ATE456579T1 - Angiopoietin-like 4 protein hemmer kombinationen und deren verwendung - Google Patents
Angiopoietin-like 4 protein hemmer kombinationen und deren verwendungInfo
- Publication number
- ATE456579T1 ATE456579T1 AT05790352T AT05790352T ATE456579T1 AT E456579 T1 ATE456579 T1 AT E456579T1 AT 05790352 T AT05790352 T AT 05790352T AT 05790352 T AT05790352 T AT 05790352T AT E456579 T1 ATE456579 T1 AT E456579T1
- Authority
- AT
- Austria
- Prior art keywords
- angiopoietin
- protein inhibitor
- inhibitor combinations
- cancer
- treatment
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/06—Antiabortive agents; Labour repressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2839—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Cardiology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Heart & Thoracic Surgery (AREA)
- Reproductive Health (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Ophthalmology & Optometry (AREA)
- Epidemiology (AREA)
- Gynecology & Obstetrics (AREA)
- Oncology (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Hematology (AREA)
- Pregnancy & Childbirth (AREA)
- Obesity (AREA)
- Zoology (AREA)
- Orthopedic Medicine & Surgery (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58978204P | 2004-07-20 | 2004-07-20 | |
| PCT/US2005/025734 WO2006014729A2 (en) | 2004-07-20 | 2005-07-19 | Inhibitors of angiopoietin-like 4 protein, combinations, and their use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE456579T1 true ATE456579T1 (de) | 2010-02-15 |
Family
ID=35787710
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05790352T ATE456579T1 (de) | 2004-07-20 | 2005-07-19 | Angiopoietin-like 4 protein hemmer kombinationen und deren verwendung |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US7740846B2 (de) |
| EP (3) | EP2361931B1 (de) |
| JP (2) | JP4947717B2 (de) |
| KR (1) | KR101254815B1 (de) |
| CN (2) | CN101044164A (de) |
| AT (1) | ATE456579T1 (de) |
| AU (2) | AU2005269716B2 (de) |
| BR (1) | BRPI0513534A (de) |
| CA (1) | CA2574758A1 (de) |
| CY (1) | CY1109931T1 (de) |
| DE (1) | DE602005019167D1 (de) |
| DK (1) | DK1771474T3 (de) |
| ES (1) | ES2339789T3 (de) |
| IL (1) | IL180725A0 (de) |
| MX (1) | MX2007000784A (de) |
| NO (1) | NO20070951L (de) |
| NZ (1) | NZ552956A (de) |
| PL (1) | PL1771474T3 (de) |
| PT (1) | PT1771474E (de) |
| RU (1) | RU2392966C2 (de) |
| SI (1) | SI1771474T1 (de) |
| WO (1) | WO2006014729A2 (de) |
| ZA (1) | ZA200701183B (de) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6582959B2 (en) * | 1991-03-29 | 2003-06-24 | Genentech, Inc. | Antibodies to vascular endothelial cell growth factor |
| US20050123925A1 (en) | 2002-11-15 | 2005-06-09 | Genentech, Inc. | Compositions and methods for the diagnosis and treatment of tumor |
| WO2005007819A2 (en) | 2003-07-09 | 2005-01-27 | Wisconsin Alumni Research Foundation | Charge-dynamic polymers and delivery of anionic compounds |
| WO2006014678A2 (en) | 2004-07-20 | 2006-02-09 | Genentech, Inc. | Compositions and methods of using angiopoietin-like 4 protein |
| ES2339789T3 (es) | 2004-07-20 | 2010-05-25 | Genentech, Inc. | Inhibidores de proteina 4 de tipo angiopoyetina, combinaciones y su utilizacion. |
| US8604185B2 (en) | 2004-07-20 | 2013-12-10 | Genentech, Inc. | Inhibitors of angiopoietin-like 4 protein, combinations, and their use |
| BRPI0606432A2 (pt) | 2005-01-07 | 2009-06-30 | Lexicon Pharmaceuticals Inc | anticorpos monoclonais contra angptl4 |
| US8734851B2 (en) * | 2005-04-29 | 2014-05-27 | Wisconsin Alumni Research Foundation | Localized delivery of nucleic acid by polyelectrolyte assemblies |
| ES2643469T3 (es) | 2006-04-07 | 2017-11-23 | Aerpio Therapeutics, Inc. | Anticuerpos que se unen a la proteína tirosina fosfatasa beta humana (HPTP-beta) y usos de los mismos |
| US7622593B2 (en) | 2006-06-27 | 2009-11-24 | The Procter & Gamble Company | Human protein tyrosine phosphatase inhibitors and methods of use |
| KR100962301B1 (ko) | 2006-11-03 | 2010-06-11 | 재단법인서울대학교산학협력재단 | 자궁경부암을 위한 치료용 조성물 |
| HUE029445T2 (en) * | 2006-12-19 | 2017-02-28 | Genentech Inc | VEGF-specific antagonists for adjuvant and neoadjuvant therapy and treatment of early-stage tumors |
