BE1011413A4 - Composition pharmaceutique pour abaisser la pression sanguine et son procede de preparation. - Google Patents

Composition pharmaceutique pour abaisser la pression sanguine et son procede de preparation. Download PDF

Info

Publication number: BE1011413A4
Authority: BE; Belgium
Prior art keywords: weight; nifedipine; sep; solution; ethyl oleate
Prior art date: 1994-07-26

Application number

BE9500646A

Other languages

English (en)

French (fr)

Inventor

Margit Nagy

Csaba Farsang

Lidia Fedina

Katalin Szemeredi

Gabor Szenasi

Janos Egri

Antal Mosonyi

Borbala Barta

Gizella Toth

Ibolya Nyaradi

Frigyes Gorgenyi

Zsuzsa Orr

Geza Floris

Original Assignee

Egyt Gyogyszervegyeszeti Gyar

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-07-26

Filing date

1995-07-24

Publication date

1999-09-07

1995-07-24 Application filed by Egyt Gyogyszervegyeszeti Gyar filed Critical Egyt Gyogyszervegyeszeti Gyar

1999-09-07 Application granted granted Critical

1999-09-07 Publication of BE1011413A4 publication Critical patent/BE1011413A4/fr

Links

238000002360 preparation method Methods 0.000 title claims abstract description 7
238000000034 method Methods 0.000 title claims abstract description 6
239000008194 pharmaceutical composition Substances 0.000 title description 13
230000036772 blood pressure Effects 0.000 title description 8
HYIMSNHJOBLJNT-UHFFFAOYSA-N nifedipine Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1[N+]([O-])=O HYIMSNHJOBLJNT-UHFFFAOYSA-N 0.000 claims abstract description 44
229960001597 nifedipine Drugs 0.000 claims abstract description 43
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims abstract description 27
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 26
LVGKNOAMLMIIKO-UHFFFAOYSA-N Elaidinsaeure-aethylester Natural products CCCCCCCCC=CCCCCCCCC(=O)OCC LVGKNOAMLMIIKO-UHFFFAOYSA-N 0.000 claims abstract description 24
LVGKNOAMLMIIKO-QXMHVHEDSA-N ethyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC LVGKNOAMLMIIKO-QXMHVHEDSA-N 0.000 claims abstract description 24
229940093471 ethyl oleate Drugs 0.000 claims abstract description 24
229920001223 polyethylene glycol Polymers 0.000 claims abstract description 13
239000002202 Polyethylene glycol Substances 0.000 claims abstract description 12
239000000654 additive Substances 0.000 claims abstract description 6
230000000996 additive effect Effects 0.000 claims abstract description 5
239000012456 homogeneous solution Substances 0.000 claims description 2
239000000203 mixture Substances 0.000 abstract description 18
239000000470 constituent Substances 0.000 abstract description 4
235000019441 ethanol Nutrition 0.000 description 8
210000002200 mouth mucosa Anatomy 0.000 description 7
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 6
239000007921 spray Substances 0.000 description 6
238000003756 stirring Methods 0.000 description 6
241001465754 Metazoa Species 0.000 description 5
229920000036 polyvinylpyrrolidone Polymers 0.000 description 5
239000001267 polyvinylpyrrolidone Substances 0.000 description 5
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 5
239000000796 flavoring agent Substances 0.000 description 4
235000013355 food flavoring agent Nutrition 0.000 description 4
230000001077 hypotensive effect Effects 0.000 description 4
239000002904 solvent Substances 0.000 description 4
206010002383 Angina Pectoris Diseases 0.000 description 3
239000000443 aerosol Substances 0.000 description 3
239000007787 solid Substances 0.000 description 3
238000012360 testing method Methods 0.000 description 3
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 2
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
230000017531 blood circulation Effects 0.000 description 2
125000004925 dihydropyridyl group Chemical class N1(CC=CC=C1)* 0.000 description 2
239000007788 liquid Substances 0.000 description 2
239000003960 organic solvent Substances 0.000 description 2
239000003380 propellant Substances 0.000 description 2
