ATE414170T1 - Wellenlängen verschiebende proben und primer - Google Patents

Wellenlängen verschiebende proben und primer

Info

Publication number
ATE414170T1
ATE414170T1 AT99937602T AT99937602T ATE414170T1 AT E414170 T1 ATE414170 T1 AT E414170T1 AT 99937602 T AT99937602 T AT 99937602T AT 99937602 T AT99937602 T AT 99937602T AT E414170 T1 ATE414170 T1 AT E414170T1
Authority
AT
Austria
Prior art keywords
primers
harvester
wavelength
probes
fluorescence
Prior art date
Application number
AT99937602T
Other languages
English (en)
Inventor
Sanjay Tyagi
Fred Kramer
Salvatore Marras
Original Assignee
Phri Properties Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22410742&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE414170(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Phri Properties Inc filed Critical Phri Properties Inc
Application granted granted Critical
Publication of ATE414170T1 publication Critical patent/ATE414170T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6816Hybridisation assays characterised by the detection means
    • C12Q1/6818Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Electrochromic Elements, Electrophoresis, Or Variable Reflection Or Absorption Elements (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
AT99937602T 1998-07-28 1999-07-28 Wellenlängen verschiebende proben und primer ATE414170T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/123,764 US6037130A (en) 1998-07-28 1998-07-28 Wavelength-shifting probes and primers and their use in assays and kits

Publications (1)

Publication Number Publication Date
ATE414170T1 true ATE414170T1 (de) 2008-11-15

Family

ID=22410742

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99937602T ATE414170T1 (de) 1998-07-28 1999-07-28 Wellenlängen verschiebende proben und primer

Country Status (8)

Country Link
US (1) US6037130A (de)
EP (1) EP1100971B1 (de)
JP (1) JP3851088B2 (de)
AT (1) ATE414170T1 (de)
AU (1) AU763106B2 (de)
CA (1) CA2336489C (de)
DE (1) DE69939902D1 (de)
WO (1) WO2000006778A1 (de)

