ATE486877T1 - Azaspiroderivate - Google Patents
AzaspiroderivateInfo
- Publication number
- ATE486877T1 ATE486877T1 AT07857806T AT07857806T ATE486877T1 AT E486877 T1 ATE486877 T1 AT E486877T1 AT 07857806 T AT07857806 T AT 07857806T AT 07857806 T AT07857806 T AT 07857806T AT E486877 T1 ATE486877 T1 AT E486877T1
- Authority
- AT
- Austria
- Prior art keywords
- azaspiro derivatives
- azaspiro
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/20—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06127334 | 2006-12-29 | ||
| PCT/EP2007/064183 WO2008080844A1 (en) | 2006-12-29 | 2007-12-19 | Azaspiro derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE486877T1 true ATE486877T1 (de) | 2010-11-15 |
Family
ID=39201403
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07857806T ATE486877T1 (de) | 2006-12-29 | 2007-12-19 | Azaspiroderivate |
Country Status (22)
| Country | Link |
|---|---|
| US (3) | US8039624B2 (de) |
| EP (1) | EP2125827B1 (de) |
| JP (1) | JP2010514727A (de) |
| KR (1) | KR101129861B1 (de) |
| CN (1) | CN101589046B (de) |
| AR (1) | AR064547A1 (de) |
| AT (1) | ATE486877T1 (de) |
| AU (1) | AU2007341379B2 (de) |
| BR (1) | BRPI0720827A2 (de) |
| CA (1) | CA2674154A1 (de) |
| CL (1) | CL2007003832A1 (de) |
| DE (1) | DE602007010359D1 (de) |
| DK (1) | DK2125827T3 (de) |
| ES (1) | ES2351949T3 (de) |
| MX (1) | MX2009006921A (de) |
| NO (1) | NO20092342L (de) |
| PE (1) | PE20081844A1 (de) |
| PL (1) | PL2125827T3 (de) |
| PT (1) | PT2125827E (de) |
| RU (1) | RU2009124419A (de) |
| TW (1) | TW200835483A (de) |
| WO (1) | WO2008080844A1 (de) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101050568B1 (ko) * | 2006-12-07 | 2011-07-19 | 에프. 호프만-라 로슈 아게 | Ｖ1ａ 수용체 길항제로서의 스피로-피페리딘 유도체 |
| WO2008077810A2 (en) * | 2006-12-22 | 2008-07-03 | F. Hoffmann-La Roche Ag | Spiro-piperidine derivatives |
| EP2448938B9 (de) | 2009-06-29 | 2015-06-10 | Incyte Corporation | Pyrimidinone als pi3k-hemmer |
| AR078948A1 (es) * | 2009-11-30 | 2011-12-14 | Lilly Co Eli | Compuestos de espiropiperidina, composicion farmaceutica que lo comprenden y su uso para preparar un medicamento util para tratar la diabetes |
| AR079529A1 (es) * | 2009-12-18 | 2012-02-01 | Incyte Corp | Derivados arilo y heteroarilo sustituidos y fundidos como inhibidores de la pi3k |
| WO2011075643A1 (en) | 2009-12-18 | 2011-06-23 | Incyte Corporation | Substituted heteroaryl fused derivatives as pi3k inhibitors |
| EP2558463A1 (de) | 2010-04-14 | 2013-02-20 | Incyte Corporation | Kondensierte derivate als i3-hemmer |
| US9062055B2 (en) | 2010-06-21 | 2015-06-23 | Incyte Corporation | Fused pyrrole derivatives as PI3K inhibitors |
| TW201249844A (en) | 2010-12-20 | 2012-12-16 | Incyte Corp | N-(1-(substituted-phenyl)ethyl)-9H-purin-6-amines as PI3K inhibitors |
| WO2012125629A1 (en) | 2011-03-14 | 2012-09-20 | Incyte Corporation | Substituted diamino-pyrimidine and diamino-pyridine derivatives as pi3k inhibitors |
| US9126948B2 (en) | 2011-03-25 | 2015-09-08 | Incyte Holdings Corporation | Pyrimidine-4,6-diamine derivatives as PI3K inhibitors |
| EP2548864B1 (de) | 2011-07-22 | 2014-02-19 | Université Joseph Fourier | Neue Bis-Indol-Derivate, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel |
| KR102030609B1 (ko) | 2011-09-02 | 2019-10-11 | 인사이트 홀딩스 코포레이션 | Ｐｉ３ｋ 억제제로서 헤테로시클릴아민 |
| CN102568615B (zh) * | 2011-12-13 | 2013-05-22 | 华中科技大学 | 一种小型精密调平装置 |
| AR090548A1 (es) | 2012-04-02 | 2014-11-19 | Incyte Corp | Azaheterociclobencilaminas biciclicas como inhibidores de pi3k |
| WO2015191677A1 (en) | 2014-06-11 | 2015-12-17 | Incyte Corporation | Bicyclic heteroarylaminoalkyl phenyl derivatives as pi3k inhibitors |
| DK3831833T3 (da) | 2015-02-27 | 2022-11-14 | Incyte Holdings Corp | Fremgangsmåder til fremstillingen af en pi3k-inhibitor |
| WO2016183063A1 (en) | 2015-05-11 | 2016-11-17 | Incyte Corporation | Crystalline forms of a pi3k inhibitor |
| US9732097B2 (en) | 2015-05-11 | 2017-08-15 | Incyte Corporation | Process for the synthesis of a phosphoinositide 3-kinase inhibitor |
