CA2178482C - Thrombopoietine - Google Patents

Thrombopoietine Download PDF

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Publication number
CA2178482C
CA2178482C CA2178482A CA2178482A CA2178482C CA 2178482 C CA2178482 C CA 2178482C CA 2178482 A CA2178482 A CA 2178482A CA 2178482 A CA2178482 A CA 2178482A CA 2178482 C CA2178482 C CA 2178482C
Authority
CA
Canada
Prior art keywords
mpl ligand
mpl
cells
ligand
dna
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA2178482A
Other languages
English (en)
Other versions
CA2178482A1 (fr
Inventor
Dan L. Eaton
Frederic J. De Sauvage
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/196,689 external-priority patent/US8357513B1/en
Priority claimed from US08/249,376 external-priority patent/US8192955B1/en
Priority claimed from US08/348,657 external-priority patent/US6660256B1/en
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of CA2178482A1 publication Critical patent/CA2178482A1/fr
Application granted granted Critical
Publication of CA2178482C publication Critical patent/CA2178482C/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/524—Thrombopoietin, i.e. C-MPL ligand
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Vehicle Body Suspensions (AREA)
  • Information Transfer Systems (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)

Abstract

L'invention a pour objet la thrombopoïétine isolée (TPO), l'ADN isolé codant la TPO et des procédés de recombinaison ou de synthèse pour préparer et purifier la TPO. Diverses formes de TPO ont une influence sur la réplication, la différenciation ou la maturation des cellules sanguines, particulièrment des mégakaryocytes et des cellules parentes de mégakaryocytes. Par conséquent, ces composés peuvent être utilisés pour le traitement de la thrombocytopénie.
CA2178482A 1994-01-03 1994-12-28 Thrombopoietine Expired - Lifetime CA2178482C (fr)

Applications Claiming Priority (15)

Application Number Priority Date Filing Date Title
US17655394A 1994-01-03 1994-01-03
US08/176553 1994-01-03
US18560794A 1994-01-21 1994-01-21
US08/185607 1994-01-21
US08/196689 1994-02-15
US08/196,689 US8357513B1 (en) 1994-01-03 1994-02-15 Nucleic acids encoding mpl ligand (thrombopoietin) and fragments thereof
US22326394A 1994-04-04 1994-04-04
US08/223263 1994-04-04
US08/249,376 US8192955B1 (en) 1994-01-03 1994-05-25 Nucleic acids encoding MPL ligand (thrombopoietin), variants, and fragments thereof
US08/249376 1994-05-25
US34865894A 1994-12-02 1994-12-02
US08/348657 1994-12-02
US08/348658 1994-12-02
US08/348,657 US6660256B1 (en) 1994-01-03 1994-12-02 Porcine mpl ligand
PCT/US1994/014553 WO1995018858A1 (fr) 1994-01-03 1994-12-28 Thrombopoietine

Publications (2)

Publication Number Publication Date
CA2178482A1 CA2178482A1 (fr) 1995-07-13
CA2178482C true CA2178482C (fr) 2012-01-03

Family

ID=27569151

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2178482A Expired - Lifetime CA2178482C (fr) 1994-01-03 1994-12-28 Thrombopoietine

Country Status (28)

Country Link
EP (1) EP0738323A1 (fr)
JP (2) JPH09508262A (fr)
CN (1) CN1134539C (fr)
AU (1) AU704266B2 (fr)
BG (1) BG63639B1 (fr)
CA (1) CA2178482C (fr)
CZ (1) CZ296130B6 (fr)
DK (1) DK149194A (fr)
ES (1) ES2114786B1 (fr)
FI (1) FI121573B (fr)
FR (1) FR2714670B1 (fr)
GB (1) GB2285446B (fr)
HR (1) HRP941020A2 (fr)
HU (1) HUT75657A (fr)
IE (1) IE72517B1 (fr)
IL (1) IL112184A (fr)
IT (1) IT1283770B1 (fr)
LU (1) LU88573A1 (fr)
LV (1) LV11632B (fr)
NL (1) NL9500010A (fr)
NO (1) NO326903B1 (fr)
NZ (1) NZ278726A (fr)
PT (1) PT101627B (fr)
RO (1) RO117110B1 (fr)
SG (1) SG47030A1 (fr)
SI (1) SI9420079A (fr)
SK (1) SK282265B6 (fr)
WO (1) WO1995018858A1 (fr)