Families Citing this family (153)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6576419B1 (en) * 1993-07-23 2003-06-10 University Of Utah Research Foundation Assay procedure using fluorogenic tracers
US20070269799A9 (en) * 1994-06-22 2007-11-22 Zhang David Y Nucleic acid amplification methods
US20020055101A1 (en) * 1995-09-11 2002-05-09 Michel G. Bergeron Specific and universal probes and amplification primers to rapidly detect and identify common bacterial pathogens and antibiotic resistance genes from clinical specimens for routine diagnosis in microbiology laboratories
US5854033A (en) * 1995-11-21 1998-12-29 Yale University Rolling circle replication reporter systems
CA2246238A1 (en) * 1996-03-01 1997-09-04 E.I. Du Pont De Nemours And Company A method for the amplification and detection of a nucleic acid fragment of interest
US20030049636A1 (en) 1999-05-03 2003-03-13 Bergeron Michel G. Species-specific, genus-specific and universal DNA probes and amplification primers to rapidly detect and identify common bacterial and fungal pathogens and associated antibiotic resistance genes from clinical specimens for diagnosis in microbiology laboratories
US20100267012A1 (en) 1997-11-04 2010-10-21 Bergeron Michel G Highly conserved genes and their use to generate probes and primers for detection of microorganisms
US7312302B2 (en) 1997-02-20 2007-12-25 Oncolmmunin, Inc. Compositions for the detection of enzyme activity in biological samples and methods of use thereof
US6893868B2 (en) * 1997-02-20 2005-05-17 Onco Immunin, Inc. Homo-doubly labeled compositions for the detection of enzyme activity in biological samples
US6037137A (en) * 1997-02-20 2000-03-14 Oncoimmunin, Inc. Fluorogenic peptides for the detection of protease activity
US7008765B1 (en) * 1997-04-10 2006-03-07 The Johns Hopkins University PCA3, PCA3 genes, and methods of use
US6518017B1 (en) * 1997-10-02 2003-02-11 Oasis Biosciences Incorporated Combinatorial antisense library
US20030165888A1 (en) * 2001-07-18 2003-09-04 Brown Bob D. Oligonucleotide probes and primers comprising universal bases for diagnostic purposes
US7595189B2 (en) * 1999-01-08 2009-09-29 Applied Biosystems, Llc Integrated optics fiber array
AU2965500A (en) * 1999-01-15 2000-08-01 Gene Logic, Inc. Immobilized nucleic acid hybridization reagent and method
US6951722B2 (en) * 1999-03-19 2005-10-04 Takara Bio Inc. Method for amplifying nucleic acid sequence
WO2000061810A1 (en) * 1999-04-08 2000-10-19 Oasis Biosciences, Inc. Antisense oligonucleotides comprising universal and/or degenerate bases
US6680377B1 (en) * 1999-05-14 2004-01-20 Brandeis University Nucleic acid-based detection
ES2459745T3 (es) * 1999-05-14 2014-05-12 Brandeis University Detección basada en aptámero
US6277607B1 (en) 1999-05-24 2001-08-21 Sanjay Tyagi High specificity primers, amplification methods and kits
WO2000079009A2 (en) * 1999-06-22 2000-12-28 Invitrogen Corporation Improved primers and methods for the detection and discrimination of nucleic acids
US6830902B1 (en) 1999-07-02 2004-12-14 Invitrogen Corporation Compositions and methods for enhanced sensitivity and specificity of nucleic acid synthesis
WO2001002850A1 (en) 1999-07-06 2001-01-11 Caliper Technologies Corp. Microfluidic systems and methods for determining modulator kinetics
US6692915B1 (en) * 1999-07-22 2004-02-17 Girish N. Nallur Sequencing a polynucleotide on a generic chip
US6440706B1 (en) 1999-08-02 2002-08-27 Johns Hopkins University Digital amplification
US6383754B1 (en) * 1999-08-13 2002-05-07 Yale University Binary encoded sequence tags
US6586177B1 (en) * 1999-09-08 2003-07-01 Exact Sciences Corporation Methods for disease detection
EP1246935B1 (de) * 1999-09-28 2013-08-14 Geneohm Sciences Canada Inc. Konservierte gene und dessen benutzung für die herstellung von sonden und primern für mikroorganismen nachweis
