ATE387221T1 - Nucleophile fluorierung an fester phase - Google Patents

Nucleophile fluorierung an fester phase

Info

Publication number
ATE387221T1
ATE387221T1 AT02740868T AT02740868T ATE387221T1 AT E387221 T1 ATE387221 T1 AT E387221T1 AT 02740868 T AT02740868 T AT 02740868T AT 02740868 T AT02740868 T AT 02740868T AT E387221 T1 ATE387221 T1 AT E387221T1
Authority
AT
Austria
Prior art keywords
fluoration
nucleophilic
solid phase
solid
phase
Prior art date
Application number
AT02740868T
Other languages
English (en)
Inventor
Sajinder Luthra
Frank Brady
Harry Wadsworth
Alexander Gibson
Matthias Glaser
Original Assignee
Ge Healthcare Ltd
Hammersmith Imanet Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ge Healthcare Ltd, Hammersmith Imanet Ltd filed Critical Ge Healthcare Ltd
Application granted granted Critical
Publication of ATE387221T1 publication Critical patent/ATE387221T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C07H5/02—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C25/00—Compounds containing at least one halogen atom bound to a six-membered aromatic ring
    • C07C25/02—Monocyclic aromatic halogenated hydrocarbons
    • C07C25/13—Monocyclic aromatic halogenated hydrocarbons containing fluorine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0491—Sugars, nucleosides, nucleotides, oligonucleotides, nucleic acids, e.g. DNA, RNA, nucleic acid aptamers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
    • C07C255/42—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being further bound to other hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
    • C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/11—Compounds covalently bound to a solid support

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Saccharide Compounds (AREA)
  • Nuclear Medicine (AREA)
AT02740868T 2001-06-29 2002-06-18 Nucleophile fluorierung an fester phase ATE387221T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0115927.6A GB0115927D0 (en) 2001-06-29 2001-06-29 Solid-phase nucleophilic fluorination

Publications (1)

Publication Number Publication Date
ATE387221T1 true ATE387221T1 (de) 2008-03-15

Family

ID=9917609

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02740868T ATE387221T1 (de) 2001-06-29 2002-06-18 Nucleophile fluorierung an fester phase

Country Status (26)

Country Link
US (1) US20040236085A1 (de)
EP (1) EP1418950B1 (de)
JP (1) JP4370162B2 (de)
KR (1) KR100893461B1 (de)
CN (1) CN1246041C (de)
AR (1) AR036120A1 (de)
AT (1) ATE387221T1 (de)
AU (1) AU2002314298B2 (de)
BG (1) BG108497A (de)
BR (1) BR0210713A (de)
CA (1) CA2450637C (de)
CZ (1) CZ20033464A3 (de)
DE (1) DE60225299T2 (de)
EE (1) EE200400008A (de)
ES (1) ES2301653T3 (de)
GB (1) GB0115927D0 (de)
HU (1) HU228974B1 (de)
IL (2) IL159260A0 (de)
MX (1) MXPA03011743A (de)
NO (1) NO330809B1 (de)
NZ (1) NZ530159A (de)
PL (1) PL204305B1 (de)
RU (1) RU2315769C9 (de)
SK (1) SK15772003A3 (de)
WO (1) WO2003002157A1 (de)
ZA (1) ZA200309558B (de)

