BG108497A - Твърдо-фазно нуклеофилно флуориране - Google Patents

Твърдо-фазно нуклеофилно флуориране

Info

Publication number
BG108497A
BG108497A BG108497A BG10849703A BG108497A BG 108497 A BG108497 A BG 108497A BG 108497 A BG108497 A BG 108497A BG 10849703 A BG10849703 A BG 10849703A BG 108497 A BG108497 A BG 108497A
Authority
BG
Bulgaria
Prior art keywords
fluoring
nucleo
solid
phase
production
Prior art date
Application number
BG108497A
Other languages
English (en)
Inventor
Sajinder Luthra
Frank Brandy
Harry Wadsworth
Original Assignee
Amersham Plc
Hammersmith Imanet Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amersham Plc, Hammersmith Imanet Limited filed Critical Amersham Plc
Publication of BG108497A publication Critical patent/BG108497A/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C25/00—Compounds containing at least one halogen atom bound to a six-membered aromatic ring
    • C07C25/02—Monocyclic aromatic halogenated hydrocarbons
    • C07C25/13—Monocyclic aromatic halogenated hydrocarbons containing fluorine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0491—Sugars, nucleosides, nucleotides, oligonucleotides, nucleic acids, e.g. DNA, RNA, nucleic acid aptamers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
    • C07C255/42—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being further bound to other hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
    • C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C07H5/02—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/11—Compounds covalently bound to a solid support

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Saccharide Compounds (AREA)
  • Nuclear Medicine (AREA)

Abstract

Изобретението се отнася до нови твърдофазни методи за производство на белязани с радиоактивен изотоп индикатори, по-специално за производство на 18F-белязани съединения, които са подходящи за използване като радиоактивни индикатори при позитронна емисионна томография (РЕТ). Изобретението се отнася и до радиоактивни фармацевтични комплекти, при които се използват тези методи. а
BG108497A 2001-06-29 2003-12-22 Твърдо-фазно нуклеофилно флуориране BG108497A (bg)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0115927.6A GB0115927D0 (en) 2001-06-29 2001-06-29 Solid-phase nucleophilic fluorination

Publications (1)

Publication Number Publication Date
BG108497A true BG108497A (bg) 2005-03-31

Family

ID=9917609

Family Applications (1)

Application Number Title Priority Date Filing Date
BG108497A BG108497A (bg) 2001-06-29 2003-12-22 Твърдо-фазно нуклеофилно флуориране

Country Status (26)

Country Link
US (1) US20040236085A1 (bg)
EP (1) EP1418950B1 (bg)
JP (1) JP4370162B2 (bg)
KR (1) KR100893461B1 (bg)
CN (1) CN1246041C (bg)
AR (1) AR036120A1 (bg)
AT (1) ATE387221T1 (bg)
AU (1) AU2002314298B2 (bg)
BG (1) BG108497A (bg)
BR (1) BR0210713A (bg)
CA (1) CA2450637C (bg)
CZ (1) CZ20033464A3 (bg)
DE (1) DE60225299T2 (bg)
EE (1) EE200400008A (bg)
ES (1) ES2301653T3 (bg)
GB (1) GB0115927D0 (bg)
HU (1) HU228974B1 (bg)
IL (2) IL159260A0 (bg)
MX (1) MXPA03011743A (bg)
NO (1) NO330809B1 (bg)
NZ (1) NZ530159A (bg)
PL (1) PL204305B1 (bg)
RU (1) RU2315769C9 (bg)
SK (1) SK15772003A3 (bg)
WO (1) WO2003002157A1 (bg)
ZA (1) ZA200309558B (bg)