US7368545B1 (en) * 1999-09-29 2008-05-06 Diagnocure Inc. PCA3 messenger RNA species in benign and malignant prostate tissues
CA2387306C (en) * 1999-10-22 2010-04-27 The Public Health Research Institute Of The City Of New York, Inc. Assays for short sequence variants
US6692965B1 (en) * 1999-11-23 2004-02-17 Chromocell Corporation Isolation of living cells and preparation of cell lines based on detection and quantification of preselected cellular ribonucleic acid sequences
US6919174B1 (en) * 1999-12-07 2005-07-19 Exact Sciences Corporation Methods for disease detection
US6936443B2 (en) * 2000-04-03 2005-08-30 Cytyc Corporation Detection and typing of human papillomavirus using PNA probes
WO2001075174A2 (en) * 2000-04-03 2001-10-11 Cytyc Corporation Detection and typing of human papillomavirus using pna probes
AU2001255754A1 (en) 2000-04-28 2001-11-12 Montclair Group Methods and compositions for the manufacture of molecular beacons
US7019129B1 (en) 2000-05-09 2006-03-28 Biosearch Technologies, Inc. Dark quenchers for donor-acceptor energy transfer
US6887664B2 (en) 2000-06-06 2005-05-03 Applera Corporation Asynchronous primed PCR
US6323009B1 (en) * 2000-06-28 2001-11-27 Molecular Staging, Inc. Multiply-primed amplification of nucleic acid sequences
GB2368809B (en) 2000-09-15 2004-09-29 Norchip As Microfabricated reaction chamber system
JP2004537257A (ja) * 2000-10-06 2004-12-16 ニューゲン テクノロジーズ, インコーポレイテッド 核酸配列の検出および/または定量のための、方法およびプローブ
WO2002050308A1 (en) * 2000-12-19 2002-06-27 Discoverx Strand displacement detection of target nucleic acid
US6573051B2 (en) * 2001-03-09 2003-06-03 Molecular Staging, Inc. Open circle probes with intramolecular stem structures
FR2822234B1 (fr) * 2001-03-14 2003-06-13 Univ Pasteur Procede de determination locale de parametres structuraux de molecules, notamment biochimiques ou pharmacologiques et utilisations dudit procede
ATE346958T1 (de) * 2001-04-17 2006-12-15 New York Blood Ct Inc Universelles nachweissystem für mehrere varianten
US20040137458A1 (en) * 2001-05-03 2004-07-15 Christian Archambault Molecular tag code for monitoring a product and process using same
WO2003000917A2 (en) * 2001-06-21 2003-01-03 The Regents Of The University Of California Electrochemical detection of mismatch nucleic acids
US7297494B2 (en) * 2001-06-25 2007-11-20 Georgia Tech Research Corporation Activatable probes and methods for in vivo gene detection
EP1409735A4 (de) * 2001-06-25 2005-10-05 Georgia Tech Res Inst Doppel-resonanzenergietransfer-nukleinsäuresonden
GB2378245A (en) 2001-08-03 2003-02-05 Mats Nilsson Nucleic acid amplification method
US20030082547A1 (en) * 2001-08-27 2003-05-01 Ewing Gregory J. Non-fluorescent quencher compounds and biomolecular assays
WO2003020898A2 (en) * 2001-08-30 2003-03-13 Spectral Genomics, Inc. Arrays comprising pre-labeled biological molecules and methods for making and using these arrays
CA2457527A1 (en) * 2001-08-31 2003-03-13 Gen-Probe Incorporated Affinity-shifted probes for quantifying analyte polynucleotides
US7070933B2 (en) * 2001-09-28 2006-07-04 Gen-Probe Incorporated Inversion probes
MXPA04003451A (es) * 2001-10-09 2005-02-17 Dimensional Pharm Inc Difeniloxazoles substituidos, la sintesis de los mismos y el uso de los mismo como detectores fluorescencia.
US20030165859A1 (en) * 2001-10-23 2003-09-04 Invitrogen Corporation Primers and methods for the detection and discrimination of nucleic acids
WO2003040397A2 (en) * 2001-10-25 2003-05-15 Gorilla Genomics, Inc. Asymmetric pcr with nuclease-free polymerase or nuclease-resistant molecular beacons
GB0200526D0 (en) * 2002-01-11 2002-02-27 Science And Technology The Methods
US7553619B2 (en) * 2002-02-08 2009-06-30 Qiagen Gmbh Detection method using dissociated rolling circle amplification
WO2003089670A2 (en) * 2002-04-22 2003-10-30 Lawler Joseph F Jr Reagents for monitoring nuclei acid amplification and methods of using same
