ATE466834T1 - Verfahren zur herstellung von aminoadamantanen - Google Patents

Verfahren zur herstellung von aminoadamantanen

Info

Publication number: ATE466834T1
Authority: AT; Austria
Prior art keywords: aminoadamantanes; producing; hydrochloride; synthesising; inorganic
Prior art date: 2005-05-10

Application number

AT06113681T

Other languages

English (en)

Inventor

Enrico Vigano'

Ernesto Landonio

Simona Lanfranconi

Renato Molteni

Original Assignee

A M S A Anonima Materie Sint E

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-05-10

Filing date

2006-05-09

Publication date

2010-05-15

2006-05-09 Application filed by A M S A Anonima Materie Sint E filed Critical A M S A Anonima Materie Sint E

2010-05-15 Application granted granted Critical

2010-05-15 Publication of ATE466834T1 publication Critical patent/ATE466834T1/de

Links

238000004519 manufacturing process Methods 0.000 title 1
LDDHMLJTFXJGPI-UHFFFAOYSA-N memantine hydrochloride Chemical compound Cl.C1C(C2)CC3(C)CC1(C)CC2(N)C3 LDDHMLJTFXJGPI-UHFFFAOYSA-N 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 1
DKNWSYNQZKUICI-UHFFFAOYSA-N amantadine Chemical class C1C(C2)CC3CC2CC1(N)C3 DKNWSYNQZKUICI-UHFFFAOYSA-N 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
229960000967 memantine hydrochloride Drugs 0.000 abstract 1
150000007522 mineralic acids Chemical class 0.000 abstract 1
150000007524 organic acids Chemical class 0.000 abstract 1
235000005985 organic acids Nutrition 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/10—Preparation of carboxylic acid amides from compounds not provided for in groups C07C231/02 - C07C231/08
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/62—Preparation of compounds containing amino groups bound to a carbon skeleton by cleaving carbon-to-nitrogen, sulfur-to-nitrogen, or phosphorus-to-nitrogen bonds, e.g. hydrolysis of amides, N-dealkylation of amines or quaternary ammonium compounds
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/08—Preparation of carboxylic acid amides from amides by reaction at nitrogen atoms of carboxamide groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/56—Ring systems containing bridged rings
- C07C2603/58—Ring systems containing bridged rings containing three rings
- C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
- C07C2603/74—Adamantanes

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT06113681T 2005-05-10 2006-05-09 Verfahren zur herstellung von aminoadamantanen ATE466834T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT000833A ITMI20050833A1 (it)	2005-05-10	2005-05-10	Nuovo procedimento per la sintesi di aminoadamantani

Publications (1)

Publication Number	Publication Date
ATE466834T1 true ATE466834T1 (de)	2010-05-15

Family

ID=36699347

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT06113681T ATE466834T1 (de)	2005-05-10	2006-05-09	Verfahren zur herstellung von aminoadamantanen

Country Status (6)

Country	Link
US (1)	US7405324B2 (de)
EP (1)	EP1721888B1 (de)
AT (1)	ATE466834T1 (de)
DE (1)	DE602006014054D1 (de)
ES (1)	ES2345623T3 (de)
IT (1)	ITMI20050833A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2007132476A2 (en) *	2006-05-15	2007-11-22	Matrix Laboratories Limited	A process for the preparation of memantine hydrochloride
WO2009151498A2 (en) *	2008-03-28	2009-12-17	Forest Laboratories Holdings Limited	Memantine formulations
EP2331495B1 (de) *	2008-08-08	2016-01-27	Merz Pharma GmbH & Co. KGaA	Verfahren zur herstellung von adamantanderivaten in hoher ausbeute
CN102432473A (zh) *	2011-11-23	2012-05-02	广州博济医药生物技术股份有限公司	一种盐酸美金刚的合成方法
EP2882291B1 (de) *	2012-08-07	2017-09-27	ZCL Chemicals Ltd.	Verbessertes verfahren zur herstellung von memantin-hydrochlorid

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3391142A (en)	1966-02-09	1968-07-02	Lilly Co Eli	Adamantyl secondary amines
ES413944A1 (es)	1972-04-20	1976-06-01	Merz & Co	Procedimiento para la preparacion de compuestos de adamen- tano trisustituidos en las posiciones 1,3,5.
GB8332608D0 (en) *	1983-12-07	1984-01-11	Ici Plc	Chemical process
ES2059602T3 (es)	1989-04-14	1994-11-16	Merz & Co Gmbh & Co	Uso de derivados de adamantano para la prevencion y tratamiento de isquemia cerebral.
CN1125033C (zh)	2001-08-29	2003-10-22	中国科学院广州化学研究所	美金刚胺盐酸盐的合成方法
WO2005062724A2 (en) *	2003-12-31	2005-07-14	Sun Pharmaceutical Industries Limited	Novel process for the preparation of aminoadamantane derivatives
EP1789380A1 (de) *	2004-07-23	2007-05-30	Justus-Liebig-Universität Giessen	Aminoadamantan-derivate, verfahren zu ihrer herstellung und ihre verwendung
WO2006076562A1 (en)	2005-01-11	2006-07-20	Teva Pharmaceutical Fine Chemicals S.R.L.	Process for the preparation of 1-amino-3,5-dimethyladamantane hydrochloride

2005
- 2005-05-10 IT IT000833A patent/ITMI20050833A1/it unknown
2006
- 2006-05-09 ES ES06113681T patent/ES2345623T3/es not_active Expired - Lifetime
- 2006-05-09 DE DE602006014054T patent/DE602006014054D1/de active Active
- 2006-05-09 EP EP06113681A patent/EP1721888B1/de not_active Expired - Lifetime
- 2006-05-09 AT AT06113681T patent/ATE466834T1/de not_active IP Right Cessation
- 2006-05-10 US US11/431,175 patent/US7405324B2/en active Active

Also Published As

Publication number	Publication date
ES2345623T3 (es)	2010-09-28
EP1721888A1 (de)	2006-11-15
DE602006014054D1 (de)	2010-06-17
US7405324B2 (en)	2008-07-29
EP1721888B1 (de)	2010-05-05
US20060258885A1 (en)	2006-11-16
ITMI20050833A1 (it)	2006-11-11

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Legal Events

Date	Code	Title	Description
2010-11-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties