ATE361915T1 - Die hiv-replikation inhibierende pyrimidine und triazine - Google Patents

Die hiv-replikation inhibierende pyrimidine und triazine

Info

Publication number
ATE361915T1
ATE361915T1 AT04737252T AT04737252T ATE361915T1 AT E361915 T1 ATE361915 T1 AT E361915T1 AT 04737252 T AT04737252 T AT 04737252T AT 04737252 T AT04737252 T AT 04737252T AT E361915 T1 ATE361915 T1 AT E361915T1
Authority
AT
Austria
Prior art keywords
triazines
pyrimidines
hiv replication
inhibiting hiv
inhibiting
Prior art date
Application number
AT04737252T
Other languages
English (en)
Inventor
Jerome Guillemont
Elisabeth Pasquier
Jan Heeres
Kurt Hertogs
Eva Bettens
Paulus Lewi
Jonge Marc De
Lucien Koymans
Frederik Daeyaert
Hendrik Vinkers
Paul Janssen
Original Assignee
Tibotec Pharm Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tibotec Pharm Ltd filed Critical Tibotec Pharm Ltd
Application granted granted Critical
Publication of ATE361915T1 publication Critical patent/ATE361915T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48Two nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT04737252T 2003-02-20 2004-02-20 Die hiv-replikation inhibierende pyrimidine und triazine ATE361915T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03100411 2003-02-20
US47501203P 2003-06-02 2003-06-02

Publications (1)

Publication Number Publication Date
ATE361915T1 true ATE361915T1 (de) 2007-06-15

Family

ID=32910137

Family Applications (2)

Application Number Title Priority Date Filing Date
AT04737251T ATE506353T1 (de) 2003-02-20 2004-02-20 Die hiv-replikation inhibierende indan- substituierte pyrimidine
AT04737252T ATE361915T1 (de) 2003-02-20 2004-02-20 Die hiv-replikation inhibierende pyrimidine und triazine

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT04737251T ATE506353T1 (de) 2003-02-20 2004-02-20 Die hiv-replikation inhibierende indan- substituierte pyrimidine

Country Status (27)

Country Link
US (2) US7442705B2 (de)
EP (2) EP1603887B1 (de)
JP (2) JP4586013B2 (de)
KR (2) KR20050094896A (de)
CN (2) CN1751031B (de)
AP (1) AP2005003373A0 (de)
AR (2) AR044499A1 (de)
AT (2) ATE506353T1 (de)
AU (2) AU2004213186B2 (de)
BR (2) BRPI0407741B8 (de)
CA (2) CA2516589C (de)
CL (2) CL2004000306A1 (de)
CY (1) CY1106788T1 (de)
DE (2) DE602004006383T2 (de)
DK (1) DK1597238T3 (de)
EA (2) EA010423B1 (de)
ES (1) ES2287734T3 (de)
HR (2) HRP20050821A2 (de)
IL (2) IL169596A (de)
MX (2) MXPA05008867A (de)
MY (1) MY138308A (de)
NO (2) NO20054312L (de)
NZ (2) NZ542428A (de)
PL (2) PL227295B1 (de)
PT (1) PT1597238E (de)
TW (2) TW200500346A (de)
WO (2) WO2004074261A1 (de)

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GB201119358D0 (en) 2011-11-10 2011-12-21 Lewi Paulus J Disubstituted triazine dimers for treatment and/or prevention of infectious diseases
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Also Published As

Publication number Publication date
NO20054311L (no) 2005-10-27
US20060142571A1 (en) 2006-06-29
CN1751031A (zh) 2006-03-22
EA011256B1 (ru) 2009-02-27
US7442705B2 (en) 2008-10-28
CN1751031B (zh) 2010-07-21
EP1603887A1 (de) 2005-12-14
WO2004074262A1 (en) 2004-09-02
US7585870B2 (en) 2009-09-08
PT1597238E (pt) 2007-08-08
AP2005003373A0 (en) 2005-09-30
NZ542428A (en) 2007-11-30
CL2004000306A1 (es) 2005-04-08
IL169596A (en) 2017-02-28
BRPI0407732A (pt) 2006-02-14
CA2516589A1 (en) 2004-09-02
AU2004213186A1 (en) 2004-09-02
AU2004213187B2 (en) 2009-11-05
AU2004213186B2 (en) 2009-10-01
KR20050094896A (ko) 2005-09-28
CY1106788T1 (el) 2012-05-23
BRPI0407741B8 (pt) 2021-05-25
IL169596A0 (en) 2007-07-04
US20060194804A1 (en) 2006-08-31
AR044500A1 (es) 2005-09-14
PL378064A1 (pl) 2006-02-20
BRPI0407741A (pt) 2006-02-14
JP4586014B2 (ja) 2010-11-24
JP2006518357A (ja) 2006-08-10
MXPA05008866A (es) 2005-10-05
AR044499A1 (es) 2005-09-14
TW200510339A (en) 2005-03-16
EP1603887B1 (de) 2011-04-20
NZ541601A (en) 2007-09-28
EP1597238B1 (de) 2007-05-09
NO20054312L (no) 2005-11-16
IL169647A0 (en) 2007-07-04
AU2004213187A1 (en) 2004-09-02
DE602004032321D1 (de) 2011-06-01
DE602004006383D1 (de) 2007-06-21
MY138308A (en) 2009-05-29
MXPA05008867A (es) 2005-10-05
CA2516699A1 (en) 2004-09-02
HRP20050821A2 (en) 2006-11-30
PL227295B1 (pl) 2017-11-30
IL169647A (en) 2013-05-30
HRP20050820A2 (en) 2006-11-30
JP4586013B2 (ja) 2010-11-24
JP2006518356A (ja) 2006-08-10
WO2004074261A1 (en) 2004-09-02
PL378136A1 (pl) 2006-03-06
KR20050099994A (ko) 2005-10-17
EA010423B1 (ru) 2008-08-29
NO20054311D0 (no) 2005-09-19
CN100572364C (zh) 2009-12-23
CL2004000303A1 (es) 2005-04-08
ES2287734T3 (es) 2007-12-16
BRPI0407741B1 (pt) 2018-05-29
NO20054312D0 (no) 2005-09-19
DE602004006383T2 (de) 2008-01-10
EA200501326A1 (ru) 2006-02-24
CN1751030A (zh) 2006-03-22
EA200501327A1 (ru) 2006-02-24
CA2516589C (en) 2012-04-17
TW200500346A (en) 2005-01-01
CA2516699C (en) 2011-07-12
ATE506353T1 (de) 2011-05-15
DK1597238T3 (da) 2007-09-10
EP1597238A1 (de) 2005-11-23
PL226954B1 (pl) 2017-10-31

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