ATE79408T1 - Herstellung heterodimerer menschlicher fruchtbarkeitshormone. - Google Patents

Herstellung heterodimerer menschlicher fruchtbarkeitshormone.

Info

Publication number
ATE79408T1
ATE79408T1 AT85900268T AT85900268T ATE79408T1 AT E79408 T1 ATE79408 T1 AT E79408T1 AT 85900268 T AT85900268 T AT 85900268T AT 85900268 T AT85900268 T AT 85900268T AT E79408 T1 ATE79408 T1 AT E79408T1
Authority
AT
Austria
Prior art keywords
production
human fertility
preparation
heterodimeric human
hormones
Prior art date
Application number
AT85900268T
Other languages
English (en)
Inventor
Vemuri B Reddy
Nancy Hsiung
Anton K Beck
Edward George Bernstine
Original Assignee
Applied Research Systems
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Research Systems filed Critical Applied Research Systems
Priority claimed from EP85900268A external-priority patent/EP0160699B1/de
Application granted granted Critical
Publication of ATE79408T1 publication Critical patent/ATE79408T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4715—Pregnancy proteins, e.g. placenta proteins, alpha-feto-protein, pregnancy specific beta glycoprotein
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
    • C12N2830/002—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/60—Vector systems having a special element relevant for transcription from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
    • C12N2830/85—Vector systems having a special element relevant for transcription from vertebrates mammalian
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/44—Vectors comprising a special translation-regulating system being a specific part of the splice mechanism, e.g. donor, acceptor

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
AT85900268T 1983-11-02 1984-10-31 Herstellung heterodimerer menschlicher fruchtbarkeitshormone. ATE79408T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US06/548,228 US4840896A (en) 1983-11-02 1983-11-02 Heteropolymeric protein
EP85900268A EP0160699B1 (de) 1983-11-02 1984-10-31 Herstellung heterodimerer menschlicher fruchtbarkeitshormone
PCT/US1984/001771 WO1985001959A1 (en) 1983-11-02 1984-10-31 Production of heterodimeric human fertlity hormones

Publications (1)

Publication Number Publication Date
ATE79408T1 true ATE79408T1 (de) 1992-08-15

Family

ID=24187922

Family Applications (1)

Application Number Title Priority Date Filing Date
AT85900268T ATE79408T1 (de) 1983-11-02 1984-10-31 Herstellung heterodimerer menschlicher fruchtbarkeitshormone.

Country Status (9)

Country Link
US (2) US4840896A (de)
EP (1) EP0487512B1 (de)
JP (6) JPH0832244B2 (de)
AT (1) ATE79408T1 (de)
DE (1) DE3485869T2 (de)
HK (1) HK26196A (de)
LU (1) LU90806I2 (de)
NL (1) NL300049I2 (de)
WO (1) WO1985001958A1 (de)

Families Citing this family (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4923805A (en) * 1983-11-02 1990-05-08 Integrated Genetics, Inc. Fsh
US4840896A (en) * 1983-11-02 1989-06-20 Integrated Genetics, Inc. Heteropolymeric protein
US5156957A (en) * 1983-11-02 1992-10-20 Genzyme Corporation Follicle stimulating hormone
US5639639A (en) * 1983-11-02 1997-06-17 Genzyme Corporation Recombinant heterodimeric human fertility hormones, and methods, cells, vectors and DNA for the production thereof
US6455282B1 (en) * 1983-11-02 2002-09-24 Genzyme Corporation Cells, vectors and methods for producing biologically active TSH
JPS60145098A (ja) * 1984-01-09 1985-07-31 Suntory Ltd 糖付加ポリペプチドの製造法
DE3520404C2 (de) * 1984-06-08 1994-06-16 Genzyme Corp Schweine-ß-FSH
AU5993186A (en) * 1985-06-04 1987-01-07 Biotechnology Research Partners Limited Autoantigen vaccines
FI98829C (fi) * 1986-01-27 1997-08-25 Chiron Corp Menetelmä rekombinoidun proteiinikompleksin valmistamiseksi, jolla on humaanitekijä VIII:C-aktiivisuutta
EP0259632B1 (de) * 1986-08-13 1995-12-13 Zymogenetics, Inc. Expression von biologisch-aktiven PDGF-Analogen in eukaryotischen Zellen
JPS63112985A (ja) * 1986-10-31 1988-05-18 Daicel Chem Ind Ltd 新規プラスミド
JPS63112978A (ja) * 1986-10-31 1988-05-18 Daicel Chem Ind Ltd エシエリチア・コリ
JP2769170B2 (ja) * 1987-12-08 1998-06-25 ザイモジェネティクス，インコーポレイティド 真核細肪中での同時発現
US5260421A (en) * 1987-12-21 1993-11-09 Applied Research Systems Ars Holding N.V. Site-directed mutagenesis modified glycoprotein hormones
US5635475A (en) * 1987-12-21 1997-06-03 Applied Research Systems Ars Holding N.V. Site-directed mutagenesis modified glycoprotein hormones and methods of use
JPH03502525A (ja) * 1988-09-01 1991-06-13 アプライド・リサーチ・システムス・エー・アール・エス・ホールディング・エヌ・ブイ ゴナドトロピンおよびｔｓｈのスーパーアゴニストの製造方法並びに該製造方法で製造したスーパーアゴニスト
US5196524A (en) * 1989-01-06 1993-03-23 Eli Lilly And Company Fusion reporter gene for bacterial luciferase
WO1990008528A1 (en) * 1989-01-11 1990-08-09 The United States Of America, Represented By The Secretary, United States Department Of Commerce Biologically active synthetic thyrotropin and cloned gene for producing same
JP3045539B2 (ja) * 1989-02-21 2000-05-29 ワシントン ユニバーシティ 改変型生殖ホルモン
US6828125B1 (en) * 1989-05-10 2004-12-07 Baxter Biotech Technology, S.A.R.L. DNA encoding fused di-alpha globins and use thereof
US5545727A (en) * 1989-05-10 1996-08-13 Somatogen, Inc. DNA encoding fused di-alpha globins and production of pseudotetrameric hemoglobin
US5240832A (en) * 1989-06-20 1993-08-31 Genzyme Corporation Heteropolymeric protein production methods
US6172039B1 (en) 1990-04-16 2001-01-09 Apex Bioscience, Inc. Expression of recombinant hemoglobin and hemoglobin variants in yeast
AU7744491A (en) * 1990-04-16 1991-11-11 Strohtech, Inc. Expression of recombinant hemoglobin in yeast
EP0611306B1 (de) * 1991-11-08 1998-07-08 Somatogen, Inc. Hämoglobine als arzneimittelabgabesystem
US6737515B2 (en) 1993-11-19 2004-05-18 Washington University Follicle stimulating hormone-glycosylation analogs
US6017697A (en) 1994-11-14 2000-01-25 Eli Lilly And Company Excitatory amino acid receptor protein and related nucleic acid compounds
EP0786523A3 (de) 1996-01-29 2000-01-12 Eli Lilly And Company Proteinkinase und Verfahren zur Verwendung
US6162905A (en) * 1996-11-07 2000-12-19 Ibsa Institut Biochimique S.A. FSH and LH separation and purification process
US6476211B1 (en) * 1998-07-16 2002-11-05 Hyseq, Inc. Methods and materials relating to CD39-like polypeptides
JP2002541213A (ja) 1999-04-13 2002-12-03 インヘール セラピューティック システムズ， インコーポレイテッド 不妊症の処置のための乾燥粉末処方物の肺投与
HK1052314A1 (zh) * 2000-08-11 2003-09-11 Favrille, Inc. 改变t细胞介导的病理的方法和组合物
US6911204B2 (en) 2000-08-11 2005-06-28 Favrille, Inc. Method and composition for altering a B cell mediated pathology
US6824822B2 (en) 2001-08-31 2004-11-30 Alkermes Controlled Therapeutics Inc. Ii Residual solvent extraction method and microparticles produced thereby
ES2411007T3 (es) 2001-10-10 2013-07-04 Novo Nordisk A/S Remodelación y glicoconjugación de péptidos
WO2003066585A2 (en) * 2002-02-08 2003-08-14 Alkermes Controlled Therapeutics, Inc. Polymer-based compositions for sustained release
CA2518268C (en) * 2003-03-04 2013-12-10 Aspenbio, Inc. Methods and kits for maintaining pregnancy, treating follicular cysts, and synchronizing ovulation using luteinizing hormone
PL1615945T3 (pl) 2003-04-09 2012-03-30 Ratiopharm Gmbh Sposoby glikopegylacji i białka/peptydy wytwarzane tymi sposobami
UA88879C2 (en) * 2003-09-02 2009-12-10 Эплайд Рисерч Системз Эрс Холдинг Н.В. Fsh glycosylation mutant
JP4412989B2 (ja) * 2003-12-15 2010-02-10 株式会社日立製作所 複数の記憶システムを有するデータ処理システム
BRPI0507174A (pt) * 2004-01-28 2008-04-01 Syntonix Pharmaceuticals Inc proteìnas de fusão hormÈnio-fc (fsh-fc) heterodiméricas estimuladoras de folìculo para o tratamento da infertilidade
CA2556266A1 (en) 2004-02-13 2005-08-25 Stem Cell Therapeutics Corp. Use of luteinizing hormone (lh), and chorionic gonadotropin (hcg) for proliferation of neural stem cells and neurogenesis
US20060110423A1 (en) * 2004-04-15 2006-05-25 Wright Steven G Polymer-based sustained release device
US8617613B2 (en) 2004-04-15 2013-12-31 Alkermes Pharma Ireland Limited Polymer-based sustained release device
US7456254B2 (en) * 2004-04-15 2008-11-25 Alkermes, Inc. Polymer-based sustained release device
US11246913B2 (en) 2005-02-03 2022-02-15 Intarcia Therapeutics, Inc. Suspension formulation comprising an insulinotropic peptide
WO2007106987A1 (en) * 2006-03-17 2007-09-27 Stem Cell Therapeutics Corp. Continuous dosing regimens for neural stem cell proliferating agents and neural stem cell differentiating agents
EP2359808B1 (de) 2006-08-09 2013-05-22 Intarcia Therapeutics, Inc Osmotisches Verabreichungssystem mit Kolbenanordnung
WO2008133908A2 (en) 2007-04-23 2008-11-06 Intarcia Therapeutics, Inc. Suspension formulations of insulinotropic peptides and uses thereof
NZ586588A (en) 2008-02-08 2012-10-26 Biogenerix Ag Formulation of ( follice stimulating hormone) fsh and varients with benzalkonium chloride and benzyl alcohol
CA2726861C (en) 2008-02-13 2014-05-27 Intarcia Therapeutics, Inc. Devices, formulations, and methods for delivery of multiple beneficial agents
JP5845170B2 (ja) 2009-04-01 2016-01-20 ラティオファーム ゲーエムベーハー 組換えｆｓｈを精製する方法
RU2547990C2 (ru) 2009-09-28 2015-04-10 Интарсия Терапьютикс, Инк. Быстрое достижение и/или прекращение существенной стабильной доставки лекарственного средства
TWI532495B (zh) 2009-10-05 2016-05-11 菲瑞茵國際中心股份有限公司 藥學製劑
EP2325194A1 (de) 2009-11-24 2011-05-25 Glycotope GmbH Verfahren zur Reinigung von Glykoproteinen
US20120208755A1 (en) 2011-02-16 2012-08-16 Intarcia Therapeutics, Inc. Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers
CN103509121B (zh) 2012-11-22 2015-01-28 苏州康宁杰瑞生物科技有限公司 一种fsh融合蛋白及其制备方法和用途
BR112015028737B1 (pt) * 2013-05-16 2022-05-10 Universidade De São Paulo - Usp Métodos para a produção e/ou purificação de hormônios
US9889085B1 (en) 2014-09-30 2018-02-13 Intarcia Therapeutics, Inc. Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c
RU2730996C2 (ru) 2015-06-03 2020-08-26 Интарсия Терапьютикс, Инк. Системы установки и извлечения имплантата
KR102574993B1 (ko) 2016-05-16 2023-09-06 인타르시아 세라퓨틱스 인코포레이티드 글루카곤-수용체 선택적 폴리펩티드 및 이들의 이용 방법
USD860451S1 (en) 2016-06-02 2019-09-17 Intarcia Therapeutics, Inc. Implant removal tool
USD840030S1 (en) 2016-06-02 2019-02-05 Intarcia Therapeutics, Inc. Implant placement guide
JP7286542B2 (ja) 2017-01-03 2023-06-05 インターシア セラピューティクス，インコーポレイティド Ｇｌｐ－１受容体アゴニストの持続的投与及び薬物の同時投与を含む方法
CN108264549A (zh) * 2018-03-29 2018-07-10 北京伟杰信生物科技有限公司 重组绒促性素rhCG的制备方法及应用
EP4008279A3 (de) 2018-10-10 2022-09-28 InnoMed Seven L.L.C. System und verfahren zur intrauterinbefruchtung
BR102019004147A2 (pt) 2019-02-28 2020-10-06 Ouro Fino Saude Animal Participacoes S.A. Gonadotrofina coriônica equina recombinante (recg) biologicamente ativa e processo para obtenção da mesma, composição veterinária e uso
CA3140267A1 (en) 2019-05-16 2020-11-19 Ceva Sante Animale Compositions and methods for increasing reproduction performance in non-human mammals using recombinant luteinizing hormone
CN116199742B (zh) * 2022-07-06 2025-01-24 华兰基因工程有限公司 一种重组人绒毛膜促性腺激素Fc融合蛋白制备方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4468464A (en) * 1974-11-04 1984-08-28 The Board Of Trustees Of The Leland Stanford Junior University Biologically functional molecular chimeras
FR2458584A1 (fr) * 1979-06-08 1981-01-02 Pasteur Institut Vecteurs pour le transfert et l'expression de materiel genetique dans une cellule eucaryote et procede pour la production d'une proteine determinee dans des cellules eucaryotes
US4401759A (en) * 1980-05-01 1983-08-30 Harvey Rubin Detection and isolation of glucagon mRNA using a synthetic oligodeoxynucleotide
JPS586475B2 (ja) * 1980-08-23 1983-02-04 株式会社 林原生物化学研究所 ヒト絨毛性性腺刺激ホルモンの製造方法
JPS585671B2 (ja) * 1980-08-27 1983-02-01 株式会社 林原生物化学研究所 ヒト卵胞刺激ホルモンの製造方法
US4394443A (en) * 1980-12-18 1983-07-19 Yale University Method for cloning genes
US4419446A (en) * 1980-12-31 1983-12-06 The United States Of America As Represented By The Department Of Health And Human Services Recombinant DNA process utilizing a papilloma virus DNA as a vector
US4385586A (en) * 1981-09-04 1983-05-31 Schriever Frederick G Escape/rescue system
EP0078154A3 (de) * 1981-10-28 1985-01-09 The Regents Of The University Of California Plasmide und Zellen für die heterologe Expression von Metallothioneinen und Verfahren zur Herstellung und Verwendung des Metallothioneins
ATE72583T1 (de) * 1981-11-23 1992-02-15 University Patents Inc Steuerung der dna-sequenzen-transkription.
US4656134A (en) * 1982-01-11 1987-04-07 Board Of Trustees Of Leland Stanford Jr. University Gene amplification in eukaryotic cells
AU2038283A (en) * 1982-08-10 1984-03-07 Trustees Of Columbia University In The City Of New York, The The use of eucaryotic promoter sequences in the production ofproteinaceous materials
GB8308235D0 (en) * 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
LU84795A1 (fr) * 1983-05-09 1985-03-21 Labofina Sa Genes conferant la resistance de la levure a des herbicides
US4923805A (en) * 1983-11-02 1990-05-08 Integrated Genetics, Inc. Fsh
US4840896A (en) * 1983-11-02 1989-06-20 Integrated Genetics, Inc. Heteropolymeric protein

Also Published As

Publication number Publication date
JPH06107692A (ja) 1994-04-19
DE3485869T2 (de) 1993-02-18
JPH07203968A (ja) 1995-08-08
NL300049I2 (nl) 2005-07-01
JP3091673B2 (ja) 2000-09-25
US4840896A (en) 1989-06-20
US5767251A (en) 1998-06-16
DE3485869D1 (de) 1992-09-17
JPS61500249A (ja) 1986-02-20
NL300049I1 (nl) 2001-10-01
WO1985001958A1 (en) 1985-05-09
JPH0832244B2 (ja) 1996-03-29
HK26196A (en) 1996-02-16
LU90806I2 (fr) 2001-09-25
EP0487512B1 (de) 1998-08-05
JPH11308992A (ja) 1999-11-09
JPS61500251A (ja) 1986-02-20
EP0487512A1 (de) 1992-05-27
JP2573817B2 (ja) 1997-01-22
JP3126348B2 (ja) 2001-01-22
JPH0884588A (ja) 1996-04-02

Similar Documents

Publication Publication Date Title
ATE79408T1 (de) Herstellung heterodimerer menschlicher fruchtbarkeitshormone.
DE122010000006I2 (de) Modifizierte formen von fortpflanzungshormonen.
FI941500A0 (fi) Hormonianalogit joissa on moninkertaisia CTP-lisäkkeitä
ES2181281T3 (es) Formulaciones liquidas de interferon beta.
NZ512792A (en) Stable liquid interferon beta formulations
LU88738I2 (fr) Hormone Folliculo-Stimulante humaine recombinante (follitropine alpha) et ses dérivés pharmaceutiquement acceptables GONAL-F
IT1232827B (it) Proteine biologicamente attive, formulazioni che le contengono e metodo per prepararle ed applicarle
ATE342061T1 (de) Verwendung eines nicht-neutralisierenden antikörpers spezifisch für die beta-untereinheit von luteinisierendem hormon zur erhöhung der fertilität
EP0289572A4 (de) Verwendung von interleukin-1-proteinen gegen arthritis.
ES2074046T5 (es) Procedimiento de construccion de una linea celular animal para la preparacion de beta-interferon humano.
GB1523825A (en) Induction of ovulation with partially desialylated human chlorionic gonadotropin
EP0315118A3 (de) Endothelin kodierendes DNA und dessen Verwendung
ES2052513T3 (es) Nuevos polipeptidos, su fabricacion y empleo.
Greenwald et al. Induction of ovulation in the hypophysectomized proestrous hamster by purified FSH or LH
KR900702048A (ko) 고나도트로핀 및 그에 의한 과할성 작용제의 제조 방법
ATE100143T1 (de) Hormone und verfahren zur herstellung, verwendung und pruefung derselben.
AU637589B2 (en) Ancrod proteins, their production and use
Li Perspectives in the biochemical endocrinology of adenohypophyseal hormones
Matteri et al. Biochemical and biological properties of urinary follicle‐stimulating hormone (FSH) from the rhesus monkey (Macaca mulatta)
IE873143L (en) HOMOGENEOUS SHEEP TllTS AS AN INTERMEDIATE FOR THE¹PREPARATION OF HUMAN Tllts, AND THE USE THEREOF
HUT55625A (en) Hair-restorer comprising animal materials as active ingredient
Nicol Effects of Lipaemia on Routine Determination of Serum Total Protein by Variants of the Biuret Method
ATE99952T1 (de) Verfahren zur behandlung von unfruchtbarkeit oder verminderter fruchtbarkeit bei erwachsenen maennern und die verwendung von praeparaten in diesem verfahren.
Smirnova Effect of histamine and prostaglandins E2 and F2 alpha on the electrical activity of stomach cells in the rat
PT85226A (en) Process for the preparation of novel trombolytic proteins

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EELA Cancelled due to lapse of time