WO2003095666A2 (en) * 2002-05-13 2003-11-20 Nanocytometry Corporation Oligonucleotide probes for in vitro, in vivo and intracellular detection
US20040005613A1 (en) * 2002-05-22 2004-01-08 Norton Michael L. Methods, probes, and accessory molecules for detecting single nucleotide polymorphisms
JP4457001B2 (ja) * 2002-05-31 2010-04-28 セクレタリー・デパートメント・オブ・アトミック・エナジー ドナー/アクセプター部分が相補鎖上となる標的核酸検出のmet/fretに基づく方法
WO2007116408A2 (en) * 2006-04-11 2007-10-18 Nanodiagnostics Israel Ltd. Pluripotent stem cells characterized by expression of germline specific genes
CA2433473A1 (en) * 2002-07-23 2004-01-23 F. Hoffmann-La Roche Ag Fluorescent hybridization probes with reduced background
EP1546346A4 (de) * 2002-07-23 2006-02-08 Nanodiagnostics Inc Embryonale stammzellen-marker und verwendungen davon
US7582470B2 (en) * 2002-07-31 2009-09-01 Gen-Probe Incorporated Device for amplifying and detecting a target nucleic acid
WO2004046339A2 (en) * 2002-11-18 2004-06-03 Genospectra, Inc. Caged sensors, regulators and compounds and uses thereof
US20040121338A1 (en) * 2002-12-19 2004-06-24 Alsmadi Osama A. Real-time detection of rolling circle amplification products
US20050042639A1 (en) * 2002-12-20 2005-02-24 Caliper Life Sciences, Inc. Single molecule amplification and detection of DNA length
CA2511381A1 (en) * 2002-12-20 2004-07-22 Stratagene California Compositions and methods for polynucleotide detection
US9487823B2 (en) * 2002-12-20 2016-11-08 Qiagen Gmbh Nucleic acid amplification
US8275554B2 (en) * 2002-12-20 2012-09-25 Caliper Life Sciences, Inc. System for differentiating the lengths of nucleic acids of interest in a sample
JP4395133B2 (ja) 2002-12-20 2010-01-06 カリパー・ライフ・サイエンシズ・インク. Dnaの単一分子増幅および検出
WO2004068112A2 (en) * 2003-01-28 2004-08-12 Gorilla Genomics, Inc. Hairpin primer amplification
EP1592809B1 (de) 2003-02-07 2013-04-10 Diagnocure Inc. Verfahren zum nachweis von prostatakrebs in einer probe
CN100439515C (zh) * 2003-03-03 2008-12-03 清华大学 一种核酸分析芯片实验室系统与应用
US7238792B2 (en) 2003-03-18 2007-07-03 Washington State University Research Foundation Foldable polymers as probes
US8043834B2 (en) * 2003-03-31 2011-10-25 Qiagen Gmbh Universal reagents for rolling circle amplification and methods of use
US20040248103A1 (en) * 2003-06-04 2004-12-09 Feaver William John Proximity-mediated rolling circle amplification
WO2005012548A2 (en) * 2003-08-01 2005-02-10 Dynal Biotech Inc. Self-hybridizing multiple target nucleic acid probes and methods of use
CN104109712A (zh) * 2004-02-18 2014-10-22 克罗莫塞尔公司 使用信号探针的方法和材料
EP1745150A4 (de) * 2004-04-20 2008-02-27 Genaco Biomedial Products Inc Verfahren zum nachweis von ncrna
US7575863B2 (en) 2004-05-28 2009-08-18 Applied Biosystems, Llc Methods, compositions, and kits comprising linker probes for quantifying polynucleotides
WO2006010038A2 (en) * 2004-07-08 2006-01-26 Biosearch Technologies, Inc. Inducible fluorescence assay
US7361469B2 (en) * 2004-08-13 2008-04-22 Stratagene California Dual labeled fluorescent probes
EP1791982B1 (de) * 2004-09-21 2011-01-05 Life Technologies Corporation Zweifarbige echtzeit/endpunkt-quantifizierung von mikro-rnas (mirnas)
WO2006045009A2 (en) * 2004-10-20 2006-04-27 Stratagene California Triplex probe compositions and methods for polynucleotide detection
US20060275792A1 (en) * 2004-11-15 2006-12-07 Lee Jun E Enhancement of nucleic acid amplification using double-stranded DNA binding proteins
US20060105348A1 (en) * 2004-11-15 2006-05-18 Lee Jun E Compositions and methods for the detection and discrimination of nucleic acids
US7842794B2 (en) 2004-12-17 2010-11-30 Roche Molecular Systems, Inc. Reagents and methods for detecting Neisseria gonorrhoeae
CA2491067A1 (en) * 2004-12-24 2006-06-24 Stichting Katholieke Universiteit Mrna rations in urinary sediments and/or urine as a prognostic marker for prostate cancer
AU2006213907A1 (en) * 2005-02-09 2006-08-17 Stratagene California Key probe compositions and methods for polynucleotide detection
US8309303B2 (en) * 2005-04-01 2012-11-13 Qiagen Gmbh Reverse transcription and amplification of RNA with simultaneous degradation of DNA
GB2424886A (en) * 2005-04-04 2006-10-11 Dxs Ltd Polynucleotide primers against epidermal growth factor receptor and method of detecting gene mutations
US20070213293A1 (en) * 2005-04-08 2007-09-13 Nastech Pharmaceutical Company Inc. Rnai therapeutic for respiratory virus infection
CA2603842A1 (en) * 2005-04-08 2006-10-19 Nastech Pharmaceutical Company Inc. Rnai therapeutic for respiratory virus infection
CA2607369A1 (en) * 2005-05-02 2006-11-09 Stratagene California Oligonucleotide probe/primer compositions and methods for polynucleotide detection
US20070048758A1 (en) * 2005-06-09 2007-03-01 Epoch Biosciences, Inc. Improved primer-based amplification methods
EP1762627A1 (de) 2005-09-09 2007-03-14 Qiagen GmbH Verfahren zur Aktivierung einer Nukleinsäure für eine Polymerase-Reaktion
JP4843044B2 (ja) * 2005-10-05 2011-12-21 エフ.ホフマン−ラ ロシュ アーゲー 非蛍光性エネルギー移動
JP2009515545A (ja) * 2005-11-15 2009-04-16 ジェノイド・ケーエフティー 方法
US7790392B2 (en) * 2005-11-25 2010-09-07 Hidex Oy Homogeneous luminescence bioassay
DK2463388T3 (en) 2005-11-29 2018-02-26 Cambridge Entpr Ltd Markers for breast cancer
US20110143344A1 (en) * 2006-03-01 2011-06-16 The Washington University Genetic polymorphisms and substance dependence
EP1996733A2 (de) * 2006-03-01 2008-12-03 Perlegen Sciences, Inc. Suchtmarker
NZ571966A (en) * 2006-03-16 2011-09-30 Pentabase Aps Oligonucleotides comprising signalling pairs and hydrophobic nucleotides, stemless beacons, for detection of nucleic acids, methylation status and mutants of nucleic acids
RU2394915C2 (ru) * 2006-03-24 2010-07-20 Александр Борисович Четверин Бесконтактные способы обнаружения молекулярных колоний, наборы реагентов и устройство для их осуществления
US8313903B2 (en) 2006-03-31 2012-11-20 The Trustees Of Columbia University In The City Of New York Binary DNA probe for fluorescent analysis of nucleic acids
FR2900158A1 (fr) * 2006-04-25 2007-10-26 Biomerieux Sa Nouvelle sonde de detection agissant par reconnaissance moleculaire
JP5437790B2 (ja) 2006-04-28 2014-03-12 チルドレンズ ホスピタル メディカル センター 膜貫通薬物送達システムに適用するためのプロサポシン由来の融合タンパク質又はポリペプチドを含む組成物
DE102006020885A1 (de) * 2006-05-05 2007-11-08 Qiagen Gmbh Einführung von Sequenzelementen in Nukleinsäuren
WO2008070198A2 (en) 2006-05-17 2008-06-12 California Institute Of Technology Thermal cycling system
US7833716B2 (en) 2006-06-06 2010-11-16 Gen-Probe Incorporated Tagged oligonucleotides and their use in nucleic acid amplification methods
US7972786B2 (en) * 2006-07-07 2011-07-05 Brandeis University Detection and analysis of influenza virus
US9045522B2 (en) 2006-07-31 2015-06-02 Wanli Bi Nucleic acid amplification using a reversibly modified oligonucleotide
US8334099B2 (en) * 2006-07-31 2012-12-18 Wanli Bi Nucleic acid amplification using a reversibly modified oligonucleotide
BRPI0715346A2 (pt) * 2006-08-01 2013-11-26 Applera Corp Detecção de analitos e ácidos nucléicos
CA2660572C (en) 2006-08-11 2014-07-22 University Of Medicine And Dentistry Of New Jersey Dual-sensitizer-containing luminescent compounds, conjugates, and uses thereof
FR2906532B1 (fr) * 2006-09-28 2008-12-12 Biomerieux Sa Nouvel oligonucleotide marque
US9938641B2 (en) * 2006-12-18 2018-04-10 Fluidigm Corporation Selection of aptamers based on geometry
FI20070163A0 (fi) 2007-02-27 2007-02-27 Hidex Oy Parannettu homogeeninen luminesenssibiotesti
US8367899B2 (en) 2007-12-31 2013-02-05 E I Du Pont De Neumours And Company Gray leaf spot tolerant maize and methods of production
US9116147B2 (en) * 2008-02-28 2015-08-25 Board Of Regents, The University Of Texas System Compositions and methods for detection of small molecules using dyes derivatized with analyte responsive receptors in a chemiluminescent assay
PT2757091T (pt) * 2008-04-01 2017-07-24 Biosearch Tech Inc Sondas de fluoróforo e supressor de fluorescência de ácido nucleico estabilizadas