Families Citing this family (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0115927D0 (en) * 2001-06-29 2001-08-22 Nycomed Amersham Plc Solid-phase nucleophilic fluorination
GB0115929D0 (en) * 2001-06-29 2001-08-22 Nycomed Amersham Plc Solid-phase electrophilic fluorination
US7344702B2 (en) 2004-02-13 2008-03-18 Bristol-Myers Squibb Pharma Company Contrast agents for myocardial perfusion imaging
GB0206117D0 (en) 2002-03-15 2002-04-24 Imaging Res Solutions Ltd Use of microfabricated devices
BR0215913A (pt) * 2002-11-05 2005-08-09 Ion Beam Applic Sa Composição de radiofármacos rotulados com 18-f e processo para obtê-los
GB0229686D0 (en) * 2002-12-20 2003-01-29 Amersham Plc Solid-phase fluorination of benzothiazoles
GB0229683D0 (en) 2002-12-20 2003-01-29 Imaging Res Solutions Ltd Preparation of radiopharmaceuticals
GB0229688D0 (en) 2002-12-20 2003-01-29 Imaging Res Solutions Ltd Solid-phase preparation of [18F] Fluorohaloalkanes
GB0229695D0 (en) * 2002-12-20 2003-01-29 Amersham Plc Solid-phase preparation of 18F-labelled amino acids
GB0317920D0 (en) 2003-07-31 2003-09-03 Amersham Plc Solid-phase synthesis
US20050049487A1 (en) * 2003-08-26 2005-03-03 Johnson Bruce Fletcher Compounds and kits for preparing imaging agents and methods of imaging
DE10346228B4 (de) * 2003-09-25 2009-04-09 Eberhard-Karls-Universität Tübingen Universitätsklinikum Herstellung von [18F]fluormarkierten aromatischen L-Aminosäuren
WO2005030677A1 (ja) * 2003-09-30 2005-04-07 Nihon Medi-Physics Co., Ltd. 放射性フッ素化合物の製造方法
GB0329716D0 (en) * 2003-12-23 2004-01-28 Amersham Plc Radical trap
GB0329812D0 (en) * 2003-12-23 2004-01-28 Amersham Plc Romp polymer synthesis
CA2555305A1 (en) * 2004-02-06 2005-08-18 The University Of Alberta, Simon Fraser University, The University Of Vi Ctoria, The University Of British Columbia And Carleton University, Coll Method of synthesizing compounds having a phosphorus-fluorine-18 bond
GB0407952D0 (en) * 2004-04-08 2004-05-12 Amersham Plc Fluoridation method
US7485283B2 (en) 2004-04-28 2009-02-03 Lantheus Medical Imaging Contrast agents for myocardial perfusion imaging
JP4730760B2 (ja) * 2004-05-25 2011-07-20 住友重機械工業株式会社 Ｒｉ標識化合物合成システム
GB0425501D0 (en) * 2004-11-19 2004-12-22 Amersham Plc Fluoridation process
KR100789847B1 (ko) * 2004-12-15 2007-12-28 (주)퓨쳐켐 알코올 용매하에서 유기플루오로 화합물의 제조방법
GB0428012D0 (en) 2004-12-22 2005-01-26 Hammersmith Imanet Ltd Radiolabelling methods
GB0506041D0 (en) * 2005-03-24 2005-04-27 Ge Healthcare Ltd Stripping method
JP2007031647A (ja) * 2005-07-29 2007-02-08 Japan Health Science Foundation 固相合成を利用した超短半減期核種を含む化合物の製造方法およびそれに用いる化合物
US7824659B2 (en) * 2005-08-10 2010-11-02 Lantheus Medical Imaging, Inc. Methods of making radiolabeled tracers and precursors thereof
GB0516564D0 (en) * 2005-08-12 2005-09-21 Ge Healthcare Ltd Fluorination process
RU2428415C2 (ru) * 2005-11-29 2011-09-10 Нихон Меди-Физикс Ко., Лтд. Соединение-предшественник органического соединения, меченного радиоактивным галогеном