| CN119258070A (zh) | 2018-06-01 | 2025-01-07 | 因赛特公司 | 治疗pi3k相关病症的给药方案 |
| AR120324A1 (es) | 2019-10-29 | 2022-02-09 | Biogen Ma Inc | Inhibidores de o-glucoproteína-2-acetamido-2-deoxi-3-d-glucopiranosidasa espirocíclica |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2761992B1 (fr) * | 1997-04-09 | 1999-06-11 | Hoechst Marion Roussel Inc | Nouveaux steroides 4-halogenes, leur procede et intermediaires de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant |
| TWI279402B (en) | 1999-08-20 | 2007-04-21 | Banyu Pharma Co Ltd | Spiro compounds having NPY antagonistic activities and agents containing the same |
| GB0003397D0 (en) | 2000-02-14 | 2000-04-05 | Merck Sharp & Dohme | Therapeutic agents |
| BRPI0417267A (pt) * | 2003-12-22 | 2007-04-17 | Pfizer | derivados de triazol como antagonistas de vasopressina |
| GB0400700D0 (en) * | 2004-01-13 | 2004-02-18 | Pfizer Ltd | Compounds useful in therapy |
| GB0504556D0 (en) * | 2005-03-04 | 2005-04-13 | Pfizer Ltd | Novel pharmaceuticals |
-
2007
- 2007-12-19 DK DK07857806.9T patent/DK2125827T3/da active
- 2007-12-19 RU RU2009124419/04A patent/RU2009124419A/ru not_active Application Discontinuation
- 2007-12-19 DE DE602007010359T patent/DE602007010359D1/de active Active
- 2007-12-19 MX MX2009006921A patent/MX2009006921A/es active IP Right Grant
- 2007-12-19 PL PL07857806T patent/PL2125827T3/pl unknown
- 2007-12-19 WO PCT/EP2007/064183 patent/WO2008080844A1/en not_active Ceased
- 2007-12-19 CA CA002674154A patent/CA2674154A1/en not_active Abandoned
- 2007-12-19 AT AT07857806T patent/ATE486877T1/de active
- 2007-12-19 AU AU2007341379A patent/AU2007341379B2/en not_active Expired - Fee Related
- 2007-12-19 JP JP2009543443A patent/JP2010514727A/ja active Pending
- 2007-12-19 EP EP07857806A patent/EP2125827B1/de not_active Not-in-force
- 2007-12-19 PT PT07857806T patent/PT2125827E/pt unknown
- 2007-12-19 ES ES07857806T patent/ES2351949T3/es active Active
- 2007-12-19 CN CN2007800479989A patent/CN101589046B/zh not_active Expired - Fee Related
- 2007-12-19 BR BRPI0720827-8A patent/BRPI0720827A2/pt not_active IP Right Cessation
- 2007-12-19 KR KR1020097015840A patent/KR101129861B1/ko not_active Expired - Fee Related
- 2007-12-20 US US11/960,823 patent/US8039624B2/en not_active Expired - Fee Related
- 2007-12-20 US US11/960,799 patent/US8044202B2/en not_active Expired - Fee Related
- 2007-12-20 US US11/960,779 patent/US8034937B2/en not_active Expired - Fee Related
- 2007-12-26 TW TW096150410A patent/TW200835483A/zh unknown
- 2007-12-27 AR ARP070105915A patent/AR064547A1/es not_active Application Discontinuation
- 2007-12-27 CL CL200703832A patent/CL2007003832A1/es unknown
-
2008
- 2008-01-02 PE PE2008000047A patent/PE20081844A1/es not_active Application Discontinuation
-
2009
- 2009-06-18 NO NO20092342A patent/NO20092342L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0720827A2 (pt) | 2014-03-04 |
| US8034937B2 (en) | 2011-10-11 |
| ES2351949T3 (es) | 2011-02-14 |
| WO2008080844A9 (en) | 2009-10-08 |
| AR064547A1 (es) | 2009-04-08 |
| WO2008080844A1 (en) | 2008-07-10 |
| AU2007341379A1 (en) | 2008-07-10 |
| US20080161333A1 (en) | 2008-07-03 |
| CA2674154A1 (en) | 2008-07-10 |
| PL2125827T3 (pl) | 2011-04-29 |
| KR101129861B1 (ko) | 2012-04-24 |
| US20080281103A1 (en) | 2008-11-13 |
| EP2125827B1 (de) | 2010-11-03 |
| RU2009124419A (ru) | 2011-02-10 |
| MX2009006921A (es) | 2009-07-06 |
| PT2125827E (pt) | 2010-11-22 |
| DE602007010359D1 (de) | 2010-12-16 |
| CN101589046A (zh) | 2009-11-25 |
| KR20090094172A (ko) | 2009-09-03 |
| AU2007341379B2 (en) | 2012-05-24 |
| NO20092342L (no) | 2009-07-02 |
| CN101589046B (zh) | 2011-09-21 |
| US8044202B2 (en) | 2011-10-25 |
| US8039624B2 (en) | 2011-10-18 |
| DK2125827T3 (da) | 2010-12-20 |
| CL2007003832A1 (es) | 2008-07-25 |
| TW200835483A (en) | 2008-09-01 |
| PE20081844A1 (es) | 2009-01-26 |
| EP2125827A1 (de) | 2009-12-02 |
| US20080161332A1 (en) | 2008-07-03 |
| JP2010514727A (ja) | 2010-05-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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