AU704266B2 - Thrombopoietin - Google Patents

Thrombopoietin Download PDF

Info

Publication number
AU704266B2
AU704266B2 AU15146/95A AU1514695A AU704266B2 AU 704266 B2 AU704266 B2 AU 704266B2 AU 15146/95 A AU15146/95 A AU 15146/95A AU 1514695 A AU1514695 A AU 1514695A AU 704266 B2 AU704266 B2 AU 704266B2
Authority
AU
Australia
Prior art keywords
mpl ligand
seq
polypeptide
mpl
dna
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU15146/95A
Other languages
English (en)
Other versions
AU1514695A (en
Inventor
Frederic J. De Sauvage
Dan L Eaton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/196,689 external-priority patent/US8357513B1/en
Priority claimed from US08/249,376 external-priority patent/US8192955B1/en
Priority claimed from US08/348,657 external-priority patent/US6660256B1/en
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of AU1514695A publication Critical patent/AU1514695A/en
Application granted granted Critical
Publication of AU704266B2 publication Critical patent/AU704266B2/en
Priority to AU40207/99A priority Critical patent/AU749175B2/en
Anticipated expiration legal-status Critical
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/524—Thrombopoietin, i.e. C-MPL ligand
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Vehicle Body Suspensions (AREA)
  • Information Transfer Systems (AREA)
AU15146/95A 1994-01-03 1994-12-28 Thrombopoietin Expired AU704266B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU40207/99A AU749175B2 (en) 1994-01-03 1999-07-19 Thrombopoietin

Applications Claiming Priority (15)

Application Number Priority Date Filing Date Title
US17655394A 1994-01-03 1994-01-03
US08/176553 1994-01-03
US18560794A 1994-01-21 1994-01-21
US08/185607 1994-01-21
US08/196,689 US8357513B1 (en) 1994-01-03 1994-02-15 Nucleic acids encoding mpl ligand (thrombopoietin) and fragments thereof
US08/196689 1994-02-15
US22326394A 1994-04-04 1994-04-04
US08/223263 1994-04-04
US08/249376 1994-05-25
US08/249,376 US8192955B1 (en) 1994-01-03 1994-05-25 Nucleic acids encoding MPL ligand (thrombopoietin), variants, and fragments thereof
US34865894A 1994-12-02 1994-12-02
US08/348657 1994-12-02
US08/348,657 US6660256B1 (en) 1994-01-03 1994-12-02 Porcine mpl ligand
US08/348658 1994-12-02
PCT/US1994/014553 WO1995018858A1 (fr) 1994-01-03 1994-12-28 Thrombopoietine

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU40207/99A Division AU749175B2 (en) 1994-01-03 1999-07-19 Thrombopoietin

Publications (2)

Publication Number Publication Date
AU1514695A AU1514695A (en) 1995-08-01
AU704266B2 true AU704266B2 (en) 1999-04-15

Family

ID=27569151

Family Applications (1)

Application Number Title Priority Date Filing Date
AU15146/95A Expired AU704266B2 (en) 1994-01-03 1994-12-28 Thrombopoietin

Country Status (28)

Country Link
EP (1) EP0738323A1 (fr)
JP (2) JPH09508262A (fr)
CN (1) CN1134539C (fr)
AU (1) AU704266B2 (fr)
BG (1) BG63639B1 (fr)
CA (1) CA2178482C (fr)
CZ (1) CZ296130B6 (fr)
DK (1) DK149194A (fr)
ES (1) ES2114786B1 (fr)
FI (1) FI121573B (fr)
FR (1) FR2714670B1 (fr)
GB (1) GB2285446B (fr)
HR (1) HRP941020A2 (fr)
HU (1) HUT75657A (fr)
IE (1) IE72517B1 (fr)
IL (1) IL112184A (fr)
IT (1) IT1283770B1 (fr)
LU (1) LU88573A1 (fr)
LV (1) LV11632B (fr)
NL (1) NL9500010A (fr)
NO (1) NO326903B1 (fr)
NZ (1) NZ278726A (fr)
PT (1) PT101627B (fr)
RO (1) RO117110B1 (fr)
SG (1) SG47030A1 (fr)
SI (1) SI9420079A (fr)
SK (1) SK282265B6 (fr)
WO (1) WO1995018858A1 (fr)

Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6270989B1 (en) * 1991-11-05 2001-08-07 Transkaryotic Therapies, Inc. Protein production and delivery
US5733761A (en) 1991-11-05 1998-03-31 Transkaryotic Therapies, Inc. Protein production and protein delivery
SK100896A3 (en) * 1994-02-14 1997-10-08 Zymogenetics Inc Hematopoietic protein and materials and methods for making it
US5795569A (en) * 1994-03-31 1998-08-18 Amgen Inc. Mono-pegylated proteins that stimulate megakaryocyte growth and differentiation
CN1229385C (zh) * 1994-03-31 2005-11-30 安姆根有限公司 刺激巨核细胞生长和分化的组合物及方法
US5986049A (en) * 1994-12-30 1999-11-16 Zymogenetics, Inc. Purified thrombopoietin and method of making it
TW387940B (en) * 1995-01-17 2000-04-21 Kirin Brewery Anti-tpo monodonal antibody
JPH11500308A (ja) 1995-02-03 1999-01-12 ジー．ディー．サール アンド カンパニー 新規ｃ−ＭＰＬリガンド
US5989538A (en) * 1995-02-15 1999-11-23 Amgen Inc. Mpl ligand analogs
US5696250A (en) * 1995-02-15 1997-12-09 Amgen Inc. DNA encoding megakaryocyte growth and development factor analogs
CN1161468C (zh) * 1995-02-15 2004-08-11 安姆根有限公司 Mpl配体类似物
TW434021B (en) * 1995-03-15 2001-05-16 Kirin Brewery Methods for preventing adsorption of thrombopoietin (TPO), and stable TPO-containing compositions
TW434020B (en) * 1995-03-15 2001-05-16 Kirin Brewery Methods for preventing adsorption of thrombopoietin (TPO), and stable top-containing compositions
ZA964382B (en) * 1995-06-06 1997-12-01 Genentech Inc Lymphotoxin and thrombopoietin for use in the treatment of cancer.
TR199701526T1 (xx) * 1995-06-07 1998-03-21 Glaxo Group Limited Bir trombopoietin resept�r�ne ba�lanan peptitler ve bile�ikler.
US5869451A (en) * 1995-06-07 1999-02-09 Glaxo Group Limited Peptides and compounds that bind to a receptor
US6251864B1 (en) 1995-06-07 2001-06-26 Glaxo Group Limited Peptides and compounds that bind to a receptor
TW497972B (en) * 1995-06-08 2002-08-11 Kirin Brewery Stable thrombopoietin (TPO)-containing lyophilized compositions
US6066318A (en) * 1995-10-05 2000-05-23 G.D. Searle & Co. Multi-functional hematopoietic fusion proteins between sequence rearranged C-MPL receptor agonists and other hematopoietic factors
US6031071A (en) * 1996-01-24 2000-02-29 Biophage, Inc. Methods of generating novel peptides
US5879673A (en) * 1996-01-25 1999-03-09 Genentech, Inc. Administration of thrombopoietin on a single day only
US7091311B2 (en) 1996-06-07 2006-08-15 Smithkline Beecham Corporation Peptides and compounds that bind to a receptor
EP0920511A1 (fr) * 1996-08-13 1999-06-09 ZymoGenetics Vecteurs d'expression, cellules et procedes servant a la preparation de polypeptides de thrombopoietine
AU7589898A (en) * 1997-05-21 1998-12-11 Genentech Inc. Novel administration of thrombopoietin
US5980893A (en) * 1997-07-17 1999-11-09 Beth Israel Deaconess Medical Center, Inc. Agonist murine monoclonal antibody as a stimulant for megakaryocytopoiesis
US6342220B1 (en) 1997-08-25 2002-01-29 Genentech, Inc. Agonist antibodies
US20030228666A1 (en) 1998-06-30 2003-12-11 Daewoong Pharmaceutical Co., Ltd. Novel human thrombopoietin mutein
KR20000006549A (ko) * 1998-06-30 2000-01-25 윤재승 생체내혈소판증식효능이향상된신규한트롬보포이에틴유도체
US6660843B1 (en) 1998-10-23 2003-12-09 Amgen Inc. Modified peptides as therapeutic agents
PT1783222E (pt) 1998-10-23 2012-07-26 Kirin Amgen Inc Péptidos diméricos de trombopoietina que simulam a ligação ao receptor mpl e têm actividade trombopoiética
CY2010012I2 (el) * 2000-05-25 2020-05-29 Novartis Ag Μιμητικα θρομβοποιητινης
UY26317A1 (es) * 2000-08-30 2000-10-31 Alfonso Cayota Carlos Pritsch Sistema de produccion de trombopoyetina humana por celulas de mamiferos en cultivo
US6673580B2 (en) 2000-10-27 2004-01-06 Genentech, Inc. Identification and modification of immunodominant epitopes in polypeptides
US7332474B2 (en) 2001-10-11 2008-02-19 Amgen Inc. Peptides and related compounds having thrombopoietic activity
US20050177884A1 (en) 2001-11-15 2005-08-11 Kirin Beer Kabushiki Kaisha Chimeric nonhuman animal
KR100467750B1 (ko) * 2001-11-29 2005-01-24 씨제이 주식회사 생체내 에리스로포이에틴 활성이 증진된 융합단백질
US20030191056A1 (en) 2002-04-04 2003-10-09 Kenneth Walker Use of transthyretin peptide/protein fusions to increase the serum half-life of pharmacologically active peptides/proteins
KR20050093759A (ko) 2002-09-18 2005-09-23 오르토-맥네일 파마슈티칼, 인코퍼레이티드 혈소판 및 조혈 줄기세포의 생산을 증가시키는 방법
US7576056B2 (en) 2003-08-28 2009-08-18 Ortho-Mcneil Pharmaceutical, Inc. Peptides and compounds that bind to a receptor
US7723295B2 (en) 2003-08-28 2010-05-25 Ortho-Mcneil Pharmaceutical, Inc. Peptides and compounds that bind to a receptor
US20090170727A1 (en) * 2004-05-18 2009-07-02 Intrexon Corporation Methods for dynamic vector assembly of dna cloning vector plasmids
WO2006010057A2 (fr) 2004-07-08 2006-01-26 Amgen Inc. Peptides therapeutiques
EA011879B1 (ru) 2004-09-24 2009-06-30 Эмджин Инк. МОЛЕКУЛЫ С МОДИФИЦИРОВАННЫМ Fc ФРАГМЕНТОМ
US8008453B2 (en) 2005-08-12 2011-08-30 Amgen Inc. Modified Fc molecules
US9012605B2 (en) 2006-01-23 2015-04-21 Amgen Inc. Crystalline polypeptides
WO2007098547A1 (fr) * 2006-03-01 2007-09-07 Apollo Life Sciences Limited Molécule et chimères de cette molécule
US7981425B2 (en) 2006-06-19 2011-07-19 Amgen Inc. Thrombopoietic compounds
AU2007278748B2 (en) 2006-07-24 2013-08-15 The University Of Queensland Method of producing a population of cells
TW200902708A (en) 2007-04-23 2009-01-16 Wyeth Corp Methods of protein production using anti-senescence compounds
EP2162540A2 (fr) 2007-05-22 2010-03-17 Amgen Inc. Compositions et procédés pour produire des protéines de fusion bioactives
WO2010085086A2 (fr) 2009-01-20 2010-07-29 한올바이오파마 주식회사 Fragment polypeptidique de thrombopoïétine humaine modifié et son procédé de fabrication
WO2014089478A1 (fr) * 2012-12-07 2014-06-12 University Of Tennessee Research Foundation Procédés d'analyse numérique pour troubles plaquettaires et supports lisibles par ordinateur et systèmes pour leur mise en œuvre
CA3177929A1 (fr) 2012-12-21 2014-06-26 Astellas Institute For Regenerative Medicine Procedes de production de plaquettes a partir de cellules souches pluripotentes, et compositions associees
CN103555760B (zh) * 2013-10-18 2015-05-20 江苏康禾生物制药有限公司 一种重组人血小板生成素的制备方法及其制剂
JP6463499B2 (ja) * 2015-12-21 2019-02-06 ブラインオン， インク 記憶力、学習力、認知力向上用組成物
GB201700621D0 (en) 2017-01-13 2017-03-01 Guest Ryan Dominic Method,device and kit for the aseptic isolation,enrichment and stabilsation of cells from mammalian solid tissue
US20230212565A1 (en) * 2019-09-20 2023-07-06 Ractigen Therapeutics Nucleic acid molecule for treating thrombocytopenia and application thereof
WO2021123832A1 (fr) 2019-12-20 2021-06-24 Instil Bio (Uk) Limited Dispositifs et procédés d'isolement de lymphocytes infiltrant les tumeurs et leurs utilisations
CN118086536A (zh) * 2024-04-23 2024-05-28 佛山科学技术学院 一种通过snp标记改善黄牛血小板生成素分泌的方法及其应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5260417A (en) 1989-04-03 1993-11-09 Genetics Institute, Inc. Megakaryocyte growth promoting activity protein
WO1990012877A1 (fr) * 1989-04-19 1990-11-01 Cetus Corporation Proteines m-csf multifonctionnelles et codage de genes pour celles-ci
US5223408A (en) * 1991-07-11 1993-06-29 Genentech, Inc. Method for making variant secreted proteins with altered properties
DE69232017T2 (de) * 1991-12-06 2002-03-21 Genentech, Inc. Prohormon Konvertase transformierte Zellen.
IL139335A (en) 1994-01-03 2005-08-31 Genentech Inc Mpl ligand polypeptides, nucleic acids encoding them, vectors and host cells comprising such nucleic acids, processes for producing such polypeptides pharmaceutical compositions containing them and use thereof in the preparation of medicaments for treating thrombocytopenia

