ATE482218T1 - Inhibitoren von mitotischem kinesin - Google Patents

Inhibitoren von mitotischem kinesin

Info

Publication number: ATE482218T1
Authority: AT; Austria
Prior art keywords: inhibitors; mitotic kinesin; relates; ksp kinesin; treating
Prior art date: 2004-07-01

Application number

AT05786157T

Other languages

English (en)

Inventor

Jeffrey Bergman

Paul Coleman

Mark Fraley

Robert Garbaccio

George Hartman

Chunze Li

Lou Anne Neilson

Christy Olson

Edward Tasber

Original Assignee

Merck Sharp & Dohme

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-07-01

Filing date

2005-06-27

Publication date

2010-10-15

2005-06-27 Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme

2010-10-15 Application granted granted Critical

2010-10-15 Publication of ATE482218T1 publication Critical patent/ATE482218T1/de

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

AT05786157T 2004-07-01 2005-06-27 Inhibitoren von mitotischem kinesin ATE482218T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US58480804P	2004-07-01	2004-07-01
US60090104P	2004-08-12	2004-08-12
PCT/US2005/022730 WO2006007491A1 (en)	2004-07-01	2005-06-27	Mitotic kinesin inhibitors

Publications (1)

Publication Number	Publication Date
ATE482218T1 true ATE482218T1 (de)	2010-10-15

Family

ID=35149059

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT05786157T ATE482218T1 (de)	2004-07-01	2005-06-27	Inhibitoren von mitotischem kinesin

Country Status (15)

Country	Link
US (1)	US7632833B2 (de)
EP (1)	EP1765830B1 (de)
JP (1)	JP2008505085A (de)
KR (1)	KR20070039885A (de)
CN (1)	CN1980938B (de)
AT (1)	ATE482218T1 (de)
AU (1)	AU2005262373B2 (de)
BR (1)	BRPI0512832A (de)
CA (1)	CA2571807A1 (de)
DE (1)	DE602005023730D1 (de)
IL (1)	IL180328A0 (de)
MX (1)	MXPA06015275A (de)
NO (1)	NO20070589L (de)
RU (1)	RU2007103816A (de)
WO (1)	WO2006007491A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP5455915B2 (ja)	2007-10-19	2014-03-26	メルク・シャープ・アンド・ドーム・コーポレーション	Ｋｓｐキネシン活性を阻害するためのスピロ縮合した１，３，４−チアジアゾール誘導体
CA2772691C (en) *	2009-09-28	2017-10-03	F. Hoffmann-La Roche Ag	Benzoxazepin pi3k inhibitor compounds and methods of use
US20140087309A1 (en) *	2011-04-01	2014-03-27	The Research Foundation Of State University Of New York	Olefin-triggered acid amplifiers
JP2014511849A (ja) *	2011-04-01	2014-05-19	ザリサーチファウンデーションオブステイトユニバーシティオブニューヨーク	安定化された酸増幅剤
US9453022B2 (en)	2012-02-14	2016-09-27	Children's Hospital Medical Center	Use of small molecule inhibitors targeting the interaction between Rac GTPase and p67 (phox)
AU2014257164B2 (en) *	2013-04-22	2018-10-11	Abbvie Inc.	Thiazoles and uses thereof
PL3419979T3 (pl)	2016-02-23	2020-06-29	Pfizer Inc.	Związki 6,7-dihydro-5h-pirazolo[5,1-b][1,3]oksazyno-2- karboksyamidowe

