NO20085076L - Fremgangsmate for fremstilling av radioaktiv florinmerket organisk forbindelse - Google Patents

Fremgangsmate for fremstilling av radioaktiv florinmerket organisk forbindelse

Info

Publication number
NO20085076L
NO20085076L NO20085076A NO20085076A NO20085076L NO 20085076 L NO20085076 L NO 20085076L NO 20085076 A NO20085076 A NO 20085076A NO 20085076 A NO20085076 A NO 20085076A NO 20085076 L NO20085076 L NO 20085076L
Authority
NO
Norway
Prior art keywords
organic compound
compound
formula
florin
radiolabelled
Prior art date
Application number
NO20085076A
Other languages
English (en)
Other versions
NO341173B1 (no
Inventor
Masahito Toyama
Fumie Kurosaki
Akio Hayashi
Toshiyuki Shinmura
Emi Kaneko
Original Assignee
Nihon Mediphysics Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nihon Mediphysics Co Ltd filed Critical Nihon Mediphysics Co Ltd
Publication of NO20085076L publication Critical patent/NO20085076L/no
Publication of NO341173B1 publication Critical patent/NO341173B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/001—Acyclic or carbocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
    • C07C227/20—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters by hydrolysis of N-acylated amino-acids or derivatives thereof, e.g. hydrolysis of carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/46—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C229/48—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups and carboxyl groups bound to carbon atoms of the same non-condensed ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Det beskrives en fremgangsmåte for fremstilling av [18F]FACBC som kan redusere mengden av fremstilte urenheter. Det beskrives en fremgangsmåte for fremstilling av en organisk forbindelse som er merket med radioaktivt fluor og som omfatter: et deforestringstrinn for i en reversfase kolonne å holde tilbake en forbindelse representert med formel (l): (1) der R i er en rett eller forgrenet C1-C10 alkylkjede eller en aromatisk substituent; og R2 er en beskyttende gruppe; fylling av kolonnen med alkalisk oppløsning for å deforestre forbindelsen, og deretter; å slippe ut alkalieoppløsningen fra kolonnen for å oppnå en forbindelse representert med formel( 2): (2) der X er natrium eller kalium; og et debeskyttelsestrinn for debeskyttelse av den aminobeskyttende gruppe av forbindelsen oppnådd i deforestringstrinnet for å oppnå en forbindelse representert ved formel (3): (3)
NO20085076A 2006-05-11 2008-12-04 Fremgangsmåte for fremstilling av radioaktive, fluormerkede organiske forbindelser NO341173B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2006132089 2006-05-11
PCT/JP2007/059459 WO2007132689A1 (ja) 2006-05-11 2007-05-07 放射性フッ素標識有機化合物の製造方法

Publications (2)

Publication Number Publication Date
NO20085076L true NO20085076L (no) 2009-02-10
NO341173B1 NO341173B1 (no) 2017-09-04

Family

ID=38693787

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20085076A NO341173B1 (no) 2006-05-11 2008-12-04 Fremgangsmåte for fremstilling av radioaktive, fluormerkede organiske forbindelser

Country Status (18)

Country Link
US (1) US7897811B2 (no)
EP (1) EP2017258B1 (no)
JP (1) JP4550141B2 (no)
KR (1) KR101317258B1 (no)
CN (1) CN101443307B (no)
AT (1) ATE549312T1 (no)
AU (1) AU2007251015B2 (no)
BR (1) BRPI0711144B1 (no)
CA (1) CA2651786C (no)
DK (1) DK2017258T3 (no)
ES (1) ES2380372T3 (no)
IL (1) IL195187A (no)
NO (1) NO341173B1 (no)
NZ (1) NZ572936A (no)
PT (1) PT2017258E (no)
RU (1) RU2434846C2 (no)
TW (1) TWI389872B (no)
WO (1) WO2007132689A1 (no)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2428415C2 (ru) 2005-11-29 2011-09-10 Нихон Меди-Физикс Ко., Лтд. Соединение-предшественник органического соединения, меченного радиоактивным галогеном
BRPI0720465B8 (pt) * 2006-12-27 2021-07-27 Nihon Mediphysics Co Ltd processo para produção de composto de precursor para composto orgânico marcado com halogênio radioativo
EP2119458B9 (en) * 2007-02-13 2013-08-21 Nihon Medi-Physics Co., Ltd. Method for production of radiation diagnostic imaging agent
US8269035B2 (en) * 2007-12-19 2012-09-18 Nihon Medi-Physics Co., Ltd. Process for production of radioactive-fluorine-labeled organic compound
GB0812923D0 (en) * 2008-07-15 2008-08-20 Isis Innovation Preparation of flourine-labelled compounds
CN103221382B (zh) * 2010-11-29 2016-06-01 通用电气健康护理有限公司 制备pet前体
GB201021523D0 (en) * 2010-12-20 2011-02-02 Ge Healthcare Ltd Process simplification for precursor compound
MX2013007186A (es) * 2010-12-20 2013-07-12 Ge Healthcare Ltd Purificacion de compuesto precursor mediante cristalizacion.
GB201021530D0 (en) * 2010-12-20 2011-02-02 Ge Healthcare Ltd Purification of precursor compound by crystallisation
GB201411569D0 (en) 2014-06-30 2014-08-13 Ge Healthcare Ltd Novel formulation and method of synthesis
JP6446268B2 (ja) * 2011-12-21 2018-12-26 ジーイー・ヘルスケア・リミテッド クエン酸緩衝液中の１８ｆ−フルシクロビン組成物
US11534494B2 (en) 2011-12-21 2022-12-27 Ge Healthcare Limited Formulation and method of synthesis
GB201214220D0 (en) * 2012-08-09 2012-09-19 Ge Healthcare Ltd Radiosynthesis
GB2561122B (en) * 2012-12-21 2019-07-17 Ge Healthcare Ltd Composition comprising [18F]-Fluciclovine
GB201305687D0 (en) * 2013-03-28 2013-05-15 Ge Healthcare Ltd Radiolabelling process
US20180170822A1 (en) * 2015-06-05 2018-06-21 Nihon Medi-Physics Co., Ltd. Device and method for producing radioactively labeled compound
JP6485914B2 (ja) * 2015-10-28 2019-03-20 日本メジフィジックス株式会社 フルテメタモルの製造方法
CN106770883B (zh) * 2017-01-03 2019-01-29 原子高科股份有限公司 一种氟[18f]化钠注射液放化纯的薄层色谱分析方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5808146A (en) 1995-11-09 1998-09-15 Emory University Amino acid analogs for tumor imaging
BE1010280A3 (fr) 1996-05-02 1998-05-05 Coincidence S A Procede et dispositif de synthese de 2-[18f] fluoro-2-deoxy-d-glucose.
RU2165266C1 (ru) * 2000-06-28 2001-04-20 Центральный научно-исследовательский рентгенорадиологический институт Способ получения [2-18f]-2-дезоксиглюкозы
GB0229695D0 (en) 2002-12-20 2003-01-29 Amersham Plc Solid-phase preparation of 18F-labelled amino acids
WO2005030677A1 (ja) 2003-09-30 2005-04-07 Nihon Medi-Physics Co., Ltd. 放射性フッ素化合物の製造方法

Also Published As

Publication number Publication date
DK2017258T3 (da) 2012-07-09
RU2008148851A (ru) 2010-06-20
JP4550141B2 (ja) 2010-09-22
US20090198085A1 (en) 2009-08-06
RU2434846C2 (ru) 2011-11-27
KR20090034805A (ko) 2009-04-08
CA2651786C (en) 2014-11-04
KR101317258B1 (ko) 2013-10-14
IL195187A0 (en) 2009-08-03
JPWO2007132689A1 (ja) 2009-09-24
BRPI0711144A2 (pt) 2011-08-23
IL195187A (en) 2013-04-30
TWI389872B (zh) 2013-03-21
CA2651786A1 (en) 2007-11-22
ATE549312T1 (de) 2012-03-15
PT2017258E (pt) 2012-04-12
EP2017258A4 (en) 2011-05-25
EP2017258B1 (en) 2012-03-14
CN101443307B (zh) 2012-05-16
NO341173B1 (no) 2017-09-04
CN101443307A (zh) 2009-05-27
TW200811084A (en) 2008-03-01
WO2007132689A1 (ja) 2007-11-22
EP2017258A1 (en) 2009-01-21
ES2380372T3 (es) 2012-05-11
NZ572936A (en) 2011-01-28
AU2007251015A1 (en) 2007-11-22
HK1129884A1 (en) 2009-12-11
US7897811B2 (en) 2011-03-01
AU2007251015B2 (en) 2011-09-01
BRPI0711144B1 (pt) 2017-03-28

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