| US8834918B2 (en) * | 2007-01-22 | 2014-09-16 | Wisconsin Alumni Research Foundation | Modified multilayered film |
| EP2178531A4 (de) * | 2007-07-02 | 2012-01-11 | Yu Ming | Verfahren, zusammensetzung, ziele für kombinationskrebstherapien |
| US20090105375A1 (en) * | 2007-10-09 | 2009-04-23 | Lynn David M | Ultrathin Multilayered Films for Controlled Release of Anionic Reagents |
| US8126437B1 (en) | 2008-01-24 | 2012-02-28 | Invent Again | Ubiquitous voice messaging |
| US8324333B2 (en) | 2008-06-05 | 2012-12-04 | Wisconsin Alumni Research Foundation | Anionic charge-dynamic polymers for release of cationic agents |
| CN102625714B (zh) * | 2008-07-16 | 2015-08-19 | 贝勒研究院 | 基于将最大化的gag和nef靶向树突细胞的hiv疫苗 |
| HUE032693T2 (en) | 2008-11-22 | 2017-10-30 | Hoffmann La Roche | Use of anti-vegf antibody in combination with chemotherapy for treating breast cancer |
| EP3556367A1 (de) | 2009-07-06 | 2019-10-23 | Aerpio Therapeutics, Inc. | Benzuosulfonamide-derivate, deren zusammensetzungen und deren verwenung bei der behandlung von krebs oder metastasen |
| US20120207770A1 (en) * | 2009-10-14 | 2012-08-16 | Nanyang Technological University | Antiproliferative agent |
| EP3421040A1 (de) | 2010-01-08 | 2019-01-02 | Ionis Pharmaceuticals, Inc. | Modulation einer angiopoietin-3-ähnlichen expression |
| US9139629B2 (en) | 2010-06-05 | 2015-09-22 | The Uab Research Foundation | Methods for treatment of nephrotic syndrome and related conditions |
| US9475850B2 (en) | 2010-06-05 | 2016-10-25 | The Uab Research Foundation | Methods for treatment of nephrotic syndrome and related conditions |
| ES2649340T3 (es) * | 2010-07-12 | 2018-01-11 | Threshold Pharmaceuticals, Inc. | Administración de fármacos activados por hipoxia y agentes antiangiogénicos para el tratamiento del cáncer |
| WO2012088254A1 (en) | 2010-12-22 | 2012-06-28 | Genentech, Inc. | Autophagy inducer and inhibitor combination therapy for the treatment of neoplasms |
| RU2665952C2 (ru) | 2011-07-22 | 2018-09-05 | Пасилекс Фармасьютикалз Инк. | Синтетическая летальность и лечение рака |
| WO2013022406A1 (en) * | 2011-08-08 | 2013-02-14 | Nanyang Technological University | Angiopoietin-like 4 and its use in modulating cell leakiness |
| CA2850830A1 (en) | 2011-10-13 | 2013-04-18 | Aerpio Therapeutics, Inc. | Methods for treating vascular leak syndrome and cancer |
| SG10201610869TA (en) | 2012-06-26 | 2017-02-27 | Del Mar Pharmaceuticals | Methods for treating tyrosine-kinase-inhibitor-resistant malignancies in patients with genetic polymorphisms or ahi1 dysregulations or mutations employing dianhydrogalactitol, diacetyldianhydrogalacti |
| SG11201408340SA (en) * | 2012-08-14 | 2015-01-29 | Univ Nanyang Tech | Angiopoietin-like 4 antibody and a method of its use in cancer treatment |
| US9259435B2 (en) | 2012-08-31 | 2016-02-16 | W. L. Gore & Associates, Inc. | Reactive oxidative species generating materials and methods of use |
| EP3858350A1 (de) * | 2012-10-30 | 2021-08-04 | Pacylex Pharmaceuticals Inc. | Synthetische letalität und behandlung von krebs |
| KR101407730B1 (ko) * | 2012-11-23 | 2014-06-12 | 인하대학교 산학협력단 | 안지오포이에틴-4 단백질을 유효성분으로 포함하는 발기부전의 예방 또는 치료용 조성물 |
| GB201301313D0 (en) * | 2013-01-25 | 2013-03-06 | Univ Singapore | Respiratory Tract Infections |
| US20150050277A1 (en) | 2013-03-15 | 2015-02-19 | Aerpio Therapeutics Inc. | Compositions and methods for treating ocular diseases |
| KR20160061911A (ko) | 2013-04-08 | 2016-06-01 | 데니스 엠. 브라운 | 최적하 투여된 화학 화합물의 치료 효과 |
| DK2991656T3 (da) | 2013-05-01 | 2020-03-23 | Ionis Pharmaceuticals Inc | Sammensætninger og fremgangsmåder til modulering af apolipoprotein c-iii-ekspression |
| KR102198082B1 (ko) | 2013-12-24 | 2021-01-05 | 아이오니스 파마수티컬즈, 인코포레이티드 | 안지오포이에틴-유사 3 발현의 조절 |
| CN106456614A (zh) | 2014-03-14 | 2017-02-22 | 爱尔皮奥治疗有限公司 | HPTP‑β抑制剂 |
| JP2017521045A (ja) * | 2014-05-01 | 2017-08-03 | アイオーニス ファーマシューティカルズ, インコーポレーテッドIonis Pharmaceuticals,Inc. | アンジオポエチン様因子3発現を調節するための組成物及び方法 |
| EP3194437B1 (de) | 2014-08-07 | 2021-01-20 | Novartis AG | Antikörper gegen angiopoietinähnliches protein 4 und deren verwendung |