GB0524851D0 (en) * 2005-12-06 2006-01-11 Ge Healthcare Ltd Radiolabelling method using polymers
GB0524987D0 (en) 2005-12-08 2006-01-18 Ge Healthcare Ltd Novel imaging agents for fibrosis
CN100563812C (zh) * 2006-03-22 2009-12-02 上海化工研究院 一种可制备多种氟标试剂的化学合成装置
US7641860B2 (en) 2006-06-01 2010-01-05 Nanotek, Llc Modular and reconfigurable multi-stage microreactor cartridge apparatus
US7998418B1 (en) 2006-06-01 2011-08-16 Nanotek, Llc Evaporator and concentrator in reactor and loading system
US7854902B2 (en) 2006-08-23 2010-12-21 Nanotek, Llc Modular and reconfigurable multi-stage high temperature microreactor cartridge apparatus and system for using same
BRPI0716554A2 (pt) * 2006-09-08 2013-09-24 Bayer Schering Pharma Ag compostos de mÉtodos para agentes rotulados de 18f
EP1985624A3 (en) * 2007-04-23 2008-12-24 Bayer Schering Pharma Aktiengesellschaft Single step method of radiofluorination of biologically active compounds or biomolecules
GB0625523D0 (en) 2006-12-21 2007-01-31 Ge Healthcare Ltd In vivo imaging agents
BRPI0720465B8 (pt) * 2006-12-27 2021-07-27 Nihon Mediphysics Co Ltd processo para produção de composto de precursor para composto orgânico marcado com halogênio radioativo
US7797988B2 (en) 2007-03-23 2010-09-21 Advion Biosystems, Inc. Liquid chromatography-mass spectrometry
GB0709561D0 (en) * 2007-05-18 2007-06-27 Siemens Medical Solutions Assessment of vascular compartment volume PET modeling
EP2238074A2 (en) * 2008-01-03 2010-10-13 GE Healthcare UK Limited Fluoride processing method
KR101616139B1 (ko) 2008-02-29 2016-04-27 랜티우스 메디컬 이메징, 인크. 관류 영상화를 포함하는 용도를 위한 조영제
KR100973724B1 (ko) * 2008-03-14 2010-08-04 류현욱 신발창용 쿠션부재
EP2110367A1 (en) 2008-04-14 2009-10-21 Bayer Schering Pharma Aktiengesellschaft Purification strategy for direct nucleophilic procedures
US20110184159A1 (en) * 2008-07-07 2011-07-28 Bayer Schering Pharma Aktiengesellschaft Process for production of radiopharmaceuticals
US9302990B2 (en) 2008-10-21 2016-04-05 Nutech Ventures Fluorination of aromatic ring systems
ES2861578T3 (es) 2008-10-21 2021-10-06 Nutech Ventures Fluoración de sistemas de anillos aromáticos
KR101155403B1 (ko) * 2008-11-06 2013-12-20 서울대학교산학협력단 플루오린이 도입된 벤조타이아졸 유도체, 이의 제조방법 및 이를 이용한 알츠하이머 질환 진단용 영상화제
GB0904715D0 (en) 2009-03-19 2009-05-06 Ge Healthcare Ltd Aryloxyanilide derivataives
GB0905328D0 (en) 2009-03-27 2009-05-13 Ge Healthcare Ltd Indole derivatives
GB0905438D0 (en) * 2009-03-30 2009-05-13 Ge Healthcare Ltd Radiolabelling reagents and methods
CN102458396B (zh) 2009-04-15 2017-05-10 兰休斯医疗成像公司 使用抗坏血酸稳定化放射性药物组合物
JP5237880B2 (ja) * 2009-04-30 2013-07-17 Ｊｆｅテクノス株式会社 マイクロチップを用いたｐｅｔ用標識化合物の製造方法及び装置
CN102471176A (zh) 2009-07-11 2012-05-23 拜耳医药股份有限公司 非极性和极性离去基团
US8377704B2 (en) 2009-10-20 2013-02-19 Nutech Ventures Detection and quantification of anions
GB0921967D0 (en) 2009-12-17 2010-02-03 Ge Healthcare Ltd Novel Aryloxyanilide Derivatives
