2018-07-04 | 2025-04-04 | 래디어스 파마슈티컬스, 인코포레이티드 | Rad1901-2hcl의 다형 형태 |
| EP3628683A1 (de) | 2018-09-28 | 2020-04-01 | Zealand Pharma A/S | Formulierungen von analoga des glucagon-like-peptid-2 (glp-2) |
| EP3628682A1 (de) | 2018-09-28 | 2020-04-01 | Zealand Pharma A/S | Formulierungen von analoga des glucagon-like-peptid-2 (glp-2) |
| JP7422754B2 (ja) * | 2018-10-26 | 2024-01-26 | ノヴォ ノルディスク アー/エス | 安定性セマグルチド組成物およびその使用 |
| MX2021009569A (es) | 2019-02-12 | 2021-09-08 | Radius Pharmaceuticals Inc | Procesos y compuestos. |
| CA3138715A1 (en) | 2019-06-14 | 2020-12-17 | Zealand Pharma A/S | Pharmaceutical parenteral composition of dual glp1/2 agonist |
| CN114096269B (zh) | 2019-07-12 | 2024-06-11 | 诺和诺德股份有限公司 | 高浓度胰岛素制剂 |
| WO2021119482A1 (en) | 2019-12-13 | 2021-06-17 | Progenity, Inc. | Ingestible device for delivery of therapeutic agent to the gastrointestinal tract |
| MX2022008649A (es) | 2020-01-13 | 2022-09-23 | Takeda Pharmaceuticals Co | Inhibidores de calicreina plasmatica y sus usos para tratar episodios de angioedema hereditario pediatrico. |
| BR112022013795A2 (pt) | 2020-02-18 | 2022-09-13 | Novo Nordisk As | Composição farmacêutica líquida, e, kit |
| EP4154869A4 (de) * | 2020-05-22 | 2025-01-22 | Hanmi Pharm. Co., Ltd. | Flüssige formulierung eines langwirkenden glp-2-konjugats |
| AU2021286563A1 (en) | 2020-06-09 | 2023-01-19 | Vectivbio Ag | Manufacture, formulation and dosing of apraglutide |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63307827A (ja) * | 1987-06-08 | 1988-12-15 | Kitasato Inst:The | 安定化された生ウイルスワクチンおよびその製造法 |
| US5997856A (en) * | 1988-10-05 | 1999-12-07 | Chiron Corporation | Method and compositions for solubilization and stabilization of polypeptides, especially proteins |
| US5652216A (en) * | 1994-05-26 | 1997-07-29 | Novo Nordisk A/S | Pharmaceutical preparation |
| PT1516628E (pt) * | 1995-07-27 | 2013-09-24 | Genentech Inc | Formulação de proteína liofilizada isotónica estável |
| US5912229A (en) * | 1996-03-01 | 1999-06-15 | Novo Nordisk Als | Use of a pharmaceutical composition comprising an appetite-suppressing peptide |
| EP1231219B1 (de) | 1996-04-12 | 2010-08-25 | 1149336 Ontario Inc. | Dem Glukagon ähnliches Peptid-2 |
| TW518219B (en) * | 1996-04-26 | 2003-01-21 | Chugai Pharmaceutical Co Ltd | Erythropoietin solution preparation |
| US5994500A (en) * | 1996-07-19 | 1999-11-30 | 1149336 Ontario Inc. | Antagonists of intestinotrophic GLP-2 peptides |
| US5952301A (en) * | 1996-12-10 | 1999-09-14 | 1149336 Ontario Inc. | Compositions and methods for enhancing intestinal function |
| WO1998025955A2 (en) * | 1996-12-13 | 1998-06-18 | Allelix Biopharmaceuticals Inc. | Cloned glucagon-like peptide-2 receptors |
| WO1999043361A1 (en) * | 1998-02-27 | 1999-09-02 | Novo Nordisk A/S | Glp-2 derivatives with helix-content exceeding 25 %, forming partially structured micellar-like aggregates |
| GB9930882D0 (en) * | 1999-12-30 | 2000-02-23 | Nps Allelix Corp | GLP-2 formulations |
-
1999
- 1999-12-30 GB GBGB9930882.7A patent/GB9930882D0/en not_active Ceased
-
2000
- 2000-12-29 ES ES00988416T patent/ES2282161T3/es not_active Expired - Lifetime
- 2000-12-29 CA CA2395814A patent/CA2395814C/en not_active Expired - Lifetime
- 2000-12-29 AU AU24626/01A patent/AU782110B2/en not_active Expired
- 2000-12-29 DE DE60033437T patent/DE60033437T2/de not_active Expired - Lifetime
- 2000-12-29 JP JP2001549681A patent/JP5001498B2/ja not_active Expired - Lifetime
- 2000-12-29 EP EP00988416A patent/EP1246639B1/de not_active Expired - Lifetime
- 2000-12-29 PT PT00988416T patent/PT1246639E/pt unknown
- 2000-12-29 DK DK00988416T patent/DK1246639T3/da active