| BR112017002173B1 (pt) * | 2014-08-07 | 2023-11-21 | Novartis Ag | Anticorpo isolado anti-angptl4, ou fragmento de ligação ao antígeno do mesmo, seu uso, e composição farmacêutica |
| US11788145B2 (en) | 2015-07-17 | 2023-10-17 | Pacylex Pharmaceuticals Inc. | Epigeneiic silencing of NMT2 |
| MX387804B (es) | 2015-09-23 | 2025-03-19 | Aerpio Therapeutics Inc | Metodos para tratar presion intraocular con activadores de tie-2 |
| CN106596979B (zh) * | 2017-02-28 | 2018-10-09 | 汉氏联合(天津)干细胞研究院有限公司 | 一种用于帕金森综合症检测的试剂盒及其检测方法 |
| US12024708B2 (en) * | 2018-11-13 | 2024-07-02 | Lipigon Pharmaceuticals Ab | ANGPTL4 oligonucleotides influencing the regulation of the fatty acid metabolism |
| WO2020223209A1 (en) | 2019-04-29 | 2020-11-05 | Aerpio Pharmaceuticals, Inc. | Tie-2 activators targeting the schlemm's canal |
| JP2023514000A (ja) * | 2019-12-09 | 2023-04-05 | エンピリコ インク. | アンジオポエチン様4(angptl4)関連疾患の処置のためのオリゴヌクレオチド |
| CN112611877B (zh) * | 2020-12-31 | 2022-09-16 | 四川大学华西医院 | 一款利用angptl4预测急性呼吸窘迫综合征患病及预后的试剂盒 |
| US20240279663A1 (en) * | 2021-06-07 | 2024-08-22 | Empirico Inc. | Treatment of angptl4 related diseases |
| CN113797355B (zh) * | 2021-10-14 | 2023-07-21 | 四川大学华西医院 | 具有滑膜炎症抑制功能的纳米材料的制备方法及应用 |
| WO2025040097A1 (zh) * | 2023-08-22 | 2025-02-27 | 成都先衍生物技术有限公司 | 一种靶向ANGPTL4的siRNA及其缀合物和用途 |
| CN119405811A (zh) * | 2024-11-13 | 2025-02-11 | 杭州师范大学 | 禁食诱导因子Angptl4蛋白作为分子靶点在治疗或预防压力性脱发中的应用 |
Family Cites Families (151)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| US3896111A (en) | 1973-02-20 | 1975-07-22 | Research Corp | Ansa macrolides |
| US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| US4151042A (en) | 1977-03-31 | 1979-04-24 | Takeda Chemical Industries, Ltd. | Method for producing maytansinol and its derivatives |
| US4137230A (en) | 1977-11-14 | 1979-01-30 | Takeda Chemical Industries, Ltd. | Method for the production of maytansinoids |
| USRE30985E (en) | 1978-01-01 | 1982-06-29 | Serum-free cell culture media | |
| FR2413974A1 (fr) | 1978-01-06 | 1979-08-03 | David Bernard | Sechoir pour feuilles imprimees par serigraphie |
| US4265814A (en) | 1978-03-24 | 1981-05-05 | Takeda Chemical Industries | Matansinol 3-n-hexadecanoate |
| US4307016A (en) | 1978-03-24 | 1981-12-22 | Takeda Chemical Industries, Ltd. | Demethyl maytansinoids |
| JPS5562090A (en) | 1978-10-27 | 1980-05-10 | Takeda Chem Ind Ltd | Novel maytansinoid compound and its preparation |
| JPS55164687A (en) | 1979-06-11 | 1980-12-22 | Takeda Chem Ind Ltd | Novel maytansinoid compound and its preparation |
| US4256746A (en) | 1978-11-14 | 1981-03-17 | Takeda Chemical Industries | Dechloromaytansinoids, their pharmaceutical compositions and method of use |
| JPS5566585A (en) | 1978-11-14 | 1980-05-20 | Takeda Chem Ind Ltd | Novel maytansinoid compound and its preparation |
| JPS55102583A (en) | 1979-01-31 | 1980-08-05 | Takeda Chem Ind Ltd | 20-acyloxy-20-demethylmaytansinoid compound |
| JPS55162791A (en) | 1979-06-05 | 1980-12-18 | Takeda Chem Ind Ltd | Antibiotic c-15003pnd and its preparation |
| JPS55164685A (en) | 1979-06-08 | 1980-12-22 | Takeda Chem Ind Ltd | Novel maytansinoid compound and its preparation |
| JPS55164686A (en) | 1979-06-11 | 1980-12-22 | Takeda Chem Ind Ltd | Novel maytansinoid compound and its preparation |
| JPS6023084B2 (ja) | 1979-07-11 | 1985-06-05 | 味の素株式会社 | 代用血液 |
| US4309428A (en) | 1979-07-30 | 1982-01-05 | Takeda Chemical Industries, Ltd. | Maytansinoids |
| JPS5645483A (en) | 1979-09-19 | 1981-04-25 | Takeda Chem Ind Ltd | C-15003phm and its preparation |
| EP0028683A1 (de) | 1979-09-21 | 1981-05-20 | Takeda Chemical Industries, Ltd. | Antibiotikum C-15003 PHO und seine Herstellung |
| JPS5645485A (en) | 1979-09-21 | 1981-04-25 | Takeda Chem Ind Ltd | Production of c-15003pnd |
| WO1982001188A1 (en) | 1980-10-08 | 1982-04-15 | Takeda Chemical Industries Ltd | 4,5-deoxymaytansinoide compounds and process for preparing same |
| US4450254A (en) | 1980-11-03 | 1984-05-22 | Standard Oil Company | Impact improvement of high nitrile resins |
