ATE392475T1 - Elongase gene und ihre verwendung - Google Patents

Elongase gene und ihre verwendung

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Publication number
ATE392475T1
ATE392475T1 AT99943978T AT99943978T ATE392475T1 AT E392475 T1 ATE392475 T1 AT E392475T1 AT 99943978 T AT99943978 T AT 99943978T AT 99943978 T AT99943978 T AT 99943978T AT E392475 T1 ATE392475 T1 AT E392475T1
Authority
AT
Austria
Prior art keywords
elongase genes
elongase
genes
Prior art date
Application number
AT99943978T
Other languages
English (en)
Inventor
Pradip Mukerji
Amanda LEONARD
Yung-Sheng Huang
Jennifer Thurmond
Stephen Kirchner
Jennifer Parker-Barnes
Tapas Das
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Application granted granted Critical
Publication of ATE392475T1 publication Critical patent/ATE392475T1/de

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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36Carboxylic acids; Salts or anhydrides thereof
    • A61K8/361Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23DEDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS OR COOKING OILS
    • A23D9/00Other edible oils or fats, e.g. shortenings or cooking oils
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23KFODDER
    • A23K20/00Accessory food factors for animal feeding-stuffs
    • A23K20/10Organic substances
    • A23K20/158Fatty acids; Fats; Products containing oils or fats
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/20Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/202Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
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    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60Sugars; Derivatives thereof
    • A61K8/606Nucleosides; Nucleotides; Nucleic acids
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    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • C12N15/8247Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving modified lipid metabolism, e.g. seed oil composition
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    • C12N9/10Transferases (2.)
    • C12N9/1025Acyltransferases (2.3)
    • C12N9/1029Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
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    • C12P7/6409Fatty acids
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    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/64Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
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    • C12P7/00Preparation of oxygen-containing organic compounds
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AT99943978T 1998-09-02 1999-08-30 Elongase gene und ihre verwendung ATE392475T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/145,828 US6403349B1 (en) 1998-09-02 1998-09-02 Elongase gene and uses thereof

Publications (1)

Publication Number Publication Date
ATE392475T1 true ATE392475T1 (de) 2008-05-15

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Application Number Title Priority Date Filing Date
AT99943978T ATE392475T1 (de) 1998-09-02 1999-08-30 Elongase gene und ihre verwendung

Country Status (13)

Country Link
US (1) US6403349B1 (de)
EP (1) EP1108039B1 (de)
JP (2) JP5421508B2 (de)
AR (1) AR021789A1 (de)
AT (1) ATE392475T1 (de)
AU (1) AU768301B2 (de)
CA (3) CA2633074C (de)
CO (1) CO5021164A1 (de)
DE (1) DE69938554T2 (de)
DK (1) DK1108039T3 (de)
ES (1) ES2306523T3 (de)
PT (1) PT1108039E (de)
WO (1) WO2000012720A2 (de)