239000004094 surface-active agent Substances 0.000 description 2
HMUNWXXNJPVALC-UHFFFAOYSA-N 1-[4-[2-(2,3-dihydro-1H-inden-2-ylamino)pyrimidin-5-yl]piperazin-1-yl]-2-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)ethanone Chemical group C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)N1CCN(CC1)C(CN1CC2=C(CC1)NN=N2)=O HMUNWXXNJPVALC-UHFFFAOYSA-N 0.000 description 1
DEXFNLNNUZKHNO-UHFFFAOYSA-N 6-[3-[4-[2-(2,3-dihydro-1H-inden-2-ylamino)pyrimidin-5-yl]piperidin-1-yl]-3-oxopropyl]-3H-1,3-benzoxazol-2-one Chemical group C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)C1CCN(CC1)C(CCC1=CC2=C(NC(O2)=O)C=C1)=O DEXFNLNNUZKHNO-UHFFFAOYSA-N 0.000 description 1
JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical compound CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 description 1
241000700159 Rattus Species 0.000 description 1
238000010521 absorption reaction Methods 0.000 description 1
230000009471 action Effects 0.000 description 1
239000013543 active substance Substances 0.000 description 1
239000008280 blood Substances 0.000 description 1
210000004369 blood Anatomy 0.000 description 1
230000037396 body weight Effects 0.000 description 1
239000012159 carrier gas Substances 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
OJYGBLRPYBAHRT-IPQSZEQASA-N chloralose Chemical compound O1[C@H](C(Cl)(Cl)Cl)O[C@@H]2[C@@H](O)[C@@H]([C@H](O)CO)O[C@@H]21 OJYGBLRPYBAHRT-IPQSZEQASA-N 0.000 description 1
229950009941 chloralose Drugs 0.000 description 1
239000003086 colorant Substances 0.000 description 1
230000003247 decreasing effect Effects 0.000 description 1
239000003085 diluting agent Substances 0.000 description 1
201000010099 disease Diseases 0.000 description 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
238000001035 drying Methods 0.000 description 1
230000000694 effects Effects 0.000 description 1
150000002148 esters Chemical class 0.000 description 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
210000001105 femoral artery Anatomy 0.000 description 1
239000000706 filtrate Substances 0.000 description 1
239000011521 glass Substances 0.000 description 1
125000003976 glyceryl group Chemical group [H]C([*])([H])C(O[H])([H])C(O[H])([H])[H] 0.000 description 1
230000009474 immediate action Effects 0.000 description 1
238000001802 infusion Methods 0.000 description 1
239000004615 ingredient Substances 0.000 description 1
238000001990 intravenous administration Methods 0.000 description 1
230000007794 irritation Effects 0.000 description 1
238000012423 maintenance Methods 0.000 description 1
238000004519 manufacturing process Methods 0.000 description 1
229910052757 nitrogen Inorganic materials 0.000 description 1
229940049964 oleate Drugs 0.000 description 1
ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
238000012545 processing Methods 0.000 description 1
230000002035 prolonged effect Effects 0.000 description 1
230000009467 reduction Effects 0.000 description 1
230000001105 regulatory effect Effects 0.000 description 1
238000005507 spraying Methods 0.000 description 1
238000011477 surgical intervention Methods 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Epidemiology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Nutrition Science (AREA)
Oil, Petroleum & Natural Gas (AREA)
Physiology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Detergent Compositions (AREA)

BE9500646A 1994-07-26 1995-07-24 Composition pharmaceutique pour abaisser la pression sanguine et son procede de preparation. BE1011413A4 (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
HU9402193A HU214582B (hu)	1994-07-26	1994-07-26	Porlasztható, vérnyomáscsökkentő hatású gyógyszerkészítmény és eljárás előállítására

Publications (1)

Publication Number	Publication Date
BE1011413A4 true BE1011413A4 (fr)	1999-09-07

Family

ID=10985460

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BE9500646A BE1011413A4 (fr)	1994-07-26	1995-07-24	Composition pharmaceutique pour abaisser la pression sanguine et son procede de preparation.

Country Status (18)

Country	Link
JP (1)	JPH08169829A (de)
AT (1)	AT402690B (de)
AU (1)	AU699386B2 (de)
BE (1)	BE1011413A4 (de)
CZ (1)	CZ286399B6 (de)
DE (1)	DE19527140A1 (de)
EE (1)	EE9500029A (de)
FR (1)	FR2722988B1 (de)
GB (1)	GB2291593B (de)
HR (1)	HRP950374A2 (de)
HU (1)	HU214582B (de)
IT (1)	IT1277348B1 (de)
LT (1)	LT4042B (de)
LV (1)	LV11026B (de)
PL (1)	PL181069B1 (de)
SK (1)	SK280463B6 (de)
UA (1)	UA39880C2 (de)
YU (1)	YU50795A (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7632517B2 (en)	1997-10-01	2009-12-15	Novadel Pharma Inc.	Buccal, polar and non-polar spray containing zolpidem
US20030095925A1 (en) *	1997-10-01	2003-05-22	Dugger Harry A.	Buccal, polar and non-polar spray or capsule containing drugs for treating metabolic disorders
WO1999016417A1 (en) *	1997-10-01	1999-04-08	Flemington Pharmaceutical Corporation	Buccal, polar and non-polar spray or capsule
EP2767163A1 (de) *	2005-02-17	2014-08-20	Abbott Laboratories	Transmukosale Verabreichung von Arzneimittelzusammensetzungen zur Behandlung und Vorbeugung von Erkrankungen bei Tieren
DE102006027794A1 (de) *	2006-06-16	2007-12-20	Lts Lohmann Therapie-Systeme Ag	Antihypertonie-Kombinationswafer
FR2906140B1 (fr) *	2006-09-22	2008-12-05	Philippe Perovitch	Forme galenique pour l'administration par voie trans-muqueuse de principes actifs

Citations (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2592378A1 (fr) *	1985-12-18	1987-07-03	Bayer Ag	Preparation pulverisable de dihydropyridine, son procede de production et son utilisation pharmaceutique
EP0240484A1 (de) *	1986-03-10	1987-10-07	Kurt Dr. Burghart	Pharmazeutische Zubereitung sowie Verfahren zur Herstellung derselben
JPS63170316A (ja) *	1986-12-30	1988-07-14	Fujimoto Seiyaku Kk	ニフエジピン経皮吸収外用製剤
EP0288895A1 (de) *	1987-04-30	1988-11-02	Kali-Chemie Pharma GmbH	Arzneimittelformulierung
EP0376917A1 (de) *	1988-12-30	1990-07-04	Kurt Dr. Burghart	Pharmazeutische Zubereitung

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3307422A1 (de) *	1983-03-03	1984-09-06	Bayer Ag, 5090 Leverkusen	Fluessigzubereitungen von dihydropyridinen, ein verfahren zu ihrer herstellung, sowie ihre verwendung bei der bekaempfung von erkrankungen
EP0175671A1 (de)	1984-08-23	1986-03-26	Kuhlemann & Co.	Pharmazeutische Zubereitung sowie Verfahren zum Darreichen dieser pharmazeutischen Zubereitung
US4863970A (en) *	1986-11-14	1989-09-05	Theratech, Inc.	Penetration enhancement with binary system of oleic acid, oleins, and oleyl alcohol with lower alcohols
DE3779999T2 (de) *	1986-11-14	1992-12-10	Theratech Inc	Erhoehung des penetrationsvermoegens mittels eines aus die zellhuelle veraendernden substanzen und kurzkettigen alkoholen bestehenden binaeren systems.
GB8828477D0 (en) *	1988-12-06	1989-01-05	Riker Laboratories Inc	Medical aerosol formulations
US5298258A (en) *	1989-12-28	1994-03-29	Nitto Denko Corporation	Acrylic oily gel bioadhesive material and acrylic oily gel preparation
HU205249B (en) *	1990-11-09	1992-04-28	Egyt Gyogyszervegyeszeti Gyar	Process for producing suspensive aerosole composition

