ATE437641T1 - Verfahren zur herstellung von medikamenten zur verringerung der amyloid-abscheidung, amyloid- neurotoxizität und mikrogliosis - Google Patents

Verfahren zur herstellung von medikamenten zur verringerung der amyloid-abscheidung, amyloid- neurotoxizität und mikrogliosis

Info

Publication number
ATE437641T1
ATE437641T1 AT04752432T AT04752432T ATE437641T1 AT E437641 T1 ATE437641 T1 AT E437641T1 AT 04752432 T AT04752432 T AT 04752432T AT 04752432 T AT04752432 T AT 04752432T AT E437641 T1 ATE437641 T1 AT E437641T1
Authority
AT
Austria
Prior art keywords
amyloid
microgliosis
reducing
animals
neurotoxicity
Prior art date
Application number
AT04752432T
Other languages
English (en)
Inventor
Michael Mullan
Daniel Paris
Original Assignee
Roskamp Res Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=33551420&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE437641(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Roskamp Res Llc filed Critical Roskamp Res Llc
Application granted granted Critical
Publication of ATE437641T1 publication Critical patent/ATE437641T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Preparation (AREA)
AT04752432T 2003-05-15 2004-05-17 Verfahren zur herstellung von medikamenten zur verringerung der amyloid-abscheidung, amyloid- neurotoxizität und mikrogliosis ATE437641T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US47069403P 2003-05-15 2003-05-15
PCT/US2004/015417 WO2004110354A2 (en) 2003-05-15 2004-05-17 Method for reducing amyloid deposition, amyloid neurotoxicity and microgliosis

Publications (1)

Publication Number Publication Date
ATE437641T1 true ATE437641T1 (de) 2009-08-15

Family

ID=33551420

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04752432T ATE437641T1 (de) 2003-05-15 2004-05-17 Verfahren zur herstellung von medikamenten zur verringerung der amyloid-abscheidung, amyloid- neurotoxizität und mikrogliosis

Country Status (10)

Country Link
US (1) US7732467B2 (de)
EP (1) EP1628663B1 (de)
JP (1) JP4971794B2 (de)
CN (1) CN100444840C (de)
AT (1) ATE437641T1 (de)
CA (1) CA2525970C (de)
DE (1) DE602004022284D1 (de)
DK (1) DK1628663T3 (de)
ES (1) ES2334029T3 (de)
WO (1) WO2004110354A2 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1858325A4 (de) * 2005-01-07 2010-06-30 Roskamp Res Llc Verbindungen zur hemmung der beta-amyloidproduktion und verfahren zum identifizieren dieser verbindungen
PT1874311E (pt) * 2005-04-15 2011-11-25 Res & Innovation S P A Método para prevenir, retardar ou reverter a deposição anómala de amilóide
WO2007103683A2 (en) * 2006-03-01 2007-09-13 Roskamp Research Llc Compounds for inhibiting beta-amyloid production
EP2120557A4 (de) * 2006-12-08 2010-02-10 Roskamp Res Llc Polyhydrochinolinverbindungen und dihydropyridinverbindungen zur hemmung der beta-amyloid-produktion
US8709394B2 (en) * 2007-09-28 2014-04-29 Ndsu Research Foundation Antimicrobial polysiloxane materials containing metal species
WO2009046338A1 (en) * 2007-10-05 2009-04-09 Roskamp Research Llc Method for increasing cerebral blood flow with (+)-nilvadipine enantiomer
NZ584729A (en) * 2007-10-05 2012-12-21 Alzheimer S Inst Of America Inc Method for reducing amyloid deposition, amyloid neurotoxicity, and microgliosis with (-)-nilvadipine enantiomer
US20100093810A1 (en) * 2007-10-05 2010-04-15 Alzheimer's Institute Of America, Inc. Pharmaceutical Compositions for Reducing Amyloid Deposition, Amyloid Neurotoxicity, and Microgliosis
WO2010132671A1 (en) * 2009-05-15 2010-11-18 The University Of Kentucky Research Foundation Treatment of mci and alzheimer's disease
EP2311823A1 (de) * 2009-10-15 2011-04-20 AC Immune S.A. 2,6-Diaminopyridinverbindungen zur Behandlung von Krankheiten im Zusammenhang mit Amyloidproteinen oder zur Behandlung von Augenkrankheiten
KR20140128230A (ko) * 2013-04-26 2014-11-05 한국과학기술연구원 혈액 중 단백질 응집체의 용해를 통한 단백질의 비정상적인 응집 또는 미스폴딩과 관련된 질환 또는 질병을 진단하는 진단키트

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Also Published As

Publication number Publication date
US20050009885A1 (en) 2005-01-13
DE602004022284D1 (de) 2009-09-10
WO2004110354A3 (en) 2005-02-10
DK1628663T3 (da) 2010-03-08
HK1092358A1 (en) 2007-02-09
JP2007501277A (ja) 2007-01-25
EP1628663A4 (de) 2006-05-24
CN100444840C (zh) 2008-12-24
CA2525970C (en) 2011-03-22
ES2334029T3 (es) 2010-03-04
EP1628663A2 (de) 2006-03-01
US7732467B2 (en) 2010-06-08
JP4971794B2 (ja) 2012-07-11
CA2525970A1 (en) 2004-12-23
WO2004110354A2 (en) 2004-12-23
CN1809352A (zh) 2006-07-26
EP1628663B1 (de) 2009-07-29

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