Families Citing this family (108)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7885697B2 (en) 2004-07-13 2011-02-08 Dexcom, Inc. Transcutaneous analyte sensor
US6677145B2 (en) * 1998-09-02 2004-01-13 Abbott Laboratories Elongase genes and uses thereof
US6403349B1 (en) * 1998-09-02 2002-06-11 Abbott Laboratories Elongase gene and uses thereof
US6913916B1 (en) 1998-09-02 2005-07-05 Abbott Laboratories Elongase genes and uses thereof
US20030163845A1 (en) 1998-09-02 2003-08-28 Pradip Mukerji Elongase genes and uses thereof
CA2365096A1 (en) * 1999-03-18 2000-09-21 The University Of Bristol Polyunsaturated fatty acid (pufa) elongase from caenorhabditis elegans
AU5394100A (en) * 1999-05-20 2000-12-12 Karolinska Innovations Ab Fatty acid elongation genes and uses thereof
DE10030976A1 (de) 2000-06-30 2002-01-10 Basf Ag DELTA6-Desaturasegene exprimierende Pflanzen und PUFAS enthaltende Öle aus diesen Pflanzen und ein Verfahren zur Herstellung ungesättigter Fettsäuren
US7070970B2 (en) 1999-08-23 2006-07-04 Abbott Laboratories Elongase genes and uses thereof
AU1346701A (en) * 1999-10-28 2001-05-08 Curagen Corporation Human gold-induced glycoprotein 30-like protein and nucleic acid encoding the same
EP1228092A4 (de) * 1999-11-12 2003-11-12 Human Genome Sciences Inc 24 menschliche, sekretierte proteine
JP4547122B2 (ja) * 2000-02-09 2010-09-22 ビーエーエスエフ ソシエタス・ヨーロピア 新規エロンガーゼ遺伝子および高度不飽和脂肪酸の生産方法
EP1911837B1 (de) 2000-09-28 2011-05-25 Bioriginal Food & Science Corp. FAD5-2, Mitglied der Desaturase-Familie und Verwendungen davon
AU2002221404B2 (en) * 2000-11-29 2008-01-03 Xenon Genetics Inc Human elongase genes and uses thereof
WO2002064761A2 (en) * 2001-02-09 2002-08-22 Bayer Aktiengesellschaft Regulation of human long chain polyunsaturated fatty acid elongation enzyme-like protein
US20040121044A1 (en) * 2001-03-14 2004-06-24 John Tiano Nutritional product with high protein, low carbohydrate content and good physical stability
GB0107510D0 (en) * 2001-03-26 2001-05-16 Univ Bristol New elongase gene and a process for the production of -9-polyunsaturated fatty acids
US7045683B2 (en) 2001-05-04 2006-05-16 Abbott Laboratories Δ4-desaturase genes and uses thereof
WO2003040392A2 (en) * 2001-11-06 2003-05-15 Decode Genetics Ehf. Nucleic acids encoding very long chain fatty acid biosynthesis enzymes
US7211656B2 (en) * 2002-01-30 2007-05-01 Abbott Laboratories Desaturase genes, enzymes encoded thereby, and uses thereof
US9247901B2 (en) 2003-08-22 2016-02-02 Dexcom, Inc. Systems and methods for replacing signal artifacts in a glucose sensor data stream
US8260393B2 (en) 2003-07-25 2012-09-04 Dexcom, Inc. Systems and methods for replacing signal data artifacts in a glucose sensor data stream
US9282925B2 (en) 2002-02-12 2016-03-15 Dexcom, Inc. Systems and methods for replacing signal artifacts in a glucose sensor data stream
US8010174B2 (en) 2003-08-22 2011-08-30 Dexcom, Inc. Systems and methods for replacing signal artifacts in a glucose sensor data stream
US6979468B1 (en) 2002-12-06 2005-12-27 Sirius Laboratories Oral composition and method for the treatment of inflammatory cutaneous disorders
US8084074B2 (en) 2003-02-12 2011-12-27 E. I. Du Pont De Nemours And Company Production of very long chain polyunsaturated fatty acids in oil seed plants
US20040172682A1 (en) 2003-02-12 2004-09-02 Kinney Anthony J. Production of very long chain polyunsaturated fatty acids in oilseed plants
US7125672B2 (en) 2003-05-07 2006-10-24 E. I. Du Pont De Nemours And Company Codon-optimized genes for the production of polyunsaturated fatty acids in oleaginous yeasts
US7238482B2 (en) * 2003-05-07 2007-07-03 E. I. Du Pont De Nemours And Company Production of polyunsaturated fatty acids in oleaginous yeasts
US11952581B2 (en) 2003-08-01 2024-04-09 Basf Plant Science Gmbh Process for the production of polyunsaturated fatty acids in transgenic organisms
US7774145B2 (en) 2003-08-01 2010-08-10 Dexcom, Inc. Transcutaneous analyte sensor
US8761856B2 (en) 2003-08-01 2014-06-24 Dexcom, Inc. System and methods for processing analyte sensor data
US8275437B2 (en) 2003-08-01 2012-09-25 Dexcom, Inc. Transcutaneous analyte sensor
EP2166067B1 (de) 2003-08-01 2015-07-01 BASF Plant Science GmbH Verfahren zur Herstellung mehrfach ungesättigter Fettsäuren in transgenen Organismen
US20190357827A1 (en) 2003-08-01 2019-11-28 Dexcom, Inc. Analyte sensor
US7591801B2 (en) 2004-02-26 2009-09-22 Dexcom, Inc. Integrated delivery device for continuous glucose sensor
