ATE387221T1 - Nucleophile fluorierung an fester phase - Google Patents

Nucleophile fluorierung an fester phase

Info

Publication number
ATE387221T1
ATE387221T1 AT02740868T AT02740868T ATE387221T1 AT E387221 T1 ATE387221 T1 AT E387221T1 AT 02740868 T AT02740868 T AT 02740868T AT 02740868 T AT02740868 T AT 02740868T AT E387221 T1 ATE387221 T1 AT E387221T1
Authority
AT
Austria
Prior art keywords
fluoration
nucleophilic
solid phase
solid
phase
Prior art date
Application number
AT02740868T
Other languages
English (en)
Inventor
Sajinder Luthra
Frank Brady
Harry Wadsworth
Alexander Gibson
Matthias Glaser
Original Assignee
Ge Healthcare Ltd
Hammersmith Imanet Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ge Healthcare Ltd, Hammersmith Imanet Ltd filed Critical Ge Healthcare Ltd
Application granted granted Critical
Publication of ATE387221T1 publication Critical patent/ATE387221T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C07H5/02—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C25/00—Compounds containing at least one halogen atom bound to a six-membered aromatic ring
    • C07C25/02—Monocyclic aromatic halogenated hydrocarbons
    • C07C25/13—Monocyclic aromatic halogenated hydrocarbons containing fluorine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0491—Sugars, nucleosides, nucleotides, oligonucleotides, nucleic acids, e.g. DNA, RNA, nucleic acid aptamers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
    • C07C255/42—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being further bound to other hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
    • C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/11—Compounds covalently bound to a solid support

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Saccharide Compounds (AREA)
  • Nuclear Medicine (AREA)
AT02740868T 2001-06-29 2002-06-18 Nucleophile fluorierung an fester phase ATE387221T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0115927.6A GB0115927D0 (en) 2001-06-29 2001-06-29 Solid-phase nucleophilic fluorination

Publications (1)

Publication Number Publication Date
ATE387221T1 true ATE387221T1 (de) 2008-03-15

Family

ID=9917609

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02740868T ATE387221T1 (de) 2001-06-29 2002-06-18 Nucleophile fluorierung an fester phase

Country Status (26)

Country Link
US (1) US20040236085A1 (de)
EP (1) EP1418950B1 (de)
JP (1) JP4370162B2 (de)
KR (1) KR100893461B1 (de)
CN (1) CN1246041C (de)
AR (1) AR036120A1 (de)
AT (1) ATE387221T1 (de)
AU (1) AU2002314298B2 (de)
BG (1) BG108497A (de)
BR (1) BR0210713A (de)
CA (1) CA2450637C (de)
CZ (1) CZ20033464A3 (de)
DE (1) DE60225299T2 (de)
EE (1) EE200400008A (de)
ES (1) ES2301653T3 (de)
GB (1) GB0115927D0 (de)
HU (1) HU228974B1 (de)
IL (2) IL159260A0 (de)
MX (1) MXPA03011743A (de)
NO (1) NO330809B1 (de)
NZ (1) NZ530159A (de)
PL (1) PL204305B1 (de)
RU (1) RU2315769C9 (de)
SK (1) SK15772003A3 (de)
WO (1) WO2003002157A1 (de)
ZA (1) ZA200309558B (de)

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GB0229688D0 (en) 2002-12-20 2003-01-29 Imaging Res Solutions Ltd Solid-phase preparation of [18F] Fluorohaloalkanes
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US7824659B2 (en) * 2005-08-10 2010-11-02 Lantheus Medical Imaging, Inc. Methods of making radiolabeled tracers and precursors thereof
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GB0524851D0 (en) * 2005-12-06 2006-01-11 Ge Healthcare Ltd Radiolabelling method using polymers
GB0524987D0 (en) 2005-12-08 2006-01-18 Ge Healthcare Ltd Novel imaging agents for fibrosis
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GB0905438D0 (en) * 2009-03-30 2009-05-13 Ge Healthcare Ltd Radiolabelling reagents and methods
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JP5237880B2 (ja) * 2009-04-30 2013-07-17 Ｊｆｅテクノス株式会社 マイクロチップを用いたｐｅｔ用標識化合物の製造方法及び装置
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Also Published As

Publication number Publication date
RU2315769C2 (ru) 2008-01-27
CZ20033464A3 (cs) 2004-12-15
CA2450637A1 (en) 2003-01-09
CN1520315A (zh) 2004-08-11
US20040236085A1 (en) 2004-11-25
NO20035545D0 (no) 2003-12-12
MXPA03011743A (es) 2004-07-01
IL159260A (en) 2009-09-22
HK1065945A1 (en) 2005-03-11
GB0115927D0 (en) 2001-08-22
DE60225299D1 (de) 2008-04-10
NO330809B1 (no) 2011-07-25
KR100893461B1 (ko) 2009-04-17
KR20040022434A (ko) 2004-03-12
HUP0400253A3 (en) 2005-11-28
ES2301653T3 (es) 2008-07-01
PL204305B1 (pl) 2009-12-31
AR036120A1 (es) 2004-08-11
EP1418950A1 (de) 2004-05-19
CN1246041C (zh) 2006-03-22
ZA200309558B (en) 2004-09-27
RU2003137589A (ru) 2005-05-20
WO2003002157A1 (en) 2003-01-09
DE60225299T2 (de) 2009-03-12
BG108497A (bg) 2005-03-31
EP1418950B1 (de) 2008-02-27
BR0210713A (pt) 2004-07-20
JP4370162B2 (ja) 2009-11-25
RU2315769C9 (ru) 2008-05-27
HU228974B1 (en) 2013-07-29
PL367772A1 (en) 2005-03-07
CA2450637C (en) 2010-08-17
JP2005512952A (ja) 2005-05-12
SK15772003A3 (sk) 2005-01-03
EE200400008A (et) 2004-02-16
IL159260A0 (en) 2004-06-01
AU2002314298B2 (en) 2005-07-07
HUP0400253A2 (hu) 2004-08-30
NZ530159A (en) 2005-08-26

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