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GB0229686D0 (en) * 2002-12-20 2003-01-29 Amersham Plc Solid-phase fluorination of benzothiazoles
GB0229683D0 (en) 2002-12-20 2003-01-29 Imaging Res Solutions Ltd Preparation of radiopharmaceuticals
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US20050049487A1 (en) * 2003-08-26 2005-03-03 Johnson Bruce Fletcher Compounds and kits for preparing imaging agents and methods of imaging
DE10346228B4 (de) * 2003-09-25 2009-04-09 Eberhard-Karls-Universität Tübingen Universitätsklinikum Herstellung von [18F]fluormarkierten aromatischen L-Aminosäuren
US20070036258A1 (en) * 2003-09-30 2007-02-15 Osamu Ito Process for producing radioactive fluorine compound
GB0329812D0 (en) * 2003-12-23 2004-01-28 Amersham Plc Romp polymer synthesis
GB0329716D0 (en) * 2003-12-23 2004-01-28 Amersham Plc Radical trap
CA2555305A1 (en) * 2004-02-06 2005-08-18 The University Of Alberta, Simon Fraser University, The University Of Vi Ctoria, The University Of British Columbia And Carleton University, Coll Method of synthesizing compounds having a phosphorus-fluorine-18 bond
GB0407952D0 (en) * 2004-04-08 2004-05-12 Amersham Plc Fluoridation method
US7485283B2 (en) 2004-04-28 2009-02-03 Lantheus Medical Imaging Contrast agents for myocardial perfusion imaging
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KR100789847B1 (ko) * 2004-12-15 2007-12-28 (주)퓨쳐켐 알코올 용매하에서 유기플루오로 화합물의 제조방법
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US7824659B2 (en) * 2005-08-10 2010-11-02 Lantheus Medical Imaging, Inc. Methods of making radiolabeled tracers and precursors thereof
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WO2007063824A1 (ja) * 2005-11-29 2007-06-07 Nihon Medi-Physics Co., Ltd. 放射性ハロゲン標識有機化合物の前駆体化合物
GB0524851D0 (en) * 2005-12-06 2006-01-11 Ge Healthcare Ltd Radiolabelling method using polymers
GB0524987D0 (en) 2005-12-08 2006-01-18 Ge Healthcare Ltd Novel imaging agents for fibrosis
CN100563812C (zh) * 2006-03-22 2009-12-02 上海化工研究院 一种可制备多种氟标试剂的化学合成装置
US7998418B1 (en) 2006-06-01 2011-08-16 Nanotek, Llc Evaporator and concentrator in reactor and loading system
US7641860B2 (en) 2006-06-01 2010-01-05 Nanotek, Llc Modular and reconfigurable multi-stage microreactor cartridge apparatus
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CA2662449A1 (en) * 2006-09-08 2008-03-13 Bayer Schering Pharma Aktiengesellschaft Compounds and methods for 18f labeled agents
EP1985624A3 (de) * 2007-04-23 2008-12-24 Bayer Schering Pharma Aktiengesellschaft Einschrittiges Verfahren zur Radiofluorierung von biologisch aktiven Verbindungen oder Biomolekülen
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WO2008078589A1 (ja) 2006-12-27 2008-07-03 Nihon Medi-Physics Co., Ltd. 放射性ハロゲン標識有機化合物の前駆体化合物の製造方法
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RU2475448C2 (ru) * 2008-01-03 2013-02-20 ДжиИ ХЕЛТКЕР ЛИМИТЕД Способ обработки фторида
WO2009110984A2 (en) 2008-02-29 2009-09-11 Lantheus Medical Imaging, Inc. Contrast agents for applications including perfusion imaging
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EP2110367A1 (de) * 2008-04-14 2009-10-21 Bayer Schering Pharma Aktiengesellschaft Reinigungsstrategie für direkte nukleophile Verfahren
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US9302990B2 (en) * 2008-10-21 2016-04-05 Nutech Ventures Fluorination of aromatic ring systems
ES2861578T3 (es) 2008-10-21 2021-10-06 Nutech Ventures Fluoración de sistemas de anillos aromáticos
EP2365974B1 (de) * 2008-11-06 2013-12-25 SNU R&DB Foundation Fluorierte benzothiazolderivate, verfahren zu deren herstellung und bilddarstellendes mittel für die diagnose von alzheimer-krankheit, welches diese verwendet
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GB0905328D0 (en) 2009-03-27 2009-05-13 Ge Healthcare Ltd Indole derivatives
GB0905438D0 (en) * 2009-03-30 2009-05-13 Ge Healthcare Ltd Radiolabelling reagents and methods
EP2419096B1 (de) 2009-04-15 2019-11-13 Lantheus Medical Imaging, Inc. Stabilisierung von radiopharmazeutischen zusammensetzungen mit ascorbinsäure
JP5237880B2 (ja) * 2009-04-30 2013-07-17 Ｊｆｅテクノス株式会社 マイクロチップを用いたｐｅｔ用標識化合物の製造方法及び装置
EP2454216A1 (de) 2009-07-11 2012-05-23 Bayer Pharma Aktiengesellschaft Nicht-polare und polare abgangsruppen
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US8546578B2 (en) 2010-02-04 2013-10-01 Nutech Ventures Iodonium Cyclophanes for SECURE arene functionalization
CN102858752B (zh) 2010-02-08 2018-10-16 兰休斯医疗成像公司 用于合成显像剂和其中间体的方法和装置
WO2011099480A1 (ja) 2010-02-12 2011-08-18 国立大学法人東京工業大学 18f標識化合物の製造方法及びその方法に用いる高分子化合物
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CN103755679A (zh) * 2014-02-14 2014-04-30 宁德新能源科技有限公司 一种亚烷基二磺酸酐的制备方法
CN109988085B (zh) * 2017-12-29 2021-11-09 张家港市国泰华荣化工新材料有限公司 金属离子含量低的1,3-丙二烷基磺酸的制备方法
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Also Published As

Publication number Publication date
ES2301653T3 (es) 2008-07-01
CZ20033464A3 (cs) 2004-12-15
DE60225299D1 (de) 2008-04-10
EP1418950A1 (de) 2004-05-19
JP2005512952A (ja) 2005-05-12
PL367772A1 (en) 2005-03-07
HUP0400253A3 (en) 2005-11-28
HK1065945A1 (en) 2005-03-11
CA2450637C (en) 2010-08-17
IL159260A (en) 2009-09-22
NZ530159A (en) 2005-08-26
IL159260A0 (en) 2004-06-01
GB0115927D0 (en) 2001-08-22
NO20035545D0 (no) 2003-12-12
MXPA03011743A (es) 2004-07-01
EP1418950B1 (de) 2008-02-27
CN1246041C (zh) 2006-03-22
RU2315769C9 (ru) 2008-05-27
WO2003002157A1 (en) 2003-01-09
AU2002314298B2 (en) 2005-07-07
SK15772003A3 (sk) 2005-01-03
CN1520315A (zh) 2004-08-11
BR0210713A (pt) 2004-07-20
BG108497A (en) 2005-03-31
HUP0400253A2 (hu) 2004-08-30
KR20040022434A (ko) 2004-03-12
EE200400008A (et) 2004-02-16
NO330809B1 (no) 2011-07-25
ZA200309558B (en) 2004-09-27
RU2315769C2 (ru) 2008-01-27
RU2003137589A (ru) 2005-05-20
PL204305B1 (pl) 2009-12-31
JP4370162B2 (ja) 2009-11-25
KR100893461B1 (ko) 2009-04-17
DE60225299T2 (de) 2009-03-12
CA2450637A1 (en) 2003-01-09
HU228974B1 (en) 2013-07-29
US20040236085A1 (en) 2004-11-25
AR036120A1 (es) 2004-08-11

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