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH04501108A (ja)	1988-09-22	1992-02-27	イー・アイ・デユポン・ドウ・ヌムール・アンド・カンパニー	置換インダゾール殺節足動物剤
PH27357A (en)	1989-09-22	1993-06-21	Fujisawa Pharmaceutical Co	Pyrazole derivatives and pharmaceutical compositions comprising the same
US5719147A (en)	1992-06-29	1998-02-17	Merck & Co., Inc.	Morpholine and thiomorpholine tachykinin receptor antagonists
US5604260A (en)	1992-12-11	1997-02-18	Merck Frosst Canada Inc.	5-methanesulfonamido-1-indanones as an inhibitor of cyclooxygenase-2
EP0679157B1 (de)	1993-01-15	1997-11-19	G.D. Searle & Co.	3,4-diarylthiophene und analoga davon, sowie deren verwendung als entzündungshemmende mittel
US5409944A (en)	1993-03-12	1995-04-25	Merck Frosst Canada, Inc.	Alkanesulfonamido-1-indanone derivatives as inhibitors of cyclooxygenase
US5380738A (en)	1993-05-21	1995-01-10	Monsanto Company	2-substituted oxazoles further substituted by 4-fluorophenyl and 4-methylsulfonylphenyl as antiinflammatory agents
GB9602877D0 (en)	1996-02-13	1996-04-10	Merck Frosst Canada Inc	3,4-Diaryl-2-hydroxy-2,5- dihydrofurans as prodrugs to cox-2 inhibitors
US5436265A (en)	1993-11-12	1995-07-25	Merck Frosst Canada, Inc.	1-aroyl-3-indolyl alkanoic acids and derivatives thereof useful as anti-inflammatory agents
US5474995A (en)	1993-06-24	1995-12-12	Merck Frosst Canada, Inc.	Phenyl heterocycles as cox-2 inhibitors
US5344991A (en)	1993-10-29	1994-09-06	G.D. Searle & Co.	1,2 diarylcyclopentenyl compounds for the treatment of inflammation
US5466823A (en)	1993-11-30	1995-11-14	G.D. Searle & Co.	Substituted pyrazolyl benzenesulfonamides
US5393790A (en)	1994-02-10	1995-02-28	G.D. Searle & Co.	Substituted spiro compounds for the treatment of inflammation
US5633272A (en)	1995-02-13	1997-05-27	Talley; John J.	Substituted isoxazoles for the treatment of inflammation
US6020343A (en)	1995-10-13	2000-02-01	Merck Frosst Canada, Inc.	(Methylsulfonyl)phenyl-2-(5H)-furanones as COX-2 inhibitors
WO1997038986A1 (en)	1996-04-12	1997-10-23	G.D. Searle & Co.	Substituted benzenesulfonamide derivatives as prodrugs of cox-2 inhibitors
US5861419A (en)	1996-07-18	1999-01-19	Merck Frosst Canad, Inc.	Substituted pyridines as selective cyclooxygenase-2 inhibitors
DE19805117A1 (de)	1998-02-09	1999-08-12	Bayer Ag	Neue Oxazolidinone mit azolhaltigen Tricyclen
DE19905278A1 (de)	1999-02-09	2000-08-10	Bayer Ag	Oxazolidinone und ihre Verwendung als antibakterielle Mittel
US7378411B2 (en) *	2001-12-06	2008-05-27	Merck & Co., Inc.	Substituted thienopyrimidinones as a mitotic kinesin inhibitor
AU2003249597B2 (en)	2002-03-08	2007-06-28	Merck Sharp & Dohme Corp.	Mitotic kinesin inhibitors