US20090270269A1 (en) * 2008-04-28 2009-10-29 Ashok Kumar Nano-scale fluoro-biosensors exhibiting a low false alarm rate for rapid detection of biological contaminants
EP2806037B1 (de) * 2008-05-13 2016-09-21 Gen-Probe Incorporated Inaktivierbare Target-Capture-Oligomere zur Verwendung bei der selektiven Hybridisierung und beim Fangen von Zielnukleinsäuresequenzen
FR2933410B1 (fr) * 2008-07-04 2010-08-20 Biomerieux Sa Nouvelle sonde de detection
WO2010011884A2 (en) * 2008-07-25 2010-01-28 University Of Florida Research Foundation, Inc. Novel nucleic acid-based molecular probes
GB0912509D0 (en) 2009-07-17 2009-08-26 Norchip As A microfabricated device for metering an analyte
WO2011011426A2 (en) 2009-07-20 2011-01-27 Bar Harbor Biotechnology, Inc. Methods for assessing disease risk
JP5575239B2 (ja) * 2009-07-21 2014-08-20 ジェン−プローブ・インコーポレーテッド 拡張されたダイナミックレンジにわたる核酸配列の定量的検出のための方法および組成物
US8815515B1 (en) 2009-09-24 2014-08-26 University Of Utah Research Foundation Methods, compositions, and kits for rare allele detection
US9221759B2 (en) 2010-01-13 2015-12-29 Rutgers, The State University Of New Jersey Fluorophore chelated lanthanide luminescent probes with improved quantum efficiency
AR080022A1 (es) 2010-01-26 2012-03-07 Pioneer Hi Bred Int Secuencias de polinucleotidos y polipeptidos asociadas con la tolerancia a los herbicidas
US20130157279A1 (en) * 2010-09-01 2013-06-20 Nec Corporation Method for detecting target substance and aptamer set, sensor, and apparatus used in the method
US20120174246A1 (en) 2010-12-30 2012-07-05 Chaky Julian M Methods of identifying aphid resistant soybeans
EP3733867A1 (de) * 2011-01-17 2020-11-04 Life Technologies Corporation Enzymatische ligation von nukleinsäuren
US20120196294A1 (en) 2011-01-17 2012-08-02 Life Technologies Corporation Workflow for detection of ligands using nucleic acids
ES2769028T3 (es) 2011-04-15 2020-06-24 Becton Dickinson Co Termociclador microfluídico de barrido en tiempo real
WO2013067202A1 (en) 2011-11-04 2013-05-10 Handylab, Inc. Polynucleotide sample preparation device
US9284574B2 (en) 2011-12-29 2016-03-15 Pioneer Hi Bred International Inc Rag-based selection methods for improving aphid resistance in soybeans
US9347105B2 (en) 2012-06-15 2016-05-24 Pioneer Hi Bred International Inc Genetic loci associated with resistance of soybean to cyst nematode and methods of use
EP3848046A1 (de) 2013-06-18 2021-07-14 New York University Pharmazeutische zusammensetzungen enthaltend mutierte leukocidin e
WO2015061548A1 (en) 2013-10-25 2015-04-30 Pioneer Hi-Bred International, Inc. Stem canker tolerant soybeans and methods of use
US10344319B2 (en) * 2013-10-28 2019-07-09 Dots Technology Corp. Allergen detection
BR112017016348A2 (pt) 2015-01-29 2018-03-27 Pioneer Hi Bred Int método de detecção de uma primeira planta, kit, polinucleotídeo isolado, método de reprodução de plantas
US20160289734A1 (en) 2015-04-03 2016-10-06 University Of Massachusetts Methods of using oligonucleotide-guided argonaute proteins
CA3002670A1 (en) 2015-12-18 2017-06-22 Donald Earl Kyle Genetic loci associated with reproductive growth phenotypes in soybean and methods of use
US11096344B2 (en) 2016-02-05 2021-08-24 Pioneer Hi-Bred International, Inc. Genetic loci associated with brown stem rot resistance in soybean and methods of use
US11028453B2 (en) 2016-02-11 2021-06-08 Pioneer Hi-Bred International, Inc. QTLs associated with and methods for identifying lodging resistance in soybean
US10718017B2 (en) * 2016-03-31 2020-07-21 Arizona Board Of Regents On Behalf Of Arizona State University Probes and methods for measuring tandem repeats
EP3978625A1 (de) 2016-05-12 2022-04-06 Pioneer Hi-Bred International, Inc. Verfahren zur gleichzeitigen gepoolten genotypisierung von pflanzen
US11242568B2 (en) 2017-12-29 2022-02-08 City Of Hope DNA methylation diagnostic test for breast cancer

