ATE514729T1 - Biomaterialien die durch nukleophile reaktion auf konjugierten ungesättigten gruppen addiert sind - Google Patents

Biomaterialien die durch nukleophile reaktion auf konjugierten ungesättigten gruppen addiert sind

Info

Publication number
ATE514729T1
ATE514729T1 AT00910049T AT00910049T ATE514729T1 AT E514729 T1 ATE514729 T1 AT E514729T1 AT 00910049 T AT00910049 T AT 00910049T AT 00910049 T AT00910049 T AT 00910049T AT E514729 T1 ATE514729 T1 AT E514729T1
Authority
AT
Austria
Prior art keywords
biomaterials
unsaturated groups
added
nucleophilic reaction
conjugate unsaturated
Prior art date
Application number
AT00910049T
Other languages
English (en)
Inventor
Jeffrey Hubbell
Donald Elbert
Matthias Lutolf
Alison Pratt
Ronald Schoenmakers
Nicola Tirelli
Brent Vernon
Original Assignee
Eidgenoess Tech Hochschule
Univ Zuerich
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eidgenoess Tech Hochschule, Univ Zuerich filed Critical Eidgenoess Tech Hochschule
Application granted granted Critical
Publication of ATE514729T1 publication Critical patent/ATE514729T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6903—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being semi-solid, e.g. an ointment, a gel, a hydrogel or a solidifying gel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0031—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/043—Mixtures of macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0052—Mixtures of macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0061—Use of materials characterised by their function or physical properties
    • A61L26/008—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/26—Mixtures of macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/041—Mixtures of macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/145—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G81/00—Macromolecular compounds obtained by interreacting polymers in the absence of monomers, e.g. block polymers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S524/00—Synthetic resins or natural rubbers -- part of the class 520 series
    • Y10S524/916—Hydrogel compositions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Surgery (AREA)
  • Dispersion Chemistry (AREA)
  • Materials Engineering (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Polymers & Plastics (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Materials For Medical Uses (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT00910049T 1999-02-01 2000-02-01 Biomaterialien die durch nukleophile reaktion auf konjugierten ungesättigten gruppen addiert sind ATE514729T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11809399P 1999-02-01 1999-02-01
PCT/US2000/002608 WO2000044808A1 (en) 1999-02-01 2000-02-01 Biomaterials formed by nucleophilic addition reaction to conjugated unsaturated groups

Publications (1)

Publication Number Publication Date
ATE514729T1 true ATE514729T1 (de) 2011-07-15

Family

ID=22376466

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00910049T ATE514729T1 (de) 1999-02-01 2000-02-01 Biomaterialien die durch nukleophile reaktion auf konjugierten ungesättigten gruppen addiert sind

Country Status (10)

Country Link
US (1) US7744912B1 (de)
EP (2) EP1181323B1 (de)
JP (2) JP4954370B2 (de)
AT (1) ATE514729T1 (de)
AU (1) AU773914B2 (de)
CA (1) CA2359318C (de)
DK (1) DK1181323T3 (de)
ES (2) ES2632564T3 (de)
MX (1) MXPA01007777A (de)
WO (1) WO2000044808A1 (de)