| US4419446A (en) | 1980-12-31 | 1983-12-06 | The United States Of America As Represented By The Department Of Health And Human Services | Recombinant DNA process utilizing a papilloma virus DNA as a vector |
| US4315929A (en) | 1981-01-27 | 1982-02-16 | The United States Of America As Represented By The Secretary Of Agriculture | Method of controlling the European corn borer with trewiasine |
| US4313946A (en) | 1981-01-27 | 1982-02-02 | The United States Of America As Represented By The Secretary Of Agriculture | Chemotherapeutically active maytansinoids from Trewia nudiflora |
| JPS57192389A (en) | 1981-05-20 | 1982-11-26 | Takeda Chem Ind Ltd | Novel maytansinoid |
| US4485045A (en) | 1981-07-06 | 1984-11-27 | Research Corporation | Synthetic phosphatidyl cholines useful in forming liposomes |
| NZ201705A (en) | 1981-08-31 | 1986-03-14 | Genentech Inc | Recombinant dna method for production of hepatitis b surface antigen in yeast |
| NZ201918A (en) | 1981-09-18 | 1987-04-30 | Genentech Inc | N-terminal methionyl analogues of bovine growth hormone |
| US4640835A (en) | 1981-10-30 | 1987-02-03 | Nippon Chemiphar Company, Ltd. | Plasminogen activator derivatives |
| US4601978A (en) | 1982-11-24 | 1986-07-22 | The Regents Of The University Of California | Mammalian metallothionein promoter system |
| US4560655A (en) | 1982-12-16 | 1985-12-24 | Immunex Corporation | Serum-free cell culture medium and process for making same |
| US4657866A (en) | 1982-12-21 | 1987-04-14 | Sudhir Kumar | Serum-free, synthetic, completely chemically defined tissue culture media |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| DD266710A3 (de) | 1983-06-06 | 1989-04-12 | Ve Forschungszentrum Biotechnologie | Verfahren zur biotechnischen Herstellung van alkalischer Phosphatase |
| US4544545A (en) | 1983-06-20 | 1985-10-01 | Trustees University Of Massachusetts | Liposomes containing modified cholesterol for organ targeting |
| US4767704A (en) | 1983-10-07 | 1988-08-30 | Columbia University In The City Of New York | Protein-free culture medium |
| US4496689A (en) | 1983-12-27 | 1985-01-29 | Miles Laboratories, Inc. | Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer |
| US4965199A (en) | 1984-04-20 | 1990-10-23 | Genentech, Inc. | Preparation of functional human factor VIII in mammalian cells using methotrexate based selection |
| US4879231A (en) | 1984-10-30 | 1989-11-07 | Phillips Petroleum Company | Transformation of yeasts of the genus pichia |
| EP0206448B1 (de) | 1985-06-19 | 1990-11-14 | Ajinomoto Co., Inc. | Hämoglobin, das an ein Poly(alkenylenoxid) gebunden ist |
| GB8516415D0 (en) | 1985-06-28 | 1985-07-31 | Celltech Ltd | Culture of animal cells |
| US4676980A (en) | 1985-09-23 | 1987-06-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Target specific cross-linked heteroantibodies |
| JPS63502716A (ja) | 1986-03-07 | 1988-10-13 | マサチューセッツ・インステチュート・オブ・テクノロジー | 糖タンパク安定性の強化方法 |
| US4927762A (en) | 1986-04-01 | 1990-05-22 | Cell Enterprises, Inc. | Cell culture medium with antioxidant |
| GB8610600D0 (en) | 1986-04-30 | 1986-06-04 | Novo Industri As | Transformation of trichoderma |
| US4791192A (en) | 1986-06-26 | 1988-12-13 | Takeda Chemical Industries, Ltd. | Chemically modified protein with polyethyleneglycol |
| US5567610A (en) | 1986-09-04 | 1996-10-22 | Bioinvent International Ab | Method of producing human monoclonal antibodies and kit therefor |
| IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
| US5770701A (en) | 1987-10-30 | 1998-06-23 | American Cyanamid Company | Process for preparing targeted forms of methyltrithio antitumor agents |
| US5606040A (en) | 1987-10-30 | 1997-02-25 | American Cyanamid Company | Antitumor and antibacterial substituted disulfide derivatives prepared from compounds possessing a methyl-trithio group |
| US5053394A (en) | 1988-09-21 | 1991-10-01 | American Cyanamid Company | Targeted forms of methyltrithio antitumor agents |
| WO1990003430A1 (en) | 1988-09-23 | 1990-04-05 | Cetus Corporation | Cell culture medium for enhanced cell growth, culture longevity and product expression |