US8845536B2 (en) 2003-08-01 2014-09-30 Dexcom, Inc. Transcutaneous analyte sensor
US7920906B2 (en) 2005-03-10 2011-04-05 Dexcom, Inc. System and methods for processing analyte sensor data for sensor calibration
US20140121989A1 (en) 2003-08-22 2014-05-01 Dexcom, Inc. Systems and methods for processing analyte sensor data
EP1685239B1 (de) 2003-11-12 2014-05-21 E.I. Du Pont De Nemours And Company Zur änderung der niveaus mehrfach ungesättigter fettsäuren in ölsamenpflanzen und öliger hefe geeignete delta-15-desaturasen
WO2005051170A2 (en) 2003-11-19 2005-06-09 Dexcom, Inc. Integrated receiver for continuous analyte sensor
US9247900B2 (en) 2004-07-13 2016-02-02 Dexcom, Inc. Analyte sensor
US11633133B2 (en) 2003-12-05 2023-04-25 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US8423114B2 (en) 2006-10-04 2013-04-16 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US8364231B2 (en) 2006-10-04 2013-01-29 Dexcom, Inc. Analyte sensor
US8774886B2 (en) 2006-10-04 2014-07-08 Dexcom, Inc. Analyte sensor
EP1711791B1 (de) 2003-12-09 2014-10-15 DexCom, Inc. Signalverarbeitung für kontinuierlich arbeitenden analytsensor
CN1894405B (zh) * 2003-12-17 2011-02-02 三得利控股株式会社 含有花生四烯酸的植物体及其利用
US8808228B2 (en) 2004-02-26 2014-08-19 Dexcom, Inc. Integrated medicament delivery device for use with continuous analyte sensor
PL1720988T3 (pl) 2004-02-27 2012-05-31 Basf Plant Science Gmbh Sposób wytwarzania nienasyconych kwasów tłuszczowych omega-3 w organizmach transgenicznych
MXPA06009572A (es) 2004-02-27 2007-05-23 Basf Plant Science Gmbh Metodo para la produccion de acidos grasos poliinsaturados en plantas transgenicas.
JP2005255653A (ja) * 2004-03-15 2005-09-22 Taisho Pharmaceut Co Ltd 鉄化合物配合内服液剤
US20050220901A1 (en) * 2004-03-22 2005-10-06 Huttenbauer Samuel Jr Methods of pharmaceutical separation from plants
JP4481702B2 (ja) * 2004-03-31 2010-06-16 サントリーホールディングス株式会社 脂質生産菌の育種方法およびその利用
BR122019013214B1 (pt) 2004-04-22 2022-04-12 Commonwealth Scientific And Industrial Research Organisation Polinucleotídeo isolado, vetor, célula recombinante, método para produzir uma célula recombinante, método para produzir um ou mais ácido graxo(s) poliinsaturado de cadeia longa, método para produzir uma semente transgênica, método para produzir óleo, método para produzir uma semente oleaginosa, extrato da semente transgênica, composição compreendendo o referido extrato, ração e uso da referida célula recombinante ou extrato
DK1756280T3 (en) 2004-04-22 2015-02-02 Commw Scient Ind Res Org SYNTHESIS OF CHAIN, polyunsaturated fatty acids BY RECOMBINANT CELLS
US7364883B2 (en) * 2004-05-07 2008-04-29 Yeastern Biotech Co., Ltd. Process for producing poly-unsaturated fatty acids by oleaginous yeasts
WO2005118814A2 (en) * 2004-06-04 2005-12-15 Fluxome Sciences A/S Metabolically engineered cells for the production of polyunsaturated fatty acids
AU2005267202B2 (en) 2004-06-25 2011-10-27 Corteva Agriscience Llc Delta-8 desaturase and its use in making polyunsaturated fatty acids
US8565848B2 (en) 2004-07-13 2013-10-22 Dexcom, Inc. Transcutaneous analyte sensor
US8452368B2 (en) 2004-07-13 2013-05-28 Dexcom, Inc. Transcutaneous analyte sensor
US7588931B2 (en) 2004-11-04 2009-09-15 E. I. Du Pont De Nemours And Company High arachidonic acid producing strains of Yarrowia lipolytica
US20060246115A1 (en) * 2005-03-04 2006-11-02 Ricardo Rueda Nutritional products for ameliorating symptoms of rheumatoid arthritis
US8133178B2 (en) 2006-02-22 2012-03-13 Dexcom, Inc. Analyte sensor
DE102005013779A1 (de) 2005-03-22 2006-09-28 Basf Plant Science Gmbh Verfahren zur Herstellung von mehrfach ungesättigten C20- und C22-Fettsäuren mit mindestens vier Doppelbindungen in transgenen Pflanzen
CA2609367C (en) * 2005-05-23 2014-08-19 Arcadia Biosciences, Inc. Safflower with elevated gamma-linolenic acid
DE102005038036A1 (de) 2005-08-09 2007-02-15 Basf Plant Science Gmbh Verfahren zur Herstellung von Arachidonsäure und/oder Eicosapentaensäure in transgenen Nutzpflanzen
GB2431158A (en) * 2005-10-13 2007-04-18 Rothamsted Res Ltd Process for the production of arachidonic and/or eicosapentaenoic acid
US7470532B2 (en) * 2005-10-19 2008-12-30 E.I. Du Pont De Nemours And Company Mortierella alpina C16/18 fatty acid elongase
AU2006318738B2 (en) 2005-11-23 2011-12-22 E. I. Du Pont De Nemours And Company Delta-9 elongases and their use in making polyunsaturated fatty acids
JP2009518424A (ja) * 2005-12-09 2009-05-07 ドラッグテック コーポレイション 必須脂肪酸乳剤の静脈投与