US8546578B2 (en) 2010-02-04 2013-10-01 Nutech Ventures Iodonium Cyclophanes for SECURE arene functionalization
AU2011213568B2 (en) 2010-02-08 2016-05-12 Lantheus Medical Imaging, Inc. Methods and apparatus for synthesizing imaging agents, and intermediates thereof
WO2011099480A1 (ja) 2010-02-12 2011-08-18 国立大学法人東京工業大学 18f標識化合物の製造方法及びその方法に用いる高分子化合物
US10639608B2 (en) 2010-04-08 2020-05-05 Siemens Medical Solutions Usa, Inc. System, device and method for preparing tracers and transferring materials during radiosynthesis
US9023316B2 (en) 2010-04-08 2015-05-05 Siemens Medical Solutions Usa, Inc. Synthesis of 18F-labeled tracers in hydrous organic solvents
GB201016038D0 (en) 2010-09-24 2010-11-10 Ge Healthcare Ltd In vivo imaging method
GB201016411D0 (en) 2010-09-30 2010-11-10 Ge Healthcare Ltd In vivo imaging method for cancer
WO2012081880A2 (ko) 2010-12-14 2012-06-21 서강대학교산학협력단 18f 방사성의약품 제조를 위한 고체 지지체에 연결된 전구체 화합물, 이의 제조방법 및 응용
US9550704B2 (en) 2012-05-24 2017-01-24 Futurechem Co., Ltd. Method for synthesizing radiopharmaceuticals using a cartridge
AU2013203000B9 (en) 2012-08-10 2017-02-02 Lantheus Medical Imaging, Inc. Compositions, methods, and systems for the synthesis and use of imaging agents
CN103755679A (zh) * 2014-02-14 2014-04-30 宁德新能源科技有限公司 一种亚烷基二磺酸酐的制备方法
CN109988085B (zh) * 2017-12-29 2021-11-09 张家港市国泰华荣化工新材料有限公司 金属离子含量低的1,3-丙二烷基磺酸的制备方法
WO2020009945A1 (en) * 2018-07-03 2020-01-09 The Regents Of The University Of California Mild and site-selective 18f-labeling of small molecules and/or biomolecules via a thiol-reactive synthon
CN114685583A (zh) * 2020-12-30 2022-07-01 西格莱(苏州)生物医药有限公司 一类糖苷化合物及其制备方法与用途
CN114524943B (zh) * 2022-04-22 2022-09-16 天津凯莱英制药有限公司 聚乙二醇-甘油衍生物及其中间体各自的制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5510522A (en) * 1995-02-22 1996-04-23 Regents Of The University Of California Synthesis of N-formyl-3,4-di-t-butoxycarbonyloxy-6-(trimethylstannyl)-L-phenylalanine ethyl ester and its regioselective radiofluorodestannylation to 6- 18 F!fluoro-1-dopa
CA2307002C (en) * 1997-10-30 2008-07-29 Raymond W. Klecker Antitumour uridine analogues
EP1105163A4 (en) * 1998-08-20 2003-05-02 Univ California METHOD FOR MARKING AMYLOID PLAQUES AND NEUROFIBRILLIC GIFTS
RU2165266C1 (ru) * 2000-06-28 2001-04-20 Центральный научно-исследовательский рентгенорадиологический институт Способ получения [2-18f]-2-дезоксиглюкозы
GB0115927D0 (en) * 2001-06-29 2001-08-22 Nycomed Amersham Plc Solid-phase nucleophilic fluorination
GB0115929D0 (en) * 2001-06-29 2001-08-22 Nycomed Amersham Plc Solid-phase electrophilic fluorination
GB0229683D0 (en) * 2002-12-20 2003-01-29 Imaging Res Solutions Ltd Preparation of radiopharmaceuticals
GB0229686D0 (en) * 2002-12-20 2003-01-29 Amersham Plc Solid-phase fluorination of benzothiazoles
GB0229688D0 (en) * 2002-12-20 2003-01-29 Imaging Res Solutions Ltd Solid-phase preparation of [18F] Fluorohaloalkanes

Also Published As

Publication number Publication date
RU2315769C2 (ru) 2008-01-27
CZ20033464A3 (cs) 2004-12-15
CA2450637A1 (en) 2003-01-09
CN1520315A (zh) 2004-08-11
US20040236085A1 (en) 2004-11-25
NO20035545D0 (no) 2003-12-12
MXPA03011743A (es) 2004-07-01
IL159260A (en) 2009-09-22
HK1065945A1 (en) 2005-03-11
ATE387221T1 (de) 2008-03-15
GB0115927D0 (en) 2001-08-22
DE60225299D1 (de) 2008-04-10
NO330809B1 (no) 2011-07-25
KR100893461B1 (ko) 2009-04-17
KR20040022434A (ko) 2004-03-12
HUP0400253A3 (en) 2005-11-28
ES2301653T3 (es) 2008-07-01
PL204305B1 (pl) 2009-12-31
AR036120A1 (es) 2004-08-11
EP1418950A1 (en) 2004-05-19
CN1246041C (zh) 2006-03-22
ZA200309558B (en) 2004-09-27
RU2003137589A (ru) 2005-05-20
WO2003002157A1 (en) 2003-01-09
DE60225299T2 (de) 2009-03-12
EP1418950B1 (en) 2008-02-27
BR0210713A (pt) 2004-07-20
JP4370162B2 (ja) 2009-11-25
RU2315769C9 (ru) 2008-05-27
HU228974B1 (en) 2013-07-29
PL367772A1 (en) 2005-03-07
CA2450637C (en) 2010-08-17
JP2005512952A (ja) 2005-05-12
SK15772003A3 (sk) 2005-01-03
EE200400008A (et) 2004-02-16
IL159260A0 (en) 2004-06-01
AU2002314298B2 (en) 2005-07-07
HUP0400253A2 (hu) 2004-08-30
NZ530159A (en) 2005-08-26

Similar Documents

Publication Publication Date Title
HUP0400253A2 (hu) Szilárd fázisú nukleofil fluorozás
IL181529A (en) A method for radiofluorination, a compound containing radioactive fluorine and its use in the preparation of a radioactive drug
BRPI0409133A (pt) formulações farmacêuticas contendo metilnaltrexona
DK1404377T3 (da) Forbedrede chelatorkonjugater
NO20085004L (no) Radioaktivt merkede dihydrotetrabenazinderivater og deres anvendelse som avbildningsmidler
DK1487763T3 (da) Anvendelse af mikrofremstillede indretninger til radiosyntese
WO2015073746A3 (en) 18f labeling of proteins using sortases
EA200200530A1 (ru) Гетероциклические замещенные пиразолоны
CY1110923T1 (el) Συζυγη που περιλαμβανουν ενα αντισωμα ειδικο για την ed-β περιοχη της ινονεκτινης και η χρηση τους για τον εντοπισμο και την αντιμετωπιση ογκων
NO20076349L (no) Stereoselektiv syntese av aminosyreanaloger for tumorbilleddannelse
DK1207904T3 (da) Nye kliniske parametre til bestemmelse af hæmatologisk toksicitet forud for radioimmunterapi
DK1517890T3 (da) Kationisk substituerede diphenylazetidinoner, fremgangsmåde til deres fremstilling, lægemidler indeholdende disse forbindelser og deres anvendelse
CY1107681T1 (el) Χρηση παραγωγων τροπινεστερα για την παραγωγη φαρμακευτικων μεσων
MX2011010295A (es) Reactivos de radiomarcado y metodos.
EA200600605A1 (ru) Перегруппированные пентанолы, способ их получения и их применение в качестве противовоспалительных средств
EA200601217A1 (ru) Новые конденсированные пирролокарбазолы
EA200601219A1 (ru) Новые конденсированные пирролокарбазолы
TW200738271A (en) Methods of making radiolabeled tracers and precursors thereof
ATE492295T1 (de) Radioaktiv markierte verbindungen und liposome und ihre herstellungs- und anwendungsverfahren
BR0312863A (pt) Derivados de aldeìdo de polietileno glicol
BRPI0409101A (pt) método para produzir um complexo de gálio radiomarcado
EA200401289A1 (ru) Новые противоинфекционные соединения, способы их получения и фармацевтические композиции, содержащие эти соединения
BRPI9914571B8 (pt) composto, processo para sua preparação, uso do mesmo, bem como composição farmacêutica.
ATE439869T1 (de) Automatisches radioaktives markierungsverafhren
WO2007122488A3 (en) Radiofluorinated compounds and their preparation