1994
- 1994-07-26 HU HU9402193A patent/HU214582B/hu unknown
1995
- 1995-06-27 AU AU23269/95A patent/AU699386B2/en not_active Ceased
- 1995-06-30 HR HRP9402193A patent/HRP950374A2/hr not_active Application Discontinuation
- 1995-07-13 CZ CZ19951811A patent/CZ286399B6/cs not_active IP Right Cessation
- 1995-07-17 FR FR9508598A patent/FR2722988B1/fr not_active Expired - Fee Related
- 1995-07-17 AT AT0121495A patent/AT402690B/de not_active IP Right Cessation
- 1995-07-20 SK SK922-95A patent/SK280463B6/sk unknown
- 1995-07-20 LT LT95-084A patent/LT4042B/lt not_active IP Right Cessation
- 1995-07-21 JP JP7185275A patent/JPH08169829A/ja active Pending
- 1995-07-24 PL PL95309757A patent/PL181069B1/pl not_active IP Right Cessation
- 1995-07-24 BE BE9500646A patent/BE1011413A4/fr not_active IP Right Cessation
- 1995-07-25 LV LVP-95-225A patent/LV11026B/en unknown
- 1995-07-25 DE DE19527140A patent/DE19527140A1/de not_active Withdrawn
- 1995-07-25 UA UA95073513A patent/UA39880C2/uk unknown
- 1995-07-25 EE EE9500029A patent/EE9500029A/xx unknown
- 1995-07-25 GB GB9515205A patent/GB2291593B/en not_active Expired - Fee Related
- 1995-07-26 YU YU50795A patent/YU50795A/sh unknown
- 1995-07-26 IT IT95MI001621A patent/IT1277348B1/it active IP Right Grant

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2592378A1 (fr) *	1985-12-18	1987-07-03	Bayer Ag	Preparation pulverisable de dihydropyridine, son procede de production et son utilisation pharmaceutique
EP0240484A1 (de) *	1986-03-10	1987-10-07	Kurt Dr. Burghart	Pharmazeutische Zubereitung sowie Verfahren zur Herstellung derselben
JPS63170316A (ja) *	1986-12-30	1988-07-14	Fujimoto Seiyaku Kk	ニフエジピン経皮吸収外用製剤
EP0288895A1 (de) *	1987-04-30	1988-11-02	Kali-Chemie Pharma GmbH	Arzneimittelformulierung
EP0376917A1 (de) *	1988-12-30	1990-07-04	Kurt Dr. Burghart	Pharmazeutische Zubereitung

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Section Ch Week 8834, Derwent World Patents Index; Class B03, AN 88-238131, XP002084473 *

Also Published As

Publication number	Publication date
ITMI951621A0 (it)	1995-07-26
EE9500029A (et)	1996-02-15
LT4042B (en)	1996-09-25
PL309757A1 (en)	1996-02-05
DE19527140A1 (de)	1996-02-01
CZ181195A3 (en)	1996-02-14
CZ286399B6 (en)	2000-04-12
FR2722988A1 (fr)	1996-02-02
SK280463B6 (sk)	2000-02-14
HUT75457A (en)	1997-05-28
AU699386B2 (en)	1998-12-03
GB2291593A (en)	1996-01-31
YU50795A (sh)	1998-05-15
IT1277348B1 (it)	1997-11-10
LV11026B (en)	1996-04-20
PL181069B1 (pl)	2001-05-31
GB9515205D0 (en)	1995-09-20
ITMI951621A1 (it)	1997-01-26
HU214582B (hu)	1998-04-28
ATA121495A (de)	1996-12-15
LV11026A (lv)	1996-02-20
HRP950374A2 (en)	1997-10-31
SK92295A3 (en)	1996-05-08
UA39880C2 (uk)	2001-07-16
HU9402193D0 (en)	1994-09-28
AU2326995A (en)	1996-02-08
JPH08169829A (ja)	1996-07-02
LT95084A (en)	1996-06-25
GB2291593B (en)	1998-03-11
FR2722988B1 (fr)	1999-10-08
AT402690B (de)	1997-07-25

Legal Events

Date

Code

Title

Description

2000-01-31

RE

Patent lapsed

Owner name: EGIS GYOGYSZERGYAR RT.

Effective date: 19990731

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