Families Citing this family (145)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997022371A1 (en) 1995-12-18 1997-06-26 Collagen Corporation Crosslinked polymer compositions and methods for their use
US6833408B2 (en) 1995-12-18 2004-12-21 Cohesion Technologies, Inc. Methods for tissue repair using adhesive materials
US6872384B1 (en) 1998-02-23 2005-03-29 Life Medical Sciences, Inc. Treatment of trauma
US6958212B1 (en) 1999-02-01 2005-10-25 Eidgenossische Technische Hochschule Zurich Conjugate addition reactions for the controlled delivery of pharmaceutically active compounds
DK1181323T3 (da) 1999-02-01 2011-10-17 Eidgenoess Tech Hochschule Biomaterialer dannet med nukleofil additionsreaktion med konjugerede uimættede grupper
CA2363048A1 (en) 1999-02-23 2000-08-31 Phairson Medical, Inc. Treatment of trauma
AUPP939299A0 (en) * 1999-03-23 1999-04-15 University Of Melbourne, The Polymer gels and methods for their preparation
EP1142596A1 (de) 2000-04-03 2001-10-10 Universiteit Gent Zusammensetzung von vernetzbaren Prepolymeren zum Gebrauch in therapeutisch aktiven, bioabbaubaren Implantaten
MXPA02011891A (es) * 2000-06-02 2004-04-02 Eidgenoess Tech Hochschule Reacciones de adicion conjugadas para la entrega controlada de compuestos farmaceuticamente activos.
US7291673B2 (en) 2000-06-02 2007-11-06 Eidgenossiche Technische Hochschule Zurich Conjugate addition reactions for the controlled delivery of pharmaceutically active compounds
WO2002055185A2 (en) * 2000-10-19 2002-07-18 Eidgenoess Tech Hochschule Block copolymers for multifunctional self-assembled systems
EP1245272A1 (de) * 2001-03-30 2002-10-02 Ucb S.A. Herstellung und Verwendung von Substraten
WO2002085422A1 (en) * 2001-04-25 2002-10-31 Eidgenössische Technische Hochschule Zürich Drug delivery matrices to enhance wound healing
EP1387885A1 (de) * 2001-05-01 2004-02-11 Universite Du Quebec A Montreal Dreidimensionale biokompatible stützstruktur für bioartifizielle organe und deren verwendung
US6967234B2 (en) 2002-12-18 2005-11-22 Ethicon, Inc. Alkyd-lactone copolymers for medical applications
US7034037B2 (en) 2001-06-29 2006-04-25 Ethicon, Inc. Compositions and medical devices utilizing bioabsorbable polymeric waxes and rapamycin
US7030127B2 (en) 2001-06-29 2006-04-18 Ethicon, Inc. Composition and medical devices utilizing bioabsorbable polymeric waxes
US7288608B2 (en) * 2001-10-10 2007-10-30 Regents Of The University Of Colorado Degradable thiol-ene polymers
KR101054023B1 (ko) * 2001-11-07 2011-08-04 아이드게노시셰 테크시셰 호흐쉘 취리히 세포 내증식 및 조직 재생을 제어하기 위한 합성 매트릭스
US20070264227A1 (en) * 2001-11-07 2007-11-15 Eidgenossische Technische Hochschule Zurich Synthetic Matrix for Controlled Cell Ingrowth and Tissue Regeneration
US7491690B2 (en) * 2001-11-14 2009-02-17 Northwestern University Self-assembly and mineralization of peptide-amphiphile nanofibers
US7247609B2 (en) 2001-12-18 2007-07-24 Universitat Zurich Growth factor modified protein matrices for tissue engineering
JP4560291B2 (ja) * 2001-12-18 2010-10-13 イジュノシッヒ テクニッヒ ホッフシューラ チューリッヒ 組織操作のための成長因子改変タンパク質マトリクス
AU2002360765C1 (en) 2001-12-20 2009-06-11 Trivascular, Inc. Advanced endovascular graft
WO2003070749A2 (en) 2002-02-15 2003-08-28 Northwestern University Self-assembly of peptide-amphiphile nanofibers under physiological conditions
US8282912B2 (en) * 2002-03-22 2012-10-09 Kuros Biosurgery, AG Compositions for tissue augmentation
EP1494730B1 (de) * 2002-03-22 2012-01-18 Kuros Biosurgery AG Zusammensetzung für die verstärkung von hartem gewebe
US7005136B2 (en) 2002-03-29 2006-02-28 Ethicon, Inc. Bone replacement materials utilizing bioabsorbable liquid polymers
US7326426B2 (en) 2002-03-29 2008-02-05 Ethicon, Inc. Compositions and medical devices utilizing bioabsorbable liquid polymers
US7368125B2 (en) 2002-06-05 2008-05-06 Ethicon, Inc. Amphiphilic polymers for medical applications
US7026374B2 (en) 2002-06-25 2006-04-11 Aruna Nathan Injectable microdispersions for medical applications
US7101566B2 (en) 2002-06-28 2006-09-05 Ethicon, Inc. Polymer coated microparticles for sustained release
AU2003262760A1 (en) 2002-08-21 2004-03-11 Northwestern University Charged peptide-amphiphile solutions and self-assembled peptide nanofiber networks formed therefrom
US7554021B2 (en) 2002-11-12 2009-06-30 Northwestern University Composition and method for self-assembly and mineralization of peptide amphiphiles
AU2003298647A1 (en) 2002-11-14 2004-06-15 Claussen, Randal, C. Synthesis and self-assembly of abc triblock bola peptide
EP1564220A4 (de) 2002-11-21 2010-03-17 Chugai Pharmaceutical Co Ltd Retard-arzneistoffträger
US6872799B2 (en) 2002-12-18 2005-03-29 Ethicon, Inc. Functionalized polymers for medical applications
EP1581260B1 (de) 2002-12-31 2014-09-17 Nektar Therapeutics Polymerreagentien mit einer keto- oder verwandten funktion
EP1606065A4 (de) 2003-02-11 2010-09-29 Univ Northwestern Verfahren und materialien für nanokristalline oberflächenbeschichtungen und befestigung von amphiphilen peptid-nanofasern daran
US7632291B2 (en) 2003-06-13 2009-12-15 Trivascular2, Inc. Inflatable implant
US7217294B2 (en) 2003-08-20 2007-05-15 Histogenics Corp. Acellular matrix implants for treatment of articular cartilage, bone or osteochondral defects and injuries and method for use thereof
JP4742491B2 (ja) * 2003-09-30 2011-08-10 株式会社豊田中央研究所 細胞着床方法及び細胞組織作製方法
EP1558215A4 (de) * 2003-10-14 2007-09-12 Wockhardt Ltd Sterile geliermittel
US20050090804A1 (en) * 2003-10-22 2005-04-28 Trivascular, Inc. Endoluminal prosthesis endoleak management
CA2544779A1 (en) 2003-11-03 2005-05-12 Medtronic, Inc. Hydrogel providing cell-specific ingrowth
JP4745826B2 (ja) 2003-11-14 2011-08-10 中外製薬株式会社 架橋多糖微粒子およびその製造方法
US7544661B2 (en) 2003-12-05 2009-06-09 Northwestern University Self-assembling peptide amphiphiles and related methods for growth factor delivery
EP1696944A4 (de) 2003-12-05 2008-11-05 Univ Northwestern Verzweigte peptid-amphiphile, verwandte epitope verbindungen und selbst zusammengesetzte strukturen davon
US20080026444A1 (en) * 2003-12-24 2008-01-31 Shionogi & Co., Ltd. Process For Producing Protein-Polymer Complex
JP2007517614A (ja) * 2004-01-07 2007-07-05 ボストン サイエンティフィック サンタ ローザ コーポレイション 身体内腔の閉塞方法、閉塞合成物および機器
US7803178B2 (en) 2004-01-30 2010-09-28 Trivascular, Inc. Inflatable porous implants and methods for drug delivery
CN104174071A (zh) 2004-04-28 2014-12-03 安希奥设备国际有限责任公司 用于形成交联生物材料的组合物和系统及关联的制备方法与用途
CA2828619C (en) 2004-05-05 2018-09-25 Direct Flow Medical, Inc. Prosthetic valve with an elastic stent and a sealing structure
US7282584B2 (en) 2004-06-16 2007-10-16 Straumann Holding Ag Methylene blue
DE602004011660T2 (de) 2004-06-16 2009-01-29 Straumann Holding Ag Abdeckmembran
EP1764404B1 (de) 2005-09-16 2009-11-04 Straumann Holding AG Verwendung von Methylenblau als Polymerisationsinhibitor
EP2111872B1 (de) * 2004-07-05 2020-12-23 Ascendis Pharma GmbH Hydrogel-konjugate
EP1625856A1 (de) * 2004-08-13 2006-02-15 Complex Biosystems GmbH Hydrogel Polymer Prodroge Konjugate
US7968085B2 (en) 2004-07-05 2011-06-28 Ascendis Pharma A/S Hydrogel formulations
WO2006026554A1 (en) 2004-08-30 2006-03-09 Neville Alleyne Method of using an implant for treatment of ligaments and tendons
AU2005279772A1 (en) 2004-08-30 2006-03-09 Spineovations, Inc. Method of treating spinal internal disk derangement
EP1796602A4 (de) 2004-09-17 2016-10-19 Angiotech Pharm Inc Multifunktionelle verbindungen zur erzeugung vernetzter biomaterialien sowie herstellungs- und verwendungsverfahren dafür
EP1862170B1 (de) 2004-12-10 2012-03-14 Straumann Holding AG Emailleformulierung mit Amelogenin
EP1830863A2 (de) 2004-12-10 2007-09-12 Straumann Holding AG Proteinformulierung
SE0403014D0 (sv) 2004-12-10 2004-12-10 Straumann Holding Ag New protein formulation
US8575101B2 (en) 2005-01-06 2013-11-05 Kuros Biosurgery Ag Supplemented matrices for the repair of bone fractures
WO2006073711A2 (en) 2005-01-06 2006-07-13 Kuros Biosurgery Ag Use of a matrix comprising a contrast agent in soft tissues
WO2006096614A2 (en) 2005-03-04 2006-09-14 Northwestern University Angiogenic heparin binding peptide amphiphiles
US20060222596A1 (en) 2005-04-01 2006-10-05 Trivascular, Inc. Non-degradable, low swelling, water soluble radiopaque hydrogel polymer
WO2007008300A2 (en) 2005-05-31 2007-01-18 ECOLE POLYTECHNIQUE FéDéRALE DE LAUSANNE Triblock copolymers for cytoplasmic delivery of gene-based drugs
JP5119148B2 (ja) 2005-06-07 2013-01-16 ダイレクト フロウ メディカル、 インク． 半径方向の強度が高いステントレス大動脈弁置換
JP2009508596A (ja) 2005-09-19 2009-03-05 ヒストジェニックス コーポレイション 細胞支持基材及びその調製方法
EP1820522B1 (de) * 2006-02-20 2012-05-16 Straumann Holding AG Granulatematrix
EP2001529A4 (de) * 2006-03-21 2011-11-09 Agency Science Tech & Res An zellen haftendes polyelektrolyt-material zur verwendung als membran und überzug
AU2007247763B2 (en) * 2006-05-05 2013-06-06 The University Of Sydney Bis-pyridinium compounds
US8133213B2 (en) 2006-10-19 2012-03-13 Direct Flow Medical, Inc. Catheter guidance through a calcified aortic valve
US7935144B2 (en) 2006-10-19 2011-05-03 Direct Flow Medical, Inc. Profile reduction of valve implant
US20080096976A1 (en) * 2006-10-24 2008-04-24 Neville Alleyne Method of treating spinal internal disk derangement
AR064286A1 (es) * 2006-12-13 2009-03-25 Quiceno Gomez Alexandra Lorena Produccion de dispositivos oftalmicos basados en la polimerizacion por crecimiento escalonado fotoinducida
AU2008224435B2 (en) 2007-03-15 2014-01-09 Ortho-Space Ltd. Prosthetic devices and methods for using same
DK2136850T3 (da) 2007-04-13 2012-04-10 Kuros Biosurgery Ag Polymervævforsegling
US8076295B2 (en) 2007-04-17 2011-12-13 Nanotope, Inc. Peptide amphiphiles having improved solubility and methods of using same
EP2143446B1 (de) 2007-05-01 2019-07-24 National University Corporation Tokyo Medical and Dental University Hybridgel mit chemisch vernetztem hyaluronsäurederivat und arzneimittel damit
EP2014256A1 (de) * 2007-07-12 2009-01-14 Straumann Holding AG Verbundmaterial zur Knochenreparatur
CA2978267A1 (en) 2007-08-23 2009-02-23 Dfm, Llc Translumenally implantable heart valve with formed in place support
AU2008308474B2 (en) 2007-10-04 2014-07-24 Trivascular, Inc. Modular vascular graft for low profile percutaneous delivery
WO2009083544A2 (en) 2007-12-28 2009-07-09 Kuros Biosurgery Ag Pdgf fusion proteins incorporated into fibrin foams
US8469961B2 (en) 2008-03-05 2013-06-25 Neville Alleyne Methods and compositions for minimally invasive capsular augmentation of canine coxofemoral joints
DE202008005131U1 (de) 2008-04-14 2008-08-28 Eidgenössische Technische Hochschule Zürich Synthetische Matrix für das gesteuerte Einwachsen von Zellen und Geweberegeneration
WO2010027471A2 (en) 2008-09-04 2010-03-11 The General Hospital Corporation Hydrogels for vocal cord and soft tissue augmentation and repair
US9271929B2 (en) 2008-11-25 2016-03-01 École Polytechnique Fédérale De Lausanne (Epfl) Block copolymers and uses thereof
MX2011010780A (es) 2009-04-13 2011-10-28 Univ Northwestern Andamios novedosos basados en peptido para la regeneracion de cartilagos y metodos para su uso.
NZ597964A (en) 2009-07-31 2014-04-30 Sanofi Aventis Deutschland Long acting insulin composition
US9138462B2 (en) 2009-07-31 2015-09-22 Sanofi-Aventis Deutschland Gmbh Prodrugs comprising an insulin linker conjugate
WO2011025893A1 (en) 2009-08-28 2011-03-03 The Trustees Of Columbia University In The City Of New York Systems, methods, and devices for production of gas-filled microbubbles
ES2671907T3 (es) * 2010-01-13 2018-06-11 Georg Bischof Composición para la generación de una oclusión intestinal temporal
WO2011090428A1 (en) * 2010-01-19 2011-07-28 Organoclick Ab Heterogeneous thiol-ene click modifications of solid polysaccharide-based materials
US9198568B2 (en) 2010-03-04 2015-12-01 The General Hospital Corporation Methods and systems of matching voice deficits with a tunable mucosal implant to restore and enhance individualized human sound and voice production
EP2380920A1 (de) 2010-04-22 2011-10-26 QGel SA Hydrogelvorstufenformulierung und Herstellungsverfahren dafür
US9603708B2 (en) 2010-05-19 2017-03-28 Dfm, Llc Low crossing profile delivery catheter for cardiovascular prosthetic implant
US20130224880A1 (en) 2011-05-27 2013-08-29 Ptm Biolabs, Inc. Reagents and methods for detecting protein crotonylation
CN102375065A (zh) * 2010-05-27 2012-03-14 杭州景杰生物科技有限公司 蛋白质中赖氨酸丁烯酰化的鉴定方法及其亲和试剂研制
CA2804771C (en) 2010-07-09 2018-02-20 Highlife Sas Transcatheter atrio-ventricular valve prosthesis
DE102010034331A1 (de) * 2010-08-14 2012-02-16 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Polymer-gestützte Kultursysteme
EP2438930A1 (de) 2010-09-17 2012-04-11 Sanofi-Aventis Deutschland GmbH Prodrug mit einem exendinbindenden Konjugat
US8518440B2 (en) * 2010-12-21 2013-08-27 Confluent Surgical, Inc. Biodegradable osmotic pump implant for drug delivery
US20140038826A1 (en) 2011-01-28 2014-02-06 The Regents Of The University Of Colorado, A Body Corporate Covalently cross linked hydrogels and methods of making and using same
EP2686027B1 (de) 2011-03-16 2021-05-05 Kuros Biosurgery AG Pharmazeutische formulierung zur verwendung für die wirbelsäulenfusion
EP2720722A4 (de) 2011-06-16 2014-12-03 Univ Hong Kong Science & Techn Molekül mit mehreren vinylsulfonen
US9289307B2 (en) 2011-10-18 2016-03-22 Ortho-Space Ltd. Prosthetic devices and methods for using same
US9988433B2 (en) 2013-03-14 2018-06-05 Mosaic Biosciences, Inc. Covalent modification of biological macromolecules
WO2013116791A1 (en) 2012-02-02 2013-08-08 Mosaic Biosciences, Inc. Biomaterials for delivery of blood extracts and methods of using same
US9993328B2 (en) 2012-04-03 2018-06-12 Trivascular, Inc. Advanced kink resistant stent graft
US8992595B2 (en) 2012-04-04 2015-03-31 Trivascular, Inc. Durable stent graft with tapered struts and stable delivery methods and devices
US9498363B2 (en) 2012-04-06 2016-11-22 Trivascular, Inc. Delivery catheter for endovascular device
US9445897B2 (en) 2012-05-01 2016-09-20 Direct Flow Medical, Inc. Prosthetic implant delivery device with introducer catheter
US9540428B2 (en) 2012-07-03 2017-01-10 Ecole Polytechnique Federale De Lausanne (Epfl) Extracellular matrix heparin-binding domains
US9879062B2 (en) 2012-07-03 2018-01-30 Ecole Polytechnique Federale De Lausanne Protein-binding peptide isolated from placenta growth factor
US9395468B2 (en) 2012-08-27 2016-07-19 Ocular Dynamics, Llc Contact lens with a hydrophilic layer
EP2906144B1 (de) 2012-10-10 2017-08-02 TriVascular, Inc. Endovaskuläres transplantat für aneurysmen mit beteiligung von grossen verzweigten gefässen
US20150299412A1 (en) * 2012-11-02 2015-10-22 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Thiol Acrylate Nanocomposite Foams
US20160089151A1 (en) 2013-05-24 2016-03-31 Cedars-Sinai Medical Center Left atrial appendage occlusion devices and methods
US20160114081A1 (en) * 2013-05-31 2016-04-28 Francesco Serino Methods and compositions for blood vessel tissue repair and engineering
WO2015013510A1 (en) 2013-07-25 2015-01-29 Ecole Polytechnique Federale De Lausanne Epfl High aspect ratio nanofibril materials
US11123205B2 (en) 2013-09-24 2021-09-21 Trivascular, Inc. Tandem modular endograft
AU2014348502B2 (en) 2013-11-15 2019-08-15 Tangible Science, Inc. Contact lens with a hydrophilic layer
US9873769B2 (en) 2014-07-10 2018-01-23 Cambridge Polymer Group, Inc. Thiolated PEG-PVA hydrogels
US10077420B2 (en) 2014-12-02 2018-09-18 Histogenics Corporation Cell and tissue culture container
CN107206119B (zh) 2014-12-09 2021-01-29 实体科学公司 具有生物相容性层的医疗设备涂层
WO2016115532A1 (en) 2015-01-16 2016-07-21 Spineovations, Inc. Method of treating spinal disk
WO2016130573A2 (en) 2015-02-09 2016-08-18 Mosaic Biosciences, Inc. Degradable thiol-ene polymers and methods of making thereof
WO2017046647A1 (en) 2015-09-18 2017-03-23 Ortho-Space Ltd. Intramedullary fixated subacromial spacers
CN109563353B (zh) 2016-07-27 2022-01-14 东丽株式会社 树脂组合物
EP3573806A4 (de) 2017-01-30 2019-12-11 Ortho-Space Ltd. Bearbeitungsmaschine und verfahren zur verarbeitung von tauchgeformten artikeln
FR3078261B1 (fr) * 2018-02-28 2020-02-07 Universite de Bordeaux Hydrogel pour stimuler la neurotisation, l'osteogenese et l'angiogenese
US20220075098A1 (en) * 2018-12-19 2022-03-10 Tangible Science, Inc. Systems and methods of treating a hydrogel-coated medical device
WO2020156968A2 (en) 2019-01-30 2020-08-06 Ventana Medical Systems, Inc. Calibration slides for digital pathology
CA3151983A1 (en) * 2019-09-21 2021-03-25 Ozgul TEZGEL Dmso-free synthesis of oligopeptide-modified poly(beta-amino ester)s and their use in nanoparticle delivery systems
KR102863855B1 (ko) * 2019-10-09 2025-09-24 피닉스 이글 컴퍼니 피티와이 엘티디 프로테아제의 단백질 분해 활성의 강화 및 안정화
KR20220011903A (ko) 2020-07-22 2022-02-03 삼성전자주식회사 식기 세척기
KR102425509B1 (ko) * 2020-10-13 2022-07-27 고려대학교 산학협력단 줄기세포의 거동 조절용 나노코일-기판 복합체, 이의 제조방법 및 이를 이용한 줄기세포의 부착 및 분화 조절 방법
CN117065080A (zh) * 2022-05-10 2023-11-17 万华化学集团股份有限公司 一种医用黏合剂及其制备方法
US12611313B2 (en) 2023-04-06 2026-04-28 33 Medical, Inc. Minimally invasive compliant devices for total lumbar disc replacement
KR20260021016A (ko) 2023-06-02 2026-02-12 33 메디칼, 인크. 추간판성 통증의 치료를 위한 조성물, 및 그의 제조 및 사용 방법
EP4616875A1 (de) 2024-03-12 2025-09-17 Novonexile AG Halb-interpenetrierende polymernetzwerke

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA992105A (en) 1970-03-26 1976-06-29 Exxon Research And Engineering Company Polythioethers formed by anionic ring opening of episulfides
JPS6198734A (ja) * 1984-10-19 1986-05-17 Showa Denko Kk 硬化性組成物
US4618400A (en) 1984-12-28 1986-10-21 Shell Oil Company Wastepaper deinking process
US4711903A (en) * 1986-01-31 1987-12-08 G. D. Searle & Co. Phenolic thioethers as inhibitors of 5-lipoxygenase
US5575815A (en) 1988-08-24 1996-11-19 Endoluminal Therapeutics, Inc. Local polymeric gel therapy
US5247041A (en) * 1989-02-22 1993-09-21 Toray Industries, Inc. Thiol methacrylate or acrylate resin obtained by polymerizing a thiol methacrylate or acrylate compound
US5268305A (en) * 1989-06-15 1993-12-07 Biocircuits Corporation Multi-optical detection system
US5330911A (en) 1989-09-28 1994-07-19 Board Of Regents, The University Of Texas System Surfaces having desirable cell adhesive effects
US5852182A (en) 1990-01-11 1998-12-22 Isis Pharmaceuticals Inc. Thiol-derivatized oligonucleosides
US5410016A (en) 1990-10-15 1995-04-25 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
US5529914A (en) 1990-10-15 1996-06-25 The Board Of Regents The Univeristy Of Texas System Gels for encapsulation of biological materials
US5573934A (en) * 1992-04-20 1996-11-12 Board Of Regents, The University Of Texas System Gels for encapsulation of biological materials
AU4406793A (en) 1992-06-04 1993-12-30 Clover Consolidated, Limited Water-soluble polymeric carriers for drug delivery
US5292514A (en) * 1992-06-24 1994-03-08 Minnesota Mining And Manufacturing Company Azlactone-functional substrates, corneal prostheses, and manufacture and use thereof
RU2146668C1 (ru) 1992-08-25 2000-03-20 Джи Ди Сирл энд Компани Сульфонилалканоиламино-гидроксиэтиламино-сульфонамидное соединение, фармацевтические композиции и способы лечения и ингибирования ретровирусных протеаз
WO1994005282A1 (en) 1992-09-04 1994-03-17 The Scripps Research Institute Water soluble taxol derivatives
US5321095A (en) * 1993-02-02 1994-06-14 Enzon, Inc. Azlactone activated polyalkylene oxides
NZ262679A (en) 1993-02-22 1997-08-22 Vivorx Pharmaceuticals Inc Compositions for in vivo delivery of pharmaceutical agents where the agents are contained in a polymeric shell
US5428014A (en) 1993-08-13 1995-06-27 Zymogenetics, Inc. Transglutaminase cross-linkable polypeptides and methods relating thereto
US5880131A (en) 1993-10-20 1999-03-09 Enzon, Inc. High molecular weight polymer-based prodrugs
US5446090A (en) 1993-11-12 1995-08-29 Shearwater Polymers, Inc. Isolatable, water soluble, and hydrolytically stable active sulfones of poly(ethylene glycol) and related polymers for modification of surfaces and molecules
JPH0848770A (ja) * 1994-06-03 1996-02-20 Toyo Ink Mfg Co Ltd 液状樹脂組成物、その製造方法、および硬化性樹脂組成物
JPH0892369A (ja) * 1994-07-29 1996-04-09 Toyo Ink Mfg Co Ltd 硬化性液状樹脂組成物およびその硬化物の製造方法
US5932462A (en) 1995-01-10 1999-08-03 Shearwater Polymers, Inc. Multiarmed, monofunctional, polymer for coupling to molecules and surfaces
US5702717A (en) 1995-10-25 1997-12-30 Macromed, Inc. Thermosensitive biodegradable polymers based on poly(ether-ester)block copolymers
WO1997018314A1 (de) 1995-11-16 1997-05-22 Boehringer Mannheim Gmbh Verfahren zur herstellung von peptiden über streptavidin-fusionsproteine
WO1997022371A1 (en) 1995-12-18 1997-06-26 Collagen Corporation Crosslinked polymer compositions and methods for their use
US5752974A (en) 1995-12-18 1998-05-19 Collagen Corporation Injectable or implantable biomaterials for filling or blocking lumens and voids of the body
US5914182A (en) 1996-06-03 1999-06-22 Gore Hybrid Technologies, Inc. Materials and methods for the immobilization of bioactive species onto polymeric substrates
US20020064546A1 (en) 1996-09-13 2002-05-30 J. Milton Harris Degradable poly(ethylene glycol) hydrogels with controlled half-life and precursors therefor
US6258351B1 (en) 1996-11-06 2001-07-10 Shearwater Corporation Delivery of poly(ethylene glycol)-modified molecules from degradable hydrogels
WO1998032466A1 (en) 1997-01-29 1998-07-30 Polymasc Pharmaceuticals Plc Pegylation process
DE19705963A1 (de) 1997-02-17 1998-08-20 Hoechst Ag Vernetzte Vinylpolymere mit Gallensäure-Adsorberwirkung
PT1053019E (pt) 1998-01-07 2004-04-30 Debio Rech Pharma Sa Acrilatos de poli(etileno-glicol) heterobifuncional degradaveis e geles e conjugados derivados dos mesmos
US5958874A (en) 1998-02-18 1999-09-28 The Research Foundation Of State University Of New York Recombinant fibronectin-based extracellular matrix for wound healing
US6514534B1 (en) 1998-08-14 2003-02-04 Incept Llc Methods for forming regional tissue adherent barriers and drug delivery systems
DK1181323T3 (da) 1999-02-01 2011-10-17 Eidgenoess Tech Hochschule Biomaterialer dannet med nukleofil additionsreaktion med konjugerede uimættede grupper
JO2291B1 (en) 1999-07-02 2005-09-12 اف . هوفمان لاروش ايه جي Erythropoietin derivatives
US7291673B2 (en) * 2000-06-02 2007-11-06 Eidgenossiche Technische Hochschule Zurich Conjugate addition reactions for the controlled delivery of pharmaceutically active compounds
WO2002055185A2 (en) 2000-10-19 2002-07-18 Eidgenoess Tech Hochschule Block copolymers for multifunctional self-assembled systems
US20030044468A1 (en) 2001-03-20 2003-03-06 Francesco Cellesi Two-phase processing of thermosensitive polymers for use as biomaterials
KR101054023B1 (ko) 2001-11-07 2011-08-04 아이드게노시셰 테크시셰 호흐쉘 취리히 세포 내증식 및 조직 재생을 제어하기 위한 합성 매트릭스

Also Published As

Publication number Publication date
JP2012101095A (ja) 2012-05-31
JP4954370B2 (ja) 2012-06-13
EP2311895A1 (de) 2011-04-20
CA2359318A1 (en) 2000-08-03
ES2368988T3 (es) 2011-11-24
DK1181323T3 (da) 2011-10-17
EP1181323A1 (de) 2002-02-27
MXPA01007777A (es) 2003-10-06
WO2000044808A1 (en) 2000-08-03
AU3220400A (en) 2000-08-18
EP1181323B1 (de) 2011-06-29
AU773914B2 (en) 2004-06-10
EP2311895B1 (de) 2017-04-12
CA2359318C (en) 2009-06-30
US7744912B1 (en) 2010-06-29
EP1181323A4 (de) 2005-04-20
JP2002535108A (ja) 2002-10-22
ES2632564T3 (es) 2017-09-14

Similar Documents

Publication Publication Date Title
ATE514729T1 (de) Biomaterialien die durch nukleophile reaktion auf konjugierten ungesättigten gruppen addiert sind
BR9508031A (pt) Composto antiviral composição farmacéutica ou veterinária e processo para o tratamento antiviral profilático ou terapéuitco de um humano ou animal náo humano e uso do composto
ATE541587T1 (de) Konjugat-additionsreaktionen zur kontrollierten abgabe von pharmazeutisch wirksamen substanzen
ATE504561T1 (de) Röntgendichte polymerische biomateriale
BR9802570A (pt) Caixa de câmbio
DE602004014380D1 (de) Medizinische vorrichtungen
DE122004000025I2 (de) Borons{ure-und-esterverbindungen, deren Systhese und Verwendungen
PT897904E (pt) 2-metoxibenzofenonas fungicidas
CY1114535T1 (el) Ρετινοειδη παραγωγα με αντιαγγειογονικες, αντιογκικες και προαποπτωτικες δραστικοτητες
AR027355A1 (es) Acidos tiazolidincarboxilicos
BR0109585A (pt) Veìculo automotor com caixa de câmbio
ES2167436T3 (es) Tabletas de flubendazol masticables para animales de compañia.
IL140391A0 (en) Process for the production of an aqueous monoester peroxycarboxylic acid solution, the solution obtainable by this process and its use as disinfectant
DE69632643D1 (de) Verwendungen von nukleinsäuren die ein retrovirus aus schweinen entnommen sind
BR9807883A (pt) Compostos de tetraidropirido
BR0105906A (pt) Dispositivo de ativação
DE60029084D1 (de) Neue depsipeptid-verbindung
DE50004236D1 (de) Verfahren zur Herstellung von 1,1,4,4-Tetramethoxybuten-2
NL1012219A1 (nl) Werkwijze voor de polymersitie van overzadigde polyalkylpiperidinen.
DE60033542D1 (de) Zusammensetzungen für die elektroporation
ATE222103T1 (de) Inklusionskomplexe in waessriger loesung
ATE377608T1 (de) Hemoglobin konjugate
BR9901387A (pt) Composições para a cura de polìmero.
BR9901390A (pt) Composições para a cura de polìmero
ES1042732Y (es) Dispositivo electrofisico de desinfeccion.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1181323

Country of ref document: EP