GB0603160D0 (en) 2006-02-16 2006-03-29 Rothamsted Res Ltd Nucleic acid
AR059376A1 (es) 2006-02-21 2008-03-26 Basf Plant Science Gmbh Procedimiento para la produccion de acidos grasos poliinsaturados
US7943823B2 (en) 2006-04-28 2011-05-17 E.I. Du Pont De Nemours And Company Delta-8 desaturase and its use in making polyunsaturated fatty acids
US7695950B2 (en) * 2006-05-17 2010-04-13 E. I. Du Pont De Nemours And Company Δ5 desaturase and its use in making polyunsaturated fatty acids
US7678560B2 (en) * 2006-05-17 2010-03-16 E.I. Du Pont De Nemours And Company Δ 5 desaturase and its use in making polyunsaturated fatty acids
CN101578363A (zh) 2006-08-29 2009-11-11 联邦科学技术研究组织 脂肪酸的合成
US7666369B2 (en) * 2006-09-29 2010-02-23 Tyco Healthcare Group Lp System and method for recycling sterilant gas
EP2177605B1 (de) 2006-10-06 2014-12-10 BASF Plant Science GmbH Delta-5 Desaturasen und Verfahren zur Herstellung mehrfach ungesättigter Fettsäuren in transgenen nicht-humanen Organismen
AU2007322223B2 (en) 2006-10-23 2012-12-13 Corteva Agriscience Llc Delta-8 desaturases and their use in making polyunsaturated fatty acids
WO2008085841A1 (en) * 2007-01-03 2008-07-17 Monsanto Technology, Llc Food compositions incorporating stearidonic acid.
US8389808B2 (en) 2007-02-12 2013-03-05 E.I. Du Pont De Nemours And Company Production of arachidonic acid in oilseed plants
DK2129777T3 (en) * 2007-04-03 2016-01-25 Du Pont MULTIZYMER AND USE THEREOF FOR THE PRODUCTION OF polyunsaturated fatty acids
US7790156B2 (en) 2007-04-10 2010-09-07 E. I. Du Pont De Nemours And Company Δ-8 desaturases and their use in making polyunsaturated fatty acids
US8119860B2 (en) 2007-04-16 2012-02-21 E. I. Du Pont De Nemours And Company Delta-9 elongases and their use in making polyunsaturated fatty acids
US8957280B2 (en) 2007-05-03 2015-02-17 E. I. Du Pont De Nemours And Company Delta-5 desaturases and their use in making polyunsaturated fatty acids
CA2688184A1 (en) 2007-06-08 2008-12-18 Dexcom, Inc. Integrated medicament delivery device for use with continuous analyte sensor
US8318914B2 (en) 2007-07-31 2012-11-27 Bioriginal Food & Science Corp. Elongases and methods for producing polyunsaturated fatty acids in transgenic organisms
EP4468309A3 (de) 2007-10-09 2024-12-11 DexCom, Inc. Integriertes insulinabgabesystem mit kontinuierlichem glucosesensor
US8591455B2 (en) 2008-02-21 2013-11-26 Dexcom, Inc. Systems and methods for customizing delivery of sensor data
EP2108702A1 (de) * 2008-04-07 2009-10-14 Organo Balance GmbH Synthese mehrfach ungesättigter Fettsäuren in Hefe
CA2734810C (en) 2008-08-26 2018-06-19 Basf Plant Science Gmbh Nucleic acids encoding desaturases and modified plant oil
CN113957054B (zh) 2008-11-18 2024-07-16 联邦科学技术研究组织 产生ω-3脂肪酸的酶和方法
WO2010067352A1 (en) * 2008-12-09 2010-06-17 Ben Gurion University Of The Negev Research And Development Authority Polyunsaturated fatty acid elongase
EP2410910A4 (de) 2009-03-27 2014-10-15 Dexcom Inc Verfahren und systeme zur förderung eines blutzuckermanagements
US20110027453A1 (en) 2009-07-02 2011-02-03 Dexcom, Inc. Continuous analyte sensors and methods of making same
US8658413B2 (en) 2010-08-26 2014-02-25 E I Du Pont De Nemours And Company Mutant HPGG motif and HDASH motif delta-5 desaturases and their use in making polyunsaturated fatty acids
WO2012142502A2 (en) 2011-04-15 2012-10-18 Dexcom Inc. Advanced analyte sensor calibration and error detection
CA2866601C (en) 2012-03-01 2021-07-13 Nestec S.A. Nutritional products having a modulated off-taste intensity and methods for making and using same
ES2769448T3 (es) 2012-04-12 2020-06-25 Rothamsted Res Limited Producción de ácidos grasos poliinsaturados omega-3 de cadena larga
SG11201408362SA (en) 2012-06-15 2015-01-29 Commw Scient Ind Res Org Production of long chain polyunsaturated fatty acids in plant cells
GB201217524D0 (en) 2012-10-01 2012-11-14 Rothamsted Res Ltd Recombinant organisms
KR102386838B1 (ko) 2013-12-18 2022-04-15 커먼웰쓰 사이언티픽 앤 인더스트리알 리서치 오거니제이션 장쇄 다중불포화 지방산을 포함하는 지질
SG11201610596PA (en) 2014-06-27 2017-01-27 Commw Scient Ind Res Org Lipid comprising docosapentaenoic acid
US11331022B2 (en) 2017-10-24 2022-05-17 Dexcom, Inc. Pre-connected analyte sensors
EP3700416B1 (de) 2017-10-24 2024-06-26 Dexcom, Inc. Vorverbundene analytsensoren
CN110373436B (zh) * 2018-12-11 2022-09-23 山东理工大学 一种产双高-γ-亚麻酸卷枝毛霉细胞工厂的构建方法及发酵技术
CN114452309B (zh) * 2022-01-17 2022-12-02 广东海洋大学 杨叶肖槿内生真菌发酵提取物及其制备方法与用途

