ATE549312T1 - Verfahren zur herstellung einer radioaktiven, mit fluor markierten organischen verbindung - Google Patents
Verfahren zur herstellung einer radioaktiven, mit fluor markierten organischen verbindungInfo
- Publication number
- ATE549312T1 ATE549312T1 AT07742894T AT07742894T ATE549312T1 AT E549312 T1 ATE549312 T1 AT E549312T1 AT 07742894 T AT07742894 T AT 07742894T AT 07742894 T AT07742894 T AT 07742894T AT E549312 T1 ATE549312 T1 AT E549312T1
- Authority
- AT
- Austria
- Prior art keywords
- formula
- organic compound
- compound
- fluorine
- producing
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 4
- 229910052731 fluorine Inorganic materials 0.000 title abstract 2
- 239000011737 fluorine Substances 0.000 title abstract 2
- 150000002894 organic compounds Chemical class 0.000 title abstract 2
- 230000002285 radioactive effect Effects 0.000 title abstract 2
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 5
- 239000012670 alkaline solution Substances 0.000 abstract 2
- 238000007257 deesterification reaction Methods 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 abstract 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical group C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical group [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 238000010511 deprotection reaction Methods 0.000 abstract 1
- 238000007599 discharging Methods 0.000 abstract 1
- NTEDWGYJNHZKQW-DGMDOPGDSA-N fluciclovine ((18)F) Chemical compound OC(=O)[C@]1(N)C[C@H]([18F])C1 NTEDWGYJNHZKQW-DGMDOPGDSA-N 0.000 abstract 1
- 229940027541 fluciclovine f-18 Drugs 0.000 abstract 1
- 239000012535 impurity Substances 0.000 abstract 1
- 229910052700 potassium Chemical group 0.000 abstract 1
- 239000011591 potassium Chemical group 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
- 229910052708 sodium Inorganic materials 0.000 abstract 1
- 239000011734 sodium Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/001—Acyclic or carbocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
- C07C227/20—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters by hydrolysis of N-acylated amino-acids or derivatives thereof, e.g. hydrolysis of carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/46—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C229/48—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups and carboxyl groups bound to carbon atoms of the same non-condensed ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2006132089 | 2006-05-11 | ||
| PCT/JP2007/059459 WO2007132689A1 (ja) | 2006-05-11 | 2007-05-07 | 放射性フッ素標識有機化合物の製造方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE549312T1 true ATE549312T1 (de) | 2012-03-15 |
Family
ID=38693787
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07742894T ATE549312T1 (de) | 2006-05-11 | 2007-05-07 | Verfahren zur herstellung einer radioaktiven, mit fluor markierten organischen verbindung |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US7897811B2 (de) |
| EP (1) | EP2017258B1 (de) |
| JP (1) | JP4550141B2 (de) |
| KR (1) | KR101317258B1 (de) |
| CN (1) | CN101443307B (de) |
| AT (1) | ATE549312T1 (de) |
| AU (1) | AU2007251015B2 (de) |
| BR (1) | BRPI0711144B1 (de) |
| CA (1) | CA2651786C (de) |
| DK (1) | DK2017258T3 (de) |
| ES (1) | ES2380372T3 (de) |
| IL (1) | IL195187A (de) |
| NO (1) | NO341173B1 (de) |
| NZ (1) | NZ572936A (de) |
| PT (1) | PT2017258E (de) |
| RU (1) | RU2434846C2 (de) |
| TW (1) | TWI389872B (de) |
| WO (1) | WO2007132689A1 (de) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101608755B1 (ko) | 2005-11-29 | 2016-04-04 | 니혼 메디피직스 가부시키가이샤 | 방사성 할로겐 표식 유기 화합물의 전구체 화합물 |
| EP2128130B1 (de) | 2006-12-27 | 2018-10-10 | Nihon Medi-Physics Co., Ltd. | Verfahren zur herstellung einer vorstufe für eine mit radioaktivem halogen markierte organische verbindung |
| JP5258583B2 (ja) * | 2007-02-13 | 2013-08-07 | 日本メジフィジックス株式会社 | 放射性画像診断剤の製造方法 |
| JP5732198B2 (ja) * | 2007-12-19 | 2015-06-10 | 日本メジフィジックス株式会社 | 放射性フッ素標識有機化合物の製造方法 |
| GB0812923D0 (en) * | 2008-07-15 | 2008-08-20 | Isis Innovation | Preparation of flourine-labelled compounds |
| CA2820363A1 (en) * | 2010-11-29 | 2012-06-07 | Ge Healthcare Limited | Preparation of pet precursor |
| US9061977B2 (en) * | 2010-12-20 | 2015-06-23 | Ge Healthcare Limited | Purification of precursor compound by crystallisation |
| GB201021523D0 (en) * | 2010-12-20 | 2011-02-02 | Ge Healthcare Ltd | Process simplification for precursor compound |
| GB201021530D0 (en) * | 2010-12-20 | 2011-02-02 | Ge Healthcare Ltd | Purification of precursor compound by crystallisation |
| EP2793954B1 (de) * | 2011-12-21 | 2020-10-21 | GE Healthcare Limited | 18f-fluciclovinzusammensetzungen in citratpuffern |
| GB201411569D0 (en) | 2014-06-30 | 2014-08-13 | Ge Healthcare Ltd | Novel formulation and method of synthesis |
| US11534494B2 (en) | 2011-12-21 | 2022-12-27 | Ge Healthcare Limited | Formulation and method of synthesis |
| GB201214220D0 (en) * | 2012-08-09 | 2012-09-19 | Ge Healthcare Ltd | Radiosynthesis |
| GB2561122B (en) * | 2012-12-21 | 2019-07-17 | Ge Healthcare Ltd | Composition comprising [18F]-Fluciclovine |
| GB201305687D0 (en) | 2013-03-28 | 2013-05-15 | Ge Healthcare Ltd | Radiolabelling process |
| KR20180016361A (ko) * | 2015-06-05 | 2018-02-14 | 니혼 메디피직스 가부시키가이샤 | 방사성 표식 화합물의 제조 장치 및 제조 방법 |
| JP6485914B2 (ja) * | 2015-10-28 | 2019-03-20 | 日本メジフィジックス株式会社 | フルテメタモルの製造方法 |
| CN106770883B (zh) * | 2017-01-03 | 2019-01-29 | 原子高科股份有限公司 | 一种氟[18f]化钠注射液放化纯的薄层色谱分析方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5808146A (en) | 1995-11-09 | 1998-09-15 | Emory University | Amino acid analogs for tumor imaging |
| BE1010280A3 (fr) | 1996-05-02 | 1998-05-05 | Coincidence S A | Procede et dispositif de synthese de 2-[18f] fluoro-2-deoxy-d-glucose. |
| RU2165266C1 (ru) * | 2000-06-28 | 2001-04-20 | Центральный научно-исследовательский рентгенорадиологический институт | Способ получения [2-18f]-2-дезоксиглюкозы |
| GB0229695D0 (en) | 2002-12-20 | 2003-01-29 | Amersham Plc | Solid-phase preparation of 18F-labelled amino acids |
| JP4979945B2 (ja) * | 2003-09-30 | 2012-07-18 | 日本メジフィジックス株式会社 | 放射性フッ素化合物の製造方法 |
-
2007
- 2007-05-07 ES ES07742894T patent/ES2380372T3/es active Active
- 2007-05-07 EP EP07742894A patent/EP2017258B1/de active Active
- 2007-05-07 NZ NZ572936A patent/NZ572936A/en unknown
- 2007-05-07 AU AU2007251015A patent/AU2007251015B2/en active Active
- 2007-05-07 DK DK07742894.4T patent/DK2017258T3/da active
- 2007-05-07 CN CN2007800171253A patent/CN101443307B/zh active Active
- 2007-05-07 AT AT07742894T patent/ATE549312T1/de active
- 2007-05-07 WO PCT/JP2007/059459 patent/WO2007132689A1/ja not_active Ceased
- 2007-05-07 CA CA2651786A patent/CA2651786C/en active Active
- 2007-05-07 RU RU2008148851/04A patent/RU2434846C2/ru active
- 2007-05-07 PT PT07742894T patent/PT2017258E/pt unknown
- 2007-05-07 BR BRPI0711144A patent/BRPI0711144B1/pt active IP Right Grant
- 2007-05-07 KR KR1020087027346A patent/KR101317258B1/ko active Active
- 2007-05-07 JP JP2008515492A patent/JP4550141B2/ja active Active
- 2007-05-07 US US12/227,240 patent/US7897811B2/en active Active
- 2007-05-08 TW TW096116347A patent/TWI389872B/zh active
-
2008
- 2008-11-10 IL IL195187A patent/IL195187A/en active IP Right Grant
- 2008-12-04 NO NO20085076A patent/NO341173B1/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL195187A (en) | 2013-04-30 |
| KR101317258B1 (ko) | 2013-10-14 |
| TWI389872B (zh) | 2013-03-21 |
| IL195187A0 (en) | 2009-08-03 |
| HK1129884A1 (en) | 2009-12-11 |
| EP2017258B1 (de) | 2012-03-14 |
| AU2007251015B2 (en) | 2011-09-01 |
| US20090198085A1 (en) | 2009-08-06 |
| NZ572936A (en) | 2011-01-28 |
| RU2434846C2 (ru) | 2011-11-27 |
| PT2017258E (pt) | 2012-04-12 |
| EP2017258A1 (de) | 2009-01-21 |
| EP2017258A4 (de) | 2011-05-25 |
| BRPI0711144A2 (pt) | 2011-08-23 |
| BRPI0711144B1 (pt) | 2017-03-28 |
| RU2008148851A (ru) | 2010-06-20 |
| CN101443307B (zh) | 2012-05-16 |
| NO341173B1 (no) | 2017-09-04 |
| CN101443307A (zh) | 2009-05-27 |
| US7897811B2 (en) | 2011-03-01 |
| JPWO2007132689A1 (ja) | 2009-09-24 |
| AU2007251015A1 (en) | 2007-11-22 |
| NO20085076L (no) | 2009-02-10 |
| CA2651786A1 (en) | 2007-11-22 |
| KR20090034805A (ko) | 2009-04-08 |
| ES2380372T3 (es) | 2012-05-11 |
| JP4550141B2 (ja) | 2010-09-22 |
| DK2017258T3 (da) | 2012-07-09 |
| TW200811084A (en) | 2008-03-01 |
| WO2007132689A1 (ja) | 2007-11-22 |
| CA2651786C (en) | 2014-11-04 |
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