ATE524179T1 - Verwendung von quartären pyridiniumsalzen als gefässschutzmittel - Google Patents

Verwendung von quartären pyridiniumsalzen als gefässschutzmittel

Info

Publication number: ATE524179T1
Authority: AT; Austria
Prior art keywords: pyridinium salts; protection agents; vascular protection; quarternary; quarternary pyridinium
Prior art date: 2004-01-12

Application number

AT05726215T

Other languages

English (en)

Inventor

Jerzy Gebicki

Stefan Chlopicki

Original Assignee

Pharmena Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-01-12

Filing date

2005-01-07

Publication date

2011-09-15

2005-01-07 Application filed by Pharmena Sa filed Critical Pharmena Sa

2011-09-15 Application granted granted Critical

2011-09-15 Publication of ATE524179T1 publication Critical patent/ATE524179T1/de

Links

JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical class C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 title abstract 2
239000011814 protection agent Substances 0.000 title 1
230000009441 vascular protection Effects 0.000 title 1
101710129448 Glucose-6-phosphate isomerase 2 Proteins 0.000 abstract 1
208000035150 Hypercholesterolemia Diseases 0.000 abstract 1
235000015872 dietary supplement Nutrition 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
230000004064 dysfunction Effects 0.000 abstract 1
230000003511 endothelial effect Effects 0.000 abstract 1
210000003989 endothelium vascular Anatomy 0.000 abstract 1
KAQKFAOMNZTLHT-VVUHWYTRSA-N epoprostenol Chemical compound O1C(=CCCCC(O)=O)C[C@@H]2[C@@H](/C=C/[C@@H](O)CCCCC)[C@H](O)C[C@@H]21 KAQKFAOMNZTLHT-VVUHWYTRSA-N 0.000 abstract 1
229960001123 epoprostenol Drugs 0.000 abstract 1
208000006575 hypertriglyceridemia Diseases 0.000 abstract 1
230000036542 oxidative stress Effects 0.000 abstract 1
230000002265 prevention Effects 0.000 abstract 1
230000002666 vasoprotective effect Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/30—Dietetic or nutritional methods, e.g. for losing weight
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4406—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/00—Medicinal preparations containing organic active ingredients
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4425—Pyridinium derivatives, e.g. pralidoxime, pyridostigmine
- A—HUMAN NECESSITIES
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- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
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- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- A61P9/00—Drugs for disorders of the cardiovascular system
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Epidemiology (AREA)
Diabetes (AREA)
Hematology (AREA)
Heart & Thoracic Surgery (AREA)
Obesity (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Cardiology (AREA)
Nutrition Science (AREA)
Pulmonology (AREA)
Polymers & Plastics (AREA)
Food Science & Technology (AREA)
Mycology (AREA)
Ophthalmology & Optometry (AREA)
Endocrinology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Physiology (AREA)
Surgery (AREA)
Emergency Medicine (AREA)
Oncology (AREA)
Psychology (AREA)
Gastroenterology & Hepatology (AREA)
Rheumatology (AREA)

AT05726215T 2004-01-12 2005-01-07 Verwendung von quartären pyridiniumsalzen als gefässschutzmittel ATE524179T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
PL04364348A PL364348A1 (en)	2004-01-12	2004-01-12	Application of quaternary pyridine salts as vessel protection agent
PCT/EP2005/050057 WO2005067927A2 (en)	2004-01-12	2005-01-07	The use of quaternary pyridinium salts as vasoprotective agents

Publications (1)

Publication Number	Publication Date
ATE524179T1 true ATE524179T1 (de)	2011-09-15

Family

ID=34793495

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT05726215T ATE524179T1 (de)	2004-01-12	2005-01-07	Verwendung von quartären pyridiniumsalzen als gefässschutzmittel

Country Status (13)

Country	Link
US (6)	US7935717B2 (de)
EP (2)	EP2279738A1 (de)
JP (2)	JP5052138B2 (de)
CN (1)	CN1905875B (de)
AT (1)	ATE524179T1 (de)
AU (1)	AU2005205066C1 (de)
CA (1)	CA2547234C (de)
DK (1)	DK1713480T3 (de)
ES (1)	ES2372756T3 (de)
PL (2)	PL364348A1 (de)
PT (1)	PT1713480E (de)
RU (1)	RU2366420C2 (de)
WO (1)	WO2005067927A2 (de)