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4261968A (en) * 1979-05-10 1981-04-14 Syva Company Fluorescence quenching with immunological pairs in immunoassays
CA1190838A (en) * 1981-07-17 1985-07-23 Cavit Akin Homogeneous nucleic acid hybridization diagnostics by non-radiative energy transfer
CA1223831A (en) * 1982-06-23 1987-07-07 Dean Engelhardt Modified nucleotides, methods of preparing and utilizing and compositions containing the same
US5241060A (en) * 1982-06-23 1993-08-31 Enzo Diagnostics, Inc. Base moiety-labeled detectable nucleatide
US5260433A (en) * 1982-06-23 1993-11-09 Enzo Diagnostics, Inc. Saccharide specific binding system labeled nucleotides
US4766062A (en) * 1984-05-07 1988-08-23 Allied Corporation Displacement polynucleotide assay method and polynucleotide complex reagent therefor
JP2609238B2 (ja) * 1985-05-02 1997-05-14 ジエネテイツクス・インスチチユ−ト・インコ−ポレ−テツド 標的ヌクレオチド配列の検定に有用な試薬複合体を作製するための方法および核酸構築物
US4822733A (en) * 1985-05-28 1989-04-18 Amoco Corporation Lifetime-resolved assay procedures
US4725537A (en) * 1985-09-19 1988-02-16 Allied Corporation Assay, reagent and kit employing nucleic acid strand displacement and restriction endonuclease cleavage
US4725536A (en) * 1985-09-19 1988-02-16 Genetics Institute, Inc. Reagent polynucleotide complex with multiple target binding regions, and kit and methods
US4752566A (en) * 1985-12-17 1988-06-21 Genetics Institute, Inc. Displacement polynucleotide method and reagent complex employing labeled probe polynucleotide
EP0232967B1 (de) * 1986-01-10 1993-04-28 Amoco Corporation Kompetitiver homogener Test
US5082830A (en) * 1988-02-26 1992-01-21 Enzo Biochem, Inc. End labeled nucleotide probe
US5118801A (en) * 1988-09-30 1992-06-02 The Public Health Research Institute Nucleic acid process containing improved molecular switch
CA1339731C (en) * 1988-10-12 1998-03-17 Charles T. Caskey Multiplex genomic dna amplification for deletion detection
AU7579891A (en) * 1990-03-14 1991-10-10 Regents Of The University Of California, The Multichromophore fluorescent probes
US5401847A (en) * 1990-03-14 1995-03-28 Regents Of The University Of California DNA complexes with dyes designed for energy transfer as fluorescent markers
US5312921A (en) * 1990-03-14 1994-05-17 Regents Of The University Of California Dyes designed for high sensitivity detection of double-stranded DNA
US5210015A (en) * 1990-08-06 1993-05-11 Hoffman-La Roche Inc. Homogeneous assay system using the nuclease activity of a nucleic acid polymerase
JP3085756B2 (ja) * 1991-10-30 2000-09-11 株式会社日立製作所 核酸の検出方法
US5411875A (en) * 1991-11-01 1995-05-02 University Of Iowa Research Foundation Method for retrieval of unknown flanking DNA sequence
ATE272068T1 (de) * 1991-11-07 2004-08-15 Nanotronics Inc Hybridisierung von mit chromophoren und fluorophoren konjugierten polynukleotiden zur erzeugung eines donor-donor energietransfersystems
US5348853A (en) * 1991-12-16 1994-09-20 Biotronics Corporation Method for reducing non-specific priming in DNA amplification
US5332659A (en) * 1992-04-09 1994-07-26 The United States Of America As Represented By The Secretary Of The Navy Light emission-or absorbance-based binding assays for polynucleic acids
EP0601889A2 (de) * 1992-12-10 1994-06-15 Maine Medical Center Research Institute Nukleinsäure-Sonden
CA2129787A1 (en) * 1993-08-27 1995-02-28 Russell G. Higuchi Monitoring multiple amplification reactions simultaneously and analyzing same
AU697841B2 (en) * 1993-11-12 1998-10-15 Phri Properties, Inc. Hybridization probes for nucleic acid detection, universal stems, methods and kits
US5925517A (en) * 1993-11-12 1999-07-20 The Public Health Research Institute Of The City Of New York, Inc. Detectably labeled dual conformation oligonucleotide probes, assays and kits
US5538848A (en) * 1994-11-16 1996-07-23 Applied Biosystems Division, Perkin-Elmer Corp. Method for detecting nucleic acid amplification using self-quenching fluorescence probe
US5654419A (en) * 1994-02-01 1997-08-05 The Regents Of The University Of California Fluorescent labels and their use in separations
US5622821A (en) * 1994-06-29 1997-04-22 The Regents Of The University Of California Luminescent lanthanide chelates and methods of use
US5565554A (en) * 1994-07-29 1996-10-15 The Regents Of The University Of California Dimeric fluorescent energy transfer dyes comprising asymmetric cyanine azole-indolenine chromophores
US5491063A (en) * 1994-09-01 1996-02-13 Hoffmann-La Roche Inc. Methods for in-solution quenching of fluorescently labeled oligonucleotide probes
US5571673A (en) * 1994-11-23 1996-11-05 Hoffmann-La Roche Inc. Methods for in-solution quenching of fluorescently labeled oligonucleotide probes
US5863504A (en) * 1995-03-16 1999-01-26 Bio-Rad Laboratories, Inc. Fluorescence imaging instrument utilizing fish
US5728528A (en) * 1995-09-20 1998-03-17 The Regents Of The University Of California Universal spacer/energy transfer dyes
WO1998010096A1 (en) * 1996-04-12 1998-03-12 The Public Health Research Institute Of The City Of New York, Inc. Detection probes, kits and assays
WO1997039008A1 (en) * 1996-04-12 1997-10-23 The Public Health Research Institute Of The City Of New York, Inc. Detection probes, kits and assays
WO1999064432A2 (en) * 1998-06-12 1999-12-16 Intergen Company Multi-fluorescent hairpin energy transfer oligonucleotides