- 2000-12-29 US US09/750,022 patent/US7056886B2/en not_active Expired - Lifetime
- 2000-12-29 AT AT00988416T patent/ATE353665T1/de active
- 2000-12-29 WO PCT/US2000/035512 patent/WO2001049314A2/en not_active Ceased
-
2007
- 2007-05-04 CY CY20071100588T patent/CY1106558T1/el unknown
-
2012
- 2012-02-10 JP JP2012027323A patent/JP5604463B2/ja not_active Expired - Lifetime
-
2014
- 2014-05-07 JP JP2014095701A patent/JP5934739B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| ES2282161T3 (es) | 2007-10-16 |
| CY1106558T1 (el) | 2012-01-25 |
| AU2462601A (en) | 2001-07-16 |
| EP1246639B1 (de) | 2007-02-14 |
| CA2395814A1 (en) | 2001-07-12 |
| JP2003519195A (ja) | 2003-06-17 |
| JP2012116861A (ja) | 2012-06-21 |
| US7056886B2 (en) | 2006-06-06 |
| EP1246639A2 (de) | 2002-10-09 |
| CA2395814C (en) | 2011-09-20 |
| PT1246639E (pt) | 2007-05-31 |
| GB9930882D0 (en) | 2000-02-23 |
| JP5604463B2 (ja) | 2014-10-08 |
| US20010027180A1 (en) | 2001-10-04 |
| AU782110B2 (en) | 2005-07-07 |
| JP5934739B2 (ja) | 2016-06-15 |
| DK1246639T3 (da) | 2007-06-11 |
| JP2014159463A (ja) | 2014-09-04 |
| JP5001498B2 (ja) | 2012-08-15 |
| WO2001049314A3 (en) | 2002-01-03 |
| DE60033437D1 (de) | 2007-03-29 |
| DE60033437T2 (de) | 2007-11-29 |
| WO2001049314A2 (en) | 2001-07-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE353665T1 (de) | Glp-2 enthaltende formulierungen | |
| ATE244015T1 (de) | Formulierungen fuer faktor ix | |
| EA200100519A1 (ru) | Композиции на основе тонкоизмельченного эплеренона | |
| ATE270557T1 (de) | Hochkonzentrierte, lyophilisierte und flüssige faktor-ix formulierungen | |
| BR0109943A (pt) | Composições farmacêuticas | |
| DK1086706T3 (da) | Stabiliserede sammensætninger indeholdende nootropiske lægemidler | |
| CO5700784A2 (es) | Polipeptidos de virus de papiloma humano y composiciones in- munogenas | |
| ZA981031B (en) | Methods for producing dired storage-stable platelets and compositions obtained thereby | |
| PT921812E (pt) | Preparacoes de insulina contendo um halogenuro | |
| MY122262A (en) | Lh-rh peptide analogues their uses and pharmaceutical compositions containing them | |
| DK0655917T3 (da) | Krystallinske amifostin-præparater og fremgangsmåder til fremstilling og anvendelse af samme | |
| BRPI9715334B8 (pt) | agentes estrogênicos e composição farmacêutica compreendendo os mesmos. | |
| DE69417252D1 (de) | Verbesserte immunogene zusammensetzung gegen mensliches gastrin 17 | |
| DE69508837D1 (de) | Protein enthaltende stabilisierte Formulierung und Dosierungskit | |
| ATE218581T1 (de) | Cyclosporinderivat, dessen herstellung und pharmazeutische zusammensetzung | |
| HUP0100669A2 (hu) | Szerin proteázokat gátló peptidszármazékok és alkalmazásuk, valamint e vegyületeket tartalmazó gyógyászati készítmények | |
| ATE486587T1 (de) | Formulierungen zur oralen verabreichung von wirkstoffen | |
| BR0011030A (pt) | Composições de cicloporina substancialmente livre de óleo | |
| BG99177A (bg) | Нови 7 бета-заместени-4-аза-5 алфа-холестанони като инхибитори на 5 алфа-редуктаза | |
| TR199902034T2 (xx) | Haricen kullan�m i�in nimes�lid jel sistemleri. | |
| BG66082B1 (bg) | Стабилизирани интерферонови състави | |
| BR0312889A (pt) | Polipeptìdeo t20 peguilado | |
| AR020106A1 (es) | Variantes estabilizadas del inhibidor de la subtilisina de streptomyces, gen mutante que la codifica y composicion que comprende dicha variante | |
| DK201879A (da) | Fremgangsmaade til stabilisering af prostacyclinforbindelser | |
| ATE371737T1 (de) | Proteaseresistente flint-analoge |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1246639 Country of ref document: EP |