ATE90940T1 - Leukotrien-antagonisten. - Google Patents

Leukotrien-antagonisten.

Info

Publication number: ATE90940T1
Authority: AT; Austria
Prior art keywords: phenyl; alkyl; tetrazoyl; antagonists; leukotrian
Prior art date: 1988-12-23

Application number

AT89313261T

Other languages

English (en)

Inventor

John Gerald Gleason

Joanne Marie Smallheer

Ralph Floyd Hall

Original Assignee

Smithkline Beecham Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-12-23

Filing date

1989-12-19

Publication date

1993-07-15

1989-12-19 Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp

1993-07-15 Application granted granted Critical

1993-07-15 Publication of ATE90940T1 publication Critical patent/ATE90940T1/de

Links

239000005557 antagonist Substances 0.000 title 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
125000000217 alkyl group Chemical group 0.000 abstract 2
125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
101100295741 Gallus gallus COR4 gene Proteins 0.000 abstract 1
125000005055 alkyl alkoxy group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000003199 leukotriene receptor blocking agent Substances 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
125000003107 substituted aryl group Chemical group 0.000 abstract 1
238000002560 therapeutic procedure Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/52—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/56—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pulmonology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT89313261T 1988-12-23 1989-12-19 Leukotrien-antagonisten. ATE90940T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US07/288,827 US4954513A (en)	1988-12-23	1988-12-23	Leukotriene antagonists
EP89313261A EP0375348B1 (de)	1988-12-23	1989-12-19	Leukotrien-Antagonisten

Publications (1)

Publication Number	Publication Date
ATE90940T1 true ATE90940T1 (de)	1993-07-15

Family

ID=23108809

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT89313261T ATE90940T1 (de)	1988-12-23	1989-12-19	Leukotrien-antagonisten.

Country Status (12)

Country	Link
US (1)	US4954513A (de)
EP (1)	EP0375348B1 (de)
JP (1)	JPH0684344B2 (de)
AT (1)	ATE90940T1 (de)
AU (1)	AU4678789A (de)
CA (1)	CA2005349A1 (de)
DE (1)	DE68907329T2 (de)
DK (1)	DK644889A (de)
ES (1)	ES2057153T3 (de)
IE (1)	IE894104L (de)
PT (1)	PT92724A (de)
ZA (1)	ZA899721B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2018437A1 (en) *	1989-06-14	1990-12-14	James Simpson Frazee	Leukotriene antagonists
ATE96149T1 (de) *	1989-07-27	1993-11-15	Bayer Ag	Arylalkensaeurederivate als leukotrienantagonisten.
US5266713A (en) *	1989-07-27	1993-11-30	Miles Inc.	Aryl alkenoic acid derivatives as leukotriene antagonists
WO1991017149A1 (en) *	1990-05-01	1991-11-14	Smithkline Beecham Corporation	3-naphthyl-3-carboxyalkylthio or oxy substituted alkanoic acid leukotriene antagonists
EP0528957A4 (en) *	1990-05-01	1993-05-05	Smith-Kline Beecham Corporation	Five-membered ring alkanoic acid leukotriene antagonists
WO2009001374A2 (en) *	2007-06-25	2008-12-31	Aptuit Laurus Pvt Ltd	Preparation of ethyl-3'-[((7-chloro-2-quinolinyl)ethenyl)phenyl]-3-oxopropanoate, a key intermediate for montelukast sodium

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US66592A (en) *		1867-07-09		Geobge iewin
US66588A (en) *		1867-07-09		hicks
BE787235A (fr) *	1971-08-06	1973-02-05	Sandoz Sa	Nouveaux derives du thiophene, leur preparation et leur application comme medicaments
CA1090811A (en) *	1976-10-18	1980-12-02	Genichi Tsuchihashi	.alpha.-THIO-ALKANOIC ACID DERIVATIVES
US4513005A (en) *	1981-06-18	1985-04-23	Lilly Industries Limited	SRS-A antagonists
NZ205559A (en) *	1982-09-23	1987-08-31	Merck Frosst Canada Inc	Leukotriene antagonists, pharmaceutical compositions, and intermediates
US4661505A (en) *	1982-11-03	1987-04-28	Eli Lilly And Company	Leukotriene antagonists
DE3469169D1 (en) *	1983-04-21	1988-03-10	Merck Frosst Canada Inc	Leukotriene antagonists, their production and use and compositions containing them
US4609744A (en) *	1983-04-21	1986-09-02	Merck Frosst Canada Inc.	4-oxo-benzopyran carboxylic acids
US5105017A (en) *	1983-07-18	1992-04-14	Eli Lilly And Company	Leukotriene antagonist intermediates
GR81524B (de) *	1983-07-18	1984-12-11	Lilly Co Eli
GB8320943D0 (en) *	1983-08-03	1983-09-07	Lilly Industries Ltd	Organic compounds
GB8432144D0 (en) *	1984-12-20	1985-01-30	Lilly Industries Ltd	Organic compounds
GB8502258D0 (en) *	1985-01-30	1985-02-27	Lilly Industries Ltd	Organic compounds
DE3688561T2 (de) *	1985-04-19	1993-09-23	Smithkline Beckman Corp	Zwischenprodukte fuer die herstellung von leukotrien-antagonisten.
GB8530222D0 (en) *	1985-12-07	1986-01-15	Lilly Industries Ltd	Organic compounds
CA1334200C (en) *	1987-06-24	1995-01-31	James Simpson Frazee	Leukotriene antagonists
AU610528B2 (en) *	1987-10-29	1991-05-23	Smithkline Beckman Corporation	Leukotriene antagonists

1988
- 1988-12-23 US US07/288,827 patent/US4954513A/en not_active Expired - Fee Related
1989
- 1989-12-13 CA CA002005349A patent/CA2005349A1/en not_active Abandoned
- 1989-12-15 AU AU46787/89A patent/AU4678789A/en not_active Abandoned
- 1989-12-19 DK DK644889A patent/DK644889A/da not_active Application Discontinuation
- 1989-12-19 AT AT89313261T patent/ATE90940T1/de not_active IP Right Cessation
- 1989-12-19 DE DE89313261T patent/DE68907329T2/de not_active Expired - Fee Related
- 1989-12-19 ZA ZA899721A patent/ZA899721B/xx unknown
- 1989-12-19 ES ES89313261T patent/ES2057153T3/es not_active Expired - Lifetime
- 1989-12-19 EP EP89313261A patent/EP0375348B1/de not_active Expired - Lifetime
- 1989-12-20 IE IE894104A patent/IE894104L/xx unknown
- 1989-12-22 PT PT92724A patent/PT92724A/pt not_active Application Discontinuation
- 1989-12-22 JP JP1334673A patent/JPH0684344B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
EP0375348B1 (de)	1993-06-23
CA2005349A1 (en)	1990-06-23
DE68907329T2 (de)	1993-09-30
US4954513A (en)	1990-09-04
DK644889A (da)	1990-06-24
JPH02215764A (ja)	1990-08-28
JPH0684344B2 (ja)	1994-10-26
ZA899721B (en)	1990-09-26
AU4678789A (en)	1990-06-28
ES2057153T3 (es)	1994-10-16
EP0375348A1 (de)	1990-06-27
DK644889D0 (da)	1989-12-19
PT92724A (pt)	1990-06-29
IE894104L (en)	1990-06-23
DE68907329D1 (de)	1993-07-29

Legal Events

Date	Code	Title	Description
1994-01-15	UEP	Publication of translation of european patent specification
1997-09-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
FI95469C (fi)	1996-02-12	Analogiamenetelmä uusien hypoglykeemisten oksatsolidiinidionien valmistamiseksi
ATE126517T1 (de)	1995-09-15	Verwendung von bis(3,4- dialkylbenzyliden)sorbitolacetale und diese enthaltende zusammensetzungen.
IT1216687B (it)	1990-03-08	Complessi di platino (ii), loro preparazione e impiego come antitumorali.
DE69728544D1 (de)	2004-05-13	Totalsynthese von acylfulvenen mit antitumorwirkung
DE3772135D1 (de)	1991-09-19	Phenolische korrosionsinhibitoren fuer anstrichstoffe.
FI860369A0 (fi)	1986-01-27	Imidazolderivat, deras framstaellning och anvaendning samt dessa derivat innehaollande farmaceutiska kompositioner.
DE68907329D1 (de)	1993-07-29	Leukotrien-antagonisten.
FI923033A0 (fi)	1992-06-30	N-fenyltioureaderivat och farmaceutisk anvaendning av dem.
FI925501A0 (fi)	1992-12-03	Imidazolfoereningar, deras framstaellning och anvaendning
ATE86860T1 (de)	1993-04-15	Praeparat gegen ulcus.
NO894563L (no)	1990-06-11	Substituerte imidazolderivater og fremstilling og anvendelse derav.
ES2058275T3 (es)	1994-11-01	Derivados biciclicos de sulfonamida y su preparacion, su uso y formulaciones que los contienen.
DK37691A (da)	1991-03-01	Substituerede beta-diketoner, farmaceutiske midler indeholdende disse forbindelser samt anvendelse deraf
NO875357D0 (no)	1987-12-21	Kjemiske sammensetninger og deres bruk som brennstoff additiver.
ATE92066T1 (de)	1993-08-15	Sulfonyldecahydro-8h-isochino(2,1g>(1,6>naphthyridine, optische isomere davon und verwandte verbindungen.
DK681187D0 (da)	1987-12-22	Forbindelse, der absorberer ultraviolet lys, samt praeparat indeholdende samme
NO895165D0 (no)	1989-12-21	Pyrazolopyridin-type mevalono-laktoner.
ATE97409T1 (de)	1993-12-15	Benzodiazepin-analoge.
DE69108195D1 (de)	1995-04-20	Astaxanthin-Zwischenprodukte.
DE69107080D1 (de)	1995-03-09	Organozinnverbindungen mit Antitumoraktivität und Zusammensetzungen mit Antitumorwirkung.
ES2058779T3 (es)	1994-11-01	Nitrato de piridinio, su produccion y uso.
NO980842L (no)	1998-08-31	Nye benzensulfonylaminforbindelser, fremgangsmåte ved fremstilling derav, samt farmasöytiske sammensetninger inneholdende slike
GB1118026A (en)	1968-06-26	í¸-pyrroline derivatives
ATE1585T1 (de)	1982-10-15	Clavulansaeurederivate, ihre herstellung und sie enthaltende pharmazeutische praeparate.
DE69707793D1 (de)	2001-12-06	Alkynylaminosäure Derivate und ihre Verwendung als pharmazeutische Verbindungen