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| US5750373A (en) | 1990-12-03 | 1998-05-12 | Genentech, Inc. | Enrichment method for variant proteins having altered binding properties, M13 phagemids, and growth hormone variants |
| FR2646437B1 (fr) | 1989-04-28 | 1991-08-30 | Transgene Sa | Nouvelles sequences d'adn, leur application en tant que sequence codant pour un peptide signal pour la secretion de proteines matures par des levures recombinantes, cassettes d'expression, levures transformees et procede de preparation de proteines correspondant |
| EP0402226A1 (de) | 1989-06-06 | 1990-12-12 | Institut National De La Recherche Agronomique | Transformationsvektoren für Hefe Yarrowia |
| DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
| AU641673B2 (en) | 1989-06-29 | 1993-09-30 | Medarex, Inc. | Bispecific reagents for aids therapy |
| US5013556A (en) | 1989-10-20 | 1991-05-07 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| CA2026147C (en) | 1989-10-25 | 2006-02-07 | Ravi J. Chari | Cytotoxic agents comprising maytansinoids and their therapeutic use |
| US5208020A (en) | 1989-10-25 | 1993-05-04 | Immunogen Inc. | Cytotoxic agents comprising maytansinoids and their therapeutic use |
| US5229275A (en) | 1990-04-26 | 1993-07-20 | Akzo N.V. | In-vitro method for producing antigen-specific human monoclonal antibodies |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| DE69133476T2 (de) | 1990-08-29 | 2006-01-05 | GenPharm International, Inc., Palo Alto | Transgene Mäuse fähig zur Produktion heterologer Antikörper |
| US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| US5122469A (en) | 1990-10-03 | 1992-06-16 | Genentech, Inc. | Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins |
| US5571894A (en) | 1991-02-05 | 1996-11-05 | Ciba-Geigy Corporation | Recombinant antibodies specific for a growth factor receptor |
| US6582959B2 (en) | 1991-03-29 | 2003-06-24 | Genentech, Inc. | Antibodies to vascular endothelial cell growth factor |
| US20030206899A1 (en) | 1991-03-29 | 2003-11-06 | Genentech, Inc. | Vascular endothelial cell growth factor antagonists |
| WO1992020373A1 (en) | 1991-05-14 | 1992-11-26 | Repligen Corporation | Heteroconjugate antibodies for treatment of hiv infection |
| ES2206447T3 (es) | 1991-06-14 | 2004-05-16 | Genentech, Inc. | Anticuerpo humanizado para heregulina. |
| US5565332A (en) | 1991-09-23 | 1996-10-15 | Medical Research Council | Production of chimeric antibodies - a combinatorial approach |
| FI941572A7 (fi) | 1991-10-07 | 1994-05-27 | Oncologix Inc | Anti-erbB-2-monoklonaalisten vasta-aineiden yhdistelmä ja käyttömenete lmä |
| WO1993008829A1 (en) | 1991-11-04 | 1993-05-13 | The Regents Of The University Of California | Compositions that mediate killing of hiv-infected cells |
| JPH07501451A (ja) | 1991-11-25 | 1995-02-16 | エンゾン・インコーポレイテッド | 多価抗原結合タンパク質 |
| EP0625200B1 (de) | 1992-02-06 | 2005-05-11 | Chiron Corporation | Marker für krebs und biosynthetisches bindeprotein dafür |
| US5573905A (en) | 1992-03-30 | 1996-11-12 | The Scripps Research Institute | Encoded combinatorial chemical libraries |
| ZA932522B (en) | 1992-04-10 | 1993-12-20 | Res Dev Foundation | Immunotoxins directed against c-erbB-2(HER/neu) related surface antigens |
| WO1994004690A1 (en) | 1992-08-17 | 1994-03-03 | Genentech, Inc. | Bispecific immunoadhesins |
| RU2170589C2 (ru) * | 1992-10-28 | 2001-07-20 | Генентек Инк. | Композиция для ингибирования ангиогенеза, моноклональное антитело, полипептид, способ ингибирования роста опухоли (варианты) |
| CZ291047B6 (cs) | 1992-10-28 | 2002-12-11 | Genentech, Inc. | Farmaceutický prostředek obsahující antagonisty faktoru růstu vaskulárních endoteliálních buněk |
| PL174494B1 (pl) | 1992-11-13 | 1998-08-31 | Idec Pharma Corp | Kompozycja farmaceutyczna do leczenia chłoniaka z limfocytów B i sposób wytwarzania kompozycji farmaceutycznej do leczenia chłoniaka z limfocytów B |
| US5641756A (en) | 1993-07-27 | 1997-06-24 | Hybridon, Inc. | Modified VEGF oligonucleotides |
| US5643755A (en) | 1994-10-07 | 1997-07-01 | Regeneron Pharmaceuticals Inc. | Nucleic acid encoding tie-2 ligand |
