ATE482218T1 - Inhibitoren von mitotischem kinesin - Google Patents

Inhibitoren von mitotischem kinesin

Info

Publication number: ATE482218T1
Authority: AT; Austria
Prior art keywords: inhibitors; mitotic kinesin; relates; ksp kinesin; treating
Prior art date: 2004-07-01

Application number

AT05786157T

Other languages

English (en)

Inventor

Jeffrey Bergman

Paul Coleman

Mark Fraley

Robert Garbaccio

George Hartman

Chunze Li

Lou Anne Neilson

Christy Olson

Edward Tasber

Original Assignee

Merck Sharp & Dohme

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-07-01

Filing date

2005-06-27

Publication date

2010-10-15

2005-06-27 Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme

2010-10-15 Application granted granted Critical

2010-10-15 Publication of ATE482218T1 publication Critical patent/ATE482218T1/de

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

AT05786157T 2004-07-01 2005-06-27 Inhibitoren von mitotischem kinesin ATE482218T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US58480804P	2004-07-01	2004-07-01
US60090104P	2004-08-12	2004-08-12
PCT/US2005/022730 WO2006007491A1 (en)	2004-07-01	2005-06-27	Mitotic kinesin inhibitors

Publications (1)

Publication Number	Publication Date
ATE482218T1 true ATE482218T1 (de)	2010-10-15

Family

ID=35149059

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT05786157T ATE482218T1 (de)	2004-07-01	2005-06-27	Inhibitoren von mitotischem kinesin

Country Status (15)

Country	Link
US (1)	US7632833B2 (de)
EP (1)	EP1765830B1 (de)
JP (1)	JP2008505085A (de)
KR (1)	KR20070039885A (de)
CN (1)	CN1980938B (de)
AT (1)	ATE482218T1 (de)
AU (1)	AU2005262373B2 (de)
BR (1)	BRPI0512832A (de)
CA (1)	CA2571807A1 (de)
DE (1)	DE602005023730D1 (de)
IL (1)	IL180328A0 (de)
MX (1)	MXPA06015275A (de)
NO (1)	NO20070589L (de)
RU (1)	RU2007103816A (de)
WO (1)	WO2006007491A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2009052288A1 (en)	2007-10-19	2009-04-23	Schering Corporation	Spiro-condensed 1, 3, 4-thiadiazole derivatives for inhibiting ksp kinesin activity
TWI423980B (zh) *	2009-09-28	2014-01-21	Hoffmann La Roche	苯并氧氮呯ｐｉ３ｋ抑制劑化合物及使用方法
US20140087309A1 (en) *	2011-04-01	2014-03-27	The Research Foundation Of State University Of New York	Olefin-triggered acid amplifiers
US20140193752A1 (en) *	2011-04-01	2014-07-10	The Research Foundation Of State University Of New York	Stabilized acid amplifiers
CA2864331C (en)	2012-02-14	2018-10-09	Children's Hospital Medical Center	Use of small molecule inhibitors targeting the interaction between rac gtpase and p67(phox)
US10233179B2 (en)	2013-04-22	2019-03-19	Abbvie Inc.	Thiazoles and uses thereof
KR102148587B1 (ko) *	2016-02-23	2020-08-26	화이자 인코포레이티드	6,7-디히드로-5H-피라졸로[5,1-b][1,3]옥사진-2-카르복스아미드 화합물

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH04501108A (ja)	1988-09-22	1992-02-27	イー・アイ・デユポン・ドウ・ヌムール・アンド・カンパニー	置換インダゾール殺節足動物剤
PH27357A (en)	1989-09-22	1993-06-21	Fujisawa Pharmaceutical Co	Pyrazole derivatives and pharmaceutical compositions comprising the same
US5719147A (en)	1992-06-29	1998-02-17	Merck & Co., Inc.	Morpholine and thiomorpholine tachykinin receptor antagonists
US5604260A (en)	1992-12-11	1997-02-18	Merck Frosst Canada Inc.	5-methanesulfonamido-1-indanones as an inhibitor of cyclooxygenase-2
AU6027694A (en)	1993-01-15	1994-08-15	G.D. Searle & Co.	Novel 3,4-diaryl thiophenes and analogs thereof having use as antiinflammatory agents
US5409944A (en)	1993-03-12	1995-04-25	Merck Frosst Canada, Inc.	Alkanesulfonamido-1-indanone derivatives as inhibitors of cyclooxygenase
US5380738A (en)	1993-05-21	1995-01-10	Monsanto Company	2-substituted oxazoles further substituted by 4-fluorophenyl and 4-methylsulfonylphenyl as antiinflammatory agents
US5436265A (en)	1993-11-12	1995-07-25	Merck Frosst Canada, Inc.	1-aroyl-3-indolyl alkanoic acids and derivatives thereof useful as anti-inflammatory agents
US5474995A (en)	1993-06-24	1995-12-12	Merck Frosst Canada, Inc.	Phenyl heterocycles as cox-2 inhibitors
GB9602877D0 (en)	1996-02-13	1996-04-10	Merck Frosst Canada Inc	3,4-Diaryl-2-hydroxy-2,5- dihydrofurans as prodrugs to cox-2 inhibitors
US5344991A (en)	1993-10-29	1994-09-06	G.D. Searle & Co.	1,2 diarylcyclopentenyl compounds for the treatment of inflammation
US5466823A (en)	1993-11-30	1995-11-14	G.D. Searle & Co.	Substituted pyrazolyl benzenesulfonamides
US5393790A (en)	1994-02-10	1995-02-28	G.D. Searle & Co.	Substituted spiro compounds for the treatment of inflammation
US5633272A (en)	1995-02-13	1997-05-27	Talley; John J.	Substituted isoxazoles for the treatment of inflammation
US6020343A (en)	1995-10-13	2000-02-01	Merck Frosst Canada, Inc.	(Methylsulfonyl)phenyl-2-(5H)-furanones as COX-2 inhibitors
GEP20032998B (en)	1996-04-12	2003-06-25	Searle & Co	Substituted Benzenesulfonamide Derivatives as Prodrugs of Cox-2 Inhibitors
US5861419A (en)	1996-07-18	1999-01-19	Merck Frosst Canad, Inc.	Substituted pyridines as selective cyclooxygenase-2 inhibitors
DE19805117A1 (de)	1998-02-09	1999-08-12	Bayer Ag	Neue Oxazolidinone mit azolhaltigen Tricyclen
DE19905278A1 (de)	1999-02-09	2000-08-10	Bayer Ag	Oxazolidinone und ihre Verwendung als antibakterielle Mittel
ATE372341T1 (de) *	2001-12-06	2007-09-15	Merck & Co Inc	Inhibitoren von mitotischem kinesin
EP1492487B1 (de)	2002-03-08	2009-11-11	Merck & Co., Inc.	Mitotische kinesin-hemmer