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PL364348A1 (en)	2004-01-12	2005-07-25	PHARMENA Sp.z o.o.	Application of quaternary pyridine salts as vessel protection agent
AU2006329564A1 (en)	2005-07-11	2007-07-05	Pharmena North America Inc.	Formulations for treatment of lipoprotein abnormalities comprising a statin a statin and a methylnicotinamide derivative
EP1963270B1 (de) *	2005-12-09	2009-08-05	Cerecon AG	Quaternäre 3-amido, n-methylpyridiniumsalze als entzündungshemmende mittel
CA2657606A1 (en)	2006-03-08	2007-09-13	Cortria Corporation	Combination therapy with non-selective cox inhibitors to prevent cox-related gastric injuries
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PL381862A1 (pl)	2007-02-28	2008-09-01	Trigendo Spółka Z Ograniczoną Odpowiedzialnością	Zastosowanie związków pirydyniowych i sposób leczenia
WO2009042440A1 (en) *	2007-09-28	2009-04-02	Cortria Corporation	1-methyl nicotinamide and derivatives for treatment of gastric injury
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US8304439B1 (en)	2007-10-12	2012-11-06	Politechnika Lodzka	Use of quaternary pyridinium salts as a therapeutic or preventing agent against ionizing radiation-induced damage
WO2009047290A1 (en) *	2007-10-12	2009-04-16	Politechnika Lodzka	Use of quaternary pyridinium salts for radioprotection
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WO2010000673A1 (en) *	2008-07-01	2010-01-07	Politechnika Lódzka	N'-nitroxyalkylnicotinamides for the treatment of cardiovascular diseases
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RU2425672C1 (ru) *	2010-04-12	2011-08-10	Государственное образовательное учреждение высшего профессионального образования "Курский государственный медицинский университет Федерального агентства по здравоохранению и социальному развитию"	Способ коррекции гипергомоцистеин-индуцированной эндотелиальной дисфункции смесью растворов гомеопатических разведений поликлональных кроличьих антител к эндотелиальной синтазе оксида азота человека - с12, с30, с200
KR101309576B1 (ko) *	2011-05-25	2013-09-17	연세대학교 산학협력단	대사물질을 이용한 심부전 바이오마커
PL226999B1 (pl) *	2013-06-11	2017-10-31	Univ Jagiellonski	Azotan (III) 3 -karbamoilo -1-metylopirydyniowy, sposób jego otrzymywania izastosowanie
CN105771005A (zh) *	2016-03-24	2016-07-20	乐普（北京）医疗器械股份有限公司	一种抗风湿性血管狭窄药物支架及其制备方法和应用
WO2018015862A1 (en)	2016-07-18	2018-01-25	Pharmena S.A.	1-methylnicotinamide salts for use in raising the blood levels of adiponectin
ES2967074T3 (es) *	2016-07-18	2024-04-25	Pharmena S A	1 metilnicotinamida para el tratamiento de una enfermedad cardiovascular
CN118221546A (zh) *	2017-07-27	2024-06-21	密歇根大学董事会	纤维蛋白溶酶原活化物抑制因子-1（pai-1）抑制剂和使用方法
PL238932B1 (pl) *	2017-12-31	2021-10-18	Univ Jagiellonski	Pochodne soli pirydyniowych oraz ich zastosowanie
PH12021551394B1 (en) *	2019-01-02	2024-04-26	Celagenex Res India Pvt Ltd	Potent synergistic compositions of vasoactive mediators enhancers for improving vascular endothelial function
WO2021205341A1 (en)	2020-04-07	2021-10-14	Pharmena S.A.	1-methylnicotinamide for the prevention/treatment of inflammatory airway diseases
EP4213821A2 (de) *	2020-09-21	2023-07-26	The Regents of the University of California	Immunologische wirkungen von metaboliten
CN115837023B (zh) *	2023-02-20	2023-05-16	中山大学附属第八医院（深圳福田）	1-甲基烟酰胺在制备抗血管钙化药物中的应用
US20240350475A1 (en) *	2023-04-13	2024-10-24	University Of South Carolina	Trigonelline mitigates cardiomyopathy caused by sars-cov-2 spike protein under obesity
PL447656A1 (pl) *	2024-01-31	2025-08-04	Politechnika Poznańska	Nowe czwartorzędowe sole amoniowe zawierające anion pochodzący od kwasu nikotynowego oraz kation N-alkilonikotynamidowy, sposób ich otrzymywania oraz zastosowanie jako substancje o aktywności przeciwbakteryjnej
PL248942B1 (pl) *	2024-01-31	2026-02-16	Politechnika Poznanska	Czwartorzędowe sole amoniowe zawierające anion 2-furanokarboksylanowy i kation będący alkilową pochodną nikotynamidu, sposób ich otrzymywania i zastosowanie jako środki myjąco-dezynfekujące
PL449092A1 (pl) *	2024-07-01	2026-01-05	Uniwersytet Jagielloński	Synergiczna kombinacja 1-metylonikotynamidu (MNA) i witaminy K do zastosowania w leczeniu lub zapobieganiu powikłaniom sercowo-naczyniowym terapii przeciwnowotworowych
PL450543A1 (pl) *	2024-12-11	2026-06-15	Politechnika Poznańska	Czwartorzędowe sole amoniowe z kationem 3-karbamoilo-1-alkilopirydyniowym i anionem (R)-migdalanowym, sposób ich otrzymywania oraz zastosowanie jako substancje o aktywności przeciwbakteryjnej
PL450542A1 (pl) *	2024-12-11	2026-06-15	Politechnika Poznańska	Czwartorzędowe sole amoniowe zawierające kation 3-karbamoiIo-1-alkilopirydyniowy i anion 4- aminobenzoesanowy, sposób ich otrzymywania i zastosowanie jako środki bakteriobójcze
PL450544A1 (pl) *	2024-12-11	2026-06-15	Politechnika Poznańska	Czwartorzędowe sole amoniowe z kationem 3-karbamoilo-1-alkilopirydyniowym i anionem (S)-migdalanowym, sposób ich otrzymywania oraz zastosowanie jako substancje o aktywności przeciwbakteryjnej
PL452423A1 (pl) *	2025-06-20	2026-08-03	Politechnika Poznańska	Sposób określania właściwości przeciwzapalnych czwartorzędowych soli amoniowych zawierających kation 3-karbamoilo-1-alkilopirydyniowy i anion 4-aminobenzoesanowy z użyciem albuminy jaja kurzego
PL452422A1 (pl) *	2025-06-20	2026-08-03	Politechnika Poznańska	Sposób określania właściwości przeciwzapalnych czwartorzędowych soli amoniowych zawierających anion pochodzący od kwasu nikotynowego oraz kation N-alkilonikotynamidowy z użyciem albuminy jaja kurzego

