ATE518852T1 - Tricyclische anilid-spirohydantoin-cgrp- rezeptorantagonisten - Google Patents

Tricyclische anilid-spirohydantoin-cgrp- rezeptorantagonisten

Info

Publication number
ATE518852T1
ATE518852T1 AT05796599T AT05796599T ATE518852T1 AT E518852 T1 ATE518852 T1 AT E518852T1 AT 05796599 T AT05796599 T AT 05796599T AT 05796599 T AT05796599 T AT 05796599T AT E518852 T1 ATE518852 T1 AT E518852T1
Authority
AT
Austria
Prior art keywords
receptor antagonists
cgrp receptor
anilide
tricyclic
spirohydantoin
Prior art date
Application number
AT05796599T
Other languages
English (en)
Inventor
Ian Bell
Steven Gallicchio
C Blair Zartman
Cory Theberge
Xufang Zhang
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Application granted granted Critical
Publication of ATE518852T1 publication Critical patent/ATE518852T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AT05796599T 2004-09-13 2005-09-09 Tricyclische anilid-spirohydantoin-cgrp- rezeptorantagonisten ATE518852T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60929404P 2004-09-13 2004-09-13
PCT/US2005/032288 WO2006031676A2 (en) 2004-09-13 2005-09-09 Tricyclic anilide spirohydantoin cgrp receptor antagonists

Publications (1)

Publication Number Publication Date
ATE518852T1 true ATE518852T1 (de) 2011-08-15

Family

ID=36060577

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05796599T ATE518852T1 (de) 2004-09-13 2005-09-09 Tricyclische anilid-spirohydantoin-cgrp- rezeptorantagonisten

Country Status (8)

Country Link
US (1) US7750010B2 (de)
EP (1) EP1794146B1 (de)
JP (1) JP2008512489A (de)
CN (1) CN101076527B (de)
AT (1) ATE518852T1 (de)
AU (1) AU2005285083B2 (de)
CA (1) CA2579850A1 (de)
WO (1) WO2006031676A2 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1951042B1 (de) 2005-11-18 2012-10-10 Merck Sharp & Dohme Corp. Spirolactam tricyclische cgrp-rezeptor-antagonisten
EP1954135B1 (de) 2005-11-18 2012-10-10 Merck Sharp & Dohme Corp. Spirolactam-aryl cgrp-rezeptor-antagonisten
US7968540B2 (en) 2005-11-18 2011-06-28 Merck Sharp & Dohme Corp. Spirohydantoin tricyclic CGRP receptor antagonists
CA2629406A1 (en) 2005-11-18 2007-05-31 Merck & Co., Inc. Spirohydantoin aryl cgrp receptor antagonists
WO2007133491A1 (en) 2006-05-09 2007-11-22 Merck & Co., Inc. Substituted spirocyclic cgrp receptor antagonists
JP5511379B2 (ja) * 2006-07-21 2014-06-04 バーテックス ファーマシューティカルズ インコーポレイテッド Ｃｇｒｐレセプターアンタゴニスト
US7951795B2 (en) 2006-12-08 2011-05-31 Merck Sharp & Dohme Corp. Constrained spirocyclic compounds as CGRP receptor antagonists
US8372859B2 (en) 2007-04-11 2013-02-12 Merck, Sharp & Dohme Corp. CGRP receptor antagonists with tertiary amide, sulfonamide, carbamate and urea end groups
CA2683745A1 (en) 2007-04-16 2008-10-30 Merck & Co., Inc. Bicyclic anilide heterocyclic cgrp receptor antagonists
WO2008130524A1 (en) 2007-04-16 2008-10-30 Merck & Co., Inc. Aryl heterocyclic cgrp receptor antagonists
CA2689217C (en) * 2007-06-05 2016-02-16 Merck & Co., Inc. Carboxamide heterocyclic cgrp receptor antagonists
US8163752B2 (en) * 2007-06-07 2012-04-24 Merck, Sharp & Dohme Corp. Tricyclic anilide heterocyclic CGRP receptor antagonists
WO2010042475A1 (en) * 2008-10-07 2010-04-15 Schering Corporation Spiroaminooxazoline analogues as alpha2c adrenergic receptor modulators
HUE034911T2 (hu) 2009-07-27 2018-03-28 Gilead Sciences Inc Fúzionált heterociklusos vegyületek mint ioncsatorna modulátorok
US20110200669A1 (en) * 2010-02-15 2011-08-18 Winston Laboratories, Inc. Method and compositions of civamide to treat disease of the intestines
EP2588197B1 (de) 2010-07-02 2014-11-05 Gilead Sciences, Inc. Kondensierte heterozyklische verbindungen als ionenkanalmodulatoren
WO2012154760A1 (en) 2011-05-10 2012-11-15 Gilead Sciences, Inc. Fused heterocyclic compounds as sodium channel modulators
UY34171A (es) 2011-07-01 2013-01-31 Gilead Sciences Inc Compuestos heterocíclicos fusionados como moduladores del canal iónico
NO3175985T3 (de) 2011-07-01 2018-04-28
US8652527B1 (en) 2013-03-13 2014-02-18 Upsher-Smith Laboratories, Inc Extended-release topiramate capsules
US9101545B2 (en) 2013-03-15 2015-08-11 Upsher-Smith Laboratories, Inc. Extended-release topiramate capsules
WO2025143096A1 (ja) * 2023-12-29 2025-07-03 キッセイ薬品工業株式会社 含窒素縮環化合物

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3561198D1 (en) * 1984-03-23 1988-01-28 Pfizer Spiro-indenes and spiro-1,2-dihydro-naphthalenes for treatment of diabetic complications
MC1999A1 (fr) * 1987-12-18 1990-01-26 Hoffmann La Roche Composes tricycliques
HU201757B (en) * 1988-03-11 1990-12-28 Pfizer Process for producing pyrroloquinoline-, acridine-, benzoxazine-, benzthiazine-, indolobenzoxazine-, benzazepine and pyrrolophenothiazine carboxamides and pharmaceutical compositions comprising same
US4906655A (en) * 1989-01-24 1990-03-06 Warner-Lambert Company Novel 1,2-cyclohexylaminoaryl amides useful as analgesic agents
EP0851759A4 (de) * 1995-09-05 2000-12-06 Smithkline Beecham Corp Verbindungen und verfahren dazu
DE19963868A1 (de) * 1999-12-30 2001-07-12 Boehringer Ingelheim Pharma Neue substituierte Piperidine, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
CA2449249A1 (en) * 2001-06-12 2002-12-19 Merck & Co., Inc. Nr2b receptor antagonists for the treatment or prevention of migraines
ES2616539T3 (es) * 2002-06-05 2017-06-13 Bristol-Myers Squibb Company Antagonistas de receptores de péptidos relacionados con el gen de calcitonina
EP1606264B1 (de) 2003-03-14 2012-05-02 Merck Sharp & Dohme Corp. Monocyclische anilidspirohydantoine als cgrp-rezeptorantagonisten
EP1606286B1 (de) 2003-03-14 2011-05-11 Merck Sharp & Dohme Corp. Benzodiazepinspirohydantoine als cgrp-rezeptorantagonisten
AU2004222328B2 (en) 2003-03-14 2009-10-08 Merck Sharp & Dohme Corp. Aryl spirohydantoin CGRP receptor antagonists
JP4673294B2 (ja) 2003-03-14 2011-04-20 メルク・シャープ・エンド・ドーム・コーポレイション 二環式アニリドスピロヒダントインｃｇｒｐ受容体拮抗物質
JP2008512460A (ja) 2004-09-08 2008-04-24 メルク エンド カムパニー インコーポレーテッド 単環式アニリドスピロラクタムｃｇｒｐ受容体拮抗薬
CA2579717A1 (en) * 2004-09-09 2006-03-23 Merck & Co., Inc. Tricyclic anilide spirolactam cgrp receptor antagonists
JP2008512459A (ja) 2004-09-09 2008-04-24 メルク エンド カムパニー インコーポレーテッド アリールスピロラクタムｃｇｒｐ受容体拮抗薬
US8003792B2 (en) 2004-09-13 2011-08-23 Merck Sharp & Dohme Corp. Bicyclic anilide spirolactam CGRP receptor antagonists
US7390798B2 (en) 2004-09-13 2008-06-24 Merck & Co., Inc. Carboxamide spirolactam CGRP receptor antagonists

Also Published As

Publication number Publication date
EP1794146A4 (de) 2010-06-30
CA2579850A1 (en) 2006-03-23
JP2008512489A (ja) 2008-04-24
CN101076527B (zh) 2011-11-30
AU2005285083B2 (en) 2011-03-10
EP1794146A2 (de) 2007-06-13
CN101076527A (zh) 2007-11-21
WO2006031676A3 (en) 2007-04-26
WO2006031676A2 (en) 2006-03-23
US20090221535A1 (en) 2009-09-03
AU2005285083A1 (en) 2006-03-23
US7750010B2 (en) 2010-07-06
EP1794146B1 (de) 2011-08-03

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