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US5733761A (en) 1991-11-05 1998-03-31 Transkaryotic Therapies, Inc. Protein production and protein delivery
US6270989B1 (en) * 1991-11-05 2001-08-07 Transkaryotic Therapies, Inc. Protein production and delivery
AU691828B2 (en) * 1994-02-14 1998-05-28 University Of Washington Hematopoietic protein and materials and methods for making it
US5795569A (en) * 1994-03-31 1998-08-18 Amgen Inc. Mono-pegylated proteins that stimulate megakaryocyte growth and differentiation
US5766581A (en) * 1994-03-31 1998-06-16 Amgen Inc. Method for treating mammals with monopegylated proteins that stimulates megakaryocyte growth and differentiation
US5986049A (en) * 1994-12-30 1999-11-16 Zymogenetics, Inc. Purified thrombopoietin and method of making it
TW387940B (en) * 1995-01-17 2000-04-21 Kirin Brewery Anti-tpo monodonal antibody
WO1996023888A1 (fr) 1995-02-03 1996-08-08 G.D. Searle & Co. NOUVEAUX LIGANDS SE FIXANT A c-MPL
AU691410B2 (en) * 1995-02-15 1998-05-14 Amgen, Inc. MPL ligand analogs
US5696250A (en) * 1995-02-15 1997-12-09 Amgen Inc. DNA encoding megakaryocyte growth and development factor analogs
US5989538A (en) * 1995-02-15 1999-11-23 Amgen Inc. Mpl ligand analogs
TW434020B (en) * 1995-03-15 2001-05-16 Kirin Brewery Methods for preventing adsorption of thrombopoietin (TPO), and stable top-containing compositions
TW434021B (en) * 1995-03-15 2001-05-16 Kirin Brewery Methods for preventing adsorption of thrombopoietin (TPO), and stable TPO-containing compositions
ZA964382B (en) * 1995-06-06 1997-12-01 Genentech Inc Lymphotoxin and thrombopoietin for use in the treatment of cancer.
US5869451A (en) * 1995-06-07 1999-02-09 Glaxo Group Limited Peptides and compounds that bind to a receptor
US6251864B1 (en) 1995-06-07 2001-06-26 Glaxo Group Limited Peptides and compounds that bind to a receptor
ES2303338T3 (es) * 1995-06-07 2008-08-01 Glaxo Group Limited Peptidos y compuestos que se unen a un receptor de trombopoyetina.
TW497972B (en) * 1995-06-08 2002-08-11 Kirin Brewery Stable thrombopoietin (TPO)-containing lyophilized compositions
US6066318A (en) * 1995-10-05 2000-05-23 G.D. Searle & Co. Multi-functional hematopoietic fusion proteins between sequence rearranged C-MPL receptor agonists and other hematopoietic factors
US6031071A (en) * 1996-01-24 2000-02-29 Biophage, Inc. Methods of generating novel peptides
US5879673A (en) * 1996-01-25 1999-03-09 Genentech, Inc. Administration of thrombopoietin on a single day only
US7091311B2 (en) 1996-06-07 2006-08-15 Smithkline Beecham Corporation Peptides and compounds that bind to a receptor
AU728881B2 (en) * 1996-08-13 2001-01-18 Zymogenetics Inc. Expression vectors, cells, and methods for preparing thrombopoietin polypeptides
CA2288964A1 (fr) * 1997-05-21 1998-11-26 Genentech, Inc. Nouveau procede d'administration de thrombopoietine
US5980893A (en) * 1997-07-17 1999-11-09 Beth Israel Deaconess Medical Center, Inc. Agonist murine monoclonal antibody as a stimulant for megakaryocytopoiesis
US6342220B1 (en) 1997-08-25 2002-01-29 Genentech, Inc. Agonist antibodies
KR20000006549A (ko) * 1998-06-30 2000-01-25 윤재승 생체내혈소판증식효능이향상된신규한트롬보포이에틴유도체
US20030228666A1 (en) 1998-06-30 2003-12-11 Daewoong Pharmaceutical Co., Ltd. Novel human thrombopoietin mutein
DK2319928T3 (da) 1998-10-23 2013-06-24 Kirin Amgen Inc Dimere trombopoietiske peptidomimetika, der binder til MPL-receptor og har trombopoietisk aktivitet