| US5753230A (en) * | 1994-03-18 | 1998-05-19 | The Scripps Research Institute | Methods and compositions useful for inhibition of angiogenesis |
| US5773001A (en) | 1994-06-03 | 1998-06-30 | American Cyanamid Company | Conjugates of methyltrithio antitumor agents and intermediates for their synthesis |
| US5650490A (en) | 1994-10-07 | 1997-07-22 | Regeneron Pharmaceuticals, Inc. | Tie-2 ligand 2 |
| US5814464A (en) | 1994-10-07 | 1998-09-29 | Regeneron Pharma | Nucleic acids encoding TIE-2 ligand-2 |
| US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| IL117645A (en) | 1995-03-30 | 2005-08-31 | Genentech Inc | Vascular endothelial cell growth factor antagonists for use as medicaments in the treatment of age-related macular degeneration |
| US5641870A (en) | 1995-04-20 | 1997-06-24 | Genentech, Inc. | Low pH hydrophobic interaction chromatography for antibody purification |
| US5739277A (en) | 1995-04-14 | 1998-04-14 | Genentech Inc. | Altered polypeptides with increased half-life |
| US5714586A (en) | 1995-06-07 | 1998-02-03 | American Cyanamid Company | Methods for the preparation of monomeric calicheamicin derivative/carrier conjugates |
| US5712374A (en) | 1995-06-07 | 1998-01-27 | American Cyanamid Company | Method for the preparation of substantiallly monomeric calicheamicin derivative/carrier conjugates |
| WO1999066041A1 (en) | 1998-06-16 | 1999-12-23 | Human Genome Sciences, Inc. | 94 human secreted proteins |
| US20020137890A1 (en) | 1997-03-31 | 2002-09-26 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| KR100856995B1 (ko) | 1997-04-07 | 2008-09-04 | 제넨테크, 인크. | 인간화 항체 및 인간화 항체의 제조 방법 |
| WO1998045331A2 (en) | 1997-04-07 | 1998-10-15 | Genentech, Inc. | Anti-vegf antibodies |
| US20020032315A1 (en) | 1997-08-06 | 2002-03-14 | Manuel Baca | Anti-vegf antibodies |
| US6884879B1 (en) | 1997-04-07 | 2005-04-26 | Genentech, Inc. | Anti-VEGF antibodies |
| US6348350B1 (en) | 1997-09-19 | 2002-02-19 | Genentech, Inc. | Ligand homologues |
| US20030207375A1 (en) | 1997-10-24 | 2003-11-06 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| WO1999032515A2 (en) | 1997-12-19 | 1999-07-01 | Zymogenetics, Inc. | Angiopoietin homolog, dna encoding it, and method of making it |
| EP1058737A4 (de) | 1998-03-02 | 2003-01-02 | Millennium Pharm Inc | Fdrg protein und nukleisäuremoleküle und ihre verwendung |
| AU4643699A (en) | 1998-06-24 | 2000-01-10 | Compugen Ltd. | Angiopoietin-like growth factor sequences |
| DE59914547D1 (de) | 1998-07-15 | 2007-12-20 | Max Planck Gesellschaft | Polyelektrolythüllen auf biologischen templaten |
| US6375447B1 (en) | 1998-09-29 | 2002-04-23 | Cq Inc. | Apparatus for dewatering and pelletizing particulate fuel |
| WO2001053455A2 (en) | 1999-12-23 | 2001-07-26 | Hyseq, Inc. | Novel nucleic acids and polypeptides |
| JP2000308488A (ja) | 1999-02-23 | 2000-11-07 | Herikkusu Kenkyusho:Kk | 血管新生に関連するタンパク質および該タンパク質をコードする遺伝子 |
| AU3391200A (en) | 1999-03-04 | 2000-09-21 | Corixa Corporation | Compositions and methods for breast cancer therapy and diagnosis |
| EP1175439A4 (de) | 1999-04-09 | 2002-10-09 | Human Genome Sciences Inc | 49 humane sekretierte proteine |
| EP1655368B1 (de) | 1999-04-16 | 2009-01-07 | Genentech, Inc. | Vaskuläre Endothelzellen Wachstumsfaktor (VEGF) Varianten und dessen Verwendungen |
| US6703020B1 (en) | 1999-04-28 | 2004-03-09 | Board Of Regents, The University Of Texas System | Antibody conjugate methods for selectively inhibiting VEGF |
| AU5979300A (en) | 1999-07-02 | 2001-01-22 | Bayer Aktiengesellschaft | Angiopoietin-6 and uses thereof |
| CA2379152A1 (en) | 1999-07-16 | 2001-01-25 | Hyseq, Inc. | Novel angiopoietin materials and methods |
| US20030207348A1 (en) | 1999-07-20 | 2003-11-06 | Shimkets Richard A. | Polypeptides and polynucleotides encoding same |
| AU6229100A (en) | 1999-07-20 | 2001-02-05 | Curagen Corporation | Polypeptides and polynucleotides encoding same |
| EP1285084A1 (de) | 2000-01-25 | 2003-02-26 | Hyseq, Inc. | Neuartige nukleinsäure und polypeptide |
| AU2001243142A1 (en) | 2000-02-03 | 2001-08-14 | Hyseq, Inc. | Novel nucleic acids and polypeptides |
| WO2002081628A2 (en) * | 2001-04-05 | 2002-10-17 | Ribozyme Pharmaceuticals, Incorporated | Modulation of gene expression associated with inflammation proliferation and neurite outgrowth, using nucleic acid based technologies |
| CN1315451A (zh) | 2000-03-29 | 2001-10-03 | 上海博德基因开发有限公司 | 一种新的多肽——人血管形成素类似因子45和编码这种多肽的多核苷酸 |
| AU2001249929A1 (en) | 2000-04-07 | 2001-10-23 | Dana-Farber Cancer Institute Inc. | Fdrg proteins and nucleic acid molecules and uses therefor |
| EP1292335B1 (de) | 2000-06-23 | 2007-05-30 | Bayer Schering Pharma Aktiengesellschaft | Zusammensetzungen, die mit vegf/vegf und angiopoietin/tie rezeptor-funktionen interferieren |
| US6673545B2 (en) | 2000-07-28 | 2004-01-06 | Incyte Corporation | Prostate cancer markers |
| CN1170850C (zh) * | 2000-09-19 | 2004-10-13 | 上海市肿瘤研究所 | 人血管生成素样蛋白和编码序列及其用途 |
| US20030120056A1 (en) | 2000-10-16 | 2003-06-26 | Audrey Goddard | TIE ligand homologues |
| EP1460900A4 (de) | 2001-03-27 | 2004-11-03 | Human Genome Sciences Inc | Sezernierte humanproteine |
| US7667004B2 (en) * | 2001-04-17 | 2010-02-23 | Abmaxis, Inc. | Humanized antibodies against vascular endothelial growth factor |
| DK2128246T3 (da) | 2001-04-19 | 2014-05-12 | Univ California | Fremgangsmåder og sammensætninger til fremstilling af ortogonale tRNA-aminoacyl-tRNA-syntetasepar. |
| US20030170891A1 (en) * | 2001-06-06 | 2003-09-11 | Mcswiggen James A. | RNA interference mediated inhibition of epidermal growth factor receptor gene expression using short interfering nucleic acid (siNA) |
| WO2002101039A1 (fr) | 2001-06-08 | 2002-12-19 | Sankyo Company, Limited | Procede de test de medicament destine a traiter ou a prevenir des maladies telles que l'hyperlipemie |
| WO2003010205A1 (en) | 2001-07-26 | 2003-02-06 | Duke University Medical Center | Genes induced by hypoxia |
| CA2459219A1 (en) | 2001-09-17 | 2003-03-27 | Protein Design Labs, Inc. | Methods of diagnosis of cancer compositions and methods of screening for modulators of cancer |
| US20050123925A1 (en) | 2002-11-15 | 2005-06-09 | Genentech, Inc. | Compositions and methods for the diagnosis and treatment of tumor |
| WO2003040330A2 (en) | 2001-11-05 | 2003-05-15 | Curagen Corporation | Therapeutic polypeptides, nucleic acids encoding same, and methods of use |
| US20040038230A1 (en) | 2001-11-05 | 2004-02-26 | Alsobrook John P. | Therapeutic polypeptides, nucleic acids encoding same, and methods of use |
| CN101905024A (zh) | 2001-11-16 | 2010-12-08 | 杰南技术公司 | 含有血管生成素-样蛋白质3angptl3的组合物及其使用方法 |
| WO2003048185A2 (en) | 2001-11-30 | 2003-06-12 | Genvec, Inc. | Angiopioetin related factors |
| EP1997829A1 (de) | 2001-12-21 | 2008-12-03 | Human Genome Sciences, Inc. | Albumin Fusionsproteine |
| WO2005044853A2 (en) | 2003-11-01 | 2005-05-19 | Genentech, Inc. | Anti-vegf antibodies |
| US20050106667A1 (en) | 2003-08-01 | 2005-05-19 | Genentech, Inc | Binding polypeptides with restricted diversity sequences |
| US20050239706A1 (en) | 2003-10-31 | 2005-10-27 | Washington University In St. Louis | Modulation of fiaf and the gastrointestinal microbiota as a means to control energy storage in a subject |
| CA2499791A1 (en) | 2004-03-30 | 2005-09-30 | F. Hoffmann-La Roche Ag | Angptl4/fiaf as marker for ppardelta modulation |
| ES2339789T3 (es) | 2004-07-20 | 2010-05-25 | Genentech, Inc. | Inhibidores de proteina 4 de tipo angiopoyetina, combinaciones y su utilizacion. |
| WO2006014678A2 (en) | 2004-07-20 | 2006-02-09 | Genentech, Inc. | Compositions and methods of using angiopoietin-like 4 protein |
| BRPI0606432A2 (pt) | 2005-01-07 | 2009-06-30 | Lexicon Pharmaceuticals Inc | anticorpos monoclonais contra angptl4 |
-
2005
- 2005-07-19 ES ES05790352T patent/ES2339789T3/es not_active Expired - Lifetime
- 2005-07-19 AT AT05790352T patent/ATE456579T1/de active
- 2005-07-19 BR BRPI0513534-6A patent/BRPI0513534A/pt not_active Application Discontinuation
- 2005-07-19 EP EP10010294.6A patent/EP2361931B1/de not_active Expired - Lifetime
- 2005-07-19 SI SI200530979T patent/SI1771474T1/sl unknown
- 2005-07-19 JP JP2007522697A patent/JP4947717B2/ja not_active Expired - Fee Related