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
EXPERIMANTALHEMEATOLOGYVOL17NO.8SEP1989MCDONALDPP865-871 *
EXPERIMENTALHEMEATOLOGYVOL16NO.3MARCH1988MCDONALDPP201-205 *
EXPERIMENTALHEMEATOLOGYVOL2NO.6SEP1974MCDONALDPP 8-21 *

Also Published As

Publication number Publication date
BG63639B1 (bg) 2002-07-31
CZ192296A3 (en) 1997-05-14
ITTO950002A0 (it) 1995-01-02
IL112184A0 (en) 1995-03-15
CN1134539C (zh) 2004-01-14
CN1141061A (zh) 1997-01-22
WO1995018858A1 (fr) 1995-07-13
ITTO950002A1 (it) 1996-07-02
FI962723A0 (fi) 1996-07-02
IE72517B1 (en) 1997-04-23
IT1283770B1 (it) 1998-04-30
RO117110B1 (ro) 2001-10-30
JPH10113186A (ja) 1998-05-06
SK282265B6 (sk) 2001-12-03
GB2285446B (en) 1999-07-28
DK149194A (da) 1995-07-04
IE950002A1 (en) 1995-07-12
NO962783D0 (no) 1996-07-02
ES2114786A1 (es) 1998-06-01
SK87596A3 (en) 1997-11-05
CZ296130B6 (cs) 2006-01-11
LU88573A1 (de) 1995-06-01
JPH09508262A (ja) 1997-08-26
SG47030A1 (en) 1998-03-20
EP0738323A1 (fr) 1996-10-23
ES2114786B1 (es) 1999-01-01
FR2714670B1 (fr) 1997-01-10
NO326903B1 (no) 2009-03-16
AU1514695A (en) 1995-08-01
FI121573B (fi) 2011-01-14
NO962783L (no) 1996-09-03
BG100693A (en) 1998-01-30
GB2285446A (en) 1995-07-12
HRP941020A2 (en) 1997-04-30
GB9425831D0 (en) 1995-02-22
SI9420079A (en) 1997-02-28
HUT75657A (en) 1997-05-28
IL112184A (en) 2004-07-25
LV11632A (lv) 1996-12-20
HU9601805D0 (en) 1996-08-28
FR2714670A1 (fr) 1995-07-07
CA2178482A1 (fr) 1995-07-13
PT101627B (pt) 1996-11-29
NL9500010A (nl) 1995-08-01
CA2178482C (fr) 2012-01-03
NZ278726A (en) 1998-06-26
PT101627A (pt) 1995-11-30
FI962723L (fi) 1996-09-03
LV11632B (en) 1997-04-20

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Opponent name: KIRIN BREWERY CO, LTD

FGA Letters patent sealed or granted (standard patent)