Also Published As

Publication number Publication date
WO2000006778A1 (en) 2000-02-10
CA2336489C (en) 2011-05-03
EP1100971A1 (de) 2001-05-23
JP2002521069A (ja) 2002-07-16
US6037130A (en) 2000-03-14
CA2336489A1 (en) 2000-02-10
EP1100971B1 (de) 2008-11-12
JP3851088B2 (ja) 2006-11-29
DE69939902D1 (de) 2008-12-24
EP1100971A4 (de) 2004-11-24
AU5240299A (en) 2000-02-21
AU763106B2 (en) 2003-07-10

Similar Documents

Publication Publication Date Title
ATE414170T1 (de) Wellenlängen verschiebende proben und primer
CA2591550A1 (en) Monitoring hybridization during pcr
DK0713921T3 (da) Fremgangsmåde til dæmpning af fluorescensen i opløsning af fluorescensmærkede oligonukleotidprober
KR970028548A (ko) 핵산의 형광 편광도 검출방법
DE69637864D1 (de) Nachweis von amplifizierten nukleinsäuresequenzen durch bifunktionelle haptenisierung und farbige mikropartikel
WO2004015080A3 (en) Nucleic acid detection methods using universal priming
DE60143960D1 (de) Äuren
FI953445A0 (fi) Menetelmä nukleiinihappojen herkkään osoitukseen
DK0656955T3 (da) Elimination af falske negative testresultater i nukleinsyredetektering
AU3806701A (en) Nucleic acid detection methods using universal priming
EA200300284A1 (ru) Способ амплификации нуклеиновых кислот
ATE220726T1 (de) Oligonukleotid-primer für amplifizierung von hcv- nukleinsäure
Singh et al. Branched unwinding mechanism of the Pif1 family of DNA helicases
WO2006010038A3 (en) Inducible fluorescence assay
FI910822A0 (fi) Foerfarande foer kvantitativ bestaemning av dna-polymeras och i detta anvaendbar testfoerpackning.
WO2001068913A3 (en) Nucleic acid detection method and system
Kricka Chemiluminescence
ATE340270T1 (de) Fluoreszenzmarkierten hybridisierungssonden mit reduzierter hintergrundfluoreszenz
DE60222091D1 (de) Dendritische chemilumineszierende Substrate
DE60008290D1 (de) Enzym-substrate und assay mit intramolekularen fret
Sen et al. A paper based microfluidic platform combining LAMP-CRISPR/Cas12a for fluorometric detection of nucleic acids
Fisher et al. An amplified chemiluminescent assay for the detection of alkaline phosphatase
GB9918237D0 (en) Detection system
ATE455867T1 (de) Echtzeit-pcr unter zusatz von pyrophosphatase
Zhao et al. Amplified Chemiluminescence Detection of DNA by Strand-Displacement Polymerization Target Recycling and G-quadruplexes/Hemin DNAzyme Catalysis

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties