BE885182A - Copolymeres d'acides lactique et glycolique et leur procede de preparation - Google Patents

Copolymeres d'acides lactique et glycolique et leur procede de preparation

Info

Publication number
BE885182A
BE885182A BE1/9957A BE1009957A BE885182A BE 885182 A BE885182 A BE 885182A BE 1/9957 A BE1/9957 A BE 1/9957A BE 1009957 A BE1009957 A BE 1009957A BE 885182 A BE885182 A BE 885182A
Authority
BE
Belgium
Prior art keywords
lactic
copolymers
preparation process
glycolic acids
glycolic
Prior art date
Application number
BE1/9957A
Other languages
English (en)
Inventor
R S Nevin
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of BE885182A publication Critical patent/BE885182A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/78—Preparation processes
    • C08G63/82—Preparation processes characterised by the catalyst used
    • C08G63/823—Preparation processes characterised by the catalyst used for the preparation of polylactones or polylactides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
    • C08G63/06—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxycarboxylic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Medicinal Preparation (AREA)
  • Biological Depolymerization Polymers (AREA)
BE1/9957A 1979-09-12 1980-09-11 Copolymeres d'acides lactique et glycolique et leur procede de preparation BE885182A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/075,296 US4273920A (en) 1979-09-12 1979-09-12 Polymerization process and product

Publications (1)

Publication Number Publication Date
BE885182A true BE885182A (fr) 1981-03-11

Family

ID=22124778

Family Applications (1)

Application Number Title Priority Date Filing Date
BE1/9957A BE885182A (fr) 1979-09-12 1980-09-11 Copolymeres d'acides lactique et glycolique et leur procede de preparation

Country Status (31)

Country Link
US (1) US4273920A (fr)
EP (1) EP0026599B1 (fr)
JP (2) JPS5645920A (fr)
AR (1) AR221173A1 (fr)
AT (1) AT380689B (fr)
AU (1) AU539130B2 (fr)
BE (1) BE885182A (fr)
BG (1) BG41132A3 (fr)
CA (1) CA1185048A (fr)
CH (1) CH648048A5 (fr)
CS (1) CS221979B2 (fr)
DD (1) DD153125A5 (fr)
DE (1) DE3068116D1 (fr)
DK (1) DK155093C (fr)
EG (1) EG14381A (fr)
ES (1) ES8106542A1 (fr)
FI (1) FI66412C (fr)
FR (1) FR2464973A1 (fr)
GB (1) GB2058808B (fr)
GR (1) GR69961B (fr)
GT (1) GT198065361A (fr)
HU (1) HU191807B (fr)
IE (1) IE50236B1 (fr)
IL (1) IL61024A (fr)
IT (1) IT1141040B (fr)
NZ (1) NZ194902A (fr)
PH (1) PH15272A (fr)
PL (1) PL129779B1 (fr)
PT (1) PT71794B (fr)
RO (1) RO80864A (fr)
ZA (1) ZA805629B (fr)

Families Citing this family (89)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4333919A (en) * 1979-09-12 1982-06-08 Eli Lilly And Company Growth promotant controlled release formulations and method of treatment
IE52535B1 (en) * 1981-02-16 1987-12-09 Ici Plc Continuous release pharmaceutical compositions
US4716964A (en) * 1981-08-10 1988-01-05 Exxon Production Research Company Use of degradable ball sealers to seal casing perforations in well treatment fluid diversion
US4523591A (en) * 1982-10-22 1985-06-18 Kaplan Donald S Polymers for injection molding of absorbable surgical devices
FR2537980B1 (fr) * 1982-12-17 1986-12-19 Sandoz Sa Derives d'acides hydroxycarboxyliques oligomeres, leur preparation et leur utilisation
US4470416A (en) * 1983-06-17 1984-09-11 Ethicon, Inc. Copolymers of lactide and/or glycolide with 1,5-dioxepan-2-one
CH656884A5 (de) * 1983-08-26 1986-07-31 Sandoz Ag Polyolester, deren herstellung und verwendung.
US4594407A (en) * 1983-09-20 1986-06-10 Allied Corporation Prosthetic devices derived from krebs-cycle dicarboxylic acids and diols
JPS60100516A (ja) * 1983-11-04 1985-06-04 Takeda Chem Ind Ltd 徐放型マイクロカプセルの製造法
ATE142236T1 (de) * 1984-03-06 1996-09-15 United States Surgical Corp Ein verfahren zur herstellung von zwei-phasen- zusammensetzungen für absorbierbare chirurgische ausrüstungen
US4649042A (en) * 1984-05-31 1987-03-10 Eli Lilly And Company Rumen delivery device
JPH0678425B2 (ja) * 1984-07-06 1994-10-05 和光純薬工業株式会社 重合体の新規製造法
CA1256638A (fr) * 1984-07-06 1989-06-27 Motoaki Tanaka Polymere, et sa production
DE3428640A1 (de) * 1984-08-03 1986-02-06 Akzo Gmbh, 5600 Wuppertal Mikroporoese, pulverfoermige polylactide
US4595713A (en) * 1985-01-22 1986-06-17 Hexcel Corporation Medical putty for tissue augmentation
DE3678308D1 (de) * 1985-02-07 1991-05-02 Takeda Chemical Industries Ltd Verfahren zur herstellung von mikrokapseln.
JP2551756B2 (ja) * 1985-05-07 1996-11-06 武田薬品工業株式会社 ポリオキシカルボン酸エステルおよびその製造法
US5618547A (en) * 1985-05-20 1997-04-08 British Technology Group Limited Control of ectoparasites
JPH0610252B2 (ja) * 1985-08-21 1994-02-09 和光純薬工業株式会社 重合体の製造法
US5061281A (en) * 1985-12-17 1991-10-29 Allied-Signal Inc. Bioresorbable polymers and implantation devices thereof
GB8609537D0 (en) * 1986-04-18 1986-05-21 Ici Plc Polyesters
US4744365A (en) * 1986-07-17 1988-05-17 United States Surgical Corporation Two-phase compositions for absorbable surgical devices
DE3641692A1 (de) * 1986-12-06 1988-06-09 Boehringer Ingelheim Kg Katalysatorfreie resorbierbare homopolymere und copolymere
SE8701479L (sv) * 1987-04-09 1988-10-10 Carbomatrix Ab Metod foer inneslutning av biologiskt verksamma preparat samt anvaendning daerav
US4804691A (en) * 1987-08-28 1989-02-14 Richards Medical Company Method for making a biodegradable adhesive for soft living tissue
OA09249A (fr) * 1988-12-19 1992-06-30 Lilly Co Eli Composés de macrolides.
JP2986509B2 (ja) * 1989-05-26 1999-12-06 三井化学株式会社 変性ポリエステル樹脂組成物、その製造方法、およびその用途
DE4005415C2 (de) * 1990-02-21 1996-04-11 Boehringer Ingelheim Kg Verfahren zum Herstellen von Polyestern auf der Basis von Hydroxycarbonsäuren
US5302694A (en) * 1990-02-21 1994-04-12 Boehringer Ingelheim Gmbh Process for preparing polyesters based on hydroxycarboxylic acids
DE69129770T2 (de) * 1990-04-13 1998-11-19 Takeda Chemical Industries Ltd Biologisch abbaubare hochmolekulare Polymere, ihre Herstellung und ihre Verwendung
MY108621A (en) * 1990-08-01 1996-10-31 Novartis Ag Polylactide preparation and purification
US6353030B1 (en) * 1990-08-01 2002-03-05 Novartis Ag Relating to organic compounds
US5108422A (en) * 1990-10-22 1992-04-28 United States Surgical Corporation Skin fastener
US5593423A (en) * 1990-10-22 1997-01-14 United States Surgical Corporation Skin fastener
US5320624A (en) * 1991-02-12 1994-06-14 United States Surgical Corporation Blends of glycolide and/or lactide polymers and caprolactone and/or trimethylene carbonate polymers and absorbable surgical devices made therefrom
US6228954B1 (en) 1991-02-12 2001-05-08 United States Surgical Corporation Blends of glycolide and/or lactide polymers and caprolactone and/or trimethylene carbonate polymers and absorabable surgical devices made therefrom
IT1249045B (it) * 1991-02-21 1995-02-11 Himont Inc Processo per la sintesi allo stato solido di polimeri dell'acido lattico e prodotti cosi ottenuti
US5232648A (en) * 1991-07-19 1993-08-03 United States Surgical Corporation Bioabsorbable melt spun fiber based on glycolide-containing copolymer
US5206341A (en) * 1991-11-21 1993-04-27 Southern Research Institute Polymers from hydroxy acids and polycarboxylic acids
ES2139646T3 (es) * 1991-12-19 2000-02-16 Mitsui Chemicals Inc Acido polihidroxido carboxilico y su procedimiento de obtencion.
US5258488A (en) * 1992-01-24 1993-11-02 Cargill, Incorporated Continuous process for manufacture of lactide polymers with controlled optical purity
US6326458B1 (en) 1992-01-24 2001-12-04 Cargill, Inc. Continuous process for the manufacture of lactide and lactide polymers
US6005067A (en) * 1992-01-24 1999-12-21 Cargill Incorporated Continuous process for manufacture of lactide polymers with controlled optical purity
US5247059A (en) * 1992-01-24 1993-09-21 Cargill, Incorporated Continuous process for the manufacture of a purified lactide from esters of lactic acid
US5247058A (en) * 1992-01-24 1993-09-21 Cargill, Incorporated Continuous process for manufacture of lactide polymers with controlled optical purity
US5142023A (en) * 1992-01-24 1992-08-25 Cargill, Incorporated Continuous process for manufacture of lactide polymers with controlled optical purity
US5338822A (en) * 1992-10-02 1994-08-16 Cargill, Incorporated Melt-stable lactide polymer composition and process for manufacture thereof
DE69330046T2 (de) * 1992-10-02 2001-11-15 Cargill, Inc. Schmelzstabiles lactidpolymergewebe und verfahren zu seiner herstellung
NZ256978A (en) * 1992-10-02 1996-05-28 Cargill Inc Paper product coated with a poly(lactide) composition comprising no more than 5 wt % lactide monomer, the poly(lactide) having a number average mw of 10,000 to 200,000
US6005068A (en) 1992-10-02 1999-12-21 Cargill Incorporated Melt-stable amorphous lactide polymer film and process for manufacture thereof
US5591606A (en) * 1992-11-06 1997-01-07 Dowelanco Process for the production of A83543 compounds with Saccharopolyspora spinosa
TW333456B (en) * 1992-12-07 1998-06-11 Takeda Pharm Ind Co Ltd A pharmaceutical composition of sustained-release preparation the invention relates to a pharmaceutical composition of sustained-release preparation which comprises a physiologically active peptide.
US5444143A (en) * 1992-12-25 1995-08-22 Mitsui Toatsu Chemicals, Inc. Preparation process of polyhydroxycarboxylic acid
WO1994020518A1 (fr) * 1993-03-12 1994-09-15 Dowelanco Nouveaux composes a83543 et procede de production desdits composes
KR970002523B1 (en) * 1993-04-24 1997-03-05 Korea Inst Sci & Tech Biodegradable polylactic acid having improved properties and method for manufacturing the same
US5522841A (en) * 1993-05-27 1996-06-04 United States Surgical Corporation Absorbable block copolymers and surgical articles fabricated therefrom
US5403347A (en) * 1993-05-27 1995-04-04 United States Surgical Corporation Absorbable block copolymers and surgical articles fabricated therefrom
WO1995010577A1 (fr) 1993-10-15 1995-04-20 H.B. Fuller Licensing & Financing Inc. Adhesifs thermofusibles biodegradables/recyclables en compost constitues de polyester d'acide lactique
US5431679A (en) * 1994-03-10 1995-07-11 United States Surgical Corporation Absorbable block copolymers and surgical articles fabricated therefrom
US5543202A (en) * 1994-03-14 1996-08-06 Kimberly-Clark Corporation Process for producing a crimp-bonded fibrous cellulosic laminate
CN1058736C (zh) * 1994-05-27 2000-11-22 北京市星辰现代控制工程研究所 生物降解组合物及其制备方法和应用
US5578662A (en) 1994-07-22 1996-11-26 United States Surgical Corporation Bioabsorbable branched polymers containing units derived from dioxanone and medical/surgical devices manufactured therefrom
US6339130B1 (en) * 1994-07-22 2002-01-15 United States Surgical Corporation Bioabsorbable branched polymers containing units derived from dioxanone and medical/surgical devices manufactured therefrom
US6206908B1 (en) 1994-09-16 2001-03-27 United States Surgical Corporation Absorbable polymer and surgical articles fabricated therefrom
CA2158420C (fr) 1994-09-16 2007-05-01 Mark S. Roby Polymeres absorbables et articles chirurgicaux fabriques a partir de ceux-ci
US5618313A (en) * 1994-10-11 1997-04-08 United States Surgical Corporation Absorbable polymer and surgical articles fabricated therefrom
US5770683A (en) 1994-11-02 1998-06-23 Mitsui Toatsu Chemicals, Inc. Preparation process of polyhydroxycarboxylic acid
US5997568A (en) * 1996-01-19 1999-12-07 United States Surgical Corporation Absorbable polymer blends and surgical articles fabricated therefrom
US6001981A (en) * 1996-06-13 1999-12-14 Dow Agrosciences Llc Synthetic modification of Spinosyn compounds
US5756651A (en) * 1996-07-17 1998-05-26 Chronopol, Inc. Impact modified polylactide
US6191236B1 (en) 1996-10-11 2001-02-20 United States Surgical Corporation Bioabsorbable suture and method of its manufacture
US6007565A (en) * 1997-09-05 1999-12-28 United States Surgical Absorbable block copolymers and surgical articles fabricated therefrom
US6277927B1 (en) 1997-11-26 2001-08-21 United States Surgical Corporation Absorbable block copolymers and surgical articles fabricated therefrom
JPH11203837A (ja) 1998-01-16 1999-07-30 Sony Corp 編集システムおよび編集方法
AR023940A1 (es) 2000-05-03 2002-09-04 Eriochem Sa Procedimiento para la produccion de microcapsulas de liberacion prolongada de peptidos solubles en agua
CN1269870C (zh) * 2000-08-07 2006-08-16 和光纯药工业株式会社 乳酸聚合物及其制备方法
AU2001290515B2 (en) 2000-08-16 2007-02-01 Covidien Lp High consistency absorbable polymeric resin
TWI332407B (en) * 2001-06-29 2010-11-01 Takeda Chemical Industries Ltd Controlled release composition and method of producting the same
JP4612239B2 (ja) * 2001-07-18 2011-01-12 三井化学株式会社 生体吸収性ポリヒドロキシカルボン酸の製造方法
US7163545B2 (en) * 2002-07-29 2007-01-16 Mayo Foundation For Medical Education And Research Spinal cord surgical implant
KR100684682B1 (ko) * 2002-09-24 2007-02-22 아사히 가세이 케미칼즈 가부시키가이샤 글리콜산 공중합체 및 그의 제조 방법
EP1440992A1 (fr) * 2003-01-21 2004-07-28 Société de Conseils de Recherches et d'Applications Scientifiques ( S.C.R.A.S.) Système catalytique de (co)polymérisation du lactide et du glycolide
FR2867698B1 (fr) * 2004-03-16 2007-11-16 Beaufour Ipsen S C R A S Systeme catalttique de (co) oligomerisation du lactide et du glycolide
WO2005105908A1 (fr) * 2004-04-28 2005-11-10 Keio University Procédé de dépolymérisation de polymère ayant un lien d'ester dans la chaine principale et procédé pour produire le polymere ayant le lien d'ester dans la chaine princpale depuis le produit de dépolymérisation
MX2009006653A (es) 2006-12-18 2009-07-02 Takeda Pharmaceutical Composicion de liberacion prolongada y metodo para producirla.
CN101284883B (zh) * 2008-05-14 2011-02-16 西北大学 聚乳酸-壳聚糖接枝共聚物的制备方法
RU2404198C2 (ru) * 2008-11-12 2010-11-20 Федеральное государственное унитарное предприятие "Ордена Трудового Красного Знамени Научно-исследовательский физико-химический институт имени Л.Я. Карпова" Способ получения сополимеров стирола с молочной кислотой
CN103300120B (zh) * 2013-06-25 2015-04-22 南京工业大学 一种绿色家禽家畜脱毛剂及其制备方法
IL272809B2 (en) 2017-08-31 2025-05-01 Evonik Corp Improved resorbable polymer purification process

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2362511A (en) * 1939-11-21 1944-11-14 Du Pont Modified glycolide resins
US2703316A (en) * 1951-06-05 1955-03-01 Du Pont Polymers of high melting lactide
US2758987A (en) * 1952-06-05 1956-08-14 Du Pont Optically active homopolymers containing but one antipodal species of an alpha-monohydroxy monocarboxylic acid
US3268487A (en) * 1963-12-23 1966-08-23 Shell Oil Co Process for polymerization of lactides
US3535419A (en) * 1965-12-15 1970-10-20 Syntex Corp Veterinary compositions and methods
US3442871A (en) * 1966-05-04 1969-05-06 American Cyanamid Co Process for polymerizing a glycolide
US3458622A (en) * 1967-04-07 1969-07-29 Squibb & Sons Inc Controlled release tablet
US3887699A (en) * 1969-03-24 1975-06-03 Seymour Yolles Biodegradable polymeric article for dispensing drugs
US3773919A (en) * 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
BE758156R (fr) * 1970-05-13 1971-04-28 Ethicon Inc Element de suture absorbable et sa
US3736646A (en) * 1971-10-18 1973-06-05 American Cyanamid Co Method of attaching surgical needles to multifilament polyglycolic acid absorbable sutures
US3839297A (en) * 1971-11-22 1974-10-01 Ethicon Inc Use of stannous octoate catalyst in the manufacture of l(-)lactide-glycolide copolymer sutures
US3982543A (en) * 1973-04-24 1976-09-28 American Cyanamid Company Reducing capillarity of polyglycolic acid sutures
US3991766A (en) * 1973-05-31 1976-11-16 American Cyanamid Company Controlled release of medicaments using polymers from glycolic acid
US4144317A (en) * 1975-05-30 1979-03-13 Alza Corporation Device consisting of copolymer having acetoxy groups for delivering drugs
US4011312A (en) * 1975-06-25 1977-03-08 American Home Products Corporation Prolonged release drug form for the treatment of bovine mastitis
US4010196A (en) * 1975-06-25 1977-03-01 American Home Products Corporation Linear polyester salts
ZA782039B (en) * 1977-05-23 1979-09-26 American Cyanamid Co Surgical articles

Also Published As

Publication number Publication date
AR221173A1 (es) 1980-12-30
GT198065361A (es) 1982-03-04
FI802840A7 (fi) 1981-03-13
PT71794A (en) 1980-10-01
AU6216680A (en) 1981-03-19
NZ194902A (en) 1983-05-31
DK155093C (da) 1989-06-19
HU191807B (en) 1987-04-28
IE801902L (en) 1981-03-12
IE50236B1 (en) 1986-03-05
ES494974A0 (es) 1981-08-16
EP0026599A1 (fr) 1981-04-08
ES8106542A1 (es) 1981-08-16
CS221979B2 (en) 1983-04-29
RO80864A (fr) 1983-02-01
JPH0198617A (ja) 1989-04-17
DK155093B (da) 1989-02-06
FR2464973A1 (fr) 1981-03-20
DE3068116D1 (en) 1984-07-12
IL61024A0 (en) 1980-11-30
IT8024607A0 (it) 1980-09-11
JPS5645920A (en) 1981-04-25
GB2058808B (en) 1983-11-16
JPH0445525B2 (fr) 1992-07-27
AU539130B2 (en) 1984-09-13
PL129779B1 (en) 1984-06-30
FR2464973B1 (fr) 1983-06-10
IT1141040B (it) 1986-10-01
CH648048A5 (fr) 1985-02-28
EP0026599B1 (fr) 1984-06-06
EG14381A (en) 1983-12-31
GB2058808A (en) 1981-04-15
DK387380A (da) 1981-03-13
DD153125A5 (de) 1981-12-23
FI66412B (fi) 1984-06-29
AT380689B (de) 1986-06-25
FI66412C (fi) 1984-10-10
GR69961B (fr) 1982-07-22
ZA805629B (en) 1982-04-28
PL226653A1 (fr) 1981-10-16
JPH0121166B2 (fr) 1989-04-20
IL61024A (en) 1983-02-23
US4273920A (en) 1981-06-16
PT71794B (en) 1981-07-07
ATA455380A (de) 1985-11-15
BG41132A3 (bg) 1987-04-15
CA1185048A (fr) 1985-04-02
PH15272A (en) 1982-11-02

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Date Code Title Description
RE Patent lapsed

Owner name: ELI LILLY AND CY

Effective date: 19950930