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2004
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2005
- 2005-01-07 AU AU2005205066A patent/AU2005205066C1/en not_active Expired
- 2005-01-07 WO PCT/EP2005/050057 patent/WO2005067927A2/en not_active Ceased
- 2005-01-07 US US10/585,892 patent/US7935717B2/en active Active
- 2005-01-07 JP JP2006548308A patent/JP5052138B2/ja not_active Expired - Lifetime
- 2005-01-07 PT PT05726215T patent/PT1713480E/pt unknown
- 2005-01-07 CN CN2005800017124A patent/CN1905875B/zh not_active Expired - Lifetime
- 2005-01-07 ES ES05726215T patent/ES2372756T3/es not_active Expired - Lifetime
- 2005-01-07 AT AT05726215T patent/ATE524179T1/de active
- 2005-01-07 PL PL05726215T patent/PL1713480T3/pl unknown
- 2005-01-07 RU RU2006129299/15A patent/RU2366420C2/ru active
- 2005-01-07 EP EP10180501A patent/EP2279738A1/de not_active Withdrawn
- 2005-01-07 EP EP05726215A patent/EP1713480B1/de not_active Expired - Lifetime
- 2005-01-07 DK DK05726215.6T patent/DK1713480T3/da active
- 2005-01-07 CA CA2547234A patent/CA2547234C/en not_active Expired - Lifetime
2010
- 2010-01-11 US US12/685,377 patent/US8124631B2/en not_active Expired - Lifetime
2011
- 2011-04-08 US US13/083,106 patent/US8969391B2/en active Active
- 2011-10-24 JP JP2011233155A patent/JP5597179B2/ja not_active Expired - Lifetime
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2015
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Also Published As

Publication number	Publication date
WO2005067927A2 (en)	2005-07-28
CA2547234A1 (en)	2005-07-28
US8124631B2 (en)	2012-02-28
RU2006129299A (ru)	2008-02-20
US9333196B2 (en)	2016-05-10
JP5052138B2 (ja)	2012-10-17
WO2005067927A3 (en)	2005-12-01
EP2279738A1 (de)	2011-02-02
US20160346265A1 (en)	2016-12-01
ES2372756T3 (es)	2012-01-26
JP2007517833A (ja)	2007-07-05
CN1905875B (zh)	2010-07-28
US9119844B2 (en)	2015-09-01
AU2005205066B2 (en)	2010-04-29
JP5597179B2 (ja)	2014-10-01
EP1713480B1 (de)	2011-09-14
US20110245297A1 (en)	2011-10-06
EP1713480A2 (de)	2006-10-25
US20080207702A1 (en)	2008-08-28
US20140296305A1 (en)	2014-10-02
PL364348A1 (en)	2005-07-25
CN1905875A (zh)	2007-01-31
PL1713480T3 (pl)	2011-12-30
US9675601B2 (en)	2017-06-13
US20100173956A1 (en)	2010-07-08
AU2005205066C1 (en)	2010-08-26
US7935717B2 (en)	2011-05-03
US20150133508A1 (en)	2015-05-14
CA2547234C (en)	2010-07-20
DK1713480T3 (da)	2012-01-16
RU2366420C2 (ru)	2009-09-10
AU2005205066A1 (en)	2005-07-28
US8969391B2 (en)	2015-03-03
JP2012072150A (ja)	2012-04-12
PT1713480E (pt)	2011-11-28

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