US6660843B1 (en) 1998-10-23 2003-12-09 Amgen Inc. Modified peptides as therapeutic agents
CY2010012I2 (el) * 2000-05-25 2020-05-29 Novartis Ag Μιμητικα θρομβοποιητινης
UY26317A1 (es) * 2000-08-30 2000-10-31 Alfonso Cayota Carlos Pritsch Sistema de produccion de trombopoyetina humana por celulas de mamiferos en cultivo
US6673580B2 (en) 2000-10-27 2004-01-06 Genentech, Inc. Identification and modification of immunodominant epitopes in polypeptides
US7332474B2 (en) 2001-10-11 2008-02-19 Amgen Inc. Peptides and related compounds having thrombopoietic activity
JP4087338B2 (ja) 2001-11-15 2008-05-21 キリンファーマ株式会社 キメラ非ヒト動物
KR100467750B1 (ko) * 2001-11-29 2005-01-24 씨제이 주식회사 생체내 에리스로포이에틴 활성이 증진된 융합단백질
US20030191056A1 (en) 2002-04-04 2003-10-09 Kenneth Walker Use of transthyretin peptide/protein fusions to increase the serum half-life of pharmacologically active peptides/proteins
MXPA05003057A (es) 2002-09-18 2006-04-18 Johnson & Johnson Metodos para aumentar la produccion de celulas madre hematopoyeticas y plaquetas.
US7723295B2 (en) 2003-08-28 2010-05-25 Ortho-Mcneil Pharmaceutical, Inc. Peptides and compounds that bind to a receptor
RS56387B1 (sr) 2003-08-28 2017-12-29 Ortho Mcneil Pharm Inc Peptidi i jedinjenja koja se vežu za trombopoetinski receptor
EP1751298A4 (fr) 2004-05-18 2009-11-11 Intrexon Corp Methodes pour assemblage de vecteurs dynamiques au moyen de plasmides vecteurs de clonage d'adn
CA2572765C (fr) 2004-07-08 2013-05-21 Amgen Inc. Peptides therapeutiques
CN101103045B (zh) 2004-09-24 2015-11-25 安姆根有限公司 修饰的Fc分子
US8008453B2 (en) 2005-08-12 2011-08-30 Amgen Inc. Modified Fc molecules
WO2007102946A2 (fr) 2006-01-23 2007-09-13 Amgen Inc. Polypeptides cristallins
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US7981425B2 (en) 2006-06-19 2011-07-19 Amgen Inc. Thrombopoietic compounds
JP5543778B2 (ja) 2006-07-24 2014-07-09 ザ・ユニバーシティ・オブ・クイーンズランド 細胞集団を産生する方法
TW200902708A (en) 2007-04-23 2009-01-16 Wyeth Corp Methods of protein production using anti-senescence compounds
JP5591691B2 (ja) 2007-05-22 2014-09-17 アムジエン・インコーポレーテツド 生物活性を有する融合タンパク質を作製するための組成物及び方法
WO2010085086A2 (fr) 2009-01-20 2010-07-29 한올바이오파마 주식회사 Fragment polypeptidique de thrombopoïétine humaine modifié et son procédé de fabrication
WO2014089478A1 (fr) * 2012-12-07 2014-06-12 University Of Tennessee Research Foundation Procédés d'analyse numérique pour troubles plaquettaires et supports lisibles par ordinateur et systèmes pour leur mise en œuvre
CA3177929A1 (fr) 2012-12-21 2014-06-26 Astellas Institute For Regenerative Medicine Procedes de production de plaquettes a partir de cellules souches pluripotentes, et compositions associees
CN103555760B (zh) * 2013-10-18 2015-05-20 江苏康禾生物制药有限公司 一种重组人血小板生成素的制备方法及其制剂
SG11201804902UA (en) * 2015-12-21 2018-07-30 Brainon Inc A composition for improving memory, learning ability, and cognitive ability
GB201700621D0 (en) 2017-01-13 2017-03-01 Guest Ryan Dominic Method,device and kit for the aseptic isolation,enrichment and stabilsation of cells from mammalian solid tissue
AU2020349991A1 (en) * 2019-09-20 2022-04-07 Ractigen Therapeutics Nucleic acid molecule for treating immune thrombocytopenia and application thereof
CN115244173A (zh) 2019-12-20 2022-10-25 英研生物(英国)有限公司 用于分离肿瘤浸润淋巴细胞的装置及方法及其用途
CN118086536A (zh) * 2024-04-23 2024-05-28 佛山科学技术学院 一种通过snp标记改善黄牛血小板生成素分泌的方法及其应用

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US5260417A (en) 1989-04-03 1993-11-09 Genetics Institute, Inc. Megakaryocyte growth promoting activity protein
WO1990012877A1 (fr) * 1989-04-19 1990-11-01 Cetus Corporation Proteines m-csf multifonctionnelles et codage de genes pour celles-ci
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IL139335A (en) 1994-01-03 2005-08-31 Genentech Inc Mpl ligand polypeptides, nucleic acids encoding them, vectors and host cells comprising such nucleic acids, processes for producing such polypeptides pharmaceutical compositions containing them and use thereof in the preparation of medicaments for treating thrombocytopenia

Also Published As

Publication number Publication date
LV11632B (en) 1997-04-20
IT1283770B1 (it) 1998-04-30
CN1134539C (zh) 2004-01-14
GB2285446B (en) 1999-07-28
HUT75657A (en) 1997-05-28
EP0738323A1 (fr) 1996-10-23
FI962723L (fi) 1996-09-03
HRP941020A2 (en) 1997-04-30
RO117110B1 (ro) 2001-10-30
CZ192296A3 (en) 1997-05-14
SK87596A3 (en) 1997-11-05
NO962783L (no) 1996-09-03
LU88573A1 (de) 1995-06-01
CZ296130B6 (cs) 2006-01-11
SG47030A1 (en) 1998-03-20
CA2178482A1 (fr) 1995-07-13
DK149194A (da) 1995-07-04
GB2285446A (en) 1995-07-12
FI962723A0 (fi) 1996-07-02
CN1141061A (zh) 1997-01-22
NL9500010A (nl) 1995-08-01
SI9420079A (en) 1997-02-28
FR2714670B1 (fr) 1997-01-10
LV11632A (lv) 1996-12-20
IL112184A (en) 2004-07-25
BG100693A (en) 1998-01-30
FI121573B (fi) 2011-01-14
AU1514695A (en) 1995-08-01
ITTO950002A1 (it) 1996-07-02
IL112184A0 (en) 1995-03-15
NO962783D0 (no) 1996-07-02
FR2714670A1 (fr) 1995-07-07
ES2114786A1 (es) 1998-06-01
PT101627A (pt) 1995-11-30
ITTO950002A0 (it) 1995-01-02
GB9425831D0 (en) 1995-02-22
NZ278726A (en) 1998-06-26
SK282265B6 (sk) 2001-12-03
WO1995018858A1 (fr) 1995-07-13
HU9601805D0 (en) 1996-08-28
JPH09508262A (ja) 1997-08-26
IE950002A1 (en) 1995-07-12
AU704266B2 (en) 1999-04-15
NO326903B1 (no) 2009-03-16
BG63639B1 (bg) 2002-07-31
ES2114786B1 (es) 1999-01-01
JPH10113186A (ja) 1998-05-06
PT101627B (pt) 1996-11-29
IE72517B1 (en) 1997-04-23

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Effective date: 20141229