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0285405A1 (de) 1987-03-31 1988-10-05 Schering Biotech Corporation Glycosylierungshemmender Faktor
GB8714772D0 (en) 1987-06-24 1987-07-29 Efamol Ltd Essential fatty acid compositions
FR2648347B1 (fr) * 1989-06-15 1994-04-29 Sederma Sa Preparations cosmetiques possedant des proprietes adoucissantes
ATE110778T1 (de) 1990-05-25 1994-09-15 Du Pont Nukleotidsequenz des gens für stearoyl-acp- desaturase aus soja.
PH31293A (en) 1991-10-10 1998-07-06 Rhone Poulenc Agrochimie Production of y-linolenic acid by a delta6-desaturage.
DK0616644T3 (da) 1991-12-04 2003-10-27 Du Pont Fedtsyredesaturase-gener fra planter
CA2149223C (en) 1992-11-17 2007-04-24 Jonathan Edward Lightner Genes for microsomal delta-12 fatty acid desaturases and related enzymes from plants
US5484724A (en) 1994-05-26 1996-01-16 Merck & Co., Inc. DNA encoding GLSI
US5545553A (en) 1994-09-26 1996-08-13 The Rockefeller University Glycosyltransferases for biosynthesis of oligosaccharides, and genes encoding them
US5654402A (en) 1994-10-26 1997-08-05 Michigan State University Methods and compositions relating to plant Δ6 palmitoyl-acyl carrier protein desaturase
JP3792309B2 (ja) 1996-08-30 2006-07-05 サントリー株式会社 不飽和脂肪酸含有油脂の製造方法
US6403349B1 (en) * 1998-09-02 2002-06-11 Abbott Laboratories Elongase gene and uses thereof
CA2365096A1 (en) * 1999-03-18 2000-09-21 The University Of Bristol Polyunsaturated fatty acid (pufa) elongase from caenorhabditis elegans
CA2365421A1 (en) * 1999-04-07 2000-10-12 Incyte Pharmaceuticals, Inc. Vesicle associated proteins
US7070970B2 (en) * 1999-08-23 2006-07-04 Abbott Laboratories Elongase genes and uses thereof

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