- 2005-07-19 DE DE602005019167T patent/DE602005019167D1/de not_active Expired - Lifetime
- 2005-07-19 WO PCT/US2005/025734 patent/WO2006014729A2/en not_active Ceased
- 2005-07-19 US US11/185,215 patent/US7740846B2/en not_active Expired - Lifetime
- 2005-07-19 CN CNA2005800316893A patent/CN101044164A/zh active Pending
- 2005-07-19 PL PL05790352T patent/PL1771474T3/pl unknown
- 2005-07-19 DK DK05790352.8T patent/DK1771474T3/da active
- 2005-07-19 CN CN2012100589479A patent/CN102641503A/zh active Pending
- 2005-07-19 EP EP05790352A patent/EP1771474B1/de not_active Revoked
- 2005-07-19 KR KR1020077003872A patent/KR101254815B1/ko not_active Expired - Fee Related
- 2005-07-19 EP EP09013335A patent/EP2172482A1/de not_active Withdrawn
- 2005-07-19 AU AU2005269716A patent/AU2005269716B2/en not_active Expired
- 2005-07-19 PT PT05790352T patent/PT1771474E/pt unknown
- 2005-07-19 RU RU2007106076/14A patent/RU2392966C2/ru active
- 2005-07-19 CA CA002574758A patent/CA2574758A1/en not_active Abandoned
- 2005-07-19 NZ NZ552956A patent/NZ552956A/en not_active IP Right Cessation
- 2005-07-19 ZA ZA200701183A patent/ZA200701183B/en unknown
- 2005-07-19 MX MX2007000784A patent/MX2007000784A/es active IP Right Grant
-
2006
- 2006-09-28 US US11/540,884 patent/US20070026002A1/en not_active Abandoned
-
2007
- 2007-01-16 IL IL180725A patent/IL180725A0/en unknown
- 2007-02-19 NO NO20070951A patent/NO20070951L/no not_active Application Discontinuation
-
2010
- 2010-03-30 CY CY20101100299T patent/CY1109931T1/el unknown
-
2011
- 2011-03-30 AU AU2011201436A patent/AU2011201436A1/en not_active Withdrawn
- 2011-08-10 JP JP2011175420A patent/JP2012017331A/ja not_active Withdrawn
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE456579T1 (de) | Angiopoietin-like 4 protein hemmer kombinationen und deren verwendung | |
| DE602006018057D1 (de) | Substituierte chinolone und verwendungsverfahren | |
| DE602005026105D1 (de) | Verwendung von agonisten und antagonisten von interleukin-33 (il-33) | |
| ATE538136T1 (de) | Antikörper gegen connective tissue growth factor | |
| CY1120257T1 (el) | ΠΥΡΡΟΛΟ[2,3b]ΠΥΡΙΔΙΝ-4-ΥΛΑΜΙΝΕΣ ΚΑΙ ΠΥΡΡΟΛΟ[2,3b]ΠΥΡΙΜΙΔΙΝ-4-ΥΛΑΜΙΝΕΣ ΩΣ ΑΝΑΣΤΟΛΕΙΣ ΚΙΝΑΣΩΝ JANUS | |
| IL187343A0 (en) | Compositions and methods for the diagnosis and treatment of tumor | |
| EP1912674A4 (de) | Bispezifische einzelketten-fv-antikörper-moleküle und anwendungsverfahren dafür | |
| DE60028830D1 (de) | Anti-april antikörper und hybridomazellen | |
| BRPI0618488A2 (pt) | proteìnas de fusão de ìntron de fator de crescimento de hepatócito | |
| DE60324094D1 (de) | Verwendung einer proteinkinase a-inaktivierenden verbindung in einer kosmetisch verträglichen zusammensetzung zur aufhellung der haut | |
| NZ606294A (en) | B-cell reduction using cd37-specific and cd20-specific binding molecules | |
| EA200801716A1 (ru) | Тиазольные соединения и их применение | |
| CO6270257A2 (es) | Derivados de piridazinona | |
| ES2534303T3 (es) | Procedimientos y composiciones que implican miARN y moléculas inhibidoras de miARN | |
| ATE481978T1 (de) | Zusammensetzungen und verfahren zur behandlung von herzkrankheiten | |
| ATE517901T1 (de) | Pyrazolopyrimidine als hemmer der proteinkinase b (akt) | |
| PT1242060E (pt) | Tratamento da doenca metastatica | |
| WO2007053622A3 (en) | Methods for modulating ppar activity to treat diseases caused by mutations in the cftr gene | |
| DE60029944D1 (de) | Polyamine und ihre therapeutische verwendung | |
| ATE527998T1 (de) | Illudin-analoga als krebsmittel | |
| BR0313588A (pt) | Métodos para o tratamento da demência com base em apo e genótipo | |
| ATE512146T1 (de) | Phenylharnstoffderivate als hemmstoffe von tyrosinkinasen zur behandlung von tumorerkrankungen | |
| EA200702094A1 (ru) | Производные гетероарилмочевины, пригодные для ингибирования chk1 | |
| BRPI0821114A2 (pt) | Composto, uso de um composto e método para tratar qualquer mamífero afetado por câncer | |
| ATE397000T1 (de) | Tetrahydropyridothiophenen zur verwendung in der behandlung von krebs |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1771474 Country of ref document: EP |