2005
- 2005-06-27 MX MXPA06015275A patent/MXPA06015275A/es unknown
- 2005-06-27 JP JP2007519334A patent/JP2008505085A/ja active Pending
- 2005-06-27 US US11/630,231 patent/US7632833B2/en not_active Expired - Fee Related
- 2005-06-27 CA CA002571807A patent/CA2571807A1/en not_active Abandoned
- 2005-06-27 WO PCT/US2005/022730 patent/WO2006007491A1/en not_active Ceased
- 2005-06-27 DE DE602005023730T patent/DE602005023730D1/de not_active Expired - Lifetime
- 2005-06-27 CN CN2005800225786A patent/CN1980938B/zh not_active Expired - Fee Related
- 2005-06-27 EP EP05786157A patent/EP1765830B1/de not_active Expired - Lifetime
- 2005-06-27 AU AU2005262373A patent/AU2005262373B2/en not_active Ceased
- 2005-06-27 AT AT05786157T patent/ATE482218T1/de not_active IP Right Cessation
- 2005-06-27 RU RU2007103816/04A patent/RU2007103816A/ru unknown
- 2005-06-27 BR BRPI0512832-3A patent/BRPI0512832A/pt not_active Application Discontinuation
- 2005-06-27 KR KR1020067027736A patent/KR20070039885A/ko not_active Withdrawn
2006
- 2006-12-25 IL IL180328A patent/IL180328A0/en unknown
2007
- 2007-01-31 NO NO20070589A patent/NO20070589L/no unknown

Also Published As

Publication number	Publication date
MXPA06015275A (es)	2007-03-15
EP1765830A1 (de)	2007-03-28
CA2571807A1 (en)	2006-01-19
JP2008505085A (ja)	2008-02-21
NO20070589L (no)	2007-03-22
US7632833B2 (en)	2009-12-15
WO2006007491A1 (en)	2006-01-19
AU2005262373A1 (en)	2006-01-19
DE602005023730D1 (de)	2010-11-04
CN1980938B (zh)	2010-11-03
IL180328A0 (en)	2007-07-04
EP1765830B1 (de)	2010-09-22
CN1980938A (zh)	2007-06-13
US20080287414A1 (en)	2008-11-20
BRPI0512832A (pt)	2008-04-08
RU2007103816A (ru)	2008-08-10
AU2005262373B2 (en)	2011-03-17
KR20070039885A (ko)	2007-04-13

Legal Events

Date	Code	Title	Description
2011-03-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE421512T1 (de)	2009-02-15	Inhibitoren von mitotischem kinesin
ATE356804T1 (de)	2007-04-15	Inhibitoren von mitotischem kinesin
ATE446094T1 (de)	2009-11-15	Mitotische kinesin-hemmer
ATE448207T1 (de)	2009-11-15	Mitotische kinesin-hemmer
ATE424388T1 (de)	2009-03-15	Mitotische kinesinhemmer
ATE447577T1 (de)	2009-11-15	Mitotische kinesin-hemmer
ATE372341T1 (de)	2007-09-15	Inhibitoren von mitotischem kinesin
WO2005017190A3 (en)	2005-12-15	Mitotic kinesin inhibitors
WO2005018547A3 (en)	2005-09-15	Mitotic kinesin inhibitors
WO2005060654A3 (en)	2005-12-08	Mitotic kinesin inhibitors
WO2006101761A3 (en)	2007-03-08	Mitotic kinesin inhibitors
WO2006068933A3 (en)	2006-12-07	Mitotic kinesin inhibitors
NO20070589L (no)	2007-03-22	Mitotiske kinesin-inhibitorer.
EA200800014A1 (ru)	2008-06-30	Аминохинолиновые и аминохиназолиновые модуляторы киназы
WO2006086358A3 (en)	2007-01-25	Mitotic kinesin inhibitors
WO2006031348A3 (en)	2006-10-12	Mitotic kinesin inhibitors
ATE419249T1 (de)	2009-01-15	Inhibitoren von mitotischem kinesin
ATE426605T1 (de)	2009-04-15	Inhibitoren von mitotischem kinesin
WO2006078598A3 (en)	2007-04-12	Mitotic kinesin inhibitors
WO2006007496A3 (en)	2006-10-05	Mitotic kinesin inhibitors
WO2006007501A3 (en)	2006-07-27	Mitotic kinesin inhibitors
WO2006023440A3 (en)	2007-03-15	Mitotic kinesin inhibitors
WO2004087050A3 (en)	2005-03-24	Mitotic kinesin inhibitors