ATE540956T1 - Verfahren zur herstellung von maytansinol - Google Patents
Verfahren zur herstellung von maytansinolInfo
- Publication number
- ATE540956T1 ATE540956T1 AT06844315T AT06844315T ATE540956T1 AT E540956 T1 ATE540956 T1 AT E540956T1 AT 06844315 T AT06844315 T AT 06844315T AT 06844315 T AT06844315 T AT 06844315T AT E540956 T1 ATE540956 T1 AT E540956T1
- Authority
- AT
- Austria
- Prior art keywords
- maytansinol
- bridged
- producing
- scaleable
- acetals
- Prior art date
Links
- QWPXBEHQFHACTK-UHFFFAOYSA-N Maytansinol Natural products CN1C(=O)CC(O)C2(C)OC2C(C)C(OC(=O)N2)CC2(O)C(OC)C=CC=C(C)CC2=CC(OC)=C(Cl)C1=C2 QWPXBEHQFHACTK-UHFFFAOYSA-N 0.000 title abstract 5
- QWPXBEHQFHACTK-RZKXNLMUSA-N CO[C@@H]([C@@]1(O)C[C@H](OC(=O)N1)[C@@H](C)[C@@H]1O[C@@]1(C)[C@@H](O)CC(=O)N1C)\C=C\C=C(C)\CC2=CC(OC)=C(Cl)C1=C2 Chemical compound CO[C@@H]([C@@]1(O)C[C@H](OC(=O)N1)[C@@H](C)[C@@H]1O[C@@]1(C)[C@@H](O)CC(=O)N1C)\C=C\C=C(C)\CC2=CC(OC)=C(Cl)C1=C2 QWPXBEHQFHACTK-RZKXNLMUSA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- QWPXBEHQFHACTK-KZVYIGENSA-N (10e,12e)-86-chloro-12,14,4-trihydroxy-85,14-dimethoxy-33,2,7,10-tetramethyl-15,16-dihydro-14h-7-aza-1(6,4)-oxazina-3(2,3)-oxirana-8(1,3)-benzenacyclotetradecaphane-10,12-dien-6-one Chemical compound CN1C(=O)CC(O)C2(C)OC2C(C)C(OC(=O)N2)CC2(O)C(OC)\C=C\C=C(C)\CC2=CC(OC)=C(Cl)C1=C2 QWPXBEHQFHACTK-KZVYIGENSA-N 0.000 abstract 4
- 238000000034 method Methods 0.000 abstract 3
- 150000001241 acetals Chemical class 0.000 abstract 2
- DHKHKXVYLBGOIT-UHFFFAOYSA-N acetaldehyde Diethyl Acetal Natural products CCOC(C)OCC DHKHKXVYLBGOIT-UHFFFAOYSA-N 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73433005P | 2005-11-08 | 2005-11-08 | |
| PCT/US2006/043718 WO2007056550A2 (en) | 2005-11-08 | 2006-11-08 | Processes for preparation of maytansinol |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE540956T1 true ATE540956T1 (de) | 2012-01-15 |
Family
ID=38024003
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06844315T ATE540956T1 (de) | 2005-11-08 | 2006-11-08 | Verfahren zur herstellung von maytansinol |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7411063B2 (de) |
| EP (1) | EP1945647B9 (de) |
| JP (1) | JP5117390B2 (de) |
| AT (1) | ATE540956T1 (de) |
| AU (1) | AU2006311485B2 (de) |
| CA (1) | CA2625867C (de) |
| DK (1) | DK1945647T3 (de) |
| ES (1) | ES2380687T3 (de) |
| PL (1) | PL1945647T3 (de) |
| WO (1) | WO2007056550A2 (de) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100056762A1 (en) | 2001-05-11 | 2010-03-04 | Old Lloyd J | Specific binding proteins and uses thereof |
| US7589180B2 (en) | 2001-05-11 | 2009-09-15 | Abbott Laboratories Inc. | Specific binding proteins and uses thereof |
| EP2126127B1 (de) | 2007-01-25 | 2016-09-28 | Dana-Farber Cancer Institute, Inc. | Verwendung von anti-egfr-antikörpern bei der behandlung von durch egfr-mutanten vermittelten krankheiten |
| CA2680854C (en) | 2007-03-15 | 2017-02-14 | Ludwig Institute For Cancer Research | Treatment method using egfr antibodies and src inhibitors and related formulations |
| US9283276B2 (en) | 2007-08-14 | 2016-03-15 | Ludwig Institute For Cancer Research Ltd. | Monoclonal antibody 175 targeting the EGF receptor and derivatives and uses thereof |
| FR2949469A1 (fr) * | 2009-08-25 | 2011-03-04 | Sanofi Aventis | Derives anticancereux, leur preparation et leur application en therapeutique |
| WO2012074757A1 (en) | 2010-11-17 | 2012-06-07 | Genentech, Inc. | Alaninyl maytansinol antibody conjugates |
| AU2012395148B2 (en) | 2012-11-24 | 2016-10-27 | Hangzhou Dac Biotech Co., Ltd. | Hydrophilic linkers and their uses for conjugation of drugs to cell binding molecules |
| US10208125B2 (en) | 2013-07-15 | 2019-02-19 | University of Pittsburgh—of the Commonwealth System of Higher Education | Anti-mucin 1 binding agents and uses thereof |
| TWI541022B (zh) | 2013-12-18 | 2016-07-11 | 應克隆公司 | 針對纖維母細胞生長因子受體－３（ｆｇｆｒ３）之化合物及治療方法 |
| FI3122757T3 (fi) | 2014-02-28 | 2023-10-10 | Hangzhou Dac Biotech Co Ltd | Varautuneita linkkereitä ja niiden konjugointikäyttötapoja |
| TW201711702A (zh) | 2015-06-04 | 2017-04-01 | 應克隆公司 | 使用針對纖維母細胞生長因子受體３（ｆｇｆｒ３）之化合物的療法 |
| EP3319936B1 (de) | 2015-07-12 | 2025-12-17 | Hangzhou Dac Biotech Co., Ltd. | Brückenlinker zur konjugation von zellbindenden molekülen |
| US9839687B2 (en) | 2015-07-15 | 2017-12-12 | Suzhou M-Conj Biotech Co., Ltd. | Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule |
| AU2016429272A1 (en) | 2016-11-14 | 2019-05-02 | Hangzhou Dac Biotech Co., Ltd. | Conjugation linkers, cell binding molecule-drug conjugates containing the likers, methods of making and uses such conjugates with the linkers |
| JP7350313B2 (ja) | 2016-12-16 | 2023-09-26 | ブルーフィン バイオメディシン， インコーポレイテッド | 抗ｃｕｂドメイン含有タンパク質１（ｃｄｃｐ１）抗体、抗体薬物コンジュゲート、およびその使用方法 |
| CN113825759B (zh) | 2019-03-01 | 2024-06-04 | 细胞基因公司 | 美登醇的制备 |
| CN113710674B (zh) | 2019-04-18 | 2024-03-15 | 意迪那有限公司 | 制备含硫醇或二硫化物的美登素酯及其中间体的非对映选择性方法 |
| PH12022550037A1 (en) | 2019-07-10 | 2023-04-12 | Cybrexa 3 Inc | Peptide conjugates of microtubule-targeting agents as therapeutics |
| KR20220052918A (ko) | 2019-07-10 | 2022-04-28 | 싸이브렉사 2, 인크. | 치료제로서의 사이토톡신의 펩티드 접합체 |
| JP7772363B2 (ja) | 2019-11-29 | 2025-11-18 | 日本マイクロバイオファーマ株式会社 | メイタンシノールの酵素的生産方法 |
| CN117980327A (zh) | 2021-11-03 | 2024-05-03 | 杭州多禧生物科技有限公司 | 抗体的特异性偶联 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5566586A (en) * | 1978-11-14 | 1980-05-20 | Takeda Chem Ind Ltd | Novel maytansinoid compound and its preparation |
| US6333410B1 (en) * | 2000-08-18 | 2001-12-25 | Immunogen, Inc. | Process for the preparation and purification of thiol-containing maytansinoids |
| AU2003228998A1 (en) * | 2002-05-13 | 2003-12-02 | Smithkline Beecham Corporation | Process for preparing maytansinol |
-
2006
- 2006-11-08 WO PCT/US2006/043718 patent/WO2007056550A2/en not_active Ceased
- 2006-11-08 AT AT06844315T patent/ATE540956T1/de active
- 2006-11-08 PL PL06844315T patent/PL1945647T3/pl unknown
- 2006-11-08 ES ES06844315T patent/ES2380687T3/es active Active
- 2006-11-08 EP EP06844315A patent/EP1945647B9/de not_active Not-in-force
- 2006-11-08 DK DK06844315.9T patent/DK1945647T3/da active
- 2006-11-08 AU AU2006311485A patent/AU2006311485B2/en not_active Ceased
- 2006-11-08 CA CA2625867A patent/CA2625867C/en not_active Expired - Fee Related
- 2006-11-08 US US11/594,156 patent/US7411063B2/en not_active Expired - Fee Related
- 2006-11-08 JP JP2008540200A patent/JP5117390B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20070112188A1 (en) | 2007-05-17 |
| EP1945647B9 (de) | 2012-11-14 |
| EP1945647B1 (de) | 2012-01-11 |
| US7411063B2 (en) | 2008-08-12 |
| PL1945647T3 (pl) | 2012-04-30 |
| EP1945647A4 (de) | 2010-10-20 |
| WO2007056550A2 (en) | 2007-05-18 |
| ES2380687T3 (es) | 2012-05-17 |
| EP1945647A2 (de) | 2008-07-23 |
| DK1945647T3 (da) | 2012-05-07 |
| JP2009514978A (ja) | 2009-04-09 |
| WO2007056550A3 (en) | 2007-12-06 |
| AU2006311485B2 (en) | 2012-09-27 |
| CA2625867A1 (en) | 2007-05-18 |
| AU2006311485A1 (en) | 2007-05-18 |
| JP5117390B2 (ja) | 2013-01-16 |
| CA2625867C (en) | 2014-12-23 |
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