2005
- 2005-06-27 AU AU2005262373A patent/AU2005262373B2/en not_active Ceased
- 2005-06-27 MX MXPA06015275A patent/MXPA06015275A/es unknown
- 2005-06-27 BR BRPI0512832-3A patent/BRPI0512832A/pt not_active Application Discontinuation
- 2005-06-27 AT AT05786157T patent/ATE482218T1/de not_active IP Right Cessation
- 2005-06-27 KR KR1020067027736A patent/KR20070039885A/ko not_active Withdrawn
- 2005-06-27 CA CA002571807A patent/CA2571807A1/en not_active Abandoned
- 2005-06-27 EP EP05786157A patent/EP1765830B1/de not_active Expired - Lifetime
- 2005-06-27 JP JP2007519334A patent/JP2008505085A/ja active Pending
- 2005-06-27 US US11/630,231 patent/US7632833B2/en not_active Expired - Fee Related
- 2005-06-27 WO PCT/US2005/022730 patent/WO2006007491A1/en not_active Ceased
- 2005-06-27 CN CN2005800225786A patent/CN1980938B/zh not_active Expired - Fee Related
- 2005-06-27 RU RU2007103816/04A patent/RU2007103816A/ru unknown
- 2005-06-27 DE DE602005023730T patent/DE602005023730D1/de not_active Expired - Lifetime
2006
- 2006-12-25 IL IL180328A patent/IL180328A0/en unknown
2007
- 2007-01-31 NO NO20070589A patent/NO20070589L/no unknown

Also Published As

Publication number	Publication date
US20080287414A1 (en)	2008-11-20
NO20070589L (no)	2007-03-22
DE602005023730D1 (de)	2010-11-04
CN1980938A (zh)	2007-06-13
JP2008505085A (ja)	2008-02-21
US7632833B2 (en)	2009-12-15
AU2005262373B2 (en)	2011-03-17
WO2006007491A1 (en)	2006-01-19
EP1765830B1 (de)	2010-09-22
CN1980938B (zh)	2010-11-03
AU2005262373A1 (en)	2006-01-19
IL180328A0 (en)	2007-07-04
MXPA06015275A (es)	2007-03-15
KR20070039885A (ko)	2007-04-13
BRPI0512832A (pt)	2008-04-08
RU2007103816A (ru)	2008-08-10
EP1765830A1 (de)	2007-03-28
CA2571807A1 (en)	2006-01-19

Legal Events

Date	Code	Title	Description
2011-03-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE421512T1 (de)	2009-02-15	Inhibitoren von mitotischem kinesin
ATE356804T1 (de)	2007-04-15	Inhibitoren von mitotischem kinesin
ATE446094T1 (de)	2009-11-15	Mitotische kinesin-hemmer
ATE448207T1 (de)	2009-11-15	Mitotische kinesin-hemmer
ATE424388T1 (de)	2009-03-15	Mitotische kinesinhemmer
ATE447577T1 (de)	2009-11-15	Mitotische kinesin-hemmer
ATE372341T1 (de)	2007-09-15	Inhibitoren von mitotischem kinesin
WO2005017190A3 (en)	2005-12-15	Mitotic kinesin inhibitors
WO2005018547A3 (en)	2005-09-15	Mitotic kinesin inhibitors
WO2005060654A3 (en)	2005-12-08	Mitotic kinesin inhibitors
WO2006101761A3 (en)	2007-03-08	Mitotic kinesin inhibitors
WO2006068933A3 (en)	2006-12-07	Mitotic kinesin inhibitors
NO20070589L (no)	2007-03-22	Mitotiske kinesin-inhibitorer.
EA200800014A1 (ru)	2008-06-30	Аминохинолиновые и аминохиназолиновые модуляторы киназы
WO2006086358A3 (en)	2007-01-25	Mitotic kinesin inhibitors
WO2006031348A3 (en)	2006-10-12	Mitotic kinesin inhibitors
ATE419249T1 (de)	2009-01-15	Inhibitoren von mitotischem kinesin
ATE426605T1 (de)	2009-04-15	Inhibitoren von mitotischem kinesin
WO2006078598A3 (en)	2007-04-12	Mitotic kinesin inhibitors
WO2006007496A3 (en)	2006-10-05	Mitotic kinesin inhibitors
WO2006007501A3 (en)	2006-07-27	Mitotic kinesin inhibitors
WO2006023440A3 (en)	2007-03-15	Mitotic kinesin inhibitors
WO2004087050A3 (en)	2005-03